Overview
Malignant neoplasms of the biliary tract (BTC) are aggressive and highly fatal malignancies. Advances in understanding the molecular landscape have led to new therapeutic options, though surgery remains the only potentially curative therapy with frequent recurrence 1.Diagnosis
No information provided in the abstracts.Management
Surgery is the only potentially curative therapy for BTC 1.
Adjuvant treatment with capecitabine may improve overall survival (OS) and relapse-free survival in BTC 1.
Concomitant chemoradiotherapy may be considered following R1 resection in BTC 1.
Upfront systemic chemotherapy is the treatment of choice for unresectable locally advanced BTC 1.
Locoregional therapy may be considered after an initial period of at least 3-4 months of systemic chemotherapy for unresectable BTC 1.
Cisplatin plus gemcitabine is the standard treatment for metastatic BTC 1.Special Populations
No information provided in the abstracts.Key Recommendations
Adjuvant treatment with capecitabine may improve OS and relapse-free survival in biliary tract cancer (BTC) 1. (Evidence: Moderate)
Upfront systemic chemotherapy is the treatment of choice for unresectable locally advanced BTC 1. (Evidence: Expert opinion)
Cisplatin plus gemcitabine constitutes the standard treatment for metastatic BTC 1. (Evidence: Expert opinion)References
1 Gómez-España MA, Montes AF, Garcia-Carbonero R, Mercadé TM, Maurel J, Martín AM et al.. SEOM clinical guidelines for pancreatic and biliary tract cancer (2020). Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021. link