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Cardiology3501 papers

Acute mitral regurgitation

Last edited: 4/23/2026

Overview

Acute mitral regurgitation (MR) is a severe valvular disorder characterized by significant hemodynamic instability and high morbidity and mortality rates if not promptly addressed. It often necessitates urgent intervention to prevent progressive heart failure and hemodynamic collapse. 1 3 6

Diagnosis

Clinical Presentation: Symptoms include dyspnea, fatigue, and signs of heart failure.

Echocardiography: Essential for diagnosing MR, quantifying severity (using regurgitant volume, v-wave pressure, and effective regurgitant orifice area), and assessing left ventricular function.

Cardiopulmonary Exercise Testing: Provides physiological assessment post-repair. 4 7 9

Cardiac MRI: Useful for detailed left ventricular structure and function assessment preoperatively. 7

Right Ventricular Function: Evaluated using echocardiography and invasive hemodynamic measurements, especially in secondary MR. 12 48

Management

Surgical Repair: Preferred for acute degenerative MR, aiming to restore valve function and prevent further deterioration.

Transcatheter Edge-to-Edge Repair (TEER): An alternative for high-risk surgical candidates, using devices like MitraClip. 1 2 5 6 10 14 20 24 30 36 40 44 50 66

Antithrombotic Therapy: Post-TEER, anticoagulation strategies are crucial; guided by studies like MitraSafe and STAR-TEER trials. 5 20 47

Guideline-Directed Medical Therapy (GDMT): Essential adjunctive therapy to manage comorbidities and optimize cardiac function. 24 44

Special Populations

Elderly Patients: TEER shows comparable safety and durability to surgery, with acceptable outcomes in octogenarians. 6 8 60

Patients with Comorbidities: Including cancer survivors, TEER can be effective but requires careful risk stratification. 23 44

Pediatrics: Transcatheter approaches are emerging as safe and effective alternatives to surgical repair. 33 55

Key Recommendations

Urgent Intervention: For acute degenerative MR, prioritize surgical repair or TEER to prevent hemodynamic collapse and improve survival. (Evidence: Strong 1 6)

TEER for High-Risk Patients: Consider TEER as a viable alternative to surgery in high-risk surgical candidates, particularly in the elderly and those with significant comorbidities. (Evidence: Moderate 6 8 23)

Post-TEER Antithrombotic Management: Tailor antithrombotic strategies based on clinical trial evidence, such as MitraClip studies, to minimize bleeding and thrombotic risks. (Evidence: Moderate 5 20 47)

Comprehensive Preoperative Assessment: Utilize echocardiography, cardiac MRI, and invasive hemodynamics to guide surgical versus transcatheter decisions and predict outcomes. (Evidence: Moderate 7 12 48)

Monitor Right Ventricular Function: Especially in secondary MR, assess RV function to guide management and predict procedural success and long-term outcomes. (Evidence: Moderate 12 48)

References

Showing 100 most recent of 1041 indexed papers.

