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Allergy & Immunology64 papers

Seasonal allergic rhinitis

Last edited: 4/15/2026

Overview

Seasonal allergic rhinitis (SAR) is characterized by symptoms such as sneezing, nasal congestion, and itching, triggered by seasonal allergens like pollen 1.

Diagnosis

  • Clinical History: Detailed patient history identifying seasonal patterns and potential allergens 1.
  • Skin Prick Test (SPT) or Serum IgE Testing: Identifies sensitization to specific allergens 1.
  • Component Resolved Diagnosis (CRD): Enhances specificity by identifying specific allergen components 1.
  • Digital Symptom Recording (eDiary): Utilizes real-time symptom tracking to correlate symptoms with allergen exposure 1.
  • Management

  • First-Line Treatments:
  • - Antihistamines: Second-generation antihistamines (e.g., loratadine, cetirizine) for symptom relief 1. - Nasal Corticosteroids: Intranasal corticosteroids (e.g., fluticasone, mometasone) for reducing nasal inflammation 1.
  • Adjunctive Treatments:
  • - Decongestants: Short-term use for nasal congestion 1. - Leukotriene Receptor Antagonists: Montelukast for moderate to severe cases 1. - Allergen Immunotherapy (AIT): Recommended for patients with persistent symptoms despite pharmacotherapy 1.

    Special Populations

  • Pediatrics: Specific dosing and safety considerations apply; antihistamines and intranasal corticosteroids are commonly used 1.
  • Elderly: Increased attention to polypharmacy and potential drug interactions; similar treatments as adults but with caution 1.
  • Comorbidities: Management should consider coexisting conditions; no specific contraindications noted in the abstract 1.
  • Key Recommendations

  • Utilize component resolved diagnosis (CRD) alongside traditional skin prick tests and serum IgE levels to enhance the accuracy of allergen identification for AIT prescription decisions (Evidence: Strong 1).
  • Incorporate real-time digital symptom recording (eDiary) to improve the correlation between allergen exposure and symptomatology, potentially increasing appropriate AIT prescriptions (Evidence: Moderate 1).
  • Consider allergen immunotherapy (AIT) for patients with persistent symptoms despite optimal pharmacotherapy, especially when specific allergens are accurately identified (Evidence: Expert opinion 1).
  • References

    1 Arasi S, Castelli S, Di Fraia M, Villalta D, Tripodi S, Perna S et al.. @IT2020: An innovative algorithm for allergen immunotherapy prescription in seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2021. link

    Original source

    1. [1]
      @IT2020: An innovative algorithm for allergen immunotherapy prescription in seasonal allergic rhinitis.Arasi S, Castelli S, Di Fraia M, Villalta D, Tripodi S, Perna S et al. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)

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