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Dermatology5896 papers

Demodex acne

Last edited: 4/23/2026

Overview

Demodex acne, often associated with Demodex mites, can exacerbate or contribute to acne vulgaris, particularly in adult populations. It involves follicular colonization by Demodex species, potentially leading to inflammation and comedone formation 1 3 4.

Diagnosis

Clinical presentation includes persistent inflammatory acne lesions, often on the face 1 3.

No specific diagnostic tests for Demodex infestation alone; identification typically requires microscopic examination of skin scrapings 1 3.

Grading systems for acne severity (e.g., Global Acne Grading System) can help assess the extent of the condition 1 18.

Management

First-line treatments: Topical retinoids, benzoyl peroxide, and antibiotics (e.g., clindamycin) to manage acne inflammation and bacterial load 1 5 7 20.

Adjunctive treatments:

- Demodex-specific interventions: Topical ivermectin or tea tree oil 1 3. - Energy-based devices (EBDs): Considered for persistent cases to reduce inflammation and improve skin texture 1. - Dermocosmetics: Use of non-comedogenic products and skincare routines that minimize irritation 26 27.

Combination therapy: Integrating multiple approaches, such as topical antiandrogens like clascoterone, to address hormonal influences 7 26.

Special Populations

Pregnancy: Limited evidence; avoid systemic treatments like isotretinoin; consider topical therapies cautiously 24 46.

Pediatrics: Focus on gentle skincare and topical treatments; avoid harsh interventions 1 2.

Elderly: Similar management principles apply, with emphasis on minimizing irritation and using effective yet gentle topical agents 1 3.

Comorbidities: Consider impact on treatment choices; for example, patients with depression may require additional psychological support 8 58.

Key Recommendations

Initiate with topical retinoids and benzoyl peroxide for managing inflammatory acne, including cases suspected to be influenced by Demodex infestation (Evidence: Moderate 1 5).

Consider adjunctive use of topical ivermectin or tea tree oil for patients with persistent symptoms indicative of Demodex infestation (Evidence: Weak 1 3).

Evaluate and incorporate energy-based devices for refractory cases to enhance treatment outcomes (Evidence: Moderate 1).

Tailor skincare routines to include non-comedogenic products and gentle cleansing to minimize irritation (Evidence: Expert opinion 26).

Monitor for psychological impact, especially in adolescents and young adults, and provide psychological support if necessary (Evidence: Moderate 8 58).

References

Showing 100 most recent of 5771 indexed papers.