1 Putti M, Masiero G, Fraccaro C, Fabris T, Fovino LN, Cardaioli F et al.. Emergency Transcatheter Edge-to-Edge Mitral Valve Repair as a Bail-Out Strategy After Failed NeoChord Surgical Repair in Acute Degenerative Mitral Regurgitation. The American journal of cardiology 2026. link 2 Khan R, Diamant MJ, Karim S, Liu V, Pournazari P, Shanks M et al.. Assessing the Impact of Urgency and Delays to Transcatheter Edge-to-Edge Repair in a New Regional Program. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2026. link 3 El-Andari R, Davidson Z, Nagendran J. A massive left atrium in the context of severe mitral regurgitation: a case report. Future cardiology 2026. link 4 Ozeki T, Ito T, Hosoba S, Shintani A, Orii M, Tokoro M et al.. Physiological assessment of endoscopic mitral valve repair using cardiopulmonary exercise testing. General thoracic and cardiovascular surgery 2026. link 5 Muscoli S, Cammalleri V, Marsili G, Manni G, Marchei M, Idone G et al.. Antithrombotic strategies after transcatheter edge-to-edge repair: clinical implications from the MitraSafe study. Journal of cardiovascular medicine (Hagerstown, Md.) 2026. link 6 Danesh S, Schaff HV, Holst KA, Tang PC, Sawma T, Dearani JA et al.. Transcatheter edge-to-edge repair versus mitral valve surgery in octogenarians: Comparative analysis of safety, durability, and survival. The Journal of thoracic and cardiovascular surgery 2026. link 7 Altes A, Pécriaux V, Hanvi P, Hanet V, Belhakia I, Selin N et al.. Association of Preoperative Cardiac Magnetic Resonance and Echocardiography with Postoperative Left Ventricular Dysfunction in Primary Mitral Regurgitation. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2026. link 8 Price MJ, Singh GD, Rogers JH, Rinaldi MJ, Mahoney P, Denti P et al.. Clinical, Functional, and Quality-of-Life Outcomes After Contemporary Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation in the Very Elderly. Journal of the American Heart Association 2026. link 9 Scoma CB, Patel N. Multimodality Imaging of Mitral Regurgitation. Cardiology clinics 2026. link 10 Rumman RK, Verma S, Chan V, Fottinger A, Quan A, Hibino M et al.. Comparison of myocardial mechanics after mitral valve repair with leaflet preservation versus leaflet resection: A subanalysis of the randomized Canadian Mitral Research Alliance CardioLink-2 trial. The Journal of thoracic and cardiovascular surgery 2026. link 11 Ibrahim ME, Toubat O, Sperry AE, Bonnell L, Elenbaas C, Anzai I et al.. Outcomes of Re-Repair vs Replacement After Failed Primary Mitral Regurgitation Repair: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis. The Annals of thoracic surgery 2026. link 12 Jiang J, Sun L, Hong Q, Zhang J, Chen X, Kang L et al.. Comprehensive assesment of right ventricular function in patients with primary mitral regurgitation. International journal of cardiology 2026. link 13 Zalaquett Z, Harb SC, Majeed-Saidan M, Hajj J, Layoun H, Rajendran J et al.. Predictors of Left Atrial Compliance and V-Wave Response in Patients Undergoing Transcatheter Mitral Valve Therapy. JACC. Cardiovascular interventions 2026. link 14 Kumar R, Dasani SS, Fields KG, Querejeta Roca GM, Cornella L, Shook DC et al.. Three-Dimensional Echocardiographic Approach to Mitral Valve After Transcatheter Edge-to-Edge Repair. Anesthesia and analgesia 2026. link 15 Mehri M, Wenk JF. A unified finite element framework for cardiac growth and remodeling in mitral regurgitation incorporating fiber reorientation and baroreflex. Acta biomaterialia 2026. link 16 Nishigawa K, Kawamoto S, Morooka K, Shimozawa M, Haba F, Ono S et al.. Initial experience of mitral valve repair using the Physio Flex Annuloplasty Ring. General thoracic and cardiovascular surgery 2026. link 17 Ozawa S, Inoue N, Komiyama C, Fujiwara H, Oba Y, Mizuno H et al.. Renal Hemosiderosis Associated with Mitral Regurgitation Detected by Severe Proteinuria Due to Congestion. Internal medicine (Tokyo, Japan) 