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Hematology508 papers

Red blood cell disorder

Last edited: 4/13/2026

Overview

Red blood cell (RBC) disorders encompass a wide range of conditions affecting RBC structure, function, and production, impacting oxygen delivery and overall hematological health. These disorders can be quantitative (e.g., anemia) or qualitative (e.g., hemoglobinopathies), necessitating precise diagnostic and management strategies. 50

Diagnosis

  • Complete Blood Count (CBC): Essential for identifying quantitative abnormalities like anemia, polycythemia, and abnormal RBC indices. 50
  • Peripheral Blood Smear: Critical for detecting qualitative defects such as sickle cells, target cells, or nucleated RBCs. 50
  • Hemoglobin Electrophoresis: Useful for diagnosing hemoglobinopathies like sickle cell disease and thalassemia. 50
  • Iron Studies: Including ferritin, transferrin saturation, and serum iron levels, crucial for diagnosing iron deficiency or overload. 50
  • Reticulocyte Count: Evaluates bone marrow response to anemia. 50
  • Genetic Testing: Recommended for suspected inherited RBC disorders. 50
  • Management

  • Iron Supplementation: Oral or intravenous iron for iron deficiency anemia, dose tailored to ferritin levels and response. 50
  • Erythropoietin Therapy: Used in chronic anemia, particularly in chronic kidney disease or cancer patients. 50
  • Blood Transfusions: Indicated for severe anemia or acute blood loss, guided by clinical need and compatibility testing. 50
  • Hydroxyurea: First-line treatment for sickle cell disease to reduce vaso-occlusive crises. 50
  • Splenectomy: Considered in cases of severe, transfusion-dependent thalassemia or hereditary spherocytosis. 50
  • Pharmacological Chelation: For patients with iron overload, e.g., deferoxamine or deferasirox. 50
  • Special Populations

  • Pregnancy: Iron supplementation is crucial to prevent or manage iron deficiency anemia; close monitoring of CBC and hemoglobin levels is essential. 50
  • Pediatrics: Early diagnosis and management of inherited RBC disorders are critical; genetic counseling is recommended for families. 50
  • Elderly: Increased vigilance for chronic diseases leading to anemia; regular CBC monitoring is advised. 50
  • Comorbidities: Management of RBC disorders in patients with chronic diseases (e.g., kidney disease) requires tailored approaches, considering underlying conditions. 50
  • Key Recommendations

  • Regular CBC Monitoring for early detection and management of RBC disorders (Evidence: Strong 50).
  • Genetic Testing should be considered in patients with suspected inherited RBC disorders to guide personalized treatment (Evidence: Moderate 50).
  • Iron Studies are essential for diagnosing and managing iron deficiency and overload in RBC disorders (Evidence: Strong 50).
  • Tailored Transfusion Strategies based on clinical severity and patient-specific factors are recommended (Evidence: Moderate 50).
  • Regular Follow-up in special populations, including pregnant women and the elderly, to adjust treatment as needed (Evidence: Expert opinion 50).
  • References

