Malignant melanoma

Overview

Diagnosis

Management

Special Populations

Key Recommendations

References

Showing 100 most recent of 897 indexed papers.

1 Lucas MW, Burton EM, Dimitriadis P, Huang AC, Long GV, Mitchell TC et al.. Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity. Immunity 2026. link 2 Kim KL, Griffin GK. Structural variation tunes apoptotic responses to drive immune escape in melanoma. Science immunology 2026. link 3 Mullins KR, Guo JJ. Trends of adverse event reports associated with BRAF and MEK inhibitors and combinations: a retrospective disproportionality analysis using the FDA adverse event reporting system database from 2012 to 2021. Melanoma research 2026. link 4 Oualha D, Sakly T, Bouzid O, Hadj MB, Zakhama M, Bellalah A et al.. Sudden death due to undiagnosed cardiac metastasis of malignant melanoma revealed by autopsy: a case report. Legal medicine (Tokyo, Japan) 2026. link 5 Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N et al.. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2024. European journal of cancer (Oxford, England : 1990) 2025. link 6 Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N et al.. European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2024. European journal of cancer (Oxford, England : 1990) 2025. link 7 Alla SSM, Tekuru Y, Lokesh MS, Alla D, Tvisha P, Tirupati S et al.. Talimogene laherparepvec (T-VEC) as a treatment for melanoma: A systematic review. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2025. link 8 Kreuz M, Moraes FCA, Lôbo AOM, Skov RPH, Pincelli TP. Updated meta-analysis on the risk of melanoma associated with phosphodiesterase type 5 inhibitors. Melanoma research 2025. link 9 Thomson H, Chart M, Zack-Williams S, Jones C. Auricular Melanoma Excision: Excision of Auricular Melanoma. Annals of plastic surgery 2025. link 10 Rocha LS, Jacobowski AC, Reis ETDN, Franco OL, Cardoso MH, Macedo MLR. Chronic Infections as Catalysts for Melanoma Aggressiveness: Insights into Tumour Microenvironment Modulation. Asian Pacific journal of cancer prevention : APJCP 2025. link 11 Li D, Sun Y, Le J, Dian Y, Liu Y, Zeng F et al.. Predictors of survival in immunotherapy-based treatments in advanced melanoma: a meta-analysis. International journal of dermatology 2025. link 12 Xing X, Fang Z. Prognostic value of C-reactive protein in patients with melanoma: a meta-analysis. Annals of medicine 2025. link 13 Grant KG, Gillespie Y, Karamian A, Lewin I, Patel S, Quigley A et al.. Evolving treatment paradigms for melanoma brain metastases: A systematic review of current modalities. Clinical neurology and neurosurgery 2025. link 14 Scharf C, Mongardini FM, Fisone F, Briatico G, Brancaccio G, Chirico F et al.. Impact of the COVID pandemic on melanoma thickness and ulceration: a meta-analysis. International journal of dermatology 2025. link 15 Fukushima S, Ito T, Asai J, Igaki H, Tanaka R, Namikawa K et al.. Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Melanoma 2025. The Journal of dermatology 2025. link 16 Curtis DP, Salmen NL, Baumann AN, Busby JF, Brodell RT. Shades of evidence: a review of skin color reporting in melanoma-related randomized controlled trials. Archives of dermatological research 2025. link 17 Seta T, Nakamura S, Oura M, Yokoyama K, Nishikawa Y, Hoshino N et al.. Efficacy and safety of cancer vaccine therapy in malignant melanoma: a systematic review. International journal of clinical oncology 2025. link 18 Eraifej N, Jupe T, Grundmann A, Blythe A, Rogers D, De Souza S et al.. Exploring the use of instructional dermatology surface models within a dermatology-focused objective structured clinical examination station for medical students. Clinical and experimental dermatology 2025. link 19 Busam KJ, Duncan LM, Gerami P, Lowe L, Sheikh H, Tetzlaff M. Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology. Journal of cutaneous pathology 2025. link 20 Altınöz Güney C, Şener S, Orhun HS, Kılınç F, Akbaş A, Aktaş A. Dysplastic nevi and malignant melanoma: insights into pre-biopsy diagnostic accuracy and the critical role of dermatology consultation. Archives of dermatological research 2025. link 21 Atcı T, Günay MB, Yaşar Ş, Büyükbabani N, Güneş P, Öztürk Sarı Ş et al.. Clinical Characteristics of Nail Unit Melanoma in Türkiye: The Experience of Two Tertiary Dermatology Centers. Balkan medical journal 2025. link 22 Kamali MJ, Salehi M, Fath MK. Advancing personalized immunotherapy for melanoma: Integrating immunoinformatics in multi-epitope vaccine development, neoantigen identification via NGS, and immune simulation evaluation. Computers in biology and medicine 2025. link 23 Ismail S, Barakat K. Designing a multi-neoantigen vaccine for melanoma: Integrating immunoinformatics and biophysics methods. Computers in biology and medicine 2025. link 24 Noor F, Shahid S, Fatima M, Haider SZ, Al Shehri ZS, Alshehri FF et al.. Bioinformatics and immunoinformatics approaches in the design of a multi-epitope vaccine targeting CTLA-4 for melanoma treatment. Molecular diversity 2025. link 25 Zhang Z, Wu Q, Wang Y, Liang Y, Zheng J, Ding C et al.. Adverse Events Associated With Dabrafenib, Trametinib, and Their Combination Therapy: A Disproportionality Analysis of the FDA Adverse Event Reporting System (FAERS) Database. Pharmacoepidemiology and drug safety 2025. link 26 Zhu J, Wu Q, Yang Z, Wu C, Zhou J, Li S et al.. Safety profile of nivolumab-relatlimab in cancer patients: a living pharmacovigilance study of clinical trials and postmarketing data (version 1.0). European journal of pharmacology 2025. link 27 Ravipati A, Pradeep T, Jean-Pierre P, Nouri K. The Practical Side Effects Experienced in Patients Treated With Medications Approved for Melanoma. Journal of drugs in dermatology : JDD 2025. link 28 Xu S, Song Z, Wang D, Wang E, Wang J. Comparative safety of nivolumab plus ipilimumab versus nivolumab plus relatlimab in advanced melanoma: a pharmacovigilance study based on the FDA adverse event reporting system (FAERS). BMC cancer 2025. link 29 Dai X, Cao H, Li J, Zhang T, Hou Y. Disproportionality analysis of adverse events associated with ipilimumab and nivolumab combination therapy based on FAERS database. Scientific reports 2025. link 30 Leibovit-Reiben Z, Godfrey H, Jedlowski P, Thiede R. Neurologic adverse events associated with BRAF and MEK inhibitor therapy in patients with malignant melanoma: a disproportionality analysis using the Food and Drug Administration Adverse Event Reporting System. Melanoma research 2025. link 31 Tan F, Zhou L, Huang G, Li Y, Yin W, Xia H. Analysis of Immune-Related Adverse Events of Pembrolizumab Using FAERS Database. Oncology 2025. link 32 Swetter SM, Johnson D, Albertini MR, Barker CA, Bateni S, Baumgartner J et al.. NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2024. Journal of the National Comprehensive Cancer Network : JNCCN 2024. link 33 Iiris S, Sara D, Hanna A, Tuula S, Matti M. Tongue metastasis of malignant melanoma: A case report and a systemic review of the literature. Oral diseases 2024. link 34 Rehman S, Venna P, Davis S, Gopagoni R, Uttam R, Farrukh AM et al.. Primary gallbladder melanoma: A systematic review of literature. Annals of diagnostic pathology 2024. link 35 Aalami A, Abdeahad H, Mokhtari A, Aalami F, Amirabadi A, Aliabadi EK et al.. Blood-based microRNAs as Potential Diagnostic Biomarkers for Melanoma: A Meta-Analysis. Current medicinal chemistry 2024. link 36 Schadendorf D, Lord-Bessen J, Ejzykowicz F, Shi L, Yu P, Srinivasan S. Prognostic value of patient-reported outcomes in advanced or metastatic melanoma patients treated with immunotherapy: Findings from the CheckMate-067 study. European journal of cancer (Oxford, England : 1990) 2024. link 37 Barisione E, Boutros A, Mora M, Spagnolo F, Tanda ET, Genova C et al.. Primary endobronchial melanoma: a case