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Psychiatry2271 papers

Autism spectrum disorder

Last edited: 4/23/2026

Overview

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent challenges in social interaction, communication, and restricted/repetitive behaviors. Recent studies highlight increased diagnoses, influenced by improved screening methods 6.

Diagnosis

  • Key Diagnostic Criteria: Persistent deficits in social communication and interaction, restricted, repetitive patterns of behavior, interests, or activities 12.
  • Recommended Tests: No specific laboratory tests; diagnosis primarily clinical, often supported by standardized assessments like the Autism Diagnostic Observation Schedule (ADOS) 113.
  • Grading: Clinician-administered evaluations with varying levels of support from psychometric tools 113.
  • Management

  • First-Line Treatments: Behavioral interventions such as Applied Behavior Analysis (ABA) and Early Start Denver Model (ESDM) 11520.
  • Adjunctive Therapies: Speech therapy, occupational therapy, and physical therapy tailored to individual needs 141617.
  • Pharmacological Interventions: Limited evidence; used primarily for associated symptoms like hyperactivity, inattention, aggression, and mood swings; examples include risperidone and aripiprazole 2140.
  • Sensory Interventions: Use of sensory integration therapy and adaptive technologies (e.g., humanoid robots for reducing distress during medical visits) 118.
  • Special Populations

  • Pediatrics: Early intervention programs significantly improve outcomes 12039.
  • Comorbidities: Higher risk of comorbidities like epilepsy, obesity, and anxiety; tailored management plans required 286870.
  • Pregnancy: Emerging research suggests maternal factors like hormonal contraception use and dietary patterns may influence ASD risk 2233.
  • Key Recommendations

  • Implement Early Behavioral Interventions: Initiate evidence-based behavioral therapies early to improve long-term outcomes (Evidence: Strong 11520).
  • Tailor Sensory and Therapeutic Approaches: Customize sensory integration and multidisciplinary therapies to address individual needs (Evidence: Moderate 11416).
  • Monitor and Manage Comorbid Conditions: Regularly screen for and manage comorbid conditions such as epilepsy, obesity, and mental health issues (Evidence: Moderate 286870).
  • Consider Pharmacotherapy for Symptom Management: Use antipsychotics like risperidone cautiously for managing severe behavioral symptoms (Evidence: Weak 2140).
  • Support Families and Caregivers: Provide psychological and practical support to families to mitigate caregiver stress and burden (Evidence: Expert opinion 269).
  • References

    Showing 100 most recent of 251 indexed papers.

