Overview
Local recurrence of prostate cancer refers to the reappearance of cancer in the prostate or surrounding tissues after initial treatment. This can occur after surgery, radiation, or other therapies. Management strategies aim to control or eliminate the recurrent disease.Diagnosis
No diagnostic criteria, recommended tests, or grading information were provided in the abstracts.Management
Salvage holmium laser enucleation of the prostate (HoLEP) is a potential re-treatment option after previous interventions, with comparable intraoperative parameters and improved postoperative outcomes to primary HoLEP 1.
Focal therapy, using modalities such as high-intensity focused ultrasound (HIFU), irreversible electroporation, cryoablation, and focal laser ablation, is a minimally invasive strategy for localized prostate cancer with promising functional and oncological outcomes 3.
HIFU studies reported a median of 95% pad-free patients and 85% with no clinically significant cancer 3.
A 12-week treatment regimen involving a specific dosage of an unspecified substance showed improvements in International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF-5) subscores in some groups 2.Special Populations
No information was provided regarding special populations.Key Recommendations
Salvage holmium laser enucleation of the prostate (HoLEP) is a feasible and safe re-treatment option, with postoperative outcomes comparable to primary HoLEP 1. (Evidence: Moderate)
Focal therapy, including HIFU, is a promising strategy for localized prostate cancer, demonstrating favorable functional and oncological outcomes 3. (Evidence: Moderate)
Further evaluation of specific treatment regimens, such as a 12-week course of an unspecified substance, may lead to improvements in lower urinary tract symptoms and erectile function 2. (Evidence: Moderate)References
1 Kallidonis P, Spinos T, Peteinaris A, Somani B, Liatsikos E. Salvage holmium laser enucleation of the prostate after previous interventions: a systematic review. BJU international 2024. link
2 Shin D, Zhu GQ, Tian WJ, Ahn ST, Jeon SH, Cho HJ et al.. (no title). Investigative and clinical urology 2023. link
3 Hopstaken JS, Bomers JGR, Sedelaar MJP, Valerio M, Fütterer JJ, Rovers MM. An Updated Systematic Review on Focal Therapy in Localized Prostate Cancer: What Has Changed over the Past 5 Years?. European urology 2022. link