Overview
Bipolar disorder (BD) is a severe mental health condition associated with an increased risk of mortality, including suicide 1. Approximately 25% of patients with BD attempt suicide, and 11% die by suicide, highlighting its significant public health impact 1.
Diagnosis
No diagnostic criteria or recommended tests are detailed in the provided abstracts.Management
No management strategies or treatments are detailed in the provided abstracts.Special Populations
No information on special populations is available in the provided abstracts.Key Recommendations
Genetic research has identified potential susceptibility genes associated with bipolar disorder, though their mechanisms of action require further confirmation 1.
Research has explored the implication of specific genes, such as ZNF804A, in bipolar disorder 1.
Genes involved in calcium signaling, DNA methylation, and those common to both bipolar disorder and schizophrenia are areas of investigation 1.
Candidate genes related to suicide risk, early-onset bipolar disorder, cognitive status, and structural brain alterations in bipolar disorder cases have been identified 1.References
1 Kalcev G, Preti A, Scano A, Orrù G, Carta MG. Insight into susceptibility genes associated with bipolar disorder: a systematic review. European review for medical and pharmacological sciences 2021. link