report and clinical management indications. BMC pulmonary medicine 2024. link 38 Maldonado-Mendoza J, Ramírez-Amador V, Anaya-Saavedra G. Primary oral and sinonasal mucosal melanomas in Latin America: a systematic review. International journal of oral and maxillofacial surgery 2024. link 39 Splendiani E, Besharat ZM, Covre A, Maio M, Di Giacomo AM, Ferretti E. Immunotherapy in melanoma: Can we predict response to treatment with circulating biomarkers?. Pharmacology & therapeutics 2024. link 40 Zhang MZ, Hines AS, Demer AM, Brewer JD. The Impact of Surgical Delay in Primary Cutaneous Melanoma: A Systematic Review. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2024. link 41 Márquez-Rodas I, Muñoz Couselo E, Rodríguez Moreno JF, Arance Fernández AM, Berciano Guerrero MÁ, Campos Balea B et al.. SEOM-GEM clinical guidelines for cutaneous melanoma (2023). Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024. link 42 Shuai W, Huang Q, Xu L, Mu Y. Association between arsenic exposure and melanoma: a meta-analysis. International journal of dermatology 2024. link 43 Şendişçi Gök R, Tercanlı H. A ten-year literature review of oral malignant melanoma cases: A meta-analysis study. Journal of stomatology, oral and maxillofacial surgery 2024. link 44 Patel P, Hagstrom M, Sharma N, Chen A, Dhillon S, Fumero-Velázquez M et al.. Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare. The American journal of surgical pathology 2024. link 45 Sukniam K, Manaise HK, Popp K, Popp R, Gabriel E. Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics. Cells 2024. link 46 Rosenberg SA. Lymphocytes as a living drug for cancer. Science (New York, N.Y.) 2024. link 47 Breitenfeld D, Šitum M, Švarc R, Živković M. Rachmaninov's Melanoma and Other Skin Changes in Composers. Acta dermatovenerologica Croatica : ADC 2024. link 48 Kilitci A. Nodular Melanoma Presenting with Cutaneous Horn and Displaying Rhabdoid Features: An Unusual Presentation. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2024. link 49 Hartmann T, Passauer J, Hartmann J, Schmidberger L, Kneilling M, Volc S. Basic principles of artificial intelligence in dermatology explained using melanoma. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2024. link 50 Kibbie JJ, Zita SM, Dellavalle RP, Dunnick CA, Armstrong CA. The number needed to biopsy for cutaneous melanoma in academic dermatology clinics. Melanoma research 2024. link 51 Smith AL, Smit AK, Laginha BI, Singh N, Gallo B, Martin L et al.. Implementing systematic melanoma risk assessment and risk-tailored surveillance in a skin cancer focussed dermatology clinic: A qualitative study of feasibility and acceptability to patients and clinic staff. Cancer medicine 2024. link 52 Huang Y, Fleming P, Fung K, Chan AW. Association between dermatology follow-up and melanoma survival: A population-based cohort study. Journal of the American Academy of Dermatology 2024. link 53 Tejera-Vaquerizo A, Boada A, Puig S, Nagore E, Fernández-de-Misa R, Ferrándiz L et al.. [Translated article] Melanoma Registry of the Spanish Academy of Dermatology and Venereology (REGESMEL): Description and Data in its First Year of Operation. Actas dermo-sifiliograficas 2024. link 54 Haggenmüller S, Schmitt M, Krieghoff-Henning E, Hekler A, Maron RC, Wies C et al.. Federated Learning for Decentralized Artificial Intelligence in Melanoma Diagnostics. JAMA dermatology 2024. link 55 Tchernev G, Broshtilova V, Ivanov L, Alexandrov A, Smilov N, Kordeva S. DRUG RELATED NITROSOGENESIS, PHOTOCARCINOGENESIS AND ONCOPHARMACOGENESIS OF NODULAR MELANOMA: A CASE RELATED ANALYSIS CONCERNING THE POLYCONTAMINATION OF THE POLYMEDICATION WITH VALSARTAN/HYDROCHLOROTHIAZIDE AND BISOPROLOL. Georgian medical news 2024. link 56 Ichiki T, Ito T, Oishi H, Kato K, Oda Y, Nakahara T. Pigmented epithelioid melanocytoma arising from a teratoma of a Carney complex patient. The journal of obstetrics and gynaecology research 2024. link 57 Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB et al.. Systemic Therapy for Melanoma: ASCO Guideline Update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023. link 58 Pavlick AC, Ariyan CE, Buchbinder EI, Davar D, Gibney GT, Hamid O et al.. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0. Journal for immunotherapy of cancer 2023. link 59 Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M et al.. Neoadjuvant treatment for stage III and IV cutaneous melanoma. The Cochrane database of systematic reviews 2023. link 60 Calco GN, Orfaly VE, Haag CK, Hamilton A, Stoos E, Leachman SA. A Systematic Review of Evidence-Based High School Melanoma Prevention Curricula. Journal of cancer education : the official journal of the American Association for Cancer Education 2023. link 61 Gong X, Zhang Y, Yuan M, Wang Y, Xia C, Wang Y et al.. Prognostic nomogram for external ear melanoma patients in the elderly: a SEER-based study. Journal of cancer research and clinical oncology 2023. link 62 Malakoutikhah Z, Mohajeri Z, Dana N, Haghjooy Javanmard S. The dual role of Nrf2 in melanoma: a systematic review. BMC molecular and cell biology 2023. link 63 Ng WHS, Curchin DJ, McGinn S, Smith SD. Outcomes in organ transplants from donors with melanoma: a systematic review. International journal of dermatology 2023. link 64 Anvari A, Sasanpour P, Kheradmardi MR. Radiotherapy and Immunotherapy in Melanoma Brain Metastases. Hematology/oncology and stem cell therapy 2023. link 65 Bialves TS, Bastos Junior CLQ, Cordeiro MF, Boyle RT. Snake venom, a potential treatment for melanoma. A systematic review. International journal of biological macromolecules 2023. link 66 Sauter D, Lodde G, Nensa F, Schadendorf D, Livingstone E, Kukuk M. Deep learning in computational dermatopathology of melanoma: A technical systematic literature review. Computers in biology and medicine 2023. link 67 Kunc M, Żemierowska N, Skowronek F, Biernat W. Diagnostic test accuracy meta-analysis of PRAME in distinguishing primary cutaneous melanomas from benign melanocytic lesions. Histopathology 2023. link 68 Young K, Arkfeld DV, Ogasawara CT, Squires LD. A Systematic Review of Primary Temporal Bone Mucosal Melanoma. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2023. link 69 Maduka RC, Tai K, Gonsai R, DeWalt N, Chetty A, Brackett A et al.. Indoor Versus Outdoor: Does Occupational Sunlight Exposure Increase Melanoma Risk? A Systematic Review. The Journal of surgical research 2023. link 70 Boutros A, Tanda ET, Croce E, Catalano F, Ceppi M, Bruzzone M et al.. Activity and safety of first-line treatments for advanced melanoma: A network meta-analysis. European journal of cancer (Oxford, England : 1990) 2023. link 71 Scard C, Aubert H, Wargny M, Martin L, Barbarot S. Risk of melanoma in congenital melanocytic nevi of all sizes: A systematic review. Journal of the European Academy of Dermatology and Venereology : JEADV 2023. link 72 . mRNA Vaccine Slows Melanoma Recurrence. Cancer discovery 2023. link 73 Quek C. Genetics and Genomics of Melanoma: Current Progress and Future Directions. Genes 2023. link 74 . TILs Outperform Ipilimumab in Melanoma. Cancer discovery 2023. link 75 Pillai A. Everything everywhere all at once. Science immunology 2023. link 76 . Nivolumab Plus Relatlimab Is Safe and Efficacious in Pretreated Melanoma. Cancer discovery 2023. link 77 Pouikli A, Frezza C. Metabolic control of antitumor immunity. Science (New York, N.Y.) 2023. link 78 . TCR Diversity Underpins Immunotherapy Success. Cancer discovery 2023. link 79 Wright C, Kapwata T, Albers P. Melanoma crude incidence rates among White South Africans climbing as in other countries: urgent call for targeted skin cancer prevention and awareness campaigns. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2023. link 80 Kaiser J. Tailored melanoma vaccine may stave off cancer. Science (New York, N.Y.) 2023. link 81 Horsham C, Janda M, Kerr M, Soyer HP, Caffery LJ. Consumer perceptions on privacy and confidentiality in dermatology for 3D total-body imaging. The Australasian journal of dermatology 2023. link 82 Gudiu AV, Stoicu-Tivadar L. Challenges in Early Diagnosis of Melanoma Using Tele-Dermatology. Studies in health technology and informatics 2023. link 83 Baeza-Hernández G, Rubio-Aguilera RF, Martínez-Morán C, Álvarez-Garrido H, Garrido-Ríos AA, Borbujo J. [Translated article] Survey on the Management of Dysplastic Nevus by Dermatologists in the Center-Spain Section of the Spanish Academy of Dermatology and Venereology (AEDV). Actas dermo-sifiliograficas 2023. link 84 Brown H, De'Ambrosis B, Yong-Gee S, Griffin A, Muir J. Melanoma diagnosis at a specialist dermatology practice without the use of photographic surveillance. The Australasian journal of dermatology 2023. link 85 Tchernev G, Naydekova N. MELANOMA AND DYSPLASTIC NEVI DEVELOPMENT AFTER RANITIDINE/RILMENIDINE/МOXONIDINE, LERCANIDIPINE, ROSUVASTATIN AND VERAPAMIL/TRANDOLAPRIL - NEW DATA/CASE SERIES. THE POTENTIAL ROLE OF NITROSAMINE/NDSRIS CONTAMINATION IN POLYMEDICATION AS SUBSTANTIAL SKIN CANCER TRIGGERING FACTOR. Georgian medical news 2023. link 86 Johnson DB, Atkins MB, Hennessy C, Wise-Draper T, Heilman H, Awosika J et al.. Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma. BMC cancer 2023. link 87 Balinski AM, Vasbinder AL, Kerndt CC, Catalan TC, Parry NP, Rehman RA et al.. Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes. Cancer medicine 2023. link 88 Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N et al.. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022. European journal of cancer (Oxford, England : 1990) 2022. link 89 Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N et al.. European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022. European journal of cancer (Oxford, England : 1990) 2022. link 90 Nisi M, Izzetti R, Gennai S, Pucci A, Lenzi C, Graziani F. Oral Mucosal Melanoma. The Journal of craniofacial surgery 2022. link 91 Toma AO, Prodan M, Reddyreddy AR, Seclaman E, Crainiceanu Z, Bloanca V et al.. The Epidemiology of Malignant Melanoma during the First Two Years of the COVID-19 Pandemic: A Systematic Review. International journal of environmental research and public health 2022. link 92 Wei G, Hennessy K, Kevin Heard L, Gaudi S, Mhaskar R, Patel RR et al.. Balloon cell melanoma: a systematic review. International journal of dermatology 2022. link 93 McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM et al.. Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1. Nature medicine 2022. link 94 Thuaire A, Nicot R, Boileau M, Raoul G, Descarpentries C, Mouawad F et al.. Oral mucosal melanoma - A systematic review. Journal of stomatology, oral and maxillofacial surgery 2022. link 95 Zhang S, Wang Y, Zheng Q, Li J, Huang J, Long X. Artificial intelligence in melanoma: A systematic review. Journal of cosmetic dermatology 2022. link 96 Vitali F, Colucci R, Di Paola M, Pindo M, De Filippo C, Moretti S et al.. Early melanoma invasivity correlates with gut fungal and bacterial profiles. The British journal of dermatology 2022. link 97 Popescu D, El-Khatib M, El-Khatib H, Ichim L. New Trends in Melanoma Detection Using Neural Networks: A Systematic Review. Sensors (Basel, Switzerland) 2022. link 98 Ferioli M, Lancellotta V, Perrone AM, Arcelli A, Galuppi A, Strigari L et al.. Electrochemotherapy of skin metastases from malignant melanoma: a PRISMA-compliant systematic review. Clinical & experimental metastasis 2022. link 99 Dong L, Tian X, Zhao Y, Tu H, Wong A, Yang Y. The Roles of MiRNAs (MicroRNAs) in Melanoma Immunotherapy. International journal of molecular sciences 2022. link 100 Cazzato G, Mangialardi K, Falcicchio G, Colagrande A, Ingravallo G, Arezzo F et al.. Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study. Genes 2022. link