Overview
Aganglionosis of the colon refers to the absence of ganglion cells in the distal bowel, leading to functional obstruction. It is most commonly congenital (Hirschsprung disease) but can also be acquired 1.Diagnosis
Diagnosis is typically made via rectal biopsy demonstrating the absence of ganglion cells 1.
In acquired aganglionosis, serial biopsies may show the progression from presence to absence of ganglion cells over time 1.Management
Surgical intervention, such as colostomy followed by a Soave procedure, can be curative for acquired aganglionosis 1.Key Recommendations
Surgical management, including colostomy and procedures like the Soave procedure, is indicated for acquired aganglionosis 1. (Evidence: Weak)References
1 Towne BH, Stocker JT, Thompson HE, Chang JH. Acquired aganglionosis. Journal of pediatric surgery 1979. link80246-8)