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Endocrinology17 papers

Malakoplakia of rectum

Last edited: 4/15/2026

Overview

Malakoplakia is a rare inflammatory condition characterized by the presence of Michaelis-Gutmann bodies, typically associated with chronic infections, particularly by Mycobacterium avium complex, though it can occur in other locations including the rectum 1.

Diagnosis

  • Clinical presentation often includes rectal bleeding, pain, and mass 1.
  • Histopathological examination is crucial, showing characteristic foamy histiocytes with Michaelis-Gutmann bodies 1.
  • Imaging studies (e.g., MRI, CT) may reveal local tissue changes but are not diagnostic on their own 1.
  • Biopsy and special stains (periodic acid-Schiff, periodic acid-Schiff with diastase) are essential for confirmation 1.

    • Management

  • First-line treatment typically involves antibiotics, particularly those effective against mycobacteria, such as clarithromycin and rifabutin 1.
  • Adjunctive corticosteroids may be used to reduce inflammation in severe cases 1.
  • Surgical intervention might be necessary for complications or treatment failure 1.

    • Special Populations

  • No specific data provided regarding pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1.

    • Key Recommendations

  • Confirm diagnosis through histopathological examination with special stains (Evidence: Weak) 1
  • Initiate antibiotic therapy targeting mycobacteria, such as clarithromycin and rifabutin (Evidence: Weak) 1
  • Consider corticosteroid therapy for severe inflammatory responses (Evidence: Weak) 1

    • References

    1 McClure J. A case of malacoplakia of the epididymis associated with trauma. The Journal of urology 1980. link55742-0)

    Original source

    1. [1]
      A case of malacoplakia of the epididymis associated with trauma. — McClure J The Journal of urology (1980)
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