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Journal of nanobiotechnology 2024. link 6 Qureshy Z, Nair P, Vesely SK, King AA, Lee AI, Connell NT et al.. Evaluating the impact of a year-long external mentorship pilot program in classical hematology. Blood advances 2024. link 7 Kim H, Lee GH, Yoon S, Hur M, Kim HN, Park M et al.. Performance of digital morphology analyzer Medica EasyCell assistant. Clinical chemistry and laboratory medicine 2023. link 8 Nell EM, Bailly J, Oelofse D, Linström M, Opie J, Chapanduka ZC et al.. Multicentre verification of haematology laboratory blood collection tubes during a global blood collection tube shortage. International journal of laboratory hematology 2023. link 9 Alshaghdali K, Alcantara TY, Rezgui R, Cruz CP, Alshammary MH, Almotairi YA et al.. Detecting Preanalytical Errors Using Quality Indicators in a Hematology Laboratory. Quality management in health care 2022. link 10 Cotta CV, Ondrejka SL, Nakashima MO, Theil KS. Pathology Residents as Testing Personnel in the Hematology Laboratory. Archives of pathology & laboratory medicine 2022. link 11 Daly S, Graham PA, Freeman KP. Quality control validation for a veterinary laboratory network of six Sysmex XT-2000iV hematology analyzers. Veterinary clinical pathology 2022. link 12 M Shaju A, Panicker N, Chandni V, Lakshmi Prasanna VM, Nair G, Subeesh V. Drugs-associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip. Journal of clinical pharmacy and therapeutics 2022. link 13 Daly S, Freeman KP, Graham PA. Evaluation of Sysmex XT-2000iV analyzer performance across a network of five veterinary laboratories using a commercially available quality control material. Veterinary clinical pathology 2021. link 14 Gupta SK, Gohil D, Panigrahi GC, Vaykar S, Rane P, Chavan P et al.. Comparison of different autoanalyzers for the determination of lymphocyte and neutrophil counts in mouse blood. Drug metabolism and personalized therapy 2021. link 15 Robbiano C, Birindelli S, Dolci A, Panteghini M. Impact of managing affected results in haemolysed samples of an infant-maternity hospital using an unconventional approach. Clinical biochemistry 2021. link 16 Lim MY, Greenberg CS. Impact of Benign Hematology Didactic Lectures on In-service Exam in a Hematology-Oncology Fellowship Program: a Cross-sectional Longitudinal Study. Journal of cancer education : the official journal of the American Association for Cancer Education 2020. link 17 Lim MY, Blaszczyk K, Jacobsen-Tews L, Mott L, Sarode R, Ziegler J et al.. Impact of the Hemostasis and Thrombosis Research Society trainee workshop in recruiting the next generation of nonmalignant hematologists. Journal of thrombosis and thrombolysis 2020. link 18 King AA, Vesely SK, Vettese E, Cook S, Cuker A, Stock W et al.. Impact of gender and caregiving responsibilities on academic success in hematology. Blood advances 2020. link 19 Johnston A, Bourner G, Martin T, McFarlane A, Good D, Padmore R et al.. Guidance for quality control practices and precision goals for CBCs based on IQMH patterns-of-practice survey. International journal of laboratory hematology 2019. link 20 Sharma D, Wallace N, Levinsohn EA, Marshall AL, Kayoumi K, Madero J et al.. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood advances 2019. link 21 Stephens L, Bevins NJ, Bengtsson HI, Broome HE. Comparison of Different Small Clinical Hematology Laboratory Configurations With Focus on Remote Smear Imaging. Archives of pathology & laboratory medicine 2019. link 22 . Conservation success story under poisoning threat. The Veterinary record 2018. link 23 Saito H, Hotta T, Naoe T. Brief history of the Asiatic International Society of Hematology: our roots of international cooperation with Asian countries. International journal of hematology 2018. link 24 Logan AC. Using Social Media at National Meetings in Hematology-Optimal Use, Tips, Strategies, and Limitations. Current hematologic malignancy reports 2017. link 25 Cui M, Xu L, Wang H, Ju S, Xu S, Jing R. Combining Nordtest method and bootstrap resampling for measurement uncertainty estimation of hematology analytes in a medical laboratory. Clinical biochemistry 2017. link 26 Cook AM, Moritz A, Freeman KP, Bauer N. Objective evaluation of analyzer performance based on a retrospective meta-analysis of instrument validation studies: point-of-care hematology analyzers. Veterinary clinical pathology 2017. link 27 Hsiao CC, Tiao MM, Chen CC. Using interactive multimedia e-Books for learning blood cell morphology in pediatric hematology. BMC medical education 2016. link 28 Cook AM, Moritz A, Freeman KP, Bauer N. Quality requirements for veterinary hematology analyzers in small animals-a survey about veterinary experts' requirements and objective evaluation of analyzer performance based on a meta-analysis of method validation studies: bench top hematology analyzer. Veterinary clinical pathology 2016. link 29 Sung L, Crowther M, Byrd J, Gitlin SD, Basso J, Burns L. Challenges in Measuring Benefit of Clinical Research Training Programs--the ASH Clinical Research Training Institute Example. Journal of cancer education : the official journal of the American Association for Cancer Education 2015. link 30 Thompson MA, Majhail NS, Wood WA, Perales MA, Chaboissier M. Social Media and the Practicing Hematologist: Twitter 101 for the Busy Healthcare Provider. Current hematologic malignancy reports 2015. link 31 Bourner G, De la Salle B, George T, Tabe Y, Baum H, Culp N et al.. ICSH guidelines for the verification and performance of automated cell counters for body fluids. 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Circulation of core collection monographs in an academic medical library. Bulletin of the Medical Library Association 2001. link 45 Mallozzi C, Di Stasi MA, Minetti M. Peroxynitrite-dependent activation of src tyrosine kinases lyn and hck in erythrocytes is under mechanistically different pathways of redox control. Free radical biology & medicine 2001. link00509-3) 46 Fink NE, Fernández Alberti A, Crispini I, Cabutti NV, Mazziotta D. Evaluation and additional recommendations for preparing a whole blood control material. Revista de saude publica 1998. link 47 Pastor J, Cuenca R, Velarde R, Marco I, Viñas L, Lavín S. Evaluation of a haematological analyser (Sysmex F-800) with equine blood. Zentralblatt fur Veterinarmedizin. Reihe A 1998. link 48 Veldeman F, Arien P, Pollaris P, Elen J, Willems JL, Boogaerts MA. The AMUSE-environment: a didactical environment where active multimedia use stimulates expertise. Medinfo. MEDINFO 1995. link 49 Johnson CL, Gerson B, Nunez M, Allam C. 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    Original source

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