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Geriatrics17 papers

Neonatal renal disorder

Last edited: 4/15/2026

Overview

Neonatal renal disorders encompass a range of conditions affecting kidney function in newborns, often requiring early diagnosis and intervention to prevent long-term complications.

Diagnosis

  • Fractional Excretion of Magnesium (FE Mg): Useful in diagnosing renal magnesium wasting, particularly in pediatric patients 1.
  • Hypomagnesemia Screening: Essential for identifying patients who may benefit from FE Mg testing 1.
  • Management

  • Magnesium Supplementation: Recommended for patients diagnosed with renal magnesium wasting to correct hypomagnesemia 1.
  • Monitoring: Regular monitoring of magnesium levels and renal function is crucial to adjust treatment 1.
  • Special Populations

  • Pediatrics: FE Mg is particularly relevant in pediatric nephrology practice for diagnosing magnesium wasting 1.
  • Elderly: Polypharmacy in elderly patients increases the risk of renal disorders, necessitating careful medication management to mitigate adverse events 2.
  • Key Recommendations

  • Utilize FE Mg for diagnosing renal magnesium wasting in pediatric patients (Evidence: Moderate 1).
  • Implement magnesium supplementation in neonates and children identified with hypomagnesemia due to renal magnesium wasting (Evidence: Moderate 1).
  • Exercise caution with polypharmacy in elderly patients to reduce the risk of renal disorders (Evidence: Moderate 2).
  • References

    1 Awazu M, Matsumura K. Utility of fractional excretion of magnesium in diagnosing renal magnesium wasting in pediatric nephrology practice. Clinical biochemistry 2024. link 2 Abe J, Umetsu R, Uranishi H, Suzuki H, Nishibata Y, Kato Y et al.. Analysis of polypharmacy effects in older patients using Japanese Adverse Drug Event Report database. PloS one 2017. link

    Original source

    1. [1]
    2. [2]
      Analysis of polypharmacy effects in older patients using Japanese Adverse Drug Event Report database.Abe J, Umetsu R, Uranishi H, Suzuki H, Nishibata Y, Kato Y et al. PloS one (2017)

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