1 Waibel JS, Ablon G, Andriessen A, Adzovic V, Bucay V, Draelos Z et al.. Practical Algorithm for Acne Treatment Integrating Skincare and Energy-Based Devices. Journal of drugs in dermatology : JDD 2026. link 2 Woźna J, Woźna W, Mojs E, Grzybowski A, Żaba R. From Salves to Sulzberger: The emergence of the American approach to acne treatment. Clinics in dermatology 2026. link 3 Augustin M, Dirschka T, Gerber PA, Kerscher M, Kirsten N, Ochsendorf F. Acne tarda: Recommendations for classification, treatment and care as a result of an expert discussion. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2026. link 4 Parkinson H. Adult and perimenopausal acne and the nurse's role in management. British journal of nursing (Mark Allen Publishing) 2026. link 5 Burckhardt-Bravo V, Funes-Ferrada R, Valenzuela F. Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches. Anais brasileiros de dermatologia 2026. link 6 Walter S. Dermatologic conditions and stigma: The depiction of acne in cartoons. Clinics in dermatology 2026. link 7 Balado-Simó P, Brufau-Cochs M, Morgado-Carrasco D. Clascoterone 1% in the Treatment of Acne: A Review of its Efficacy, Safety, and Therapeutic Positioning. Actas dermo-sifiliograficas 2026. link 8 Flinn C, Ungar M, Deschênes S, Nearchou F. Resilience and trajectories of depressive symptoms and suicidal ideation in the context of exposure to acne: Findings from the Lifelines Cohort Study. Journal of health psychology 2026. link 9 van Steensel MAM. The Evolving Microbial Paradigm in Acne. Biomolecules 2026. link 10 Kazmi F, Feng Z, Huang L, Kang Y, Song Y, Di X et al.. Unlocking the antibacterial potential of Zanthoxylum armatum fruit: A bioactive approach to treat acne vulgaris. Microbial pathogenesis 2026. link 11 Feng X, Chen Y, Liu Y. Truncal Acne: Pathophysiology, Clinical Features, and Management Strategies. Journal of cosmetic dermatology 2026. link 12 Huang S, Fang L, Zhang M, Sun S, Zhi H, Zhu Y et al.. The relationship between MMP-2 and TIMP-2 gene polymorphisms and skin barrier function, inflammatory cytokine levels in acne patients. Expert review of clinical immunology 2026. link 13 Kurt Oktay KN, Uysal M, Geler Kulcu D. Femoral Neck Bone Marrow Edema During Isotretinoin Therapy: A Case Report. American journal of physical medicine & rehabilitation 2026. link 14 Seibert D, Cohen LN, Boswell N, Alford B, Yeung H, Akinshemoyin Vaughn OL. Acne in Transmasculine Patients: A Scoping Review. JAMA dermatology 2026. link 15 Trejo-Hernández A, Checa A, Quijada-Ibarra R, Sepúlveda-Gutíerrez P, Soto S, Andrade-Domínguez A. Pseudolysogeny-mediated evolutionary trade-offs favor phage therapy by limiting antibiotic resistance and virulence in Cutibacterium acnes. Scientific reports 2026. link 16 Zhang Y, Fan L, Li L. Knowledge, attitudes, and practices regarding acne among university students. Scientific reports 2026. link 17 Hacinecipoğlu F, Öner Ü. Assessing Skincare Awareness in Acne Vulgaris: A Cross-Sectional Study. Advances in skin & wound care 2026. link 18 Bhatt J, Kumar VJ, Chahat. "Acne vulgaris: key insights, treatment, and future prospects". Molecular diversity 2026. link 19 Tian R, Zhang L, Zhang J, Yang S, Ren Y, Zhou A et al.. Transparent, 3D-printed microneedle patches that co-deliver ALA and guide blue light for preclinical photodynamic therapy of acne. Journal of materials chemistry. B 2026. link 20 Huang W, Tian C, Lin B, Yu H. Efficacy of different topical spironolactone treatments for acne vulgaris: A meta-analysis. Pakistan journal of pharmaceutical sciences 2026. link 21 Hong S, Park S, Park M, Park JM, Hwang DY, Lee H et al.. Anti-Acne Potential of . Journal of microbiology and biotechnology 2026. link 22 Penev J, Balabanova M, Jafferany M. Integrated CO. Journal of cosmetic dermatology 2026. link 23 Parvizi MM, Saki N, Rostami Ghotbabadi Z, Kamali M, Salmanpour N, Namazi M et al.. Medicinal Plants for Acne Vulgaris: An Evidence-Based Review of Treatments Promoted by Social Media. Journal of cosmetic dermatology 2026. link 24 Alrubaiaan MT, Bajamaan R, Altuwaijri AM, Alsenidi R, Almarzoq MS, Alashgar TM et al.. 'Oral isotretinoin plus desloratadine for acne vulgaris: an updated global meta-analysis of efficacy, safety, and patient-centered outcomes'. The Journal of dermatological treatment 2026. link 25 Zimmo S, Zaher H, Said A, El Morsy E, Litaiem N, Al Hammadi A et al.. Use of Dermocosmetics in Acne Management: A Middle East-North Africa Consensus. International journal of dermatology 2026. link 26 Han JH, Ju HJ, Kim TI, Yoon YH, Woo YJ, Kye H et al.. Personalized Approach for Acne Management With Dermocosmetics According to Initial Skin Sensitivity. Journal of cosmetic dermatology 2026. link 27 Oulès B, Saurat JH. Strategic Targets in Acne, Update 2025: The Microcomedone Is Not Just a Plug, It Is an Egg. Dermatology (Basel, Switzerland) 2026. link 28 Schulz S, Lamprecht S. Transdermal Delivery of Botulinum Toxin for the Management of Oily and Acne-Prone Skin Using TDA Technology. Journal of cosmetic dermatology 2026. link 29 He H, Qiu Y, Liu Q. Alternating ablative fractional laser and microneedling radiofrequency outperforms ablative fractional laser alone for acne scars. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2026. link 30 Jisa TA, Rahat MTI, Sumi MSA, Sultana N, Sarker JK, Nurejannath M et al.. Prevalence of Acne and Its Impact on Quality of Life, Social Appearance Anxiety and Treatment Practices Among Young Adults. Journal of cosmetic dermatology 2026. link 31 Nguyen TTM, Bae CI, Yang SJ, Jin X, Zheng Q, Yi EJ et al.. Effect of Lactiplantibacillus Plantarum THK-J112 Against Candida Overgrowth in Acne Complications. Probiotics and antimicrobial proteins 2026. link 32 Tommasino N, Annunziata MC, Potestio L, Napolitano M. Beyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne. Journal of cosmetic dermatology 2026. link 33 Mustaffa MF, Mohd Ghazali NSM, Khalid SH, Abdul Hamid K. Nanoformulations in Acne Therapy: Translational Opportunities and Barriers for Next-Generation Topical Treatments. AAPS PharmSciTech 2026. link 34 Hasan MM, Tory S, Arslan YK, Tutar Y. Alterations in the lipid profile in acne vulgaris patients: A meta-analysis. The Journal of international medical research 2026. link 35 Singh AP, Kashaw SK, Soni V. Design, optimisation and . Journal of drug targeting 2026. link 36 Faro B, Silva-Ferraz B, Faro A. Acne, self-esteem, and mental health: a scoping review. Psychology, health & medicine 2026. link 37 Yanik Hİ, Acer E, Karaman İGY, Ağaoğlu E, Erdoğan HK, Bilgin M et al.. Impulsivity, Psychological Distress, and Quality of Life Among the Patients With Acne Vulgaris: Factors Related to Acne Scars. Journal of cosmetic dermatology 2026. link 38 Visser WI, Kannenberg SM, Prevost A, Khoza N, Pillay L, Wiid KJ et al.. Dermocosmetics in Acne Vulgaris: South African Consensus Recommendations With a Focus on Skin of Color. Journal of cosmetic dermatology 2026. link 39 Eker S, Kurtipek GS, Karakucuk Y, Akyurek FT, Ugur MT, Yavuz C. Retinal Vascular Changes in Acne Patients Under Isotretinoin Treatment: An Optical Coherence Tomography Angiography Study. Current eye research 2026. link 40 Grafanaki K, Bakoli Sgourou D, Maniatis A, Zouboulis CC. Exposome involvement in the development of acne vulgaris. Frontiers in immunology 2026. link 41 Ai Levin Y, Lyu Y, He X. Improvement of Overall Skin Condition in Acne and Oily Prone Skin With an Amino Acid Cleanser Containing Salicylic Acid, Glucuronolactone, and Ceramides. Journal of cosmetic dermatology 2026. link 42 Nguyen TTM, Yi EJ, Jin X, Zheng Q, Park SJ, Yi GS et al.. Effects of nutritive and non-nutritive sweeteners on acne vulgaris: A systematic review. Fitoterapia 2026. link 43 Bansal A, Sardana K, Paliwal P, Khurana A, Sharath S, Paliwal P. What Are the Histological Changes Corresponding to Clinical Effacement of Atrophic Acne Scars After Fractional Carbon Dioxide Laser Intervention-A Prospective Interventional Study in Skin of Color. Photodermatology, photoimmunology & photomedicine 2026. link 44 Xu F, Chong MC, Zhou Y, Chen J, Ruan J, Sun Y et al.. The mediating role of psychological inflexibility and social avoidance in relationship between body image disturbance and depression among young adults with acne in China. Frontiers in public health 2026. link 45 Abunasser S, Younes S, Mina NR, Nasrallah G. Hydrogels for acne treatment: a systematic review and meta-analysis of clinical trials. Nanomedicine (London, England) 2026. link 46 Rageh MA, Ammar AM, Mohy SM, Mohsen M, Rageh K, Tawfik AA. 308-nm Excimer Light for Inflammatory Acne in Pregnancy: A Prospective Pilot Study. Photodermatology, photoimmunology & photomedicine 2026. link 47 Ciozda A, Firlej E, Bartosińska J, Raczkiewicz D. The Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and Cutibacterium acnes Colonization in Women With Oily Skin. Journal of cosmetic dermatology 2026. link 48 Sheng Y, Zheng X, Xu J. Anti-acne mechanisms of Yuqingyan, a novel multi-herbal formula derived from traditional Chinese medicine. Journal of ethnopharmacology 2026. link 49 Frederickson KL, Gui H, Barbieri JS, Daneshjou R. Artificial Intelligence Use in Acne Diagnosis and Management-A Scoping Review. International journal of dermatology 2026. link 50 Bansal A, Sardana K, Paliwal P, Khurana A, Sharath S. A cross-sectional pilot study evaluating the histopathology of atrophic acne scars with a focus on the vertical depth of ice pick, boxcar, and rolling scars and its implications in skin of colour. Indian journal of dermatology, venereology and leprology 2026. link 51 Masanta SR, Nilam N, Pal A, Kar B, Dash P, Pradhan D et al.. Lipid-Based Nanocarriers as a Promising Delivery System in the Management of Acne. Current pharmaceutical design 2026. link 52 Leti M, Garidou L, Cuisiat SV, Stennevin A, Doat G, Mias C. Plant Extracts in Acne Management: A Narrative Review. Dermatology (Basel, Switzerland) 2026. link 53 Shafiuddin M, Huang WC, Prather GW, Anton JR, Martin AL, Sillart SB et al.. Cutibacterium Adaptation to Life on Humans Provides a Potential C acnes Infection Biomarker. The Journal of investigative dermatology 2026. link 54 Lee SG, Chau NH, Ham S, Baek Y, Nguyen NH, Kim SH et al.. Microbiome-Derived