Overview
Diabetic neuropathy is a common complication of diabetes mellitus, affecting up to 50% of patients, characterized by damage to peripheral nerves leading to symptoms such as pain, numbness, and loss of sensation, particularly in the extremities 111.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 253 indexed papers.
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Frontiers in endocrinology 2023. link 27 Martin CJ, Woods S, Bertke S, Pinkerton L, Jin C. Increased Mortality Associated With Disability Among Workers' Compensation Claimants With Upper Extremity Neuropathy. Journal of occupational and environmental medicine 2023. link 28 Kumsa HT, Abdisa LG, Tolessa LT, Wubneh SA, Kusa WF, Hordofa SN et al.. Early detection and treatment device for diabetic foot neuropathy. Irish journal of medical science 2023. link 29 Sethi Y, Uniyal N, Vora V, Agarwal P, Murli H, Joshi A et al.. Hypertension the 'Missed Modifiable Risk Factor' for Diabetic Neuropathy: a Systematic Review. Current problems in cardiology 2023. link 30 Bartolo E, Giacomozzi C, Coppini DV, Gatt A. The pressure time integral: An underused, clinically significant parameter as a determinant of neuropathic ulceration in diabetes. Gait & posture 2023. link 31 Himeno T, Kamiya H, Nakamura J. Not out of the woods yet: "Diabetic neuropathy" or "neuropathy associated with diabetes"?. Journal of diabetes investigation 2022. link 32 Wang EJ, Berninger LE, Komargodski O, Smith TJ. Painful Diabetic Neuropathy - Spinal Cord Stimulation, Peripheral Nerve Stimulation, Transcutaneous Electrical Nerve Stimulation, and Scrambler Therapy: A Narrative Review. Pain physician 2022. link 33 Putz Z, Tordai D, Hajdú N, Vági OE, Kempler M, Békeffy M et al.. Vitamin D in the Prevention and Treatment of Diabetic Neuropathy. Clinical therapeutics 2022. link 34 Yammine K, Abi Kharma J, Kaypekian T, Assi C, Zeeni N. Is diabetic neuropathy associated with vitamin D status? A meta-analysis. The British journal of nutrition 2022. link 35 Pecikoza U, Tomić M, Nastić K, Micov A, Stepanović-Petrović R. Synergism between metformin and analgesics/vitamin B. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022. link 36 Mens MA, van Netten JJ, Busch-Westbroek TE, Bus SA, Streekstra GJ, Wellenberg RHH et al.. Biomechanical and musculoskeletal changes after flexor tenotomy to reduce the risk of diabetic neuropathic toe ulcer recurrence. Diabetic medicine : a journal of the British Diabetic Association 2022. link 37 Pan Y, Davis PB, Kaebler DC, Blankfield RP, Xu R. Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy. Cardiovascular diabetology 2022. link 38 Thukral N, Kaur J, Malik M. A Systematic Review and Meta-analysis on Efficacy of Exercise on Posture and Balance in Patients Suffering from Diabetic Neuropathy. Current diabetes reviews 2021. link 39 Mücke M, Cuhls H, Radbruch L, Baron R, Maier C, Tölle T et al.. Quantitative sensory testing (QST). English version. Schmerz (Berlin, Germany) 2021. link 40 Isoardo G, Ciullo S, Titolo P, Fontana E, Battiston B, Stella M et al.. The relationship between alexithymia, sensory phenotype and neurophysiological parameters in patients with chronic upper limb neuropathy. Journal of neural transmission (Vienna, Austria : 1996) 2021. link 41 Forstenpointner J, Ruscheweyh R, Attal N, Baron R, Bouhassira D, Enax-Krumova EK et al.. No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy. Pain 2021. link 42 Enax-Krumova E, Attal N, Bouhassira D, Freynhagen R, Gierthmühlen J, Hansson P et al.. Contralateral Sensory and Pain Perception Changes in Patients With Unilateral Neuropathy. Neurology 2021. link 43 Karaganis S, Song XJ. B vitamins as a treatment for diabetic pain and neuropathy. Journal of clinical pharmacy and therapeutics 2021. link 44 Ramar S, Rajsekar S, Selvaraj B, Viswanathan V, Mani R. Regular Use of FlowAid FA100 SCCD Reduces Pain While Increasing Perfusion and Tissue Oxygenation in Contralateral Limbs of Amputees With Diabetic Neuropathy and Peripheral Arterial Disease: Results of an Open, Pre-Post Intervention, Single-Center Study. The international journal of lower extremity wounds 2021. link 45 Fontalis A, Doorgakant A, Zahra W, Blundell C. Midfoot Charcot Neuro-arthropathy Precipitated by First or Fifth ray Amputation. Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons 2021. link 46 Ersen A, Lavery LA, Monga A, Richardson M, Schwarz B, Quiben MU et al.. A Biomechanical Examination of Prefabricated Total Contact Cast Kits: Relevance to Patients With Diabetic Neuropathy. The international journal of lower extremity wounds 2021. link 47 Vallat JM, Duchesne M, Corcia P, Richard L, Ghorab K, Magy L et al.. The Wide Spectrum of Pathophysiologic Mechanisms of Paraproteinemic Neuropathy. Neurology 2021. link 48 Maiga Y, Diallo S, Konipo FDN, Sangho O, Sangaré M, Diallo SH et al.. Diabetic polyneuropathy with/out neuropathic pain in Mali: A cross-sectional study in two reference diabetes treatment centers in Bamako (Mali), Western Africa. PloS one 2020. link 49 Gwathmey KG, Grogan J. Nutritional neuropathies. Muscle & nerve 2020. link 50 Zwaferink JBJ, Hijmans JM, Schrijver CM, Schrijver LK, Postema K, van Netten JJ. Mechanical Noise Improves the Vibration Perception Threshold of the Foot in People With Diabetic Neuropathy. Journal of diabetes science and technology 2020. link 51 Malik RA. Diabetic neuropathy: A focus on small fibres. Diabetes/metabolism research and reviews 2020. link 52 Teelucksingh S, Naraynsingh V, Cawich S, Islam S, Harnanan D. Rat Bites in the Diabetic Foot: Clinical Clues. The American journal of medicine 2020. link 53 Diamanti-Kandarakis E, Duntas L, Kanakis GA, Kandaraki E, Karavitaki N, Kassi E et al.. DIAGNOSIS OF ENDOCRINE DISEASE: Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview. European journal of endocrinology 2019. link 54 Rowin J. Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives. Muscle & nerve 2019. link 55 Igiri BE, Tagang JI, Okoduwa SIR, Adeyi AO, Okeh A. An integrative review of therapeutic footwear for neuropathic foot due to diabetes mellitus. Diabetes & metabolic syndrome 2019. link 56 Ibáñez L, Barouti K, Markantes GK, Armeni AK, Georgopoulos NA. Pediatric endocrinology: an overview of the last decade. Hormones (Athens, Greece) 2018. link 57 Greenhill DA, Abdelfattah H, Torg JS, Sewards JM. Atypical presentation of Parsonage-Turner syndrome confounded by surgical rotator cuff injury. BMJ case reports 2017. link 58 Wukich DK, Sadoskas D, Vaudreuil NJ, Fourman M. Comparison of Diabetic Charcot Patients With and Without Foot Wounds. Foot & ankle international 2017. link 59 Scarr D, Lovblom LE, Ostrovski I, Kelly D, Wu T, Farooqi MA et al.. Agreement between automated and manual quantification of corneal nerve fiber length: Implications for diabetic neuropathy research. Journal of diabetes and its complications 2017. link 60 Jayabalan B, Low LL. Vitamin B supplementation for diabetic peripheral neuropathy. Singapore medical journal 2016. link 61 Hotta E, Asai J, Okuzawa Y, Hanada K, Nomiyama T, Takenaka H et al.. Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?. The Journal of dermatology 2016. link 62 Cheuy VA, Hastings MK, Commean PK, Mueller MJ. Muscle and Joint Factors Associated With Forefoot Deformity in the Diabetic Neuropathic Foot. Foot & ankle international 2016. link 63 Thom SR, Hampton M, Troiano MA, Mirza Z, Malay DS, Shannon S et al.. Measurements of CD34+/CD45-dim Stem Cells Predict Healing of Diabetic Neuropathic Wounds. Diabetes 2016. link 64 La Fontaine J, Lavery L, Jude E. Current concepts of Charcot foot in diabetic patients. Foot (Edinburgh, Scotland) 2016. link 65 Peck E, Strakowski JA. Ultrasound evaluation of focal neuropathies in athletes: a clinically-focused review. British journal of sports medicine 2015. link 66 DePietro JD, Jang M, Sjogren EV, Dikkers FG, Cohen SM, Noordzij JP. Management of chronic laryngopharyngeal neuropathy in the United States and Europe. The Annals of otology, rhinology, and laryngology 2015. link 67 Mak P, Broadbear JH, Kolosov A, Goodchild CS. Long-Term Antihyperalgesic and Opioid-Sparing Effects of 5-Day Ketamine and Morphine Infusion ("Burst Ketamine") in Diabetic Neuropathic Rats. Pain medicine (Malden, Mass.) 2015. link 68 Şen HM, Şen H, Aşık M, Özkan A, Binnetoglu E, Erbağ G et al.. The importance of education in diabetic foot care of patients with diabetic neuropathy. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2015. link 69 Ghassemi A, Mossayebi AR, Jamshidi N, Naemi R, Karimi MT. Manufacturing and finite element assessment of a novel pressure reducing insole for Diabetic Neuropathic patients. Australasian physical & engineering sciences in medicine 2015. link 70 Chakraborty PP, Ray S, Biswas D, Baidya A, Bhattacharjee R, Mukhopadhyay P et al.. A comparative study between total contact cast and pressure-relieving ankle foot orthosis in diabetic neuropathic foot ulcers. Journal of diabetes science and technology 2015. link 71 Kamel JT, Vogrin SJ, Knight-Sadler RJ, Willems NK, Seiderer L, Cook MJ et al.. Combining cutaneous silent periods with quantitative sudomotor axon reflex testing in the assessment of diabetic small fiber neuropathy. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2015. link 72 Satin AM, DePalma AA, Cuellar J, Gruson KI. Lateral femoral cutaneous nerve palsy following shoulder surgery in the beach chair position: a report of 4 cases. American journal of orthopedics (Belle Mead, N.J.) 2014. link 73 DePietro JD, Stein DJ, Calloway N, Cohen SM, Noordzij PJ. U.S. practice variations in the treatment of chronic laryngopharyngeal neuropathy. The Laryngoscope 2014. link 74 Han C, Vasylyev D, Macala LJ, Gerrits MM, Hoeijmakers JG, Bekelaar KJ et al.. The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability. Journal of neurology, neurosurgery, and psychiatry 2014. link 75 Dorfman D, George MC, Tamler R, Lushing J, Nmashie A, Simpson DM. Pruritus induced self injury behavior: an overlooked risk factor for amputation in diabetic neuropathy?. Diabetes research and clinical practice 2014. link 76 Sagnelli A, Piscosquito G, Pareyson D. Inherited neuropathies: an update. Journal of neurology 2013. link 77 Hawkes CP, McNamara B, O'Mahony O, Dempsey EM. Your diagnosis? Congenital foot drop. European journal of pediatrics 2013. link 78 Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ et al.. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain 2013. link 79 Zheng Y, Wang L, Krupka TM, Wang Z, Lu G, Zhang P et al.. The feasibility of using high frequency ultrasound to assess nerve ending neuropathy in patients with diabetic foot. European journal of radiology 2013. link 80 Halpern EM, Lovblom LE, Orlov S, Ahmed A, Bril V, Perkins BA. The impact of common variation in the definition of diabetic sensorimotor polyneuropathy on the validity of corneal in vivo confocal microscopy in patients with type 1 diabetes: a brief report. 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Safety and tolerability of duloxetine in the acute management of diabetic peripheral neuropathic pain: analysis of pooled data from three placebo-controlled clinical trials. Expert opinion on drug safety 2010. link 86 Muthuraman A, Ramesh M, Sood S. Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery. Journal of neuroscience methods 2010. link 87 Orstavik K, Jørum E. Microneurographic findings of relevance to pain in patients with erythromelalgia and patients with diabetic neuropathy. Neuroscience letters 2010. link 88 Kamenov ZA, Parapunova RA, Georgieva RT. Earlier development of diabetic neuropathy in men than in women with type 2 diabetes mellitus. Gender medicine 2010. link 89 Pfund Z, Stankovics J, Decsi T, Illes Z. Childhood steroid-responsive acute erythromelalgia with axonal neuropathy of large myelinated fibers: a dysimmune neuropathy?. Neuromuscular disorders : NMD 2009. link 90 Shaibani A, Biton V, Rauck R, Koch B, Simpson J. Long-term oral lacosamide in painful diabetic neuropathy: a two-year open-label extension trial. European journal of pain (London, England) 2009. link 91 Yerdelen D, Koc F, Uysal H. Effects of colchicine on strength-duration properties of sensory and motor axons. Neurological research 2009. link 92 Ulbrecht JS, Wukich DK. The Charcot foot: medical and surgical therapy. Current diabetes reports 2008. link 93 Muscolino JE. Upper extremity paraesthesia: clinical assessment and reasoning. Journal of bodywork and movement therapies 2008. link 94 Miyamoto W, Yamamoto S, Kii R, Uchio Y. Vascular leiomyoma resulting in ulnar neuropathy: case report. The Journal of hand surgery 2008. link 95 Ndip A, Jude EB, Whitehouse R, Prescott M, Boulton AJ. Charcot neuroarthropathy triggered by osteomyelitis and/or surgery. 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