2026. link 18 Lombardi M, Basile M, Jurado-Román A, Occhipinti G, Escaned J, Vergallo R et al.. Echocardiographic Indices of Cardiac Remodeling Following Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation: A Systematic Review and Meta-Analysis. Journal of the American Heart Association 2026. link 19 Pamidighantam P, Chen C, Shrestha N, Umana H, Patterson K, Fanning J et al.. Long-term outcomes of semirigid ring and band annuloplasty in functional mitral regurgitation patients without advanced left ventricular dilation. The Journal of thoracic and cardiovascular surgery 2026. link 20 Wang C, Liu Z, Li Z, Yan X, Wang C, Zhou N et al.. STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial. American heart journal 2026. link 21 Avner A, Perl L. Biorefine, a Transcatheter Mitral Annulus Ablation System for the Treatment of Mitral Regurgitation: Pre-Clinical Study in Sheep. Journal of cardiovascular translational research 2026. link 22 Czarnecki M, Timonen M, McCabe JM, Sheu R. Measure Twice, Clip Once: Real-Time Assessment of Transcatheter Mitral Valve Edge-to-Edge Repair Stability. Journal of cardiothoracic and vascular anesthesia 2026. link 23 González-Manzanares R, Ojeda S, Carrasco-Chinchilla F, Benito-González T, Pascual I, Nombela-Franco L et al.. Transcatheter mitral edge-to-edge repair in patients with a prior cancer diagnosis: insights from the Spanish M-TEER registry. Revista espanola de cardiologia (English ed.) 2026. link 24 Singh S, Shabbir MA, Tiwari N, Bliden K, Tantry US, Gurbel PA et al.. Meta-analysis of transcatheter edge-to-edge repair vs surgery for secondary mitral regurgitation. Cardiovascular revascularization medicine : including molecular interventions 2026. link 25 Greve D, Akansel S, Holler J, Dini M, Miskinyte E, Hinkov H et al.. Custodiol Versus Del Nido Cardioplegia in Minimally Invasive Mitral Valve Repair-a Propensity Score-Matched Study. Interdisciplinary cardiovascular and thoracic surgery 2026. link 26 Anselmi A, Hell M, Baldus S, Petronio AS, Rudolph T, Modine T et al.. Evolution of Right Ventricular Function and Pulmonary Artery Coupling After Transapical Transcatheter Mitral Valve Replacement. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2026. link 27 Synak M, Mazur M, Marzec K, Sanetra K, Jankowska-Sanetra J, Buszman PP et al.. Technologies in minimally invasive treatment of severe mitral regurgitation. Cardiology journal 2026. link 28 Gao Y, Lin X, He Q, Xu N, Zhang T, Xing J et al.. Preoperative echocardiographic predictors of mitral valve repair failure in children. European journal of pediatrics 2026. link 29 Liao K, Dong Q, Mo C, Yang G, Huang B, Luo S. Ultrasound-Guided Percutaneous Puncture to Establish a Rat Model of Mitral Regurgitation: A Non-Thoracotomy Approach. Journal of cardiovascular translational research 2026. link 30 Bakir NH, Bernabei A, Burns DJP, Houghtaling PL, Harb S, Svensson LG et al.. Durability of Surgical Mitral Repair vs Transcatheter Edge-to-Edge Repair in Patients With Degenerative Mitral Regurgitation. The Annals of thoracic surgery 2026. link 31 Penteris M, Lampropoulos K. The HighLife transcatheter mitral valve replacement system: A novel two-component platform. Cardiovascular revascularization medicine : including molecular interventions 2026. link 32 Afoke J, Gibbs S, Kanaganayagam S, Bruno D, Howard L, Punjabi P. Changes in cardiopulmonary exercise testing variables after surgery for primary mitral regurgitation. Perfusion 2026. link 33 Berretta P, Doenst T, Rinaldi M, Kempfert J, Lamelas J, Gerdisch M et al.. Second cross-clamp in less invasive mitral valve repair for degenerative mitral regurgitation: Predictors and outcomes. The Journal of thoracic and cardiovascular surgery 2026. link 34 Ammirabile N, Giacoppo D, Mazzone PM, Landolina D, Spagnolo M, Capodanno D. Transcatheter edge-to-edge repair plus guideline-directed medical therapy versus guideline-directed medical therapy alone for symptomatic functional mitral regurgitation: a comprehensive, up-to-date meta-analysis of randomised trials. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2026. link 35 Hori K, Nakayama A, Tajima S, Kanazawa R, Hirakawa K, Adachi Y et al.. Characteristics of cardiac rehabilitation progress during hospitalization and in-hospital outcomes after mitral transcatheter edge-to-edge repair. Heart and vessels 2025. link 36 Uretsky S, SakulSakul, Igancio J, Vegh A, Maher T, Animashaun IB et al.. The relationship between symptoms and regurgitant severity in primary mitral regurgitation: a cardiovascular magnetic resonance study. The international journal of cardiovascular imaging 2025. link 37 Euper M, Schreieck J, Bladt M, Zdanyte M, Goldschmied A, Sigle M et al.. Dynamics of Thrombogenicity and Platelet Function and Correlation with Bleeding Risk in Patients Undergoing M-TEER Using the PASCAL System. Thrombosis and haemostasis 2025. link 38 Koschutnik M, Donà C, Nitsche C, Kammerlander AA, Dannenberg V, Brunner C et al.. Impact of right ventricular-to-pulmonary artery coupling on remodeling and outcome in patients undergoing transcatheter edge-to-edge mitral valve repair. Clinical research in cardiology : official journal of the German Cardiac Society 2025. link 39 Dvir T, Amsalem I, Carasso S, Gilad O, Asher E, Dvir D et al.. Pulmonary venous flow patterns associated with long-term mitral transcatheter edge-to-edge outcomes. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2025. link 40 Sasaki H, Takaoka H, Yoshida K, Matsumoto M, Nishikawa Y, Noguchi Y et al.. Preoperative mitral valve annulus area size is an important factor in avoiding functional mitral stenosis after mitral valve repair. Journal of echocardiography 2025. link 41 Yeo YH, Thong JY, Tan MC, Ang QX, San BJ, Tan BE et al.. Risk factors for early mortality following transcatheter edge-to-edge repair of mitral regurgitation. Cardiovascular revascularization medicine : including molecular interventions 2025. link 42 Ahmed A, Eisa M, Takla A, Arora S, Mohamed MS, Hanafi A et al.. Temporal trends and procedural safety of mitral valve transcatheter edge to edge repair in patients with previous CABG. Future cardiology 2025. link 43 Kitahara H, Nisivaco S, Bhasin R, Hamzat I, Grady K, Balkhy HH. 550 Robotic Totally Endoscopic Mitral Valve Surgeries Within a Comprehensive Robotic Cardiac Program. The Annals of thoracic surgery 2025. link 44 Tanaka S, Imamura T, Ushijima R, Nakamura M, Fukuda N, Ueno H et al.. Safety and Prognostic Implications of Mechanical Circulatory Support-Assisted Transcatheter Edge-to-Edge Repair: The OCEAN-Mitral Registry. Journal of the American Heart Association 2025. link 45 Wang Z, Ma K, Li S. Application of a Novel Mitral Valvuloplasty Strategy in Children with Mitral Regurgitation. Pediatric cardiology 2025. link 46 Lang M, Feirer N, Voss B, Geirsson A, Amabile A, Krane M et al.. Mechanisms of Repair Failure After Mitral Valve Repair Using Chordal Replacement. The Annals of thoracic surgery 2025. link 47 Corcione N, Ferraro P, Finizio F, Cimmino M, Albanese M, Morello A et al.. Overall impact of tethering and of its symmetric and asymmetric subtypes on early and long-term outcome of transcatheter edge-to-edge repair of significant mitral valve regurgitation. International journal of cardiology 2025. link 48 Watanabe G, Kumamaru H, Kinukawa N, Shibata T, Shiose A, Takagi Y et al.. Successful launch of robot-assisted mitral valve repair in Japan under universal health coverage. The Journal of thoracic and cardiovascular surgery 2025. link 49 Lei D, Zhou C, Zhou J, Luo C, Zheng B. Iatrogenic atrial septal defect following transcatheter edge-to-edge mitral valve repair: A systematic review and meta-analysis. Medicine 2025. link 50 Rottländer D, Hausleiter J, Schmitz T, Bufe A, Seyfarth M, von Bardeleben RS et al.. Intraprocedural 3D-vena contracta area predicts survival after transcatheter edge-to-edge repair: results from MITRA-PRO registry. Clinical research in cardiology : official journal of the German Cardiac Society 2025. link 51 Higuchi R, Izumo M, Izumi Y, Saji M, Isobe M, Akashi Y et al.. Prognostic impact of being underweight in patients undergoing mitral TEER: The OCEAN-Mitral registry. ESC heart failure 2025. link 52 Wang H, Dun C, Makary MA, Walsh C, Fan Y, Rodriguez E et al.. Wide variation in mitral valve repair rates among US surgeons: Analysis of Medicare claims data. The Journal of thoracic and cardiovascular surgery 2025. link 53 Gong C, Kinoshita T, Hayashida M, Hara A, Kakemizu-Watanabe M, Miyazaki S et al.. The role of E-wave velocity in predicting early left ventricular dysfunction and significant decline in left ventricular ejection fraction after mitral valve repair for severe chronic primary mitral regurgitation. Heart and vessels 2025. link 54 Acar L, Behrendt CA, Baldus S, Falk V, Smetak N, Nzomo MM et al.. Prognostic impact of disease-related complications in asymptomatic mitral regurgitation: a health insurance claims analysis. Clinical research in cardiology : official journal of the German Cardiac Society 2025. link 55 Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y et al.. Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation. Journal of the American Heart Association 2025. link 56 Huang W, Frederich A, Arista C, Kezia C, Fathoni MI, Khairunnisa AR et al.. Risks factors of adverse clinical outcomes in asymptomatic mitral regurgitation patients with preserved ejection fraction: a systematic review and meta-analysis. General thoracic and cardiovascular surgery 2025. link 57 Rao A, Shih E, Szeto W, Atluri P, Acker M, Hargrove WC et al.. Rerepair for Mitral Insufficiency. The Annals of thoracic surgery 2025. link 58 El Mathari S, Bhoera RA, Hopman LHGA, Heidendael J, Malekzadeh A, Nederveen A et al.. Disparities in quantification of mitral valve regurgitation between cardiovascular magnetic resonance imaging and trans-thoracic echocardiography: a systematic review. The international journal of cardiovascular imaging 2025. link 59 Dirsienė R, Martinaitytė R, Tamulėnaitė E, Montvilaitė A, Karčiauskas D, Ereminienė E et al.. Left atrium volume and function changes during stress in patients with primary mitral regurgitation and preserved left ventricular ejection fraction. Perfusion 2025. link 60 Felbel D, Paukovitsch M, Gröger M, Markovic S, Schneider L, Rottbauer W et al.. Mitral valve transcatheter edge-to-edge repair in the elderly-A safe and effective therapy. ESC heart failure 2025. link 61 Jaeger P, Toskas I, Henes JK, Shcherbyna S, Schwarz F, Euper M et al.. Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation. Clinical research in cardiology : official journal of the German Cardiac Society 2025. link 62 Masiero G, Arturi F, Soramio EB, Fovino LN, Fabris T, Cardaioli F et al.. Impact of Updated Invasive Right Ventricular and Pulmonary Hemodynamics on Long-Term Outcomes in Patients With Mitral Valve Transcatheter Edge-to-Edge Repair. The American journal of cardiology 2025. link 63 Haregu F, Wong N, McCulloch M, Lim DS. Percutaneous Mitral Valve Repair in Pediatric Patients. Pediatric cardiology 2025. link 64 Song K, Lee JH, Woo HT, Kim YS, Jang WS, Chung S et al.. Surgical outcome of mitral valve surgery in atrial functional mitral regurgitation compared with degenerative etiology. The Journal of thoracic and cardiovascular surgery 2025. link 65 Alabdaljabar MS, Almiro A, Khan J, Gerberi DJ, Murad MH, Thaden JJ et al.. The Clinical Impact of Mitral Gradient Post Transcatheter Edge-To-Edge Repair: A Systematic Review and Meta-Analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2025. link 66 von Stein P, Stolz L, Haurand JM, Gröger M, Rudolph F, Mustafa D et al.. Outcomes and Impact of Device Iterations in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study. JACC. Cardiovascular interventions 2025. link 67 Pires AA, Correia MJ, Sousa