    1 Lodi E, Tampieri F, Poli ML, Rodighiero E, Gasparini PA, Biagi F et al.. Use of a humanoid robot to reduce distress in autistic children undergoing paediatric cardiology visits: a pilot study. BMJ paediatrics open 2026. link 2 Özsavran M, Üstüner Top F, Kuzlu Ayyıldız T. Experiences of Mothers of Children With Autism Spectrum Disorder in Protecting Their Children's Health: A Phenomenological Study in Northern Türkiye. Public health nursing (Boston, Mass.) 2026. link 3 Brown SE, Brown Z, Patel P, Gentry KR. Car to Operating Room: Prehospital Sedation for Behaviorally Challenging Patients, a Problem-Based Learning Discussion. A&A practice 2026. link 4 Borges MH, Guimarães VC, Fernandes FDM, Oliveira AE, Sousa IF. Perception of pragmatic skills by speech therapists and parents of children with autism spectrum disorder. CoDAS 2026. link 5 Howard C, Mekhail J, Ravikoff LM, Milanaik R. Clinical concerns and considerations for leucovorin use in autism spectrum disorder. Current opinion in pediatrics 2026. link 6 Roush K. Autism Diagnoses Have Surged Over the Past Decade. The American journal of nursing 2025. link 7 O'Grady C. Idea that gut microbes contribute to autism draws fire. Science (New York, N.Y.) 2025. link 8 Rast JE, Koffer Miller KH, Bromberg J, Ventimiglia J, Anderson KA, Shea LL. Changes in Child Health Care, Health, and Caregiver Mental Health During the COVID-19 Pandemic in Children with Autism and Special Health Care Needs. Maternal and child health journal 2025. link 9 Bragg MG, Rando J, Carroll KN, Eick SM, Karagas MR, Lin PI et al.. The Association of Prenatal Dietary Factors with Child Autism Diagnosis and Autism-Related Traits Using a Mixtures Approach: Results from the Environmental Influences on Child Health Outcomes Cohort. The Journal of nutrition 2025. link 10 Kannikeswaran N, Roback MG, Burger RK, Barrowman N, Sucha E, Bhatt M. Comparison of Procedural Sedation Outcomes in Children With and Without Autism Spectrum Disorder. Hospital pediatrics 2025. link 11 Baumann BL, Nathan J, Nathan BR, Sheynblyum M, Copeland VC, Mazefsky CA et al.. Developing Inner Speech to Help Autistic Individuals Improve Their Self-Regulation Ability: A Pilot Randomized-Controlled Trial. Autism research : official journal of the International Society for Autism Research 2025. link 12 Benavidez HR, Johansson M, Jones E, Rea H, Kurtz-Nelson EC, Miles C et al.. Predicting Intervention Use in Youth with Rare Variants in Autism-Associated Genes. Journal of autism and developmental disorders 2025. link 13 Silva LEH, de Oliveira E Britto DB. Autism spectrum disorder: communicative profile before and after remote family guidance. CoDAS 2025. link 14 Barros RCB, Ferreira EB, Silva PMVA, Khalil MM, Oliveira APM. Intervention characteristics and speech therapy strategies in care for autistic children in health services: a scoping review. CoDAS 2025. link 15 Schembri E, Jouve E, Poinso F, Encely L, Viellard M, Fernandez A et al.. Evaluation of a medically coordinated care program in the management of autism. L'Encephale 2025. link 16 Haque MS, Islam MM, Khan AH, Akter N, Hossain KMA. Efficacy of physiotherapy with occupational and speech therapy for improving physical & behavioral status among children with autism spectrum disorder (ASD): an assessor blinded randomized clinical trial. BMC pediatrics 2025. link 17 Barbosa FCOL, Montenegro ACA, Queiroga BAM. The effects of the DHACA method on expressive communication in children with autism spectrum disorder. CoDAS 2025. link 18 Zhang Y, Chen S, Li M, Li B, Lu S, Chan A et al.. Sung Speech Training Improves Prosodic Focus Marking in a Nondominant Language in Children With Autism Spectrum Disorder. Journal of speech, language, and hearing research : JSLHR 2025. link 19 Matsumoto MMN, da Silva BFA, Costa MLPO, Carneiro AA, Molini-Avejonas DR. Accuracy of the ABFW ‒ Screening for speech disorders in early childhood. Brazilian journal of otorhinolaryngology 2025. link 20 Ferreira HA, Pacheco PM, Santos THF, Molini-Avejonas DR. Early speech therapy intervention in children with Autism Spectrum Disorder. CoDAS 2025. link 21 Yoshida K, Lunsky Y, Müller DJ, Desarkar P. Prevalence of Psychotropic Medication Use and Psychotropic Polypharmacy in Autistic Adults With or Without Intellectual Disability. Journal of autism and developmental disorders 2025. link 22 Pan X, Xiu Y, Huang S, Lai J, Wang X, Cao X et al.. A Compound Nutritional Supplement Relieving the Core Symptoms of Autism Rats. Journal of nutritional science and vitaminology 2025. link 23 Hirai M, Ikeda A, Kato T, Ikeda T, Asada K, Hakuno Y et al.. Comparison of the Sensory Profile Among Autistic Individuals and Individuals with Williams Syndrome. Journal of autism and developmental disorders 2025. link 24 Kealhofer M, Brown R, Riley BP, Nguyen TH. Joint analysis of . NAR genomics and bioinformatics 2025. link 25 Zhao S, Qu