Indole-3-Lactic Acid Attenuates . International journal of molecular sciences 2026. link 55 Draelos ZD, Baldwin H, Harper JC, Ghannoum M, Gold LS, Tanghetti EA et al.. Long-term efficacy and tolerability of clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for acne: pooled results from two 6-month studies. The Journal of dermatological treatment 2026. link 56 Liu X, Li X, He W, Han X, Guo S, Xiao T et al.. Integrated in vitro - in vivo evaluation of Angelica sinensis essential oil as an anti-acne agent: Mechanistic insights into bioactive compounds and multi-target therapeutic actions. Journal of ethnopharmacology 2026. link 57 Hizli P, İçöz Aytaç S, Baykan Ö, Öklü M, Kiliç FA. The Association of Acne Vulgaris and Disease Severity With Serum Amyloid A1 and Insulin Levels. Journal of cosmetic dermatology 2026. link 58 Celik C, Celik MS. Evaluation of Depression, Anxiety, and Sleep Quality in Patients With Acne Vulgaris Receiving Isotretinoin Treatment. Human psychopharmacology 2026. link 59 Lee HJ, Cho YJ, Jin N, Rintarhat P, Jung WH, Kim HS. Ecological characteristics of the truncal skin mycobiome in acne and its association with doxycycline exposure. Journal of microbiology (Seoul, Korea) 2026. link 60 Liu H, Yao C, Tan C, Wang K, Zhou Y, Liu X et al.. Non-optimal apparent temperatures can increase the risk of acne: a multi-center time-series study. International journal of biometeorology 2026. link 61 Wójcikiewicz P, Durlej G, Satora M, Tarkowski R, Kułak K. Comparison of Substances in Combined Oral Contraceptives Used in Acne Vulgaris, Hirsutism, Migraine, and Dysmenorrhea. Medical science monitor : international medical journal of experimental and clinical research 2026. link 62 Karar W, Mohamed SA, Subramaniam G, Elamin Yousif ZY, Atron B, Dawoud ED et al.. Battling biofilms: evaluating selected agents against . PeerJ 2026. link 63 Shingari M, Sharma A, Mittal V. Nature's Remedy: A Comprehensive Review Exploring Herbal Treatments and Natural Approaches for Preventing Acne Vulgaris. Recent advances in anti-infective drug discovery 2026. link 64 Jin N, Sul WJ, Do HR, Kim HS. ITS1-based profiling of the skin mycobiome in truncal acne reveals altered baseline ecology and heterogeneous doxycycline-associated patterns. Journal of microbiology (Seoul, Korea) 2026. link 65 Koizumi J, Otake R, Seyama S, Hayashi N, Nakaminami H. Functional analysis of a novel macrolide-lincosamide resistance gene erm(57) in Cutibacterium avidum. The Journal of antimicrobial chemotherapy 2026. link 66 Durgin JS, Veniaminova NA, Huyge TJ, Tsai SY, Fox J, Cai Y et al.. Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris. JCI insight 2026. link 67 Chernyshov PV, Marron SE, Boffa MJ, Pustišek N, Koumaki D, Darlenski R et al.. International Validation of the Quality of Life Relevance-Acne Questionnaire. Dermatology (Basel, Switzerland) 2026. link 68 Wang M, Yue G, Chen Y, Li K, Jiang G, Zhuoma Z et al.. Exploring the potential mechanism of Lamiophlomis rotata (Benth.) Kudo in treating acne through network pharmacology and experimental verification. Journal of ethnopharmacology 2026. link 69 Yuniarsih N, Chaerunisaa AY, Mohammed AFA, Elamin KM, Muchtaridi M, Wathoni N. Nanoencapsulated α-Mangostin Loaded Chitosan-Alginate Hydrogel Films for Enhanced Topical Anti Acne Therapy. Drug design, development and therapy 2026. link 70 Hou SX, Shi XC, Xiao Y, Liu XX, Zhang L, Cheng YQ et al.. Multifunctional mesoporous superparamagnetic Iron oxide-based nanocomposites for synergistic Photothermal/Fenton therapy in the treatment of acne vulgaris. Journal of colloid and interface science 2026. link 71 Witkam WCAM, Mathieu A, Dal Belo SE, Moreau M, Aguilar L, Verlouw JAM et al.. Distinct bacterial facial cutaneous microbiota composition in adolescents with acne vulgaris: a population-based cross-sectional observational study. The British journal of dermatology 2026. link 72 Otero-Fernández MN, Muñoz-Bellido FJ, Laffond-Yges E, Lázaro-Sastre M, Cabrera-Núñez A, Mazoteras-Martínez E et al.. Minocycline-Induced Delayed Dermographism With Tolerance to Doxycycline. The Journal of dermatology 2026. link 73 Troielli P, Moreno J, Cortes A, Cardenas P, Kerob D, Gamarra A et al.. Integrating Dermocosmetics Into Acne Care in Latin America. Journal of cosmetic dermatology 2026. link 74 Vorobeva AA, Vorobev AM, Evseev PV, Mekhtiev ER, Chaplin AV, Pasivkina MA et al.. Isolation and Genomic Characterization of Two Lytic . Viruses 2026. link 75 Hu Z, Gan Y, Song Y, Qin H, Liu L, Liu L et al.. Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne. Nature communications 2026. link 76 Nisagornsen P, Thongjaroensirikul P, Nokdhes Y, Bhorntarakcharoen W, Sittiwanaruk S, Li JB et al.. Prospective Evaluation of a Fractional 675-nm Nonablative Laser for Atrophic Acne Scars in Fitzpatrick Skin Types III-IV. Lasers in surgery and medicine 2026. link 77 Wisuitiprot V, Keawtai N, Wisuitiprot W. Differential Anti-Acne Activities of Citrus hystrix Peel Extracts: 5α-Reductase Inhibition, Anti-Inflammatory, and Antimicrobial Effects. Chemistry & biodiversity 2026. link 78 Li Y, Li S, Guo M, Zhang Y, Nie Y, Bo Y et al.. Skin-Derived Precursors-Derived Exosomes Alleviated Acne Inflammation via TLR2/MyD88/NF-κB Signaling Pathway: In Vitro and In Vivo Studies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026. link 79 Zheng L, Fu X, Qiu X, Gao S, Jiang Y, Wang X et al.. The Value of High-Frequency Ultrasound and Color Doppler Flow Imaging in Assessing the Efficacy of Moderate-to-Severe Acne Vulgaris: A Prospective Single-Arm Study. Journal of cosmetic dermatology 2026. link 80 Queille-Roussel C, Odeimi J, Broallier M, Kerob D, Tan J. Rapid, Strong, and Visible Efficacy of a Dermocosmetic in Acne Patients With Dark Skin Phototypes: Results of a Randomized Split-Face Study. Journal of cosmetic dermatology 2026. link 81 Wu H, Huang W, Cai X, He H, Wang Y, Yao S et al.. Hydroxybutyl Chitosan Hydrogel Promotes Ablative Fractional CO. Lasers in surgery and medicine 2026. link 82 Thy LTM, Thanh NNT, Duy HK, Phuong DTM, Dat NT, Dat NM. Development of Polyphenol-Rich Extract from Annona muricata L. Leaves and Its Application in Acne-Reducing Gels. Chemistry & biodiversity 2026. link 83 Yoshihara K, Seyama S, Hayashi N, Horiuchi Y, Ishida W, Yasuda T et al.. Combination Effects of Clindamycin and Benzoyl Peroxide Against Cutibacterium acnes. The Journal of dermatology 2026. link 84 Libecco J, Eichenfield LF, Hebert AA, Gold LS, Cartwright M, Moro L et al.. Efficacy and Safety of Clascoterone Cream 1% for Acne Are Independent of Age and Sex. Journal of drugs in dermatology : JDD 2026. link 85 Mahajindawong B, Kumtornrut C, Asawanonda P, Kerr SJ, Chatsuwan T, Boontaveeyuwat E. Antimicrobial photodynamic therapy using sodium iron chlorophyllin against drug-resistant Cutibacterium acnes from patients with acne vulgaris. Scientific reports 2026. link 86 Moitra P, Madan J, Shah K, Mandavkar P, Joshi R, Kalita S et al.. Almond Supplementation Improves Acne Lesions and Skin Microbial Diversity in Adults with Mild to Moderate Acne Vulgaris. Nutrients 2026. link 87 Shi Y, Xu S, Zhang W. Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional CO. Journal of cosmetic dermatology 2026. link 88 Teng X, Shu X, Huo W, Li Z, Zou L, Li L et al.. Safety and Preliminary Clinical Effects of a Herbal Balance Solution in Mild-To-Moderate Acne Vulgaris: An Open-Label, Single-Arm Pilot Study. Journal of cosmetic dermatology 2026. link 89 Queille-Roussel C, Odeimi J, Broallier M, Kerob D, Tan J. Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study. Journal of cosmetic dermatology 2026. link 90 Goldberg D, Ronan S, Bhatia A, Dhawan SS, Green JB, Kilmer SL et al.. Safe and effective acne treatment across skin types with a 1726 nm sebum-selective laser: One year data from a prospective multicenter study. Journal of the American Academy of Dermatology 2026. link 91 Layton AM, Bettoli V, Delore V, Puentes E, Tan JKL. The Burden of Acne Vulgaris on Health-Related Quality of Life and Psychosocial Well-Being Domains: A Systematic Review. American journal of clinical dermatology 2026. link 92 Brooks S, Rajagopal S, Handler MZ, Vandeven M, Carlile A. Assessing the Benefits of an Innovative Chemical Peel Containing Biofunctionals on Adult Acne-Prone Skin: An Exploratory Interventional Study: A Preliminary Report. Journal of cosmetic dermatology 2026. link 93 Ferhatosmanoğlu A, Arıca İE, Polat M, Yıldırım M, Kalkan G, Başara Şahin R et al.. Sociodemographic, clinical, and behavioral determinants of treatment adherence in acne vulgaris: a multicenter study. The Journal of dermatological treatment 2026. link 94 Altınöz Güney C, Koç HA. Isotretinoin-related adverse sexual and reproductive outcomes: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System (FAERS). Cutaneous and ocular toxicology 2026. link 95 Yang SX, Xiao WL, Zhang XJ. Essential oil of Saposhnikovia divaricata mitigates Cutibacterium acnes-induced inflammatory acne via Nrf2 pathway activation and NF-κB pathway inhibition. Journal of ethnopharmacology 2026. link 96 Dias-Barbosa C, Taylor N, Chan K, York JP, Puelles J, Chavda R. Patient Insights on Acne Hyperpigmentation, Trifarotene, and Skincare: 6-Month, LEAP Phase 4 Qualitative Exit Interview Findings. The patient 2026. link 97 Fanning JE, Foster L, Manik D, Lee D, Foppiani J, Escobar-Domingo MJ et al.. Clarifying the Role of Isotretinoin in Rhinoplasty: A Systematic Review and Analysis of an Emerging Social Media Trend. Aesthetic plastic surgery 2026. link 98 de Oliveira ECF, de Sousa FTR, Lemos FAO, Vasconcelos CP, Rocha ALL. Incidence of Acne in Women Using the Levonorgestrel-Releasing Intrauterine Device: A Systematic Review and Meta-Analysis. BJOG : an international journal of obstetrics and gynaecology 2026. link 99 Refsum E, Furu K, Cesta CE, Nørgaard M, Wittström F, Zoega H et al.. Topical retinoid use in women of reproductive age and risk of major congenital malformations in exposed pregnancies: a Nordic cohort study. The British journal of dermatology 2026. link 100 Smith CA, Kaabi O, Manatunga AK, Lash TL, Silverberg MJ, Getahun D et al.. Acne Incidence and Severity in Transgender Individuals. JAMA dermatology 2026. link

