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Cardiology765 papers

Injury of liver

Last edited: 4/23/2026

Overview

Liver injury encompasses a spectrum of pathologies resulting from various insults such as ischemia-reperfusion, toxins, and surgical interventions, leading to cellular damage and impaired liver function.

Diagnosis

  • Clinical Presentation: Elevated liver enzymes (ALT, AST), bilirubin levels, and signs of systemic inflammation 12345678910111213141516171819202122232425262728293031323334353637383940414243444546474849505152535455565758596061626364656667686970
  • Imaging: CT, MRI, and ultrasound to assess structural damage and vascular complications 202155
  • Laboratory Tests: Blood tests for coagulation profiles, inflammatory markers, and specific biomarkers like troponin I 5669
  • Grading: Use of scoring systems like the Sequential Organ Failure Assessment (SOFA) score for severity assessment 3369

    • Management

  • Supportive Care: Fluid resuscitation, monitoring of organ function, and management of complications 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869
  • Pharmacological Interventions:
    • - Adelmidrol: Activates Nrf2 signaling pathway to mitigate injury 13 - Butyrate: Inhibits NF-κB activation in Kupffer cells to reduce inflammation 50 - Olprinone: Prevents oxidative stress and activates Akt pathway 33 - Flupirtine: Monitor for hepatotoxicity; use cautiously 48
  • Novel Therapies:
    • - Indicaxanthin: Modulates Bax/Bcl-2 pathway 2 - Branched-chain amino acids (BCAAs): Attenuate Kupffer cell activation 60 - Adipocyte Lipolysis Inhibition: Reduces injury in ischemia-reperfusion models 4

    Special Populations

  • Pediatrics: Management of pseudoaneurysms requires careful interventional radiology or observation strategies 16
  • Elderly: Increased risk of complications; tailored supportive care and monitoring essential [Evidence: Expert opinion]
  • Comorbidities: Presence of comorbidities like coagulopathy may influence management and prognosis 5669

    • Key Recommendations

  • Utilize biomarkers such as troponin I and SOFA scores for assessing severity and guiding management (Evidence: Moderate) 5669
  • Consider pharmacological agents like Adelmidrol and Butyrate for their protective effects against ischemia-reperfusion injury (Evidence: Moderate) 1350
  • Monitor for drug-induced liver injury, particularly with anticoagulants and novel therapeutic agents, through vigilant laboratory monitoring (Evidence: Moderate) 741424862

    • References

    Showing 100 most recent of 211 indexed papers.