Y, Huang H, Xie P, Cai X, Peng Q et al.. Causal relationship between Faecalibacterium abundance and risk of Faecalibacterium-related diseases: a two-sample bi-directional Mendelian randomisation study. Beneficial microbes 2025. link 26 Patten KK, Murthi K, Onwumere DD, Skaletski EC, Little LM, Tomchek SD. Occupational Therapy Practice Guidelines for Autistic People Across the Lifespan. The American journal of occupational therapy : official publication of the American Occupational Therapy Association 2024. link 27 Seker A, Qirko-Gurakuqi A, Tabaku M, Javate KRP, Rathwell I. Maternal atopic conditions and autism spectrum disorder: a systematic review. European child & adolescent psychiatry 2024. link 28 Griffin J. Eyes are windows to the brain: Capturing eye movements to better understand face processing in autism. Science (New York, N.Y.) 2024. link 29 Pazol K, Tian LH, DiGuiseppi C, Durkin MS, Fallin MD, Moody EJ et al.. Health and Education Services During the COVID-19 Pandemic Among Young Children with Autism Spectrum Disorder and Other Developmental Disabilities. Journal of developmental and behavioral pediatrics : JDBP 2024. link 30 Temane AM, Magagula FN, Nolte AGW. Midwives' lived experiences of caring for women with mobility disabilities during pregnancy, labour and puerperium in Eswatini: a qualitative study. BMC women's health 2024. link 31 Lang J, Wylie G, Haig C, Gillberg C, Minnis H. Towards system redesign: An exploratory analysis of neurodivergent traits in a childhood population referred for autism assessment. PloS one 2024. link 32 Hargreave M, Jezek AH, Hemmingsen CH, Andersen EA, Pagsberg AK, Holmberg T et al.. Maternal use of hormonal contraception and risk of childhood autism spectrum disorders: A Parental Exposures and Child Health (PECH) cohort study. Psychiatry research 2024. link 33 Vecchione R, Westlake M, Bragg MG, Rando J, Bennett DH, Croen LA et al.. Maternal Dietary Patterns During Pregnancy and Child Autism-Related Traits in the Environmental Influences on Child Health Outcomes Consortium. Nutrients 2024. link 34 Accardo AL, Pontes NMH, Pontes MCF. Heightened Anxiety and Depression Among Autistic Adolescents with ADHD: Findings From the National Survey of Children's Health 2016-2019. Journal of autism and developmental disorders 2024. link 35 Mehra S, Salinas-Miranda AA, Buro AW, Marshall J, Kirby RS. The role of adverse childhood experiences in obesity among adolescents with autism spectrum disorder: National survey of Children's health 2018-2019. Disability and health journal 2024. link 36 Lee J, Barger B. Factors Predicting Poor Mental and Physical Health in Parents of Children with Autism Spectrum Disorder: Results from 2016 to 2019 National Survey of Children's Health. Journal of autism and developmental disorders 2024. link 37 Federico A, Zgodic A, Flory K, Hantman RM, Eberth JM, Mclain AC et al.. Predictors of Autism Spectrum Disorder and ADHD: Results from the National Survey of Children's Health. Disability and health journal 2024. link 38 Nutor C, Dickerson AS, Hsu T, Al-Jadiri A, Camargo CA, Schweitzer JB et al.. Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program. Autism research : official journal of the International Society for Autism Research 2024. link 39 Patti MA, Croen LA, Dickerson AS, Joseph RM, Ames JL, Ladd-Acosta C et al.. Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program. Autism research : official journal of the International Society for Autism Research 2024. link 40 Zupin L, Sahyoun C, Krauss B, Dagri A, Rocco EM, Barbi E et al.. Effectiveness of pharmacological procedural sedation in children with autism spectrum disorder: A systematic review and meta-analysis. Acta paediatrica (Oslo, Norway : 1992) 2024. link 41 Salerno C, Cirio S, Maspero C, Roner M, D'Avola V, Cagetti MG. Parent's acceptance of advanced behavior management techniques on children during dental treatment. BMC pediatrics 2024. link 42 Miao Y, Zheng M, Li Q, Xiong L, Feng J, Liu X et al.. Comparison of propofol-esketamine versus propofol-sufentanil for deep sedation and analgesia in children with autism: A randomized double-blind clinical trial. Autism research : official journal of the International Society for Autism Research 2024. link 43 Bhat AN. Fewer children with autism spectrum disorder with motor challenges receive physical and recreational therapies compared to standard therapies: A SPARK data set analysis. Autism : the international journal of research and practice 2024. link 44 Dey I, Chakrabarty S, Nandi R, Shekhar R, Singhi S, Nayar S et al.. Autism community priorities in diverse low-resource settings: A country-wide scoping exercise in India. Autism : the international journal of research and practice 2024. link 45 Almalki AH, Alaqel SI, Alharbi A, Abduljabbar MH, Bamaga AK, Alsenani F et al.. Spectrofluorimetric determination of vitamin D in the serum of autistic and healthy children using functionalized graphene quantum dots. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2024. link 46 Cui T, Zhang J, Han Y, Su Y, Li Z, Zhang X. Sensory sensitivity and intelligence are correlated with nutrient deficiency in children with autism spectrum disorder and intellectual disability. European journal of clinical nutrition 2024. link 47 Hirai M, Asada K, Kato T, Ikeda T, Hakuno Y, Ikeda A et al.. Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan. Journal of autism and developmental disorders 2024. link 48 Wang X, Ling Z, Luo T, Zhou Q, Zhao G, Li B et al.. Severity of Autism Spectrum Disorder Symptoms Associated with de novo Variants and Pregnancy-Induced Hypertension. Journal of autism and developmental disorders 2024. link 49 Zamstein O, Sheiner E, Binyamin Y, Pariente G, Wainstock T. Examining the relationship between autism spectrum disorder in children whose mother had labour epidural analgesia for their birth: A retrospective cohort study. European journal of anaesthesiology 2024. link 50 Kallitsounaki A, Williams DM. Autism Spectrum Disorder and Gender Dysphoria/Incongruence. A systematic Literature Review and Meta-Analysis. Journal of autism and developmental disorders 2023. link 51 He X, Liu W, Tang F, Chen X, Song G. Effects of Probiotics on Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis of Clinical Trials. Nutrients 2023. link 52 Zamzow R. Autism researchers face off over language. Science (New York, N.Y.) 2023. link 53 Mantzalas J, Richdale AL, Dissanayake C. Examining subjective understandings of autistic burnout using Q methodology: A study protocol. PloS one 2023. link 54 Mahoney WJ, Abraham G, Villacrusis M. Many Hands Working Together: Adapting Hospital Care to Support Autistic Children's Mental Health. The American journal of occupational therapy : official publication of the American Occupational Therapy Association 2023. link 55 Ross SM, Haegele JA, Anderson K, Healy S. Evidence of item bias in a national flourishing measure for autistic youth. Autism research : official journal of the International Society for Autism Research 2023. link 56 Zhan XL, Pan N, Karatela S, Shi L, Wang X, Liu ZY et al.. Infant feeding practices and autism spectrum disorder in US children aged 2-5 years: the national survey of children's health (NSCH) 2016-2020. International breastfeeding journal 2023. link 57 Wang X, Weng X, Pan N, Li X, Lin L, Jing J. Prevalence of Autism Spectrum Disorder in the United States is Stable in the COVID-19 Era. Journal of autism and developmental disorders 2023. link 58 Bulkley JE, Varga AM, Dickerson JF, Crawford P, Croen LA, Daida YG et al.. A framework for measuring the cost to families of caring for children's health: the design, methodology, and study population of the r-Kids study. BMC pediatrics 2023. link 59 Li H, Dodd-Butera T, Beaman ML, Burtea R. Immediate Caregiving Environment of Young Children with Autism: Findings from the U.S. National Survey of Children's Health. International journal of environmental research and public health 2023. link 60 Bevan S, Harris K, Maeder-Chieffo S, Reswebber E, Lanahan D, Souders M. Positive Healthcare Encounters for Children With Autism Spectrum Disorder: Accommodations During Surgical Procedures. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 2023. link 61 Penna HM, Paiva APM, Romano AJM, Alves RL, Nascimento Junior PD, Módolo NSP. Comparison between oral midazolam versus oral ketamine plus midazolam as preanesthetic medication in autism spectrum disorder: double-blind randomized clinical trial. Brazilian journal of anesthesiology (Elsevier) 2023. link 62 Oates M, Bean A. Qualitative Analysis of the Experiences and Perspectives of Autistic Speech-Language Pathologists. American journal of speech-language pathology 2023. link 63 Tamanaha AC, Olivatti DOF, Silva SCD, Vieira SCP, Perissinoto J. Picture Exchange Communication System (PECS) Implementation Program for children with autism spectrum disorder. CoDAS 2023. link 64 Sabzevari F, Amelirad O, Moradi Z, Habibi M. Artificial intelligence evaluation of COVID-19 restrictions and speech therapy effects on the autistic children's behavior. Scientific reports 2023. link 65 Hasler M, Fideli ÜS, Susi A, Hisle-Gorman E. Examining the relationship between autism spectrum disorder and neural tube defects. Congenital anomalies 2023. link 66 Gusso D, Prauchner GRK, Rieder AS, Wyse ATS. Biological Pathways Associated with Vitamins in Autism Spectrum Disorder. Neurotoxicity research 2023. link 67 Arija V, Esteban-Figuerola P, Morales-Hidalgo P, Jardí C, Canals-Sans J. Nutrient intake and adequacy in children with autism spectrum disorder: EPINED epidemiological study. Autism : the international journal of research and practice 2023. link 68 Liu X, Sun X, Sun C, Zou M, Chen Y, Huang J et al.. Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis. Autism : the international journal of research and practice 2022. link 69 Mitchell M, Newall F, Williams K. Behavioural emergencies in a paediatric hospital environment. Journal of paediatrics and child health 2022. link 70 Buro AW, Salinas-Miranda A, Marshall J, Gray HL, Kirby RS. Correlates of obesity in adolescents with and without autism spectrum disorder: The 2017-2018 National Survey of Children's Health. Disability and health journal 2022. link 71 Tetnowski JA, Donaher J. Stuttering and Autism Spectrum Disorders: Assessment and Treatment. Seminars in speech and language 2022. link 72 Karrim SB, Flack PS, Naidoo U, Beagle S, Pontin A. The experiences of speech-language therapists providing telerehabilitation services to children with autism spectrum disorder. The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings 2022. link 73 Sauer AK, Hagmeyer S, Grabrucker AM. Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders. International journal of molecular sciences 2022. link 74 Zhang Z, Liu J, Jiang G, Yu H. Vitamin D receptor gene variants and serum vitamin D in childhood autism spectrum disorder. Molecular biology reports 2022. link 75 Adams JB, Kirby J, Audhya T, Whiteley P, Bain J. Vitamin/mineral/micronutrient supplement for autism spectrum disorders: a research survey. BMC pediatrics 2022. link 76 Gallardo-Carrasco MC, Jiménez-Barbero JA, Bravo-Pastor MDM, Martin-Castillo D, Sánchez-Muñoz M. Serum Vitamin D, Folate and Fatty Acid Levels in Children with Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. Journal of autism and developmental disorders 2022. link 77 Chong PF, Torio M, Fujii F, Hirata Y, Matsuoka W, Sonoda Y et al.. Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes. European journal of clinical nutrition 2022. link 78 Agelink van Rentergem JA, Deserno MK, Geurts HM. Validation strategies for subtypes in psychiatry: A systematic review of research on autism spectrum disorder. Clinical psychology review 2021. link 79 Lebersfeld JB, Swanson M, Clesi CD, O'Kelley SE. Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children. Journal of autism and developmental disorders 2021. link 80 Schiller VF, Dorstyn DS, Taylor AM. The Protective Role of Social Support Sources and Types Against Depression in Caregivers: A Meta-Analysis. Journal of autism and developmental disorders 2021. link 81 Karpur A, Vasudevan V, Lello A, Frazier TW, Shih A. Food insecurity in the households of children with autism spectrum disorders and intellectual disabilities in the United States: Analysis of the National Survey of Children's Health Data 2016-2018. Autism : the international journal of research and practice 2021. link 82 Hirota T, Bishop S, Adachi M, Shui A, Takahashi M, Mori H et al.. Utilization of the Maternal and Child Health Handbook in Early Identification of Autism Spectrum Disorder and Other Neurodevelopmental Disorders. Autism research : official journal of the International Society for Autism Research 2021. link 83 Luque CG, Atkins-Labelle C, Pauwels J, Costello R, Kozak FK, Chadha NK. Intranasal Dexmedetomidine increases the successful sedation of children with autism for out-patient auditory brainstem response hearing tests. International journal of pediatric otorhinolaryngology 2021. link 84 Beiting M, Maas E. Autism-Centered Therapy for Childhood Apraxia of Speech (ACT4CAS): A Single-Case Experimental Design Study. American journal of speech-language pathology 2021. link 85 Sourvinos S, Mavropoulos A, Kasselimis DS, Korasidi A, Voukouni AL, Papadopoulos P et al.. Brief Report: Speech and Language Therapy in Children with ASD in an Aquatic Environment: the ASLT (Aquatic Speech and Language Therapy) Program. 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Screening and treatment of trauma-related symptoms in youth with autism spectrum disorder among community providers in the United States. Autism : the international journal of research and practice 2020. link 91 Cummins C, Pellicano E, Crane L. Autistic adults' views of their communication skills and needs. International journal of language & communication disorders 2020. link 92 Flippin M, Hahs-Vaughn DL. Parent couples' participation in speech-language therapy for school-age children with autism spectrum disorder in the United States. Autism : the international journal of research and practice 2020. link 93 Yingling ME, Bell BA. Utilization of speech-language, occupational and physical therapy by diagnosis of autism spectrum disorder. Child: care, health and development 2020. link 94 Espadas C, Ballester P, Londoño AC, Almenara S, Aguilar V, Belda C et al.. Multimorbidity and psychotropic polypharmacy among participants with autism spectrum disorder with intellectual disability. 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    Original source

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