Original source

[1]
Practical Algorithm for Acne Treatment Integrating Skincare and Energy-Based Devices. — Waibel JS, Ablon G, Andriessen A, Adzovic V, Bucay V, Draelos Z et al. Journal of drugs in dermatology : JDD (2026)
[2]
From Salves to Sulzberger: The emergence of the American approach to acne treatment. — Woźna J, Woźna W, Mojs E, Grzybowski A, Żaba R Clinics in dermatology (2026)
[3]
Acne tarda: Recommendations for classification, treatment and care as a result of an expert discussion. — Augustin M, Dirschka T, Gerber PA, Kerscher M, Kirsten N, Ochsendorf F Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (2026)
[4]
Adult and perimenopausal acne and the nurse's role in management. — Parkinson H British journal of nursing (Mark Allen Publishing) (2026)
[5]
Update on novel acne treatments: a narrative review focused on microbiome modulation and non-pharmacological approaches. — Burckhardt-Bravo V, Funes-Ferrada R, Valenzuela F Anais brasileiros de dermatologia (2026)
[6]
Dermatologic conditions and stigma: The depiction of acne in cartoons. — Walter S Clinics in dermatology (2026)
[7]
Clascoterone 1% in the Treatment of Acne: A Review of its Efficacy, Safety, and Therapeutic Positioning. — Balado-Simó P, Brufau-Cochs M, Morgado-Carrasco D Actas dermo-sifiliograficas (2026)
[8]
Resilience and trajectories of depressive symptoms and suicidal ideation in the context of exposure to acne: Findings from the Lifelines Cohort Study. — Flinn C, Ungar M, Deschênes S, Nearchou F Journal of health psychology (2026)
[9]
The Evolving Microbial Paradigm in Acne. — van Steensel MAM Biomolecules (2026)
[10]
Unlocking the antibacterial potential of Zanthoxylum armatum fruit: A bioactive approach to treat acne vulgaris. — Kazmi F, Feng Z, Huang L, Kang Y, Song Y, Di X et al. Microbial pathogenesis (2026)
[11]
Truncal Acne: Pathophysiology, Clinical Features, and Management Strategies. — Feng X, Chen Y, Liu Y Journal of cosmetic dermatology (2026)
[12]
The relationship between MMP-2 and TIMP-2 gene polymorphisms and skin barrier function, inflammatory cytokine levels in acne patients. — Huang S, Fang L, Zhang M, Sun S, Zhi H, Zhu Y et al. Expert review of clinical immunology (2026)
[13]
Femoral Neck Bone Marrow Edema During Isotretinoin Therapy: A Case Report. — Kurt Oktay KN, Uysal M, Geler Kulcu D American journal of physical medicine & rehabilitation (2026)
[14]
Acne in Transmasculine Patients: A Scoping Review. — Seibert D, Cohen LN, Boswell N, Alford B, Yeung H, Akinshemoyin Vaughn OL JAMA dermatology (2026)
[15]
Pseudolysogeny-mediated evolutionary trade-offs favor phage therapy by limiting antibiotic resistance and virulence in Cutibacterium acnes. — Trejo-Hernández A, Checa A, Quijada-Ibarra R, Sepúlveda-Gutíerrez P, Soto S, Andrade-Domínguez A Scientific reports (2026)
[16]
Knowledge, attitudes, and practices regarding acne among university students. — Zhang Y, Fan L, Li L Scientific reports (2026)
[17]
Assessing Skincare Awareness in Acne Vulgaris: A Cross-Sectional Study. — Hacinecipoğlu F, Öner Ü Advances in skin & wound care (2026)
[18]
"Acne vulgaris: key insights, treatment, and future prospects". — Bhatt J, Kumar VJ, Chahat Molecular diversity (2026)
[19]
Transparent, 3D-printed microneedle patches that co-deliver ALA and guide blue light for preclinical photodynamic therapy of acne. — Tian R, Zhang L, Zhang J, Yang S, Ren Y, Zhou A et al. Journal of materials chemistry. B (2026)
[20]
Efficacy of different topical spironolactone treatments for acne vulgaris: A meta-analysis. — Huang W, Tian C, Lin B, Yu H Pakistan journal of pharmaceutical sciences (2026)
[21]
Anti-Acne Potential of — Hong S, Park S, Park M, Park JM, Hwang DY, Lee H et al. Journal of microbiology and biotechnology (2026)
[22]
Integrated CO — Penev J, Balabanova M, Jafferany M Journal of cosmetic dermatology (2026)
[23]
Medicinal Plants for Acne Vulgaris: An Evidence-Based Review of Treatments Promoted by Social Media. — Parvizi MM, Saki N, Rostami Ghotbabadi Z, Kamali M, Salmanpour N, Namazi M et al. Journal of cosmetic dermatology (2026)
[24]
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Use of Dermocosmetics in Acne Management: A Middle East-North Africa Consensus. — Zimmo S, Zaher H, Said A, El Morsy E, Litaiem N, Al Hammadi A et al. International journal of dermatology (2026)
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Personalized Approach for Acne Management With Dermocosmetics According to Initial Skin Sensitivity. — Han JH, Ju HJ, Kim TI, Yoon YH, Woo YJ, Kye H et al. Journal of cosmetic dermatology (2026)
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Strategic Targets in Acne, Update 2025: The Microcomedone Is Not Just a Plug, It Is an Egg. — Oulès B, Saurat JH Dermatology (Basel, Switzerland) (2026)
[28]
Transdermal Delivery of Botulinum Toxin for the Management of Oily and Acne-Prone Skin Using TDA Technology. — Schulz S, Lamprecht S Journal of cosmetic dermatology (2026)
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Alternating ablative fractional laser and microneedling radiofrequency outperforms ablative fractional laser alone for acne scars. — He H, Qiu Y, Liu Q Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (2026)
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Beyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne. — Tommasino N, Annunziata MC, Potestio L, Napolitano M Journal of cosmetic dermatology (2026)
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Nanoformulations in Acne Therapy: Translational Opportunities and Barriers for Next-Generation Topical Treatments. — Mustaffa MF, Mohd Ghazali NSM, Khalid SH, Abdul Hamid K AAPS PharmSciTech (2026)
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Alterations in the lipid profile in acne vulgaris patients: A meta-analysis. — Hasan MM, Tory S, Arslan YK, Tutar Y The Journal of international medical research (2026)
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Design, optimisation and — Singh AP, Kashaw SK, Soni V Journal of drug targeting (2026)
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Acne, self-esteem, and mental health: a scoping review. — Faro B, Silva-Ferraz B, Faro A Psychology, health & medicine (2026)
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Impulsivity, Psychological Distress, and Quality of Life Among the Patients With Acne Vulgaris: Factors Related to Acne Scars. — Yanik Hİ, Acer E, Karaman İGY, Ağaoğlu E, Erdoğan HK, Bilgin M et al. Journal of cosmetic dermatology (2026)
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Dermocosmetics in Acne Vulgaris: South African Consensus Recommendations With a Focus on Skin of Color. — Visser WI, Kannenberg SM, Prevost A, Khoza N, Pillay L, Wiid KJ et al. Journal of cosmetic dermatology (2026)
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Retinal Vascular Changes in Acne Patients Under Isotretinoin Treatment: An Optical Coherence Tomography Angiography Study. — Eker S, Kurtipek GS, Karakucuk Y, Akyurek FT, Ugur MT, Yavuz C Current eye research (2026)
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Exposome involvement in the development of acne vulgaris. — Grafanaki K, Bakoli Sgourou D, Maniatis A, Zouboulis CC Frontiers in immunology (2026)
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Improvement of Overall Skin Condition in Acne and Oily Prone Skin With an Amino Acid Cleanser Containing Salicylic Acid, Glucuronolactone, and Ceramides. — Ai Levin Y, Lyu Y, He X Journal of cosmetic dermatology (2026)
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Effects of nutritive and non-nutritive sweeteners on acne vulgaris: A systematic review. — Nguyen TTM, Yi EJ, Jin X, Zheng Q, Park SJ, Yi GS et al. Fitoterapia (2026)
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What Are the Histological Changes Corresponding to Clinical Effacement of Atrophic Acne Scars After Fractional Carbon Dioxide Laser Intervention-A Prospective Interventional Study in Skin of Color. — Bansal A, Sardana K, Paliwal P, Khurana A, Sharath S, Paliwal P Photodermatology, photoimmunology & photomedicine (2026)
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The mediating role of psychological inflexibility and social avoidance in relationship between body image disturbance and depression among young adults with acne in China. — Xu F, Chong MC, Zhou Y, Chen J, Ruan J, Sun Y et al. Frontiers in public health (2026)
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Hydrogels for acne treatment: a systematic review and meta-analysis of clinical trials. — Abunasser S, Younes S, Mina NR, Nasrallah G Nanomedicine (London, England) (2026)
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308-nm Excimer Light for Inflammatory Acne in Pregnancy: A Prospective Pilot Study. — Rageh MA, Ammar AM, Mohy SM, Mohsen M, Rageh K, Tawfik AA Photodermatology, photoimmunology & photomedicine (2026)
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Anti-acne mechanisms of Yuqingyan, a novel multi-herbal formula derived from traditional Chinese medicine. — Sheng Y, Zheng X, Xu J Journal of ethnopharmacology (2026)
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Artificial Intelligence Use in Acne Diagnosis and Management-A Scoping Review. — Frederickson KL, Gui H, Barbieri JS, Daneshjou R International journal of dermatology (2026)
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A cross-sectional pilot study evaluating the histopathology of atrophic acne scars with a focus on the vertical depth of ice pick, boxcar, and rolling scars and its implications in skin of colour. — Bansal A, Sardana K, Paliwal P, Khurana A, Sharath S Indian journal of dermatology, venereology and leprology (2026)
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Lipid-Based Nanocarriers as a Promising Delivery System in the Management of Acne. — Masanta SR, Nilam N, Pal A, Kar B, Dash P, Pradhan D et al. Current pharmaceutical design (2026)
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Plant Extracts in Acne Management: A Narrative Review. — Leti M, Garidou L, Cuisiat SV, Stennevin A, Doat G, Mias C Dermatology (Basel, Switzerland) (2026)
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Cutibacterium Adaptation to Life on Humans Provides a Potential C acnes Infection Biomarker. — Shafiuddin M, Huang WC, Prather GW, Anton JR, Martin AL, Sillart SB et al. The Journal of investigative dermatology (2026)
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Microbiome-Derived Indole-3-Lactic Acid Attenuates — Lee SG, Chau NH, Ham S, Baek Y, Nguyen NH, Kim SH et al. International journal of molecular sciences (2026)
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Long-term efficacy and tolerability of clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for acne: pooled results from two 6-month studies. — Draelos ZD, Baldwin H, Harper JC, Ghannoum M, Gold LS, Tanghetti EA et al. The Journal of dermatological treatment (2026)
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Integrated in vitro - in vivo evaluation of Angelica sinensis essential oil as an anti-acne agent: Mechanistic insights into bioactive compounds and multi-target therapeutic actions. — Liu X, Li X, He W, Han X, Guo S, Xiao T et al. Journal of ethnopharmacology (2026)
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The Association of Acne Vulgaris and Disease Severity With Serum Amyloid A1 and Insulin Levels. — Hizli P, İçöz Aytaç S, Baykan Ö, Öklü M, Kiliç FA Journal of cosmetic dermatology (2026)
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Evaluation of Depression, Anxiety, and Sleep Quality in Patients With Acne Vulgaris Receiving Isotretinoin Treatment. — Celik C, Celik MS Human psychopharmacology (2026)
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Ecological characteristics of the truncal skin mycobiome in acne and its association with doxycycline exposure. — Lee HJ, Cho YJ, Jin N, Rintarhat P, Jung WH, Kim HS Journal of microbiology (Seoul, Korea) (2026)
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Non-optimal apparent temperatures can increase the risk of acne: a multi-center time-series study. — Liu H, Yao C, Tan C, Wang K, Zhou Y, Liu X et al. International journal of biometeorology (2026)
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Comparison of Substances in Combined Oral Contraceptives Used in Acne Vulgaris, Hirsutism, Migraine, and Dysmenorrhea. — Wójcikiewicz P, Durlej G, Satora M, Tarkowski R, Kułak K Medical science monitor : international medical journal of experimental and clinical research (2026)
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Battling biofilms: evaluating selected agents against — Karar W, Mohamed SA, Subramaniam G, Elamin Yousif ZY, Atron B, Dawoud ED et al. PeerJ (2026)
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Nature's Remedy: A Comprehensive Review Exploring Herbal Treatments and Natural Approaches for Preventing Acne Vulgaris. — Shingari M, Sharma A, Mittal V Recent advances in anti-infective drug discovery (2026)
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ITS1-based profiling of the skin mycobiome in truncal acne reveals altered baseline ecology and heterogeneous doxycycline-associated patterns. — Jin N, Sul WJ, Do HR, Kim HS Journal of microbiology (Seoul, Korea) (2026)
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Functional analysis of a novel macrolide-lincosamide resistance gene erm(57) in Cutibacterium avidum. — Koizumi J, Otake R, Seyama S, Hayashi N, Nakaminami H The Journal of antimicrobial chemotherapy (2026)
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Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris. — Durgin JS, Veniaminova NA, Huyge TJ, Tsai SY, Fox J, Cai Y et al. JCI insight (2026)
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International Validation of the Quality of Life Relevance-Acne Questionnaire. — Chernyshov PV, Marron SE, Boffa MJ, Pustišek N, Koumaki D, Darlenski R et al. Dermatology (Basel, Switzerland) (2026)
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Exploring the potential mechanism of Lamiophlomis rotata (Benth.) Kudo in treating acne through network pharmacology and experimental verification. — Wang M, Yue G, Chen Y, Li K, Jiang G, Zhuoma Z et al. Journal of ethnopharmacology (2026)
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Nanoencapsulated α-Mangostin Loaded Chitosan-Alginate Hydrogel Films for Enhanced Topical Anti Acne Therapy. — Yuniarsih N, Chaerunisaa AY, Mohammed AFA, Elamin KM, Muchtaridi M, Wathoni N Drug design, development and therapy (2026)
