Management
In a randomized dose-finding study [PMID:31060760], rectal ketamine at 6mg/kg and 8mg/kg showed significantly better feasibility (p=0.049 and p=0.027, respectively) compared to 4mg/kg during burn wound dressing procedures in children.
Children receiving 8mg/kg of rectal ketamine had a mean recovery time of 36±22 minutes, longer than the 25±15 minutes for 4mg/kg and 27±20 minutes for 6mg/kg ([PMID:31060760]). Additionally, sedation levels were significantly higher in the 8mg/kg group compared to the 4mg/kg group (p<0.0001) and 6mg/kg group (p=0.023).
Complications
One child in the group receiving 8mg/kg of rectal ketamine experienced a serious adverse event involving laryngospasm/airway obstruction, highlighting potential safety concerns ([PMID:31060760]).
References
1 Grossmann B, Nilsson A, Sjöberg F, Nilsson L. Rectal ketamine during paediatric burn wound dressing procedures: a randomised dose-finding study. Burns : journal of the International Society for Burn Injuries 2019. link
1 papers cited of 4 indexed.