Overview
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions characterized by diffuse alveolar damage, increased permeability, and pulmonary edema, often triggered by sepsis, trauma, or direct lung injury 1.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 253 indexed papers.
1 Evans CE, Behera SP, Zhang X, Machireddy N, Addisu KD, Phillips M et al.. The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial Alox15. Circulation research 2026. link 2 Gasciunas A, Barrabino B, Salim M, Teplisky D, Formia I, Sierre S et al.. Bleomycin-induced lung injury following intralesional sclerotherapy for vascular malformation. Archivos argentinos de pediatria 2026. link 3 Güneş A, Gürsoy Gürgen D, Kaplan AA, Keskin İ. Inhibition of pyroptosis by belnacasan: A potential strategy for mitigating acute lung injury and multiple organ dysfunction. Tissue & cell 2025. link 4 He Y, Zhang Y, Wu H, Luo J, Cheng C, Zhang H. The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats. Perfusion 2023. link 5 Vezzosi T, Domenech O, Croce M, Pesaresi M, Auriemma E, Romano F et al.. Fatal acute lung injury after balloon valvuloplasty in a dog with pulmonary stenosis. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 2022. link 6 Albaiceta GM, Brochard L, Dos Santos CC, Fernández R, Georgopoulos D, Girard T et al.. The central nervous system during lung injury and mechanical ventilation: a narrative review. British journal of anaesthesia 2021. link 7 Sherif IO, Al-Shaalan NH. Alleviation of remote lung injury following liver ischemia/reperfusion: Possible protective role of vildagliptin. International immunopharmacology 2021. link 8 Xia F, Chen H, Jin Z, Fu Z. Apelin-13 protects the lungs from ischemia-reperfusion injury by attenuating inflammatory and oxidative stress. Human & experimental toxicology 2021. link 9 Scultetus AH, Jefferson MA, Haque A, Hubbell JN, Arnaud FG, Moon-Massat P et al.. Histopathological Evidence of Multiple Organ Damage After Simulated Aeromedical Evacuation in a Swine Acute Lung Injury Model. Military medicine 2020. link 10 Gong LR, Kan YX, Lian Y, Dong SA, Zhao DH, Shi J et al.. Electroacupuncture Attenuates Limb Ischemia-Reperfusion-Induced Lung Injury Via p38 Mitogen-Activated Protein Kinase-Nuclear Factor Erythroid-2-Related Factor-2/Heme Oxygenase Pathway. The Journal of surgical research 2020. link 11 Kassab AA, Aboregela AM, Shalaby AM. Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2020. link 12 Magalhães CB, Casquilho NV, Machado MN, Riva DR, Travassos LH, Leal-Cardoso JH et al.. The anti-inflammatory and anti-oxidative actions of eugenol improve lipopolysaccharide-induced lung injury. Respiratory physiology & neurobiology 2019. link 13 Pao HP, Liao WI, Wu SY, Hung KY, Huang KL, Chu SJ. PG490-88, a derivative of triptolide, suppresses ischemia/reperfusion-induced lung damage by maintaining tight junction barriers and targeting multiple signaling pathways. International immunopharmacology 2019. link 14 Qu LC, Jiao Y, Jiang ZJ, Song ZP, Peng QH. Acidic Preconditioning Protects Against Ischemia-Reperfusion Lung Injury Via Inhibiting the Expression of Matrix Metalloproteinase 9. The Journal of surgical research 2019. link 15 Magruder JT, Grimm JC, Crawford TC, Johnston L, Santhanam L, Stephens RS et al.. Imatinib Is Protective Against Ischemia-Reperfusion Injury in an Ex Vivo Rabbit Model of Lung Injury. The Annals of thoracic surgery 2018. link 16 Tosif S, Duke T. Evidence to Support Oxygen Guidelines for Children with Emergency Signs in Developing Countries: A Systematic Review and Physiological and Mechanistic Analysis. Journal of tropical pediatrics 2017. link 17 Varedi M, Pajouhi N, Owji M, Naghibalhossaini F, Omrani GHR. Differential modulation of claudin 4 expression and myosin light chain phosphorylation by thyroid function in lung injury. The clinical respiratory journal 2017. link 18 Lee YL, Obiako B, Gorodnya OM, Ruchko MV, Kuck JL, Pastukh VM et al.. Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa. Shock (Augusta, Ga.) 2017. link 19 Hijiya K, Chen-Yoshikawa TF, Kondo T, Motoyama H, Ohsumi A, Nakajima D et al.. Bronchodilator Inhalation During Ex Vivo Lung Perfusion Improves Posttransplant Graft Function After Warm Ischemia. The Annals of thoracic surgery 2017. link 20 Nakajima D, Liu M, Ohsumi A, Kalaf R, Iskender I, Hsin M et al.. Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017. link 21 Grimm JC, Zhang F, Magruder JT, Crawford TC, Mishra M, Rangaramanujam KM et al.. Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury. The Journal of surgical research 2017. link 22 Küçükebe ÖB, Özzeybek D, Abdullayev R, Ustaoğlu A, Tekmen I, Küme T. Effect of dexmedetomidine on acute lung injury in experimental ischemia-reperfusion model. Brazilian journal of anesthesiology (Elsevier) 2017. link 23 Lan CC, Peng CK, Tang SE, Lin HJ, Yang SS, Wu CP et al.. Inhibition of Na-K-Cl cotransporter isoform 1 reduces lung injury induced by ischemia-reperfusion. The Journal of thoracic and cardiovascular surgery 2017. link 24 Carvalho JL, Britto A, de Oliveira AP, Castro-Faria-Neto H, Albertini R, Anatriello E et al.. Beneficial effect of low-level laser therapy in acute lung injury after i-I/R is dependent on the secretion of IL-10 and independent of the TLR/MyD88 signaling. Lasers in medical science 2017. link 25 Li D, Pan X, Zhao J, Chi C, Wu G, Wang Y et al.. Bone Marrow Mesenchymal Stem Cells Suppress Acute Lung Injury Induced by Lipopolysaccharide Through Inhibiting the TLR2, 4/NF-κB Pathway in Rats with Multiple Trauma. Shock (Augusta, Ga.) 2016. link 26 He Y, Ye ZQ, Li X, Zhu GS, Liu Y, Yao WF et al.. Alpha7 nicotinic acetylcholine receptor activation attenuated intestine-derived acute lung injury. The Journal of surgical research 2016. link 27 Almeida FM, Oliveira-Junior MC, Souza RA, Petroni RC, Soto SF, Soriano FG et al.. Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2016. link 28 Wang L, Shan Y, Ye Y, Jin L, Zhuo Q, Xiong X et al.. COX-2 inhibition attenuates lung injury induced by skeletal muscle ischemia reperfusion in rats. International immunopharmacology 2016. link 29 Zhao YR, Wang D, Liu Y, Shan L, Zhou JL. The PI3K/Akt, p38MAPK, and JAK2/STAT3 signaling pathways mediate the protection of SO2 against acute lung injury induced by limb ischemia/reperfusion in rats. The journal of physiological sciences : JPS 2016. link 30 Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL et al.. γδ T cells protect against LPS-induced lung injury. Journal of leukocyte biology 2016. link 31 Zhang D, Li C, Zhou J, Song Y, Fang X, Ou J et al.. Autophagy protects against ischemia/reperfusion-induced lung injury through alleviating blood-air barrier damage. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2015. link 32 Yang B, Ni YF, Wang WC, Du HY, Zhang H, Zhang L et al.. Melatonin attenuates intestinal ischemia--reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. The Journal of surgical research 2015. link 33 Turnbull AE, Lau BM, Ruhl AP, Mendez-Tellez PA, Shanholtz CB, Needham DM. Age and decisions to limit life support for patients with acute lung injury: a prospective cohort study. Critical care (London, England) 2014. link 34 Swol J, Buchwald D, Dudda M, Strauch J, Schildhauer TA. Veno-venous extracorporeal membrane oxygenation in obese surgical patients with hypercapnic lung failure. Acta anaesthesiologica Scandinavica 2014. link 35 Zhao W, Gan X, Su G, Wanling G, Li S, Hei Z et al.. The interaction between oxidative stress and mast cell activation plays a role in acute lung