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Multifunctional mesoporous superparamagnetic Iron oxide-based nanocomposites for synergistic Photothermal/Fenton therapy in the treatment of acne vulgaris. — Hou SX, Shi XC, Xiao Y, Liu XX, Zhang L, Cheng YQ et al. Journal of colloid and interface science (2026)
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Distinct bacterial facial cutaneous microbiota composition in adolescents with acne vulgaris: a population-based cross-sectional observational study. — Witkam WCAM, Mathieu A, Dal Belo SE, Moreau M, Aguilar L, Verlouw JAM et al. The British journal of dermatology (2026)
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Minocycline-Induced Delayed Dermographism With Tolerance to Doxycycline. — Otero-Fernández MN, Muñoz-Bellido FJ, Laffond-Yges E, Lázaro-Sastre M, Cabrera-Núñez A, Mazoteras-Martínez E et al. The Journal of dermatology (2026)
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Integrating Dermocosmetics Into Acne Care in Latin America. — Troielli P, Moreno J, Cortes A, Cardenas P, Kerob D, Gamarra A et al. Journal of cosmetic dermatology (2026)
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Isolation and Genomic Characterization of Two Lytic — Vorobeva AA, Vorobev AM, Evseev PV, Mekhtiev ER, Chaplin AV, Pasivkina MA et al. Viruses (2026)
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Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne. — Hu Z, Gan Y, Song Y, Qin H, Liu L, Liu L et al. Nature communications (2026)
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Prospective Evaluation of a Fractional 675-nm Nonablative Laser for Atrophic Acne Scars in Fitzpatrick Skin Types III-IV. — Nisagornsen P, Thongjaroensirikul P, Nokdhes Y, Bhorntarakcharoen W, Sittiwanaruk S, Li JB et al. Lasers in surgery and medicine (2026)
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Differential Anti-Acne Activities of Citrus hystrix Peel Extracts: 5α-Reductase Inhibition, Anti-Inflammatory, and Antimicrobial Effects. — Wisuitiprot V, Keawtai N, Wisuitiprot W Chemistry & biodiversity (2026)
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Skin-Derived Precursors-Derived Exosomes Alleviated Acne Inflammation via TLR2/MyD88/NF-κB Signaling Pathway: In Vitro and In Vivo Studies. — Li Y, Li S, Guo M, Zhang Y, Nie Y, Bo Y et al. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2026)
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The Value of High-Frequency Ultrasound and Color Doppler Flow Imaging in Assessing the Efficacy of Moderate-to-Severe Acne Vulgaris: A Prospective Single-Arm Study. — Zheng L, Fu X, Qiu X, Gao S, Jiang Y, Wang X et al. Journal of cosmetic dermatology (2026)
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Hydroxybutyl Chitosan Hydrogel Promotes Ablative Fractional CO — Wu H, Huang W, Cai X, He H, Wang Y, Yao S et al. Lasers in surgery and medicine (2026)
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Development of Polyphenol-Rich Extract from Annona muricata L. Leaves and Its Application in Acne-Reducing Gels. — Thy LTM, Thanh NNT, Duy HK, Phuong DTM, Dat NT, Dat NM Chemistry & biodiversity (2026)
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Combination Effects of Clindamycin and Benzoyl Peroxide Against Cutibacterium acnes. — Yoshihara K, Seyama S, Hayashi N, Horiuchi Y, Ishida W, Yasuda T et al. The Journal of dermatology (2026)
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Efficacy and Safety of Clascoterone Cream 1% for Acne Are Independent of Age and Sex. — Libecco J, Eichenfield LF, Hebert AA, Gold LS, Cartwright M, Moro L et al. Journal of drugs in dermatology : JDD (2026)
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Antimicrobial photodynamic therapy using sodium iron chlorophyllin against drug-resistant Cutibacterium acnes from patients with acne vulgaris. — Mahajindawong B, Kumtornrut C, Asawanonda P, Kerr SJ, Chatsuwan T, Boontaveeyuwat E Scientific reports (2026)
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Almond Supplementation Improves Acne Lesions and Skin Microbial Diversity in Adults with Mild to Moderate Acne Vulgaris. — Moitra P, Madan J, Shah K, Mandavkar P, Joshi R, Kalita S et al. Nutrients (2026)
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Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional CO — Shi Y, Xu S, Zhang W Journal of cosmetic dermatology (2026)
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Safety and Preliminary Clinical Effects of a Herbal Balance Solution in Mild-To-Moderate Acne Vulgaris: An Open-Label, Single-Arm Pilot Study. — Teng X, Shu X, Huo W, Li Z, Zou L, Li L et al. Journal of cosmetic dermatology (2026)
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The Burden of Acne Vulgaris on Health-Related Quality of Life and Psychosocial Well-Being Domains: A Systematic Review. — Layton AM, Bettoli V, Delore V, Puentes E, Tan JKL American journal of clinical dermatology (2026)
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Assessing the Benefits of an Innovative Chemical Peel Containing Biofunctionals on Adult Acne-Prone Skin: An Exploratory Interventional Study: A Preliminary Report. — Brooks S, Rajagopal S, Handler MZ, Vandeven M, Carlile A Journal of cosmetic dermatology (2026)
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Sociodemographic, clinical, and behavioral determinants of treatment adherence in acne vulgaris: a multicenter study. — Ferhatosmanoğlu A, Arıca İE, Polat M, Yıldırım M, Kalkan G, Başara Şahin R et al. The Journal of dermatological treatment (2026)
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Isotretinoin-related adverse sexual and reproductive outcomes: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System (FAERS). — Altınöz Güney C, Koç HA Cutaneous and ocular toxicology (2026)
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Essential oil of Saposhnikovia divaricata mitigates Cutibacterium acnes-induced inflammatory acne via Nrf2 pathway activation and NF-κB pathway inhibition. — Yang SX, Xiao WL, Zhang XJ Journal of ethnopharmacology (2026)
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Patient Insights on Acne Hyperpigmentation, Trifarotene, and Skincare: 6-Month, LEAP Phase 4 Qualitative Exit Interview Findings. — Dias-Barbosa C, Taylor N, Chan K, York JP, Puelles J, Chavda R The patient (2026)
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Clarifying the Role of Isotretinoin in Rhinoplasty: A Systematic Review and Analysis of an Emerging Social Media Trend. — Fanning JE, Foster L, Manik D, Lee D, Foppiani J, Escobar-Domingo MJ et al. Aesthetic plastic surgery (2026)
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Incidence of Acne in Women Using the Levonorgestrel-Releasing Intrauterine Device: A Systematic Review and Meta-Analysis. — de Oliveira ECF, de Sousa FTR, Lemos FAO, Vasconcelos CP, Rocha ALL BJOG : an international journal of obstetrics and gynaecology (2026)
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Topical retinoid use in women of reproductive age and risk of major congenital malformations in exposed pregnancies: a Nordic cohort study. — Refsum E, Furu K, Cesta CE, Nørgaard M, Wittström F, Zoega H et al. The British journal of dermatology (2026)
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