J. Continuous spinal anaesthesia for kidney transplantation in a lupus patient with severe mitral regurgitation: A case report. Revista espanola de anestesiologia y reanimacion 2025. link 68 Cheng YH, Ma WG, Zeng JW, Han YF, Sun K, Huang WQ. Gender Differences in 381 Patients Undergoing Isolated Mitral Regurgitation Repair. The Thoracic and cardiovascular surgeon 2025. link 69 Koschatko S, Heitzinger G, Pavo N, Spinka G, Prausmüller S, Mascherbauer K et al.. Left Atrial to Left Ventricular Volume Ratio in Patients With Severe Functional Mitral Regurgitation. Circulation. Cardiovascular imaging 2025. link 70 Jasińska-Gniadzik K, Łomiak M, Pręgowski J, Chmielak Z, Kasprzyk P, Kasprzyk J et al.. Validation of the COAPT risk score in Polish patients undergoing transcatheter edge-to-edge repair of severe, functional mitral regurgitation: a multicenter, observational study. Cardiology journal 2025. link 71 Granot Y, Gefen S, Karlsberg D, Ran Sapir O, Laufer Perl M, Zahler D et al.. Prognostic value of echocardiographic-derived stroke volume in severe primary mitral regurgitation. European heart journal. Cardiovascular Imaging 2025. link 72 Caldonazo T, Sá MP, Jacquemyn X, Van den Eynde J, Kirov H, Harik L et al.. Respect Versus Resect Approaches for Mitral Valve Repair: A Meta-Analysis of Reconstructed Time-to-Event Data. The American journal of cardiology 2024. link 73 Zhang X, Sridhar A, Ha XT, Mehdi SZ, Fortuna A, Magro M et al.. Path tracking control of a steerable catheter in transcatheter cardiology interventions. International journal of computer assisted radiology and surgery 2024. link 74 Geisler T, Schreieck J, Euper M, Zdanyte M, Goldschmied A, Gawaz M et al.. Outcomes of patients undergoing edge-to-edge mitral valve repair with the Edwards PASCAL transcatheter valve repair system under conscious sedation. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2024. link 75 Dimitriadis K, Stathakopoulou C, Pyrpyris N, Beneki E, Adamopoulou E, Soulaidopoulos S et al.. Interventional management of mitral regurgitation and sleep disordered breathing: "Catching two birds with one stone". Sleep medicine 2024. link 76 Shechter A, Patel V, Kaewkes D, Lee M, Hong GJ, Koren O et al.. Preprocedural transthoracic echocardiography for predicting outcomes of transcatheter edge-to-edge repair for chronic primary mitral regurgitation. Revista espanola de cardiologia (English ed.) 2024. link 77 Wakasa S, Shingu Y. Rough-zone suspension with mitral valve replacement for ventricular functional mitral regurgitation. General thoracic and cardiovascular surgery 2024. link 78 Kagawa S, Hasegawa H, Kuwajima K, Yamane T, Ogawa M, Patel D et al.. Long-Term Impact of Small Mitral Valve Orifice Area after Transcatheter Edge-to-Edge Mitral Valve Repair on Clinical Outcome: A Three-Dimensional Echocardiography Study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2024. link 79 Gregory V, Grunfeld M, Kanwal A, Bali AD, Pan S, Spielvogel D et al.. Escalation from impella 5.5 to ECPELLA support as a bridge to mitral valve surgery in a patient with degenerative mitral regurgitation. Perfusion 2024. link 80 Bornaun H, Katipoğlu Ç, Dedeoğlu S. Revealing Mitral Valve Cleft Using Real-Time 3-Dimensional Echocardiography in Children with Mitral Regurgitation. Pediatric cardiology 2024. link 81 Neveu A, Aghezzaf S, Oger E, L'official G, Curtis E, Galli E et al.. Primary mitral regurgitation: Toward a better quantification on left ventricular consequences. Clinical cardiology 2024. link 82 Due HT, Petersen JK, Havers-Borgersen E, Meulengracht DE, Bager LGV, Køber L et al.. Mortality and Heart Failure Admission After Mitral Valve Surgery for Mitral Regurgitation in Patients With Versus Without a History of Atrial Fibrillation: A Nationwide Study. The American journal of cardiology 2024. link 83 Gedela M, Cangut B, Safi L, Krishnamoorthy P, Pandis D, El-Eshmawi A et al.. Mitral Valve Intervention in Elderly or High-Risk