Pathophysiology
Infection by VEEV through aerosol routes notably impairs the endothelial lining of the BBB, highlighting its critical role in disease progression [PMID:36560802].
Diagnosis
The NVU model effectively captures the dynamics of infection and inflammatory responses, offering a promising tool for diagnosing and understanding VEEV-induced BBB damage [PMID:36560802].
Management
Using a human blood-brain barrier organ-on-a-chip model, omaveloxolone was effective in mitigating the deleterious effects on BBB integrity and decreasing viral and inflammatory responses post-VEEV infection [PMID:36560802].
References
1 Boghdeh NA, Risner KH, Barrera MD, Britt CM, Schaffer DK, Alem F et al.. Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus. Viruses 2022. link
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