Pathophysiology
Parainfluenza virus-specific IgE responses were observed earlier and were more pronounced in patients with croup and wheezing compared to those with upper respiratory illness [PMID:6183418].
Clinical Presentation
Histamine was significantly more often detectable in nasopharyngeal secretions of patients with croup compared to those with upper respiratory illness due to parainfluenza virus [PMID:6183418].
Diagnosis
The presence of parainfluenza virus-specific IgE antibodies in nasopharyngeal secretions can differentiate severe respiratory conditions like croup and wheezing from milder upper respiratory illnesses [PMID:6183418].
References
1 Welliver RC, Wong DT, Middleton E, Sun M, McCarthy N, Ogra PL. Role of parainfluenza virus-specific IgE in pathogenesis of croup and wheezing subsequent to infection. The Journal of pediatrics 1982. link80005-x)
1 papers cited of 3 indexed.