Overview
Epithelioid cell melanoma is a subtype of melanoma characterized by epithelioid morphology. CD146, a cell adhesion molecule first discovered in melanoma, has been established as a promoter of tumor progression and metastasis 1.Diagnosis
CD146 expression is predominantly found in triple-negative breast cancer subtypes 1.
Breast tumors overexpressing CD146 have a higher risk of lymph node metastasis 1.Management
High expression of CD146 was associated with poor prognosis in breast cancer 1.
CD146 may be a potential prognostic marker to predict metastatic potential and disease outcomes in breast cancer 1.Key Recommendations
CD146 expression is associated with poor prognosis in breast cancer 1. (Evidence: Moderate)
CD146 expression is predominantly found in triple-negative breast cancer subtypes 1. (Evidence: Moderate)
Breast tumors overexpressing CD146 have a higher risk of lymph node metastasis 1. (Evidence: Moderate)References
1 Sharma A, Somasundaram I, Chabaud MB. CD146 as a prognostic marker in breast cancer: A meta-analysis. Journal of cancer research and therapeutics 2024. link