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Cardiology1241 papers

Multiple malignancy

Last edited: 4/23/2026

Overview

Multiple malignancies refer to the presence of two or more distinct primary cancers in an individual, often complicating diagnosis and treatment strategies. These cases require multidisciplinary approaches to manage the complexities of concurrent disease processes.

Diagnosis

  • Cytological and Histopathological Analysis: Essential for identifying primary tumors and metastatic involvement 21353.
  • Imaging Studies: CT, MRI, PET/CT for assessing tumor extent, thrombus involvement, and metastasis 71623.
  • Biomarker Testing: Genetic and molecular profiling to differentiate between primary malignancies 232.
  • Body Fluid Analysis: Cytological examination of effusions for malignant cells 1553.
  • Management

  • Surgical Interventions: Segmental resection and graft replacement for IVC involvement; lobectomy for pulmonary malignancies 12344.
  • Radiation Therapy: Tailored to specific tumor types, considering cardiac radiosensitivity 4.
  • Systemic Therapy: Chemotherapy, targeted agents, and immunotherapy based on tumor biology 41217.
  • Supportive Care: Management of complications like hypercalcemia, pericardial effusions, and thromboembolic events 24511.
  • Special Populations

  • Pediatrics: Clear cell sarcoma of the kidney with IVC thrombus requires specialized pediatric oncology care 2.
  • Elderly: Consider polypharmacy impacts on treatment tolerance and outcomes 38.
  • Comorbidities: Management of infections in patients undergoing CAR-T therapy requires vigilant monitoring 26.
  • Key Recommendations

  • Multidisciplinary Team Approach: Essential for managing multiple malignancies to address complex treatment needs (Evidence: Expert opinion 123).
  • Comprehensive Imaging: Utilize advanced imaging techniques like PET/CT for accurate staging and monitoring disease progression (Evidence: Moderate 716).
  • Tailored Supportive Care: Address specific complications such as hypercalcemia and pericardial effusions to improve patient outcomes (Evidence: Moderate 245).
  • Consider Patient-Specific Factors: Tailor treatment plans considering age, comorbidities, and prior therapies (Evidence: Moderate 3826).
  • Regular Monitoring and Biomarker Assessment: Essential for detecting disease progression and treatment resistance (Evidence: Moderate 3253).
  • References

    Showing 100 most recent of 405 indexed papers.

    1 MacArthur TA, Mendes BC, Colglazier JJ, Nagorney DM, DeMartino RR, Gloviczki P et al.. Early and late outcomes of patients treated with graft replacement of the inferior vena cava for malignant disease: A single-center experience over three decades. Journal of vascular surgery. Venous and lymphatic disorders 2026. link 2 Yin B, Long X, Wang Z, Ning F, Wang K, He J. Clear cell sarcoma of the kidney with inferior vena cava tumor thrombus in a pediatric patient: a case report. The Canadian journal of urology 2026. link 3 Chiriac R, Leparc M, Stanescu M, Mery L, Milandri J, Jaillard M et al.. Hidden morphological clues in deceptive bone marrow pathologies. Annales de biologie clinique 2026. link 4 Kim Y, Bates JE, Yoon HI, Grassberger C. Cardiac radiosensitivity in the era of thoracic chemoradiotherapy and immunotherapy: a scoping review. The Lancet. Oncology 2026. link00651-5) 5 Chamsi-Pasha MAR. Malignant Pericardial Effusion: Heart-Breaking Tumors. Methodist DeBakey cardiovascular journal 2026. link 6 Ikeda S, Kasai H, Sugiura T, Tanaka R, Hayama N, Rakuman S et al.. Endovascular Stenting for Malignant Superior Vena Cava Syndrome Complicated by Interstitial Pneumonia: A Report of 2 Cases. The American journal of case reports 2026. link 7 Kumar SA, Jain S, Goyal H, Halanaik D. Imaging tumor thrombus across malignancies: current concepts and the expanding role of PET/computed tomography. Nuclear medicine communications 2026. link 8 Fish AG, Madoff DC. The Role of the Interventional Radiologist in Stopping Bleeding in Cancer Patients. Current oncology reports 2025. link 9 Jang YJ, Yang YJ, Koo HJ, Yoon HW, Uhm S, Kim SY et al.. Factors Affecting Life-Sustaining Treatment Decisions and Changes in Clinical Practice after Enforcement of the Life-Sustaining Treatment (LST) Decision Act: A Tertiary Hospital Experience in Korea. Cancer research and treatment 2025. link 10 Guevara B, Rezaei A, Baydoun A, Li Q, Layng S, Gregg KW et al.. In Silico Evaluation of Direct-to-Unit, Single-Visit Celiac Plexus Pain Ablation Using Computed Tomography Guided Adaptive Radiation Therapy. International journal of radiation oncology, biology, physics 2025. link 11 Amanati A, Van Manen R, Sajedianfard S, Shojaadini H, Boroughani M, Molavi Vardanjani H. Antineoplastic agents associated with neutropenic enterocolitis in patients with malignancy: A quantitative safety signal analysis. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2025. link 12 Tan AJ, Liu WY, Lu JL, Tan QY, Yan Y, Mo DC. A pharmacovigilance analysis of post-marketing safety of durvalumab. Scientific reports 2025. link 13 Doğan K, Kurtulan O, Onder S. Re-Categorization and Risk of Malignancy of Atypical Effusions According to the International System for Reporting Serous Fluid Cytopathology (TIS): An Institutional Experience. Diagnostic cytopathology 2025. link 14 Chen MS, Gettleman BS, Liu KC, Richardson MK, Talehakimi A, Heckmann ND et al.. Is Aspirin Safe for Thromboprophylaxis After Surgery for Lower Extremity Neoplastic Pathologic Fractures?. Journal of surgical oncology 2025. link 15 Torous VF, Pineda CM, Quintana LM, Chebib I, VanderLaan PA. Pericardial effusion cytology: malignancy rates, patterns of metastasis, comparison with pericardial window, and genomic correlates. Journal of the American Society of Cytopathology 2025. link 16 Singh A, Hammer MM. Imaging Features Differentiating Between Cardiac Sarcomas and Hematologic Neoplasms. Journal of computer assisted tomography 2025. link 17 Byron Y, Yegorova-Lee S, Tio M. Do corticosteroids affect immunotherapy efficacy in malignancy? - A systematic review. Cancer medicine 2024. link 18 Ahmed O, Ordidge K, Hussain T, Syed A, Haroon A, Shahabuddin K. Haemato-radiology: the role of the radiologist at MDT. The British journal of radiology 2024. link 19 Amicucci M, Trigoso E, Nori M, Colomer-Lahiguera S, Rostagno E, Biagioli V et al.. Role, education, policies and competencies for advanced practice in paediatric haematology-oncology nursing in Europe: A scoping review. Pediatric blood & cancer 2024. link 20 Griffiths S, Power L, Breen D. Pulmonary endoscopy - central to an interventional pulmonology program. Expert review of respiratory medicine 2024. link 21 Umman V, Girgin T, Baki BE, Bozbiyik O, Akbulut S, Yoldas T. Impact of pandemic and socioeconomic influences on decision-making for emergency ostomy procedures: Key factors affecting hospital visit decisions. Medicine 2024. link 22 Sable KA, Korger SA, Xu YG, Bennett DD, Hinshaw MA, Rosin AE. The Clinical Utility of Teledermatology in Triaging and Diagnosing Skin Malignancies: Case Series. Cutis 2024. link 23 Fatehi Hassanabad A, Ball CG, Kidd WT. Inferior vena cava tumor thrombus: clinical outcomes at a canadian tertiary center. Perfusion 2024. link 24 El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T et al.. Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism 2023. link 25 Curtis KL, Lipner SR. Metastases to the nail unit and distal phalanx: a systematic review. Archives of dermatological research 2023. link 26 Reynolds GK, Sim B, Spelman T, Thomas A, Longhitano A, Anderson MA et al.. Infections in haematology patients treated with CAR-T therapies: A systematic review and meta-analysis. Critical reviews in oncology/hematology 2023. link 27 Yuen HLA, Weinkove R, Ullman A, Marsh N, Rickard CM, Chunilal S et al.. Central venous access device practice across haematology and oncology centres in Australia and New Zealand: a cross-sectional survey. Internal medicine journal 2023. link 28 Del Principe MI, Seidel D, Criscuolo M, Dargenio M, Rácil Z, Piedimonte M et al.. Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope. Mycoses 2023. link 29 Swinn T, Butler A. Plerixafor use in New Zealand 2016-2019: an observational study. Internal medicine journal 2023. link 30 Gales L, Cribier B, Lipsker D, Lenormand C. Superficial (nodular) thrombophlebitis as a heterogeneous entity with distinctive clinico-pathological aspects: Correlation with the underlying conditions. Journal of the European Academy of Dermatology and Venereology : JEADV 2023. link 31 Henze L, Buhl C, Sandherr M, Cornely OA, Heinz WJ, Khodamoradi Y et al.. Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus. Annals of hematology 2022. link 32 . Hotspot Mutations Optimize the Oncogenic-Immunogenic Trade-off. Cancer discovery 2022. link 33 Cho HE, Kim YJ, Cho SY, Park TS, Park KS. Clinical application of an algorithm to screen for malignant cells in body fluids using an automated hematology analyzer. International journal of laboratory hematology 2022. link 34 Bris PN, Gauchez P, Devillier R, Galicier L, Collignon A, Piana G et al.. Hepatic haemophagocytosis in haematology patients with hepatic dysfunction: prognostic impact and contribution of liver biopsy combined with the haemophagocytic syndrome diagnostic score (HScore). British journal of haematology 2022. link 35 Caris MG, de Jonge NA, Punt HJ, Salet DM, de Jong VMT, Lissenberg-Witte BI et al.. Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study. Antimicrobial resistance and infection control 2022. link 36 Boldú L, Laguna J, Casanova A, García S, Molina A, Merino A. Serous body fluid evaluation using the new automated haematology analyser Mindray BC-6800Plus. Clinical chemistry and laboratory medicine 2022. link 37 Damen MDC, Westerweel PE, Levin MD, Pelle AJ. Unmet supportive care needs, anxiety and depression in haematology patients during watch-and-wait. Psycho-oncology 2022. link 38 Outlaw D, Dai C, Al-Obaidi M, Harmon C, Giri S, Bhatia S et al.. The association of polypharmacy with functional status impairments, frailty, and health-related quality of life in older adults with gastrointestinal malignancy - Results from the Cancer and Aging Resilience Evaluation (CARE) registry. Journal of geriatric oncology 2022. link 39 Booth S, Curley HM, Varnai C, Arnold R, Lee LYW, Campton NA et al.. Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy. British journal of haematology 2022. link 40 Ling Y, Li Y, Zhang X, Dong L, Wang J. Clinical features of Trousseau's syndrome with multiple acute ischemic strokes. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2022. link 41 Croft M, Lim W, Lavender N, Gormly K. Optimising CT-chest protocols and the added value of venous-phase contrast timing; Observational case-control. Journal of medical imaging and radiation oncology 2022. link 42 Higuchi S, Kabeya Y, Matsushita K, Tachibana K, Kawachi R, Takei H et al.. Clinical impact of perioperative atrial fibrillation on long-term recurrence of malignancy. Heart and vessels 2022. link 43 Imam Z, Hanna A, Jomaa D, Khasawneh M, Abonofal A, Murad MH. Hypercalcemia of Malignancy and Acute Pancreatitis. Pancreas 2021. link 44 Rothenberg SS. Thoracoscopic Lobectomy in Infants and Children. Journal of laparoendoscopic & advanced surgical techniques. Part A 2021. link 45 Spring J, Munshi L. Oncologic Emergencies: Traditional and Contemporary. Critical care clinics 2021. link 46 Zhang ML, Maglantay RJ, Cunningham VL, Goodwin MT, Feeney MW, Keefe J et al.. Improving Malignancy Detection Rates in Body Fluids Submitted to the Hematology Laboratory for Nucleated Cell Count and Differential: A Quality Improvement Study. Archives of pathology & laboratory medicine 2021. link 47 McCaughan G, Di Ciaccio P, Ananda-Rajah M, Gilroy N, MacIntyre R, Teh B et al.. COVID-19 vaccination in haematology patients: an Australian and New Zealand consensus position statement. Internal medicine journal 2021. link 48 Nada A, Jetton JG. Pediatric onco-nephrology: time to spread the word : Part I: early kidney involvement in children with malignancy. Pediatric nephrology (Berlin, Germany) 2021. link 49 Ramsay G, Wohlgemut JM, Bekheit M, Watson AJM, Jansen JO. Causes of death after emergency general surgical admission: population cohort study of mortality. BJS open 2021. link 50 Würnschimmel C, Wenzel M, Maurer T, Valdés Olmos RA, Vidal-Sicart S. Contemporary update of SPECT tracers and novelties in radioguided surgery: a perspective based on urology. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... 2021. link 51 Khadilkar MN, Pai KK, Rai T, Shenoy V, Dosemane D, Kabekkodu S. Depression profile in malignancy patients attending otorhinolaryngology clinic. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2021. link 52 Waidyaratne G, Zhou S, O'Neil T, Marks A. Management of Wound Myiasis in the Hospice and Palliative Medicine Setting. Journal of palliative medicine 2021. link 53 Lew M, Cantley R, Heider A, Jing X. Diagnosis and categorization of malignant effusions: A 6-year review from a single academic institution. Diagnostic cytopathology 2021. link 54 Shroff GS, Shroff S, Ahuja J, Truong MT, Vlahos I. Imaging spectrum of adverse events of immune checkpoint inhibitors. Clinical radiology 2021. link 55 Crocoli A, Cesaro S, Cellini M, Rossetti F, Sidro L, Pinelli F et al.. In defense of the use of peripherally inserted central catheters in pediatric patients. The journal of vascular access 2021. link 56 Itani M, Kipper B, Corwin MT, Burgan CM, Fetzer DT, Shenoy-Bhangle AS et al.. Right-sided scrotal varicocele and its association with malignancy: a multi-institutional study. Abdominal radiology (New York) 2021. link 57 Wahidi MM, Herth FJF, Chen A, Cheng G, Yarmus L. State of the Art: Interventional Pulmonology. Chest 2020. link 58 Reslan Z, Lindsay J, Kerridge I, Gellatly R. Pharmacist review of high-risk haematology outpatients to improve appropriateness of antifungal prophylaxis. International journal of clinical pharmacy 2020. link 59 Yumeen S, Mirza FN, Lewis JM, Girardi M. Research Techniques Made Simple: Preclinical Development of Combination Antitumor Targeted Therapies in Dermatology. The Journal of investigative dermatology 2020. link 60 Freitag SK, Aakalu VK, Tao JP, Wladis EJ, Foster JA, Sobel RK et al.. Sentinel Lymph Node Biopsy for Eyelid and Conjunctival Malignancy: A Report by the American Academy of Ophthalmology. Ophthalmology 2020. link 61 Alshaikh S, Lapadat R, Atieh MK, Mehrotra S, Barkan GA, Wojcik EM et al.. The utilization and utility of immunostains in body fluid cytology. Cancer cytopathology 2020. link 62 Das K, Khanna T, Arora A, Agrawal N. Parents' acceptance and regret about end of life care for children who died due to malignancy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020. link 63 Castro Corredor D, Ramírez Huaranga MA, Rebollo Giménez AI, Arenal López R, Cuadra Díaz JL. Rheumatic syndromes and occult tumor: 10-year experience in a teaching hospital. Reumatologia clinica 2020. link 64 Shirmardi SP, Saniei E, Das T, Noorvand M, Erfani M, Bagheri R. Internal dosimetry studies of . Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2020. link 65 Zhang F, Lu CD, Zhang XP, Chen ZH, Zhong CQ, Hu YR et al.. The impact of portal vein tumor thrombus on long-term survival after liver resection for primary hepatic malignancy. HPB : the official journal of the International Hepato Pancreato Biliary Association 2020. link 66 Seidensaal K, Harrabi SB, Uhl M, Debus J. Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies. The British journal of radiology 2020. link 67 Epelboym Y, Stecker MS, Fan CM, Killoran TP, Rabkin DJ, Schenker MP. Treatment of malignant inferior vena cava obstruction with Gianturco-Rosch-Z stents: a single center 13-year experience. Clinical imaging 2020. link 68 Leader A, Ten Cate V, Ten Cate-Hoek AJ, Spectre G, Beckers EAM, Raanani P et al.. Managing Anti-Platelet Therapy in Thrombocytopaenic Patients with Haematological Malignancy: A Multinational Clinical Vignette-Based Experiment. Thrombosis and haemostasis 2019. link 69 Rastogi L, Dass J, Arya V, Kotwal J. Evaluation of high-fluorescence body fluid (HF-BF) parameter as a screening tool of malignancy in body fluids. Indian journal of pathology & microbiology 2019. link 70 Geerts PAF, van der Weijden T, Loeffen PGM, Janssen LEF, Almekinders C, Wienhold TA et al.. Developing a patient portal for haematology patients requires involvement of all stakeholders and a customised design, tailored to the individual needs. BMC medical informatics and decision making 2019. link 71 McCaughan D, Roman E, Smith AG, Garry AC, Johnson MJ, Patmore RD et al.. Haematology nurses' perspectives of their patients' places of care and death: A UK qualitative interview study. European journal of oncology nursing : the official journal of European Oncology Nursing Society 2019. link 72 Biehl LM, Higgins P, Wille T, Peter K, Hamprecht A, Peter S et al.. Impact of single-room contact precautions on hospital-acquisition and transmission of multidrug-resistant Escherichia coli: a prospective multicentre cohort study in haematological and oncological wards. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2019. link 73 Tumielewicz KL, Hudak D, Kim J, Hunley DW, Murphy LA. Review of oncological emergencies in small animal patients. Veterinary medicine and science 2019. link 74 Keller JJ, Fett NM, Morrison LH. Dermatology in the Diagnosis of Noncutaneous Malignancy: Paraneoplastic Diseases. Dermatologic clinics 2019. link 75 Lucatelli P, Iezzi R, De Rubeis G, Goldberg SN, Bilbao JI, Sami A et al.. Immuno-oncology and interventional oncology: a winning combination. The latest scientific evidence. European review for medical and pharmacological sciences 2019. link 76 Garnon J, Meylheuc L, Cazzato RL, Dalili D, Koch G, Auloge P et al.. Percutaneous extra-spinal cementoplasty in patients with cancer: A systematic review of procedural details and clinical outcomes. Diagnostic and interventional imaging 2019. link 77 Oshima Y, Takahashi S, Tani K, Tojo A. Granulocyte colony-stimulating factor-associated aortitis in the Japanese Adverse Drug Event Report database. Cytokine 2019. link 78 Shimada K, Hasegawa S, Nakao S, Mukai R, Matsumoto K, Tanaka M et al.. Adverse event profiles of ifosfamide-induced encephalopathy analyzed using the Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report databases. Cancer chemotherapy and pharmacology 2019. link 79 Arima T, Muroya K, Kawamoto K, Koba Y, Omura T. Aortic Thrombosis in a Patient With Malignant Disease: A Literature Review and Case Presentation. Vascular and endovascular surgery 2019. link 80 Sato S, Nakamura A, Shimizu Y, Goto T, Kitahara A, Koike T et al.. Early and mid-term outcomes of simultaneous thoracic endovascular stent grafting and combined resection of thoracic malignancies and the aortic wall. General thoracic and cardiovascular surgery 2019. link 81 Ono K, Hidaka H, Sato M, Nakatsuka H. Preoperative continuation of aspirin administration in patients undergoing major abdominal malignancy surgery. Journal of anesthesia 2019. link 82 Hoshino H, Matsunaga T, Takamochi K, Oh S, Suzuki K. Is postoperative anticoagulation necessary after left innominate vein division in general thoracic surgery?. General thoracic and cardiovascular surgery 2019. link 83 Kurtz MP, MacDougall RD, Nelson CP. Urology mythbusters: Radiation and radiophobia. Journal of pediatric urology 2018. link 84 Ai T, Tabe Y, Takemura H, Kimura K, Takahashi T, Yang H et al.. Novel flowcytometry-based approach of malignant cell detection in body fluids using an automated hematology analyzer. 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    Original source