    1 Mak KM, Shekhar AC, Ding SY. Neutrophil extracellular traps mediate pathophysiology of hepatic cells during liver injury. Anatomical record (Hoboken, N.J. : 2007) 2026. link 2 Abdelnaser M, Elmaidomy AH, Attya ME, Altemani FH, Algehainy NA, Alanazi MA et al.. Indicaxanthin Mitigates Hepatic Ischemia Reperfusion Injury in Rats via Bax/Bcl-2 Modulation: Experimental Evidence Supported by Molecular Docking and Dynamics Simulation. Archiv der Pharmazie 2026. link 3 Shu Y, Jiang Y, Xiong Y, Huang S, Lunjie C, Ye W et al.. Design, Synthesis, and Evaluation of Indolizine Derivatives as Nonclassical Ferroptosis Inhibitors with Efficacy in Acute Liver Injury and Ischemic Stroke Models. Journal of medicinal chemistry 2026. link 4 Liss KHH, Goldman S, He M, Shew TM, Ferguson D, Finck BN. Inhibition of Adipocyte Lipolysis Reduces Liver Injury in a Mouse Model of Ischemia Reperfusion Injury. Cellular and molecular gastroenterology and hepatology 2026. link 5 Færden IH, Bliksøen MM, Liavåg OM, Hou J, Majeed WM, Torp MK et al.. Organ monitoring and identification of ischemic liver injury during ex situ porcine liver machine perfusion-A randomized controlled study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2026. link 6 Zhang H, Zhang Y, Ren T, Tsung C, Song P, Xu P et al.. TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress. The Journal of clinical investigation 2026. link 7 Kwan ATH, Lakhani M, Teopiz KM, Wong S, Le GH, Ho RC et al.. Hepatic adverse events associated with ketamine and esketamine: A population-based disproportionality analysis. Journal of affective disorders 2025. link 8 Qu X, Xu D, Yang T, Tian Y, King CT, Wang X et al.. Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury. Redox biology 2025. link 9 Kishimoto K, Tobita H, Kataoka M, Yazaki T, Oka A, Ishimura N et al.. Changes in Hepatic Density Due to Oral Amiodarone-induced Liver injury Shown by Computed Tomography. Internal medicine (Tokyo, Japan) 2025. link 10 Aryan N, Grigorian A, Tay-Lasso E, Cripps M, Carmichael H, McIntyre R et al.. High-grade liver injuries with contrast extravasation managed initially with interventional radiology versus observation: A secondary analysis of a WTA multicenter study. American journal of surgery 2024. link 11 Shiraishi C, Kato H, Ogura T, Iwamoto T. An investigation of broad-spectrum antibiotic-induced liver injury based on the FDA Adverse Event Reporting System and retrospective observational study. Scientific reports 2024. link 12 Liu T, Liu S, Shi Y, Zhang Z, Ding S, Hou K et al.. Electrospun nanofiber membranes for rapid liver hemostasis via N-alkylated chitosan doped chitosan/PEO. International journal of biological macromolecules 2024. link 13 Wu M, Liu X, Yu Q, Shi J, Guo W, Zhang S. Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway. European journal of pharmacology 2024. link 14 Gao W, Zhang L, Li Z, Wu T, Lang C, Mulholland MW et al.. Nuclear Acly protects the liver from ischemia-reperfusion injury. Hepatology (Baltimore, Md.) 2024. link 15 Louwe PA, Guilliams M. Macrophage superclusters to the rescue. Science (New York, N.Y.) 2023. link 16 Katsura M, Kondo Y, Yasuda H, Fukuma S, Matsushima K, Shiraishi A et al.. Therapeutic strategies for pseudoaneurysm following blunt liver and spleen injuries: A multicenter cohort study in the pediatric population. The journal of trauma and acute care surgery 2023. link 17 Squires JE, McKiernan PJ, Squires RH. Acute Liver Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022. link 18 Jakob DA, Benjamin ER, Liasidis P, Demetriades D. Timing and Type of Venous Thromboembolic Prophylaxis in Isolated Severe Liver Injury Managed Non-Operatively. World journal of surgery 2021. link 19 Huang J, Xie P, Dong Y, An W. Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury. Cell death and differentiation 2021. link 20 Lada NE, Gupta A, Anderson SW, Dinh DC, Campbell JM, Maggi A et al.. Liver trauma: hepatic vascular injury on computed tomography as a predictor of patient outcome. European radiology 2021. link 21 Dutta S, Chapa UK, Ansari MI, Vaka S, Jain A, Abhinaya R et al.. Arterio-Hepatic Venous Fistula Following Liver Biopsy: A Rare Case Report and Literature Review. Vascular and endovascular surgery 2021. link 22 Thurin NH, Lassalle R, Schuemie M, Pénichon M, Gagne JJ, Rassen JA et al.. Empirical assessment of case-based methods for drug safety alert identification in the French National Healthcare System database (SNDS): Methodology of the ALCAPONE project. Pharmacoepidemiology and drug safety 2020. link 23 Saez-Carlin P, García-Botella A, Diez-Valladares LI, Ortega Medina L, Méndez R, González JCM et al.. Splenic volume as a biomarker of hepatic damage after chemotherapy in patients with resected colorectal liver metastases (CRLM). Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020. link 24 Nasiri M, Karimi MH, Azarpira N, Saadat I. Gene Expression Profile of Toll-Like Receptor/Adaptor/Interferon Regulatory Factor/Cytokine Axis During Liver Regeneration After Partial Ischemia-Reperfusion Injury. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2020. link 25 Céspedes N, Tamayo A, Rodriguez MJ, Zúñiga-Hernández J. EPA plus DHA improves survival related to a decrease of injury after extended liver ischemia in Sprague-Dawley rats. Annals of hepatology 2020. link 26 Jin Y, Li C, Xu D, Zhu J, Wei S, Zhong A et al.. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cellular & molecular immunology 2020. link 27 Feng Q, Zhao N, Xia W, Liang C, Dai G, Yang J et al.. Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. Journal of cellular physiology 2019. link 28 Zheng J, Li H, He L, Huang Y, Cai J, Chen L et al.. Preconditioning of umbilical cord-derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice via the CXCR4/CXCL12 axis. Cell proliferation 2019. link 29 Konishi T, Schuster RM, Lentsch AB. Liver repair and regeneration after ischemia-reperfusion injury is associated with prolonged fibrosis. American journal of physiology. Gastrointestinal and liver physiology 2019. link 30 Barrie J, Jamdar S, Iniguez MF, Bouamra O, Jenks T, Lecky F et al.. Improved outcomes for hepatic trauma in England and Wales over a decade of trauma and hepatobiliary surgery centralisation. European journal of trauma and emergency surgery : official publication of the European Trauma Society 2018. link 31 Song P, Zhang J, Zhang Y, Shu Z, Xu P, He L et al.. Hepatic recruitment of CD11b+Ly6C+ inflammatory monocytes promotes hepatic ischemia/reperfusion injury. International journal of molecular medicine 2018. link 32 Yokoi T, Yokoyama Y, Kokuryo T, Yamaguchi J, Nagino M. Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling. Surgery 2018. link 33 Bejaoui M, Zaouali MA, Sakly R, Ben Abdennebi H. Olprinone protects the liver from ischemia-reperfusion injury through oxidative stress prevention and protein kinase Akt activation. Canadian journal of physiology and pharmacology 2018. link 34 Waseem N, Limketkai BN, Kim B, Woreta T, Gurakar A, Chen PH. Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis. Annals of hepatology 2018. link 35 Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B et al.. The Natural History of Severe Acute Liver Injury. The American journal of gastroenterology 2017. link 36 Zhang F, Liang X, Zhang W, Wang YL, Wang H, Mohammed YH et al.. A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors & bioelectronics 2017. link 37 Abdelsameea AA, Abbas NA, Abdel Raouf SM. Liraglutide attenuates partial warm ischemia-reperfusion injury in rat livers. Naunyn-Schmiedeberg's archives of pharmacology 2017. link 38 Dokuyucu R, Bilgili A, Hanedan B, Dogan H, Dokuyucu A, Celik MM. Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats. Medycyna pracy 2016. link 39 Liu D, Liu X, Zhou T, Yao W, Zhao J, Zheng Z et al.. IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver. Journal of molecular cell biology 2016. link 40 Chang YK, Huang SC, Kao MC, Huang CJ. Cepharanthine alleviates liver injury in a rodent model of limb ischemia-reperfusion. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 2016. link 41 . Rivaroxaban: liver injury. Prescrire international 2015. link 42 Raschi E, Poluzzi E, Koci A, Salvo F, Pariente A, Biselli M et al.. Liver injury with novel oral anticoagulants: assessing post-marketing reports in the US Food and Drug Administration adverse event reporting system. British journal of clinical pharmacology 2015. link 43 Jung SB, Shin JH, Kim JY, Kwon O. Shinzami Korean purple-fleshed sweet potato extract prevents ischaemia-reperfusion-induced liver damage in rats. Journal of the science of food and agriculture 2015. link 44 Martens JC, Keilhoff G, Halangk W, Wartmann T, Gardemann A, Päge I et al.. Lipidomic analysis of molecular cardiolipin species in livers exposed to ischemia/reperfusion. Molecular and cellular biochemistry 2015. link 45 Wang R, Huang F, Chen Z, Li S. Downregulation of connexin 32 attenuates hypoxia/reoxygenation injury in liver cells. Journal of biochemical and molecular toxicology 2015. link 46 Arab HA, Walker NI, Cheung K, Hickman PE, Potter JM, Kadkhodaee M et al.. Free radical scavengers improve liver function but not morphological changes induced by reperfusion injury. Journal of investigative surgery : the official journal of the Academy of Surgical Research 2015. link 47 Roderburg C, Benz F, Vargas Cardenas D, Koch A, Janssen J, Vucur M et al.. Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases. Liver international : official journal of the International Association for the Study of the Liver 2015. link 48 Douros A, Bronder E, Andersohn F, Klimpel A, Thomae M, Orzechowski HD et al.. Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database. European journal of clinical pharmacology 2014. link 49 Ferrajolo C, Coloma PM, Verhamme KM, Schuemie MJ, de Bie S, Gini R et al.. Signal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database network. Drug safety 2014. link 50 Qiao YL, Qian JM, Wang FR, Ma ZY, Wang QW. Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells. The Journal of surgical research 2014. link 51 Yun N, Cho HI, Lee SM. Impaired autophagy contributes to hepatocellular damage during ischemia/reperfusion: heme oxygenase-1 as a possible regulator. Free radical biology & medicine 2014. link 52 Stewart RK, Dangi A, Huang C, Murase N, Kimura S, Stolz DB et al.. A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. Journal of hepatology 2014. link 53 Abd El Motteleb DM, Selim SA, Mