Overview
Renal candidiasis refers to fungal infection of the renal parenchyma, often complicating underlying conditions such as diabetes and leading to acute renal failure 1.Diagnosis
Bilateral enlarged kidneys on imaging suggestive of renal involvement 1
Renal function tests showing acute renal failure
Histopathological confirmation of Candida species in renal tissue samples
Urine cultures positive for Candida speciesManagement
First-line treatment: Amphotericin B for severe cases 1
Adjunctive measures: Supportive care including fluid management and addressing underlying conditions like diabetes 1Special Populations
Diabetes: Increased susceptibility to renal candidiasis leading to acute renal failure 1Key Recommendations
Initiate amphotericin B therapy for confirmed renal candidiasis to improve renal function and reduce kidney size 1 (Evidence: Strong)
Closely monitor renal function and size in diabetic patients presenting with signs of renal candidiasis 1 (Evidence: Moderate)
Differentiate renal lesions in congenital syndromes from infectious causes like candidiasis through comprehensive imaging and histopathological examination 2 (Evidence: Expert opinion)References
1 Lasater J, Hyde HC, Aldridge GA, King RW. Acute reversible renal failure secondary to renal candidiasis. The Journal of urology 1979. link56422-8)
2 Bernstein J, Brough AJ, McAdams AJ. The renal lesion in syndromes of multiple congenital malformations. Cerebrohepatorenal syndrome; Jeune asphyxiating thoracic dystrophy; tuberous sclerosis; Meckel syndrome. Birth defects original article series 1974. link