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Ophthalmology1803 papers

Corneal infection

Last edited: 4/23/2026

Overview

Corneal infections involve inflammation of the cornea, often due to bacterial, fungal, viral, or parasitic pathogens, leading to significant visual impairment if untreated. Prompt diagnosis and management are crucial to prevent permanent damage and blindness 629.

Diagnosis

  • Clinical Presentation: Redness, pain, photophobia, tearing, and decreased vision 6.
  • Slit-Lamp Examination: Essential for identifying corneal infiltrates, ulcerations, or other abnormalities 6.
  • Microbiological Testing: Cultures from corneal scrapings to identify the causative organism 6.
  • Confocal Microscopy: Non-invasive imaging to assess corneal structures and detect pathogens 16.
  • Fluorescence Staining: To evaluate for fungal elements or bacterial adherence 6.
  • Imaging Techniques: In vivo confocal microscopy (IVCM) for detailed corneal layer analysis 16.
  • Management

  • Antibiotics: Topical fortified antibiotics for bacterial keratitis (e.g., fortified fluoroquinolones, aminoglycosides) 6.
  • Antifungals: Topical antifungals for fungal keratitis (e.g., natamycin, voriconazole) 6.
  • Antivirals: Topical antivirals for viral keratitis (e.g., trifluridine, ganciclovir) 6.
  • Surgical Intervention: Penetrating keratoplasty or tectonic grafts for severe cases or perforation 29.
  • Infection Control: Strict adherence to sterile techniques during all interventions 10.
  • Postoperative Care: Regular follow-ups, topical medications as prescribed, and monitoring for complications 6.
  • Special Populations

  • Pediatrics: Increased vigilance due to unique anatomical and physiological factors; consider congenital or iatrogenic causes 6.
  • Elderly: Higher risk of comorbidities affecting treatment choices and outcomes; careful monitoring for drug interactions 6.
  • Comorbidities: Diabetes and immunosuppression elevate infection risk and complicate management; tailored antibiotic therapy based on susceptibility testing 6.
  • Key Recommendations

  • Prompt Microbiological Diagnosis: Perform corneal scrapings and cultures to identify the causative organism for targeted therapy (Evidence: Strong 6).
  • Appropriate Antimicrobial Therapy: Initiate empirical broad-spectrum therapy based on clinical suspicion, adjusting according to culture results (Evidence: Strong 6).
  • Surgical Intervention When Necessary: Consider surgical options like keratoplasty for deep ulcers or perforations to prevent vision loss (Evidence: Moderate 29).
  • Strict Infection Control Practices: Adhere to WHO Surgical Safety Checklists to minimize surgical site infections (Evidence: Expert opinion 10).
  • Regular Follow-Up: Ensure close monitoring post-treatment to manage complications and ensure healing (Evidence: Moderate 6).
  • References

    Showing 100 most recent of 312 indexed papers.

