Overview
Chronic liver disease (CLD) encompasses a spectrum of liver conditions characterized by progressive liver injury leading to fibrosis and potential cirrhosis. It ranks as a significant global health issue, impacting liver function and increasing mortality risk.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 148 indexed papers.
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Implementing pragmatic clinical trials in hepatology. Hepatology (Baltimore, Md.) 2024. link 10 Iyengar P, Prause N, LeBrett W, Lee A, Chang L, Patel A. Opioid and Nonopioid Analgesic Prescribing Patterns of Hepatologists for Medicare Beneficiaries. Clinical and translational gastroenterology 2024. link 11 Twinkle MJS, Karjal RZ, Anushree A, Kellarai A, Shaji B, Shetty S et al.. Assessment of Drug-related Problems among Patients of Chronic liver Disease in a Tertiary Care Hospital. Ethiopian journal of health sciences 2024. link 12 Song DS, Kim HY, Jung YK, Kim TH, Yim HJ, Yoon EL et al.. Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment. Clinical and molecular hepatology 2024. link 13 Gülşen M, Özçay F, Barış Z, Haberal M. Evaluation of Vitamin D Levels in Children With Liver Transplant. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2024. link 14 Khalifa A, Rockey DC. Role of Endoscopy in the Diagnosis, Grading, and Treatment of Portal Hypertensive Gastropathy and Gastric Antral Vascular Ectasia. Gastrointestinal endoscopy clinics of North America 2024. link 15 L'Écuyer S, Charbonney E, Carrier FM, Rose CF. Implication of Hypotension in the Pathogenesis of Cognitive Impairment and Brain Injury in Chronic Liver Disease. Neurochemical research 2024. link 16 Hardt JLS, Pohlmann P, Reissfelder C, Rahbari NN. Remote ischemic preconditioning for reduction of ischemia-reperfusion injury after hepatectomy: A randomized sham-controlled trial. Surgery 2024. link 17 Tan HQ, Zhao M, Huang Z, Liu Y, Li H, Ma LH et al.. Circulating copeptin level and the clinical prognosis of patients with chronic liver disease. World journal of gastroenterology 2023. link 18 Qiu LX, Huang Y, Quan JL, Bi ZF, Zhong GH, Wang JY et al.. Prognosis of hepatitis E infection in patients with chronic liver disease: A meta-analysis. Journal of viral hepatitis 2023. link 19 Wang Y, Kong L, Ye C, Dou C, Zheng J, Xu M et al.. Causal impacts of educational attainment on chronic liver diseases and the mediating pathways: Mendelian randomization study. Liver international : official journal of the International Association for the Study of the Liver 2023. link 20 Droc G, Isac S. Perioperative Care in Patients with Chronic Liver Disease: What Can We Do More?. Medicina (Kaunas, Lithuania) 2023. link 21 Holman A, McKeown E, Quinn M, Parikh ND, Tapper EB. Medical malpractice claims in Hepatology: Rates, Reasons, and Results. Hepatology communications 2023. link 22 Pryke R, Guha IN. Time to focus on chronic liver diseases in the community: A review of primary care hepatology tools, pathways of care and reimbursement mechanisms. Journal of hepatology 2023. link 23 Motsonelidze T, Kakhadze S, Gachechiladze D, Changelia T, Gurgenidze M, Buachidze T. SIGNIFICANCE OF TWO-DIMENSIONAL SHEAR WAVE ELASTOGRAPHY IN PREDICTING ESOPHAGEAL VARICOSE VEINS DURING CHRONIC LIVER DISEASE. Georgian medical news 2023. link 24 Heo S, Lee SS, Choi SH, Kim DW, Park HJ, Kim SY et al.. CT Rule-in and Rule-out Criteria for Clinically Significant Portal Hypertension in Chronic Liver Disease. Radiology 2023. link 25 Castro Filho ÉC, Fernandes FF, Villela-Nogueira C, Madeira E, Barros F, Luz R et al.. Validation of the Baveno VI criteria to rule out high-risk varices using hepatic shear-wave elastography. European journal of gastroenterology & hepatology 2023. link 26 Danjuma MI, Naseralallah L, Ansari S, Al Shebly R, Elhams M, AlShamari M et al.. Prevalence and global trends of polypharmacy in patients with chronic liver disease: A systematic review and meta-analysis. Medicine 2023. link 27 Woodland H, Buchanan RM, Pring A, Dancox M, McCune A, Forbes K et al.. Inequity in end-of-life care for patients with chronic liver disease in England. Liver international : official journal of the International Association for the Study of the Liver 2023. link 28 Mariano da Rocha CR, Guaragna-Filho G, Kieling CO, Adami MR, Guedes RR, Gonçalves Vieira SM. Daily Vitamin D Supplementation Improves Vitamin D Deficiency in Patients With Chronic Liver Disease. Journal of pediatric gastroenterology and nutrition 2023. link 29 Thabut D, Weil D, Bouzbib C, Rudler M, Cassinotto C, Castéra L et al.. Non-invasive diagnosis and follow-up of portal hypertension. Clinics and research in hepatology and gastroenterology 2022. link 30 Cheung KS, Mok CH, Mao X, Zhang R, Hung IF, Seto WK et al.. COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis. Clinical and molecular hepatology 2022. link 31 Kong Y, Lv T, Li M, Zhao L, Meng T, Wu S et al.. Systematic review and meta-analysis: impact of anti-viral therapy on portal hypertensive complications in HBV patients with advanced chronic liver disease. Hepatology international 2022. link 32 Fromme M, Strnad P. Pathophysiology of Chronic Liver Disease Development. International journal of molecular sciences 2022. link 33 Garcia-Saenz-de-Sicilia M, Al-Obaid L, Hughes DL, Duarte-Rojo A. Mastering Core Recommendations during HEPAtology ROUNDS in Patients with Advanced Chronic Liver Disease. Seminars in liver disease 2022. link 34 Pan AY, Zilberstein NF, Farnan JM, McConville JF, Mikolajczyk AE. Recently Graduated Medical Students Lack Exposure to and Comfort with Chronic Liver Diseases. Digestive diseases and sciences 2022. link 35 Choi AY, Kolb J, Shah S, Chahine A, Hashimoto R, Patel A et al.. Endoscopic ultrasound-guided portal pressure gradient with liver biopsy: 6 years of endo-hepatology in practice. Journal of gastroenterology and hepatology 2022. link 36 Anstee QM, Castera L, Loomba R. Impact of non-invasive biomarkers on hepatology practice: Past, present and future. Journal of hepatology 2022. link 37 Zhu Y, Cheng H, Chen J, Huang Y, Liu H, Qi X. Small varices in chronic liver diseases. Current opinion in gastroenterology 2022. link 38 Saleem K, Baig FA, Khan TU, Masood A, Nawaz A, Khan W. The Predictors Of Re-Bleeding In Chronic Liver Disease Patients After Endoscopic Variceal Band Ligation. Journal of Ayub Medical College, Abbottabad : JAMC 2022. link 39 Calès P, Ravaioli F, Berger A, Farcau O, Festi D, Stefanescu H et al.. Comparison of screening strategies with two new tests to score and diagnose varices needing treatment. Clinics and research in hepatology and gastroenterology 2022. link 40 Joseph RC, Devadas K, Varghese J, Oommen TT, Hareendran A, Nahaz N et al.. Validation of Spleen Shear Wave Elastography for the Screening of High-risk Varices in Patients with Compensated Advanced Chronic Liver Disease. The Journal of the Association of Physicians of India 2022. link 41 Yan Y, Xing X, Wang X, Yang L. Liver stiffness by two-dimensional shear wave elastography for screening high-risk varices in patients with compensated advanced chronic liver disease. European radiology 2022. link 42 Cho YS, Kim Y, Sohn JH. Application of Supersonic Shear Imaging to the Baveno VI Criteria and a Combination Model with Spleen Stiffness Measurement to Rule Out High-Risk Varices in Compensated Advanced Chronic Liver Disease. Ultraschall in der Medizin (Stuttgart, Germany : 1980) 2022. link 43 Liu C, Li J, Wong YJ, Xie Q, Hirooka M, Enomoto H et al.. ABC: a novel algorithm to stratify decompensation risk in patients with compensated advanced chronic liver disease (CHESS2108): an international, multicenter cohort study. Hepatology international 2022. link 44 Mataya L, Bittermann T, Quarshie WO, Griffis H, Srinivasan V, Rand EB et al.. Status 1B designation does not adequately prioritize children with acute-on-chronic liver failure for liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2022. link 45 Shi P, Zhang J, Wu M, Zheng T, Liang A, Wen Z et al.. The effects of granulocyte-colony stimulating factor on chronic liver disease: a meta-analysis. Journal of infection in developing countries 2022. link 46 Lee HJ, Park M, Lee S, Hong SK. Clinical Effect of Preoperative 25-OH-Vitamin D3 Level in Liver Transplant Recipients. Transplantation proceedings 2022. link 47 Ravaioli F, Pivetti A, Di Marco L, Chrysanthi C, Frassanito G, Pambianco M et al.. Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease. International journal of molecular sciences 2022. link 48 Pop TL, Sîrbe C, Benţa G, Mititelu A, Grama A. The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases. International journal of molecular sciences 2022. link 49 Basu E, Mehta M, Zhang C, Zhao C, Rosenblatt R, Tapper EB et al.. Association of chronic liver disease with cognition and brain volumes in two randomized controlled trial populations. Journal of the neurological sciences 2022. link 50 Ow TW, Fatourou E, Rabinowich L, van den Boom B, Nair S, Patel VC et al.. Prevalence of Bleeding and Thrombosis in Critically Ill Patients with Chronic Liver Disease. Thrombosis and haemostasis 2022. link 51 . EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update. Journal of hepatology 2021. link 52 Sharma C, Cococcia S, Ellis N, Parkes J, Rosenberg W. Systematic review: Accuracy of the enhanced liver fibrosis test for diagnosing advanced liver fibrosis and cirrhosis. Journal of gastroenterology and hepatology 2021. link 53 Vaz K, Goodwin T, Kemp W, Roberts S, Majeed A. Artificial Intelligence in Hepatology: A Narrative Review. Seminars in liver disease 2021. link 54 McCormick PA, Campollo O. Andrew K. Burroughs: a research hepatologist extraordinaire. Annals of hepatology 2021. link 55 Mikolajczyk AE, Zilberstein N, McConville JF, Pan A, Aronsohn AI, Te HS et al.. Mandatory Hepatology Education for Internal Medicine Residents: Long-Term Effects and Implications for Workforce Needs. Hepatology communications 2021. link 56 Morelli MC, Rendina M, La Manna G, Alessandria C, Pasulo L, Lenci I et al.. Position paper on liver and kidney diseases from the Italian Association for the Study of Liver (AISF), in collaboration with the Italian Society of Nephrology (SIN). Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2021. link 57 Marasco G, Sadalla S, Vara G, Golfieri R, Festi D, Colecchia A et al.. Imaging Software-Based Sarcopenia Assessment in Gastroenterology: Evolution and Clinical Meaning. Canadian journal of gastroenterology & hepatology 2021. link 58 Hoshino Y, Sugihara T, Ikeda S, Matsuki Y, Nagahara T, Okano JI et al.. A vein-viewing application enabled detecting abdominal wall varices related to the presence of non-treated gastroesophageal varices: a cross-sectional study. BMC medical imaging 2021. link 59 Wang J, Wei W, Duan Z, Li J, Liu Y, Liu C et al.. Development and validation of a nomogram for predicting varices needing treatment in compensated advanced chronic liver disease: A multicenter study. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2021. link 60 Bernal W, Karvellas C, Saliba F, Saner FH, Meersseman P. Intensive care management of acute-on-chronic liver failure. Journal of hepatology 2021. link 61 Tessitore M, Sorrentino E, Schiano Di Cola G, Colucci A, Vajro P, Mandato C. Malnutrition in Pediatric Chronic Cholestatic Disease: An Up-to-Date Overview. Nutrients 2021. link 62 Strazzabosco M, Cortesi PA, Conti S, Okolicsanyi S, Rota M, Ciaccio A et al.. Clinical outcome indicators in chronic hepatitis B and C: A primer for value-based medicine in hepatology. Liver international : official journal of the International Association for the Study of the Liver 2020. link 63 Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K et al.. Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation. Hepatology (Baltimore, Md.) 2020. link 64 Banc-Husu AM, Neighbors K, Rychlik K, Mohammad S, Harris ZL, Alonso EM. Admission Characteristics Identify Risk of Pediatric Acute-on-Chronic Liver Failure. Journal of pediatric gastroenterology and nutrition 2020. link 65 Téllez L, Rodríguez de Santiago E, Minguez B, Payance A, Clemente A, Baiges A et al.. Prevalence, features and predictive factors of liver nodules in Fontan surgery patients: The VALDIG Fonliver prospective cohort. Journal of hepatology 2020. link 66 Mouzaki M, Bronsky J, Gupte G, Hojsak I, Jahnel J, Pai N et al.. Nutrition Support of Children With Chronic Liver Diseases: A Joint Position Paper of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Journal of pediatric gastroenterology and nutrition 2019. link 67 Brahmania M, Renner EL, Coffin CS, Yoshida EM, Wong P, Zeman M et al.. Choosing Wisely Canada-Top Five List in Hepatology: Official Position Statement of the Canadian Association for the Study of the Liver (CASL) and Choosing Wisely Canada (CWC). Annals of hepatology 2019. link 68 Schmilovitz-Weiss H, Gingold-Belfer R, Grossman A, Issa N, Boltin D, Beloosesky Y et al.. Lowering the upper limit of serum alanine aminotransferase levels may reveal significant liver disease in the elderly. PloS one 2019. link 69 Wilcock A, Charlesworth S, Prentice W, Selby P, McKenna M, Cripps S et al.. Prescribing in Chronic Severe Hepatic Impairment. Journal of pain and symptom management 2019. link 70 Lee WS, Jalaludin MY, Wong SY, Ong SY, Foo HW, Ng RT. Vitamin D non-sufficiency is prevalent in children with chronic liver disease in a tropical country. Pediatrics and neonatology 2019. link 71 Wijsman S, Ackermann BJ. Educating Australian musicians: are we playing it safe?. Health promotion international 2019. link 72 Tateishi R, Seike M, Kudo M, Tamai H, Kawazoe S, Katsube T et al.. A randomized controlled trial of lusutrombopag in Japanese patients with chronic liver disease undergoing radiofrequency ablation. Journal of gastroenterology 2019. link 73 Chamoun N, Ramia E, Lteif C, Salameh P, Zantout H, Ghanem G et al.. Assessment of bleeding in chronic liver disease and coagulopathy using the IMPROVE bleeding criteria. Current medical research and opinion 2019. link 74 Solé C, Solà E. Update on acute-on-chronic liver failure. Gastroenterologia y hepatologia 2018. link 75 Bolia R, Srivastava A, Yachha SK, Poddar U. Pediatric CLIF-SOFA score is the best predictor of 28-day mortality in children with decompensated chronic liver disease. Journal of hepatology 2018. link 76 Lal BB, Alam S, Khanna R, Rawat D. Weekly regimen of vitamin D supplementation is more efficacious than stoss regimen for treatment of vitamin D deficiency in children with chronic liver diseases. European journal of pediatrics 2018. link 77 Kim GW, Shin K, Kim TW, You HS, Jin HJ, Shim WH et al.. The importance of dermoscopy for the diagnosis of acquired bilateral telangiectatic macules: the angioid streak pattern reveals underlying chronic liver disease. Journal of the European Academy of Dermatology and Venereology : JEADV 2018. link 78 Günay N, Erdem Ş, Güvenç TS, Bulur A, Özdil K, Hasdemir H et al.. Morphologic and Functional Changes in Right-Sided Cardiac Chambers in Patients With Chronic Liver Disease and Normal Pulmonary Artery Pressure. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2018. link 79 Tajiri K, Shimizu Y. Recent advances in the management of pruritus in chronic liver diseases. World journal of gastroenterology 2017. link 80 Strazzabosco M, Allen JI, Teisberg EO. Value-based care in hepatology. Hepatology (Baltimore, Md.) 2017. link 81 Fukui N, Golabi P, Otgonsuren M, Mishra A, Venkatesan C, Younossi ZM. Demographics, Resource Utilization, and Outcomes of Elderly Patients With Chronic Liver Disease Receiving Hospice Care in the United States. The American journal of gastroenterology 2017. link 82 Bjelakovic G, Nikolova D, Bjelakovic M, Gluud C. Vitamin D supplementation for chronic liver diseases in adults. The Cochrane database of systematic reviews 2017. link 83 . Chronic liver conditions in teens linked to anxiety risk. Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2016. link 84 Mikolajczyk AE, Farnan JM, McConville JF, Jensen DM, Reddy KG, Te HS et al.. Novel educational interventions in residency increase knowledge of chronic liver disease and career interest in hepatology. Hepatology (Baltimore, Md.) 2016. link 85 Guido M, Sarcognato S, Sonzogni A, Lucà MG, Senzolo M, Fagiuoli S et al.. Obliterative portal venopathy without portal hypertension: an underestimated condition. Liver international : official journal of the International Association for the Study of the Liver 2016. link 86 Ngu PJ, Butler M, Pham A, Roberts SK, Taylor AJ. Cardiac remodelling identified by cardiovascular magnetic resonance in patients with hepatitis C infection and liver disease. The international journal of cardiovascular imaging 2016. link 87 Block PC. Understanding rare comorbidities in TAVR. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2015. link 88 Stravitz RT. Liver: Acute-on-chronic liver failure--no longer an entity without definition. Nature reviews. Gastroenterology & hepatology 2014. link 89 Sebastiani G, Ghali P, Wong P, Klein MB, Deschenes M, Myers RP. Physicians' practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey. Canadian journal of gastroenterology & hepatology 2014. link 90 Strauss C, Sivakkolunthu M, Ayantunde AA. Recurrent and troublesome variceal bleeding from parastomal caput medusae. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2014. link 91 Hsu JH, Chien IC, Lin CH, Chou YJ, Chou P. Increased risk of chronic liver disease in patients with schizophrenia: a population-based cohort study. Psychosomatics 2014. link 92 Orlandini M, Feier FH, Jaeger B, Kieling C, Vieira SG, Zanotelli ML. Frequency of and factors associated with vascular complications after pediatric liver transplantation. Jornal de pediatria 2014. link 93 Finkenstedt A, Nachbaur K, Zoller H, Joannidis M, Pratschke J, Graziadei IW et al.. Acute-on-chronic liver failure: excellent outcomes after liver transplantation but high mortality on the wait list. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2013. link 94 D'Amico F, Vitale A, Piovan D, Bertacco A, Ramirez Morales R, Chiara Frigo A et al.. Use of N-acetylcysteine during liver procurement: a prospective randomized controlled study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2013. link 95 Chu HH, Kim HC, Jae HJ, Yi NJ, Lee KW, Suh KS et al.. Percutaneous transsplenic access to the portal vein for management of vascular complication in patients with chronic liver disease. Cardiovascular and interventional radiology 2012. link 96 Tsouka A, McLin VA. Complications of chronic liver disease. Clinics and research in hepatology and gastroenterology 2012. link 97 Lippi G, Targher G, Favaloro EJ, Franchini M. Venous thromboembolism in chronic liver disease. Seminars in thrombosis and hemostasis 2011. link 98 Abbott-Johnson WJ, Kerlin P, Abiad G, Clague AE, Cuneo RC. Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment. The British journal of ophthalmology 2011. link 99 Slack A, Yeoman A, Wendon J. Renal dysfunction in chronic liver disease. Critical care (London, England) 2010. link 100 Kumar M, Herrera JL. Importance of hepatitis vaccination in patients with chronic liver disease. Southern medical journal 2010. link