injuries induced by intestinal ischemia-reperfusion. The Journal of surgical research 2014. link 36 Jing H, Yao J, Liu X, Fan H, Zhang F, Li Z et al.. Fish-oil emulsion (omega-3 polyunsaturated fatty acids) attenuates acute lung injury induced by intestinal ischemia-reperfusion through Adenosine 5'-monophosphate-activated protein kinase-sirtuin1 pathway. The Journal of surgical research 2014. link 37 Gao W, Zhao J, Kim H, Xu S, Chen M, Bai X et al.. α1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2014. link 38 Hager DN, Dinglas VD, Subhas S, Rowden AM, Neufeld KJ, Bienvenu OJ et al.. Reducing deep sedation and delirium in acute lung injury patients: a quality improvement project. Critical care medicine 2013. link 39 Weyker PD, Webb CA, Kiamanesh D, Flynn BC. Lung ischemia reperfusion injury: a bench-to-bedside review. Seminars in cardiothoracic and vascular anesthesia 2013. link 40 Zhou H, Fu Z, Wei Y, Liu J, Cui X, Yang W et al.. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2013. link 41 Guzel A, Kanter M, Guzel A, Yucel AF, Erboga M. Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion. Toxicology and industrial health 2013. link 42 Sutsko RP, Young KC, Ribeiro A, Torres E, Rodriguez M, Hehre D et al.. Long-term reparative effects of mesenchymal stem cell therapy following neonatal hyperoxia-induced lung injury. Pediatric research 2013. link 43 Shokoohi H, Boniface K. Hand ultrasound: a high-fidelity simulation of lung sliding. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2012. link 44 Wang HW, Yang W, Lu JY, Tian G, Li F, Wang XH et al.. Treatment with Fms-like tyrosine kinase 3 ligand reverses lung dendritic cell immunoparalysis and ameliorates zymosan-induced secondary lung injury in mice. Clinical and experimental immunology 2012. link 45 McKeown NJ, Burton BT. Acute lung injury following refrigeration coil deicing. Clinical toxicology (Philadelphia, Pa.) 2012. link 46 Scully M, Gang C, Condron C, Bouchier-Hayes D, Cunningham AJ. Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect. The Journal of surgical research 2012. link 47 Schmickl CN, Shahjehan K, Li G, Dhokarh R, Kashyap R, Janish C et al.. Decision support tool for early differential diagnosis of acute lung injury and cardiogenic pulmonary edema in medical critically ill patients. Chest 2012. link 48 Ali I, Gruenloh S, Gao Y, Clough A, Falck JR, Medhora M et al.. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. The Annals of thoracic surgery 2012. link 49 Kim K, Li Y, Jin G, Chong W, Liu B, Lu J et al.. Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion. Resuscitation 2012. link 50 Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS et al.. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. American journal of respiratory cell and molecular biology 2011. link 51 Koenig HC, Finkel BB, Khalsa SS, Lanken PN, Prasad M, Urbani R et al.. Performance of an automated electronic acute lung injury screening system in intensive care unit patients. Critical care medicine 2011. link 52 Walker MG, Yao LJ, Patterson EK, Joseph MG, Cepinskas G, Veldhuizen RA et al.. The effect of tidal volume on systemic inflammation in Acid-induced lung injury. Respiration; international review of thoracic diseases 2011. link 53 Wohlauer MV, Moore EE, Harr J, Eun J, Fragoso M, Banerjee A et al.. Cross-transfusion of postshock mesenteric lymph provokes acute lung injury. The Journal of surgical research 2011. link 54 Craig TR, Duffy MJ, Shyamsundar M, McDowell C, O'Kane CM, Elborn JS et al.. A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study). American journal of respiratory and critical care medicine 2011. link 55 Kreisel D, Sugimoto S, Tietjens J, Zhu J, Yamamoto S, Krupnick AS et al.. Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis. The Journal of clinical investigation 2011. link 56 Xu B, Gao X, Xu J, Lei S, Xia ZY, Xu Y et al.. Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1. The Journal of surgical research 2011. link 57 Agostoni P, Banfi C, Brioschi M, Magrì D, Sciomer S, Berna G et al.. Surfactant protein B and RAGE increases in the plasma during cardiopulmonary bypass: a pilot study. The European respiratory journal 2011. link 58 Hsu KY, Tsai PS, Lee JJ, Wang TY, Huang CJ. Platonin mitigates acute lung injury induced by bilateral lower limb ischemia-reperfusion in rats. The Journal of surgical research 2011. link 59 Peng CK, Huang KL, Wu CP, Li MH, Hu YT, Hsu CW et al.. Glutamine protects ischemia-reperfusion induced acute lung injury in isolated rat lungs. Pulmonary pharmacology & therapeutics 2011. link 60 dos Santos CC, Shan Y, Akram A, Slutsky AS, Haitsma JJ. Neuroimmune regulation of ventilator-induced lung injury. American journal of respiratory and critical care medicine 2011. link 61 Suda K, Tsuruta M, Eom J, Or C, Mui T, Jaw JE et al.. Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterol. American journal of respiratory cell and molecular biology 2011. link 62 Peng TC, Jan WC, Tsai PS, Huang CJ. Heme oxygenase-1 mediates the protective effects of ischemic preconditioning on mitigating lung injury induced by lower limb ischemia-reperfusion in rats. The Journal of surgical research 2011. link 63 Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW et al.. CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death. The American journal of pathology 2010. link 64 Kim K, Jo YH, Rhee JE, Kim TY, Lee JH, Lee JH et al.. Effect of speed of rewarming and administration of anti-inflammatory or anti-oxidant agents on acute lung injury in an intestinal ischemia model treated with therapeutic hypothermia. Resuscitation 2010. link 65 Xia ZY, Gao J, Ancharaz AK, Liu KX, Xia Z, Luo T. Ischaemic post-conditioning protects lung from ischaemia-reperfusion injury by up-regulation of haeme oxygenase-1. Injury 2010. link 66 Avgerinos ED, Kostopanagiotou G, Costopanagiotou C, Kopanakis N, Andreadou I, Lekka M et al.. Intestinal preconditioning ameliorates ischemia-reperfusion induced acute lung injury in rats: an experimental study. The Journal of surgical research 2010. link 67 Alexiou K, Matschke K, Westphal A, Stangl K, Dschietzig T. Relaxin is a candidate drug for lung preservation: relaxin-induced protection of rat lungs from ischemia-reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010. link 68 Cui T, Miksa M, Wu R, Komura H, Zhou M, Dong W et al.. Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. American journal of respiratory and critical care medicine 2010. link 69 Schnapp LM, Vaught M, Park DR, Rubenfeld G, Goodman RB, Hudson LD. Implementation and impact of a translational research training program in pulmonary and critical care medicine. Chest 2009. link 70 Vlaar AP, Honselaar WB, Binnekade JM, Groeneveld AB, Spronk PE, Schultz MJ et al.. Diagnosing acute lung injury in the critically ill: a national survey among critical care physicians. Acta anaesthesiologica Scandinavica 2009. link 71 Brander L, Sinderby C, Lecomte F, Leong-Poi H, Bell D, Beck J et al.. Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury. Intensive care medicine 2009. link 72 Liu C, Wu Q, Li Q, Liu D, Su H, Shen N et al.. Mesenteric lymphatic ducts ligation decreases the degree of gut-induced lung injury in a portal vein occlusion and reperfusion canine model. The Journal of surgical research 2009. link 73 Liu KX, Li YS, Huang WQ, Li C, Liu JX, Li Y. Immediate but not delayed postconditioning during reperfusion attenuates acute lung injury induced by intestinal ischemia/reperfusion in rats: comparison with ischemic preconditioning. The Journal of surgical research 2009. link 74 Wu H, Dong G, Liu H, Xu B, Li D, Jing H. Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase-9 expression. European journal of pharmacology 2009. link 75 Sun J, Yang D, Li S, Xu Z, Wang X, Bai C. Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats. The European respiratory journal 2009. link 76 Erbüyün K, Vatansever S, Tok D, Ok G, Türköz E, Aydede H et al.. Effects of levosimendan and dobutamine on experimental acute lung injury in rats. Acta histochemica 2009. link 77 Fan E, Shahid S, Kondreddi VP, Bienvenu OJ, Mendez-Tellez PA, Pronovost PJ et al.. Informed consent in the critically ill: a two-step approach incorporating delirium screening. Critical care medicine 2008. link 78 Fan E, Khatri P, Mendez-Tellez PA, Shanholtz C, Needham DM. Review of a large clinical series: sedation and analgesia usage with airway pressure release and assist-control ventilation for acute lung injury. Journal of intensive care medicine 2008. link 79 Tang PS, Mura M, Seth R, Liu M. Acute lung injury and cell death: how many ways can cells die?. American journal of physiology. Lung cellular and molecular physiology 2008. link 80 Kostopanagiotou G, Avgerinos E, Costopanagiotou C, Arkadopoulos N, Andreadou I, Diamantopoulou K et al.. Acute lung injury in a rat model of intestinal ischemia-reperfusion: the potential time depended role of phospholipases A(2). The Journal of surgical research 2008. link 81 Chang H, Huang KL, Li MH, Hsu CW, Tsai SH, Chu SJ. Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits. Pulmonary pharmacology & therapeutics 2008. link 82 Okutan H, Kiris I, Adiloglu AK, Savas C, Kapucuoğlu N, Altuntas I et al.. The effect of Nomega-nitro-L-arginine methyl ester and L-arginine on lung injury induced by abdominal aortic occlusion-reperfusion. Surgery today 2008. link 83 Yasa H, Yakut N, Emrecan B, Ergunes K, Ortac R, Karahan N et al.. Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model. 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Length of pressure-controlled reperfusion is critical for reducing ischaemia-reperfusion injury in an isolated rabbit lung model. Journal of cardiothoracic surgery 2007. link 93 Boutros C, Zegdi R, Lila N, Cambillau M, Fornes P, Carpentier A et al.. Carbon monoxide can prevent acute lung injury observed after ischemia reperfusion of the lower extremities. The Journal of surgical research 2007. link 94 Kurtoglu T, Sacar M, Inan BK, Duver MH, Guler A, Ucak A et al.. Erdosteine ameliorates lung injury induced by transient aortic occlusion in rats. Cardiovascular journal of Africa 2007. link 95 Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M et al.. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. American journal of respiratory cell and molecular biology 2007. link 96 Ota S, Nakamura K, Yazawa T, Kawaguchi Y, Baba Y, Kitaoka R et al.. High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion. American journal of physiology. Lung cellular and molecular physiology 2007. link 97 Nakos G, Batistatou A, Galiatsou E, Konstanti E, Koulouras V, Kanavaros P et al.. Lung and 'end organ' injury due to mechanical ventilation in animals: comparison between the prone and supine positions. Critical care (London, England) 2006. link 98 Ben-Abraham R, Guttman M, Flaishon R, Marouani N, Niv D, Weinbroum AA. Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-D-aspartate antagonist dextromethorphan. Lung 2006. link 99 Ren B, Wu H, Zhu J, Li D, Shen Y, Ying R et al.. Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha. Transplantation proceedings 2006. link 100 Goldsmith WW, Pandharipande PP. Transfusion-related acute lung injury--does the anesthesiologist need to worry about this?. Journal of clinical anesthesia 2005. link