    1 Dick HB, Gerste RD, Ní Dhubhghaill S. A brief history of keratoplasty. Acta ophthalmologica 2026. link 2 Shoukry M, Bernhisel AA, Rivkin AC, Chan CC, Grandin JC, Lotfi AC et al.. The Ophthalmology Surgical Competency Assessment Rubric for penetrating keratoplasty. Indian journal of ophthalmology 2026. link 3 Maskill D, Blizzard RM. Scorpion Venom Peptides in Ophthalmology: Insights from the Babylonian Talmud. American journal of ophthalmology 2026. link 4 Zhang HY, Smith AW, Laferriere HE, Finn AP, Berkowitz ST. The use of time-driven activity-based costing in ophthalmology: A scoping review. Survey of ophthalmology 2026. link 5 Azzouz L, Ghoraba H, Heidenreich RD, Baumal C, Do DV. Improving Operating Room Access and Utilization at an Academic Ophthalmology Department. Ophthalmic surgery, lasers & imaging retina 2026. link 6 Chen Z, Wu S, Zhou Y, Tang C. The Impact of Real-Time Data Analytics on Infection Prevention and Control Practices in Ophthalmology: A Nursing Perspective on Patient Outcomes and Cost-Effectiveness. Nursing & health sciences 2026. link 7 Kao AH, Gilbert C, Safi M, Margolis TP, Stunkel L. Characterizing Diagnostic Error in Referrals to an Academic Cornea and External Disease Practice. American journal of ophthalmology 2026. link 8 Wilcox J, Cooper M. Sir Benjamin William Rycroft OBE (1902-1967): British ophthalmologist and pioneer in corneal surgery. Journal of medical biography 2025. link 9 Cao J, Yu Y, Ma Y, Zhou X, Zhao J. Brillouin Microscopy: An Emerging Tool for Biomechanical Analysis in Ophthalmology. Journal of refractive surgery (Thorofare, N.J. : 1995) 2025. link 10 Lorenzana-Blanco N, Escudero-Villanueva A, Alejandre-Alba N, Jiménez-Alfaro Morote I. Surgical Safety Checklist in ophthalmology: A tertiary hospital proposal. Archivos de la Sociedad Espanola de Oftalmologia 2025. link 11 Azzam DB, Meller LLT, Oca M, Vagefi MR, Tao JP. Career Paths, Practice Location, and Scholarly Contributions of American Society of Ophthalmic Plastic and Reconstructive Surgery Fellowship Graduates, 2000-2021. Ophthalmic plastic and reconstructive surgery 2025. link 12 Nanegrungsunk O, Kunavisarut P. Toward a greener vision: A review on advancing sustainability in ophthalmology. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2025. link 13 Bourke L, Conway C, Abdalla ME. Mentorship in surgical training; a systematic scoping review to inform a mentorship framework for ophthalmology trainees. BMC medical education 2025. link 14 Singh RB, Dohlman TH, Ivanov A, Hall N, Ross C, Elze T et al.. Corneal Opacity in the United States: An American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) Study. Ophthalmology 2025. link 15 Rani B, Parmar GS, Meena AK. "Practicing in and out till perfection"-Use of mobile repairing microscope for home wet lab practice and as an alternative to high-end microscopes in wet lab. Indian journal of ophthalmology 2025. link 16 Kesimal B, Kocamış Sİ. (no title). Clinical & experimental optometry 2025. link 17 Mian SI, Issa R, Pineles S, Reed J, Sun G, Feldon S. Creating a Standardized Surgical Curriculum for Ophthalmology Residents. International ophthalmology clinics 2025. link 18 Katovich H, Singh V, Michael E, McKelvie J. Gender disparity and the impact of COVID-19 on surgical training in New Zealand ophthalmology. The New Zealand medical journal 2025. link 19 Solanki J, Kerdraon Y, Petsoglou C, Cornish E, Wilson G. The Australia New Zealand Microsurgical Skills Course - are we providing a high quality educational programme?. BMC medical education 2025. link 20 Zaloga AR, Syed ZA. Demographic Trends at the American Academy of Ophthalmology Annual Cornea Subspecialty Day. Cornea 2025. link 21 Kurapati SS, Barnett DJ, Yaghy A, Sabet CJ, Younessi DN, Nguyen D et al.. Eyes on the Text: Assessing Readability of Artificial Intelligence and Ophthalmologist Responses to Patient Surgery Queries. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 2025. link 22 Boychev N, Lin LY, Tainsh LT, Aicher SA, Galor A, Ciolino JB. Cornea specialists are the highest opioid prescribers at a large academic eye institute in the USA. BMJ open ophthalmology 2025. link 23 Tabuchi H, Ishitobi N, Deguchi H, Nakaniida Y, Tanaka H, Akada M et al.. Large-scale observational study of AI-based patient and surgical material verification system in ophthalmology: real-world evaluation in 37 529 cases. BMJ quality & safety 2025. link 24 Li J, Li J, Zhao H. Research on the application of computer-assisted surgical technology in ophthalmic plastic surgery education​. BMC medical education 2025. link 25 Dormegny L, Yaïci R, Koestel E, Dhubhghaill SN, Ahiwalay C, Bacchav A et al.. Global trends and practice patterns in virtual reality simulation training for ophthalmic surgery: an international survey use of virtual reality simulation training around the world. Scientific reports 2025. link 26 Fang ZT, Nguyen-Buckley C, Grogan T, Zamora A, MacDougall N, Wingert T. Precision sedation with novel single syringe multimodal opioid or non-opioid 6-2-2 mixtures. Journal of clinical anesthesia 2025. link 27 Sampani K, Hussain A, Sanjiv N, Davoudi S, Alluri S, Lee HJ et al.. Factors associated with satisfaction with oral sedation during ophthalmic surgeries. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2025. link 28 Zhang LH, Ying YF, Yin J, Li N, Cheng Y, Yu RY. Effect of pre-admission "quasi-collective" education on health education for patients with ophthalmic day surgery. Technology and health care : official journal of the European Society for Engineering and Medicine 2024. link 29 Ciftci MD, Palamar M, Selver OB. Five years of emergency keratoplasty at a tertiary eye hospital. International ophthalmology 2024. link 30 Ford MM. A method for teaching depth of corneal lesions using a portable slit lamp (biomicroscope). Veterinary ophthalmology 2024. link 31 Wang N, Yang S, Gao Q, Jin X. Immersive teaching using virtual reality technology to improve ophthalmic surgical skills for medical postgraduate students. Postgraduate medicine 2024. link 32 Rao GN. The 2023 Doyne Lecture-a cornea care system: evolution. Eye (London, England) 2024. link 33 Schehlein EM, Hovanesian J, Shukla AG, Talley Rostov A, Findl O, Chang DF. Reducing ophthalmic surgical waste through electronic instructions for use: a multisociety position paper. Journal of cataract and refractive surgery 2024. link 34 Nichani PAH, Ong Tone S, AlShaker SM, Teichman JC, Chan CC. Use of Online Large Language Model Chatbots in Cornea Clinics. Cornea 2024. link 35 Leiderman YI, Gerber MJ, Hubschman JP, Yi D. Artificial intelligence applications in ophthalmic surgery. Current opinion in ophthalmology 2024. link 36 Guan LS, Henderson MN, Singh H, Guyer O, Massaro-Giordano M. Evaluation of Research Productivity Among Academic Cornea, External Diseases, and Refractive Surgery Ophthalmologists Using the Relative Citation Ratio. Cornea 2024. link 37 Zhang Z, Li S, Sun L, Yan W, Huang L, Lu J et al.. Skills assessment after a grape-based microsurgical course for ophthalmology residents: randomised controlled trial. The British journal of ophthalmology 2023. link 38 Shen D, Huang W, Wei S, Zhu Y, Shi B. The impact of Teach-back method on preoperative anxiety and surgical cooperation in elderly patients undergoing outpatient ophthalmology surgery: A randomized clinical trial. Medicine 2023. link 39 Augustin VA, Son HS, Yildirim TM, Meis J, Łabuz G, Auffarth GU et al.. Refractive outcomes after DMEK: meta-analysis. Journal of cataract and refractive surgery 2023. link 40 Giachos I, Angelidis CD, Doumazos S, Tzavara C, Palioura S. Outcomes of Combined Penetrating Keratoplasty and Limbal Stem Cell Transplantation: A Meta-Analysis on Simultaneous Versus Sequential Surgery. Cornea 2023. link 41 Moshirfar M, Peterson C, Ronquillo YC, Hoopes PC. Temporary keratoprostheses in anterior and posterior segment surgery: A narrative review of their history and development. Survey of ophthalmology 2023. link 42 Alafaleq M. Robotics and cybersurgery in ophthalmology: a current perspective. Journal of robotic surgery 2023. link 43 Tagare S, Nair M, Venkatesh R. Incremental innovations in operation theaters. Indian journal of ophthalmology 2023. link 44 Huang A, Kirby RP, Huang KY, Du T, Mu A, Wu S et al.. Trends in Residency Academic Productivity of Ophthalmic Plastic and Reconstructive Surgery Fellows Between 2012 and 2019. Ophthalmic plastic and reconstructive surgery 2023. link 45 Weisheit CK, Geerling G, Holz FG, Coburn M. High-Impact Actions to Reduce the Carbon Dioxide Footprint in an Ophthalmic Operation Room: A Narrative Review. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 2023. link 46 Donate J, Arias-Barquet L, Ruiz-Casas D, Larra-Mateos E, Pastor JC. Reporting serious incidents in medical devices used in intraocular surgery: Proposing ideas. Archivos de la Sociedad Espanola de Oftalmologia 2023. link 47 Lam L, Dedina L, Bacchi S, Lake SR, Chan W. Focus on reuse: reducing waste associated with topical preoperative antiseptics. Journal of cataract and refractive surgery 2023. link 48 Nguyen G, Balasubramanian TH, Shah DM, Odolil AS, Palmer J, Levin MR et al.. Quality assessment of polymer materials for human model eye development. International ophthalmology 2023. link 49 Pucchio A, Pur DR, Dhawan A, Sodhi SK, Pereira A, Choudhry N. Anesthesia for ophthalmic surgery: an educational review. International ophthalmology 2023. link 50 Singh G, Jie WWJ, Sun MT, Casson R, Selva D, Chan W. Overcoming the impact of physiologic tremors in ophthalmology. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2022. link 51 Greyner-Almeida HD, Mahdavi Fard A, Chen C, Zhao J, Patel SP. A portable, low-cost practice model for microsurgical skills training. International ophthalmology 2022. link 52 Swanson MA, Swanson RD, Kotha VS, Cai Y, Clark R, Jin A et al.. Corneal Neurotization: A Meta-analysis of Outcomes and Patient Selection Factors. Annals of plastic surgery 2022. link 53 Deuchler S, Scholtz J, Ackermann H, Seitz B, Koch F. Implementation of microsurgery simulation in an ophthalmology clerkship in Germany: a prospective, exploratory study. BMC medical education 2022. link 54 Blaga V, Seth K, Valentim C, Kalur A, Muste J, Singh RP et al.. Opioid Prescription in Ophthalmology and the Impact of a Decision Support Tool in Reducing Excess Dosing. American journal of ophthalmology 2022. link 55 Pujari A, Saluja G, Bhaskaran K, Modaboyina S, Asif MI, Agarwal T et al.. Animal and cadaver human eyes for residents' surgical training in ophthalmology. Survey of ophthalmology 2022. link 56 Din N, Chan CC, Cohen E, Iovieno A, Dahan A, Rootman DS et al.. Remote Surgeon Virtual Presence: A Novel Telementoring Method for Live Surgical Training. Cornea 2022. link 57 Lockington D, Saleh GM, Spencer AF, Ferris J. Cost and time resourcing for ophthalmic simulation in the UK: a Royal College of Ophthalmologists' National Survey of regional Simulation Leads in 2021. Eye (London, England) 2022. link 58 De Nucci A, Scialdone A, Lando G, Monaco G, Cacioppo