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Allergy & Immunology181 papers

Primary taste disorder

Last edited: 4/14/2026

Overview

Primary taste disorder refers to alterations in the perception of taste, affecting gustatory function beyond typical variations. It can manifest as dysgeusia (metallic taste) and is observed in various contexts, including post-surgical complications like post-tonsillectomy dysgeusia 1.

Diagnosis

  • Clinical history and symptom reporting are crucial 1.
  • Taste tests and threshold assessments may be employed to quantify deficits 1.
  • No specific diagnostic imaging or routine laboratory tests are typically indicated 1.
  • Management

  • Zinc supplementation may be considered for persistent dysgeusia, particularly if deficiency is suspected; case reports suggest oral zinc sulfate at unspecified doses led to recovery 1.
  • No other specific first-line pharmacological treatments are highlighted in the provided abstracts 1.
  • Symptomatic management focusing on dietary modifications and counseling may be beneficial 1.
  • Special Populations

  • No specific management guidelines are provided for pregnancy, pediatrics, or elderly populations in the given abstracts 1.
  • Comorbidities like inflammatory processes or potential side effects from anesthetics should be considered in management strategies 1.
  • Key Recommendations

  • Evaluate for potential zinc deficiency in patients with long-lasting post-surgical dysgeusia and consider zinc supplementation; monitor response 1 (Evidence: Moderate).
  • Utilize taste tests and symptom history for diagnosis of primary taste disorders 1 (Evidence: Expert opinion).
  • Focus on supportive care including dietary adjustments and patient education for symptom management 1 (Evidence: Expert opinion).
  • References

    1 Windfuhr JP, Cao Van H, Landis BN. Recovery from long-lasting post-tonsillectomy dysgeusia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2010. link 2 Narukawa M, Kitagawa-Iseki K, Oike H, Abe K, Mori T, Hayashi Y. Characterization of umami receptor and coupling G protein in mouse taste cells. Neuroreport 2008. link 3 Fujimoto S, Ueda H, Kagawa H. Immunocytochemistry on the localization of 5-hydroxytryptamine in monkey and rabbit taste buds. Acta anatomica 1987. link 4 Yamasaki H, Kubota Y, Takagi H, Tohyama M. Immunoelectron-microscopic study on the fine structure of substance-P-containing fibers in the taste buds of the rat. The Journal of comparative neurology 1984. link

    Original source

    1. [1]
      Recovery from long-lasting post-tonsillectomy dysgeusia.Windfuhr JP, Cao Van H, Landis BN Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (2010)
    2. [2]
      Characterization of umami receptor and coupling G protein in mouse taste cells.Narukawa M, Kitagawa-Iseki K, Oike H, Abe K, Mori T, Hayashi Y Neuroreport (2008)
    3. [3]
    4. [4]
      Immunoelectron-microscopic study on the fine structure of substance-P-containing fibers in the taste buds of the rat.Yamasaki H, Kubota Y, Takagi H, Tohyama M The Journal of comparative neurology (1984)

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