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      Early and late outcomes of patients treated with graft replacement of the inferior vena cava for malignant disease: A single-center experience over three decades.MacArthur TA, Mendes BC, Colglazier JJ, Nagorney DM, DeMartino RR, Gloviczki P et al. Journal of vascular surgery. Venous and lymphatic disorders (2026)
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      Clear cell sarcoma of the kidney with inferior vena cava tumor thrombus in a pediatric patient: a case report.Yin B, Long X, Wang Z, Ning F, Wang K, He J The Canadian journal of urology (2026)
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      Hidden morphological clues in deceptive bone marrow pathologies.Chiriac R, Leparc M, Stanescu M, Mery L, Milandri J, Jaillard M et al. Annales de biologie clinique (2026)
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      Cardiac radiosensitivity in the era of thoracic chemoradiotherapy and immunotherapy: a scoping review.Kim Y, Bates JE, Yoon HI, Grassberger C The Lancet. Oncology (2026)
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      Malignant Pericardial Effusion: Heart-Breaking Tumors.Chamsi-Pasha MAR Methodist DeBakey cardiovascular journal (2026)
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      Endovascular Stenting for Malignant Superior Vena Cava Syndrome Complicated by Interstitial Pneumonia: A Report of 2 Cases.Ikeda S, Kasai H, Sugiura T, Tanaka R, Hayama N, Rakuman S et al. The American journal of case reports (2026)
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      In Silico Evaluation of Direct-to-Unit, Single-Visit Celiac Plexus Pain Ablation Using Computed Tomography Guided Adaptive Radiation Therapy.Guevara B, Rezaei A, Baydoun A, Li Q, Layng S, Gregg KW et al. International journal of radiation oncology, biology, physics (2025)
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      Antineoplastic agents associated with neutropenic enterocolitis in patients with malignancy: A quantitative safety signal analysis.Amanati A, Van Manen R, Sajedianfard S, Shojaadini H, Boroughani M, Molavi Vardanjani H Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2025)
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      Do corticosteroids affect immunotherapy efficacy in malignancy? - A systematic review.Byron Y, Yegorova-Lee S, Tio M Cancer medicine (2024)
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