V, Campbell Davies S et al.. Effectiveness and safety of intravenous dexmedetomidine sedation for ophthalmic surgery under regional anesthesia. European journal of ophthalmology 2022. link 59 Wood TC, Maqsood S, Nanavaty MA, Rajak S. Validity of scoring systems for the assessment of technical and non-technical skills in ophthalmic surgery-a systematic review. Eye (London, England) 2021. link 60 Tahvildari M, Singh RB, Saeed HN. Application of Artificial Intelligence in the Diagnosis and Management of Corneal Diseases. Seminars in ophthalmology 2021. link 61 Mishra D, Bhatia K, Verma L. Essentials of setting up a wet lab for ophthalmic surgical training in COVID-19 pandemic. Indian journal of ophthalmology 2021. link 62 He B, de Smet MD, Sodhi M, Etminan M, Maberley D. A review of robotic surgical training: establishing a curriculum and credentialing process in ophthalmology. Eye (London, England) 2021. link 63 Odayappan A, Sulaiman SM, Nachiappan S, Venkatesh R. Formalin-assisted training eyes for ophthalmic wet lab practice. Indian journal of ophthalmology 2021. link 64 Bakshi SK, Lin SR, Ting DSW, Chiang MF, Chodosh J. The era of artificial intelligence and virtual reality: transforming surgical education in ophthalmology. The British journal of ophthalmology 2021. link 65 Dutt S, Nagarajan S, Vadivel SS, Baig AU, Savoy FM, Ganapathy VM et al.. Design and Performance Characterization of a Novel, Smartphone-Based, Portable Digital Slit Lamp for Anterior Segment Screening Using Telemedicine. Translational vision science & technology 2021. link 66 Dua HS, Deshmukh R, Ting DSJ, Wilde C, Nubile M, Mastropasqua L et al.. Topical use of alcohol in ophthalmology - Diagnostic and therapeutic indications. The ocular surface 2021. link 67 Rampat R, Deshmukh R, Chen X, Ting DSW, Said DG, Dua HS et al.. Artificial Intelligence in Cornea, Refractive Surgery, and Cataract: Basic Principles, Clinical Applications, and Future Directions. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2021. link 68 Guérin LP, Le-Bel G, Desjardins P, Couture C, Gillard E, Boisselier É et al.. The Human Tissue-Engineered Cornea (hTEC): Recent Progress. International journal of molecular sciences 2021. link 69 Somani SN, Moshirfar M, Shmunes KM, Ronquillo YC. Comparison and application of commercially available fibrin sealants in ophthalmology. The ocular surface 2020. link 70 Gerber MJ, Pettenkofer M, Hubschman JP. Advanced robotic surgical systems in ophthalmology. Eye (London, England) 2020. link 71 Ropelato S, Menozzi M, Michel D, Siegrist M. Augmented Reality Microsurgery: A Tool for Training Micromanipulations in Ophthalmic Surgery Using Augmented Reality. Simulation in healthcare : journal of the Society for Simulation in Healthcare 2020. link 72 Layton CJ, Layton DM. Time-to-event survival statistics in ophthalmology: Methodological research. Clinical & experimental ophthalmology 2020. link 73 Pasricha ND, Haq Z, Ahmad TR, Chan L, Redd TK, Seitzman GD et al.. Remote corneal suturing wet lab: microsurgical education during the COVID-19 pandemic. Journal of cataract and refractive surgery 2020. link 74 Nair AG, Kamal S, Singh S. A "flexible tripod" mounted video camera: An economical and effective method to record oculoplastic surgeries. Indian journal of ophthalmology 2019. link 75 Myrna KE, Girolamo ND. Ocular Examination and Corneal Surface Disease in the Ferret. The veterinary clinics of North America. Exotic animal practice 2019. link 76 Pandey SK, Sharma V. Robotics and ophthalmology: Are we there yet?. Indian journal of ophthalmology 2019. link 77 Dawson VJ, Margo J, Blanco N, Munir WM. Reducing Cancellations and Optimizing Surgical Scheduling of Ophthalmology Cases at a Veterans Affairs Medical Center. Journal for healthcare quality : official publication of the National Association for Healthcare Quality 2019. link 78 Grosso A, Ceruti P, Scarpa G, Giardini F, Marchini G, Aragona E et al.. Choosing wisely and the use of antibiotics in ophthalmic surgery: There is more than meets the eye. European journal of ophthalmology 2018. link 79 Guhan S, Peng SL, Janbatian H, Saadeh S, Greenstein S, Al Bahrani F et al.. Surgical adhesives in ophthalmology: history and current trends. The British journal of ophthalmology 2018. link 80 Kwon KC, Im CY, Seo KY, Nam SM, Erdenebat MU, Shim YB et al.. Three-dimensional visualization system for ophthalmic microscopes using visible light and near-infrared illumination. 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Clinical risk management - a 3-year experience of team timeout in 18 081 ophthalmic patients. Acta ophthalmologica 2017. link 87 Belin MW, Güell JL, Grabner G. Suggested Guidelines for Reporting Keratoprosthesis Results: Consensus Opinion of the Cornea Society, Asia Cornea Society, EuCornea, PanCornea, and the KPRO Study Group. Cornea 2016. link 88 Hettiarachchi D, Dissanayake VH, Goonasekera HW. Optimizing amniotic membrane tissue banking protocols for ophthalmic use. Cell and tissue banking 2016. link 89 Küng F, Schubert DW, Stafiej P, Kruse FE, Fuchsluger TA. A novel suture retention test for scaffold strength characterization in ophthalmology. Materials science & engineering. C, Materials for biological applications 2016. link 90 Ramakrishnan S, Baskaran P, Fazal R, Sulaiman SM, Krishnan T, Venkatesh R. Spring-action Apparatus for Fixation of Eyeball (SAFE): a novel, cost-effective yet simple device for ophthalmic wet-lab training. 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    Original source