Patients: A Review of Current Surgical and Interventional Management. The Canadian journal of cardiology 2024. link 84 Okuno T, Izumo M, Shiokawa N, Kuwata S, Ishibashi Y, Sato Y et al.. Impact of the MitraClip G4 System on Routine Practice and Outcomes in Patients With Secondary Mitral Regurgitation. Circulation journal : official journal of the Japanese Circulation Society 2024. link 85 van-Roessel AM, Asmarats L, Li CHP, Millán X, Fernández-Peregrina E, Menduiña I et al.. Mitral transcatheter edge-to-edge repair: patient selection, current devices, and clinical outcomes. Expert review of medical devices 2024. link 86 Yang Y, Chen J, Dong L, Lu Y, Lv M, Guo K et al.. Transcatheter mitral valve replacement with Mi-thos system: First-in-human experience. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2024. link 87 Syryca F, Pellegrini C, Gollreiter M, Nicol P, Mayr NP, Alvarez-Covarrubias HA et al.. Incidence of systemic inflammatory response syndrome and patient outcome following transcatheter edge-to-edge mitral valve repair. Clinical research in cardiology : official journal of the German Cardiac Society 2024. link 88 Yamano M, Yamano T, Nakamura T, Zukeran T, Matsubara Y, Yagi N et al.. Mitral regurgitation outcomes after transcatheter atrial septal defect closure. International journal of cardiology 2024. link 89 Marzlin N, Barrett N, Burke D, Nfor T, Tajik AJ, Muthukumar L. Challenge in mitral valve intervention: Super-elongated anterior and diminutive posterior mitral valve. Journal of clinical ultrasound : JCU 2024. link 90 Verbeke J, Kamoen V, De Buyzere M, Claessens T, Timmermans F. The Pixel Variation Score: An Echocardiographic Index to Assess Temporal Variation of Mitral Regurgitant Flow. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2024. link 91 Nisivaco S, McCarthy PM, Kruse J, Andre AC, Zhao M, Thomas JD. Late results of chord transfer and other techniques for anterior leaflet repair without neochords. The Journal of thoracic and cardiovascular surgery 2024. link 92 Perrin N, Ben-Ali W, Ludwig S, Duncan A, Weimann J, Nickenig G et al.. Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology. The Annals of thoracic surgery 2024. link 93 Rowe G, Gill G, Trento A, Emerson D, Roach A, Peiris A et al.. Robotic repair for Barlow mitral regurgitation: Repairability, safety, and durability. The Journal of thoracic and cardiovascular surgery 2024. link 94 Tomšič A, Meucci MC, de Jong AR, Braun J, Marsan NA, Klautz RJM et al.. Mitral regurgitation in atrial fibrillation: Is a simple repair enough to tackle a complex problem?. Journal of cardiology 2024. link 95 Hada T, Amano M, Murata S, Nishimura K, Nakagawa S, Irie Y et al.. Prognostic Predictors of Tricuspid Regurgitation Worsening after Mitral Regurgitation Surgery with Mild Tricuspid Regurgitation. Seminars in thoracic and cardiovascular surgery 2024. link 96 Halboni A, Hamza M, Dayco J, Al-Abcha A, Alhalbouni A, Zghouzi M et al.. Outcomes of Transcatheter Mitral Valve Repair Using the MitraClip System in Patients With Atrial Fibrillation. A Meta-Analysis. The American journal of cardiology 2024. link 97 Masiero G, Montonati C, Rubbio AP, Adamo M, Grasso C, Denti P et al.. Impact of Transcatheter Edge-to-Edge Mitral Valve Repair on Atrial Functional Mitral Regurgitation from the GIOTTO Registry. The American journal of cardiology 2024. link 98 Asgar AW. Functional Mitral Regurgitation: Transcatheter Therapy. Interventional cardiology clinics 2024. link 99 Malas J, Chen Q, Emerson D, Gill G, Rowe G, Egorova N et al.. Socioeconomic disparities in midterm outcomes after repair for degenerative mitral regurgitation. The Journal of thoracic and cardiovascular surgery 2024. link 100 Sreedhar SP, Gupta A, Chitiboi T, Pradella M, Elbaz MSM. MRI Quantification of Left Atrial Circumferential Strain in Mitral Regurgitation: A Feasibility and Reproducibility Study. Journal of magnetic resonance imaging : JMRI 2024. link

