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Urinary tract infection caused by Klebsiella

Last edited: 4/10/2026

Overview

Urinary tract infections (UTIs) are common bacterial infections. Increasing antimicrobial resistance poses a challenge to effective treatment 1. Klebsiella species are a common cause of UTIs 1.

Diagnosis

Management

  • Sulopenem demonstrated noninferiority to amoxicillin/clavulanate for uncomplicated UTIs 1.
  • Fosfomycin was used in a study comparing antibiotic treatment to cranberry extract for uncomplicated UTIs 2.
  • Cranberry extract showed a decrease in patient complaints and increased well-being compared to fosfomycin in uncomplicated UTIs 2.

    • Special Populations

    Key Recommendations

  • Sulopenem is a potential treatment option for uncomplicated urinary tract infections, showing comparable efficacy to amoxicillin/clavulanate 1. (Evidence: Strong)
  • Cranberry extract may be a favorable alternative to antibiotics for uncomplicated and simple urinary tract infections, improving patient well-being 2. (Evidence: Strong)

    • References

    1 Puttagunta S, Aronin SI, Gupta J, Das AF, Gupta K, Dunne MW. Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection. NEJM evidence 2025. link 2 Güven O, Sayılan S, Tataroğlu Ö, Hökenek NM, Keleş DV. Antibiotic versus cranberry in the treatment of uncomplicated urinary infection: a randomized controlled trial. Revista da Associacao Medica Brasileira (1992) 2023. link

    Original source

    1. [1]
      Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection. — Puttagunta S, Aronin SI, Gupta J, Das AF, Gupta K, Dunne MW NEJM evidence (2025)
    2. [2]
      Antibiotic versus cranberry in the treatment of uncomplicated urinary infection: a randomized controlled trial. — Güven O, Sayılan S, Tataroğlu Ö, Hökenek NM, Keleş DV Revista da Associacao Medica Brasileira (1992) (2023)
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