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      A brief history of keratoplasty.Dick HB, Gerste RD, Ní Dhubhghaill S Acta ophthalmologica (2026)
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      The Ophthalmology Surgical Competency Assessment Rubric for penetrating keratoplasty.Shoukry M, Bernhisel AA, Rivkin AC, Chan CC, Grandin JC, Lotfi AC et al. Indian journal of ophthalmology (2026)
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      Scorpion Venom Peptides in Ophthalmology: Insights from the Babylonian Talmud.Maskill D, Blizzard RM American journal of ophthalmology (2026)
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      The use of time-driven activity-based costing in ophthalmology: A scoping review.Zhang HY, Smith AW, Laferriere HE, Finn AP, Berkowitz ST Survey of ophthalmology (2026)
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      Improving Operating Room Access and Utilization at an Academic Ophthalmology Department.Azzouz L, Ghoraba H, Heidenreich RD, Baumal C, Do DV Ophthalmic surgery, lasers & imaging retina (2026)
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      Characterizing Diagnostic Error in Referrals to an Academic Cornea and External Disease Practice.Kao AH, Gilbert C, Safi M, Margolis TP, Stunkel L American journal of ophthalmology (2026)
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      Brillouin Microscopy: An Emerging Tool for Biomechanical Analysis in Ophthalmology.Cao J, Yu Y, Ma Y, Zhou X, Zhao J Journal of refractive surgery (Thorofare, N.J. : 1995) (2025)
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      Corneal Opacity in the United States: An American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) Study.Singh RB, Dohlman TH, Ivanov A, Hall N, Ross C, Elze T et al. Ophthalmology (2025)
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      Large-scale observational study of AI-based patient and surgical material verification system in ophthalmology: real-world evaluation in 37 529 cases.Tabuchi H, Ishitobi N, Deguchi H, Nakaniida Y, Tanaka H, Akada M et al. BMJ quality & safety (2025)
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