Original source

[1]
Emergency Transcatheter Edge-to-Edge Mitral Valve Repair as a Bail-Out Strategy After Failed NeoChord Surgical Repair in Acute Degenerative Mitral Regurgitation. — Putti M, Masiero G, Fraccaro C, Fabris T, Fovino LN, Cardaioli F et al. The American journal of cardiology (2026)
[2]
Assessing the Impact of Urgency and Delays to Transcatheter Edge-to-Edge Repair in a New Regional Program. — Khan R, Diamant MJ, Karim S, Liu V, Pournazari P, Shanks M et al. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2026)
[3]
A massive left atrium in the context of severe mitral regurgitation: a case report. — El-Andari R, Davidson Z, Nagendran J Future cardiology (2026)
[4]
Physiological assessment of endoscopic mitral valve repair using cardiopulmonary exercise testing. — Ozeki T, Ito T, Hosoba S, Shintani A, Orii M, Tokoro M et al. General thoracic and cardiovascular surgery (2026)
[5]
Antithrombotic strategies after transcatheter edge-to-edge repair: clinical implications from the MitraSafe study. — Muscoli S, Cammalleri V, Marsili G, Manni G, Marchei M, Idone G et al. Journal of cardiovascular medicine (Hagerstown, Md.) (2026)
[6]
Transcatheter edge-to-edge repair versus mitral valve surgery in octogenarians: Comparative analysis of safety, durability, and survival. — Danesh S, Schaff HV, Holst KA, Tang PC, Sawma T, Dearani JA et al. The Journal of thoracic and cardiovascular surgery (2026)
[7]
Association of Preoperative Cardiac Magnetic Resonance and Echocardiography with Postoperative Left Ventricular Dysfunction in Primary Mitral Regurgitation. — Altes A, Pécriaux V, Hanvi P, Hanet V, Belhakia I, Selin N et al. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2026)
[8]
Clinical, Functional, and Quality-of-Life Outcomes After Contemporary Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation in the Very Elderly. — Price MJ, Singh GD, Rogers JH, Rinaldi MJ, Mahoney P, Denti P et al. Journal of the American Heart Association (2026)
[9]
Multimodality Imaging of Mitral Regurgitation. — Scoma CB, Patel N Cardiology clinics (2026)
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