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Rotor syndrome

Last edited: 4/15/2026

Overview

Rotor syndrome is a rare disorder characterized by conjugated hyperbilirubinemia without hemolysis, often presenting with elevated levels of urinary bilirubin glucuronide and normal liver function tests 1.

Diagnosis

  • Elevated conjugated bilirubin in blood and urine 1.
  • Normal liver function tests (ALT, AST, ALP, GGT) 1.
  • Presence of bilirubin glucuronide in urine 1.
  • Exclusion of other causes of hyperbilirubinemia such as Gilbert's syndrome, Dubin-Johnson syndrome, and Crigler-Najjar syndrome 1.

    • Management

  • No specific pharmacological treatment; management focuses on supportive care 1.
  • Monitoring for complications and underlying causes 1.
  • Lifestyle modifications and regular follow-up to assess bilirubin levels 1.

    • Special Populations

  • No specific data provided regarding pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1.

    • Key Recommendations

  • Confirm diagnosis by measuring elevated conjugated bilirubin and identifying bilirubin glucuronide in urine (Evidence: Expert opinion) 1.
  • Exclude other causes of hyperbilirubinemia through comprehensive clinical evaluation and laboratory testing (Evidence: Expert opinion) 1.
  • Implement supportive care measures and regular monitoring for any underlying conditions or complications (Evidence: Expert opinion) 1.

    • References

    1 Kaeding TS. Deviations of frequency and the mode of vibration of commercially available whole-body vibration training devices. The Journal of sports medicine and physical fitness 2015. link

    Original source

    1. [1]
      Deviations of frequency and the mode of vibration of commercially available whole-body vibration training devices. — Kaeding TS The Journal of sports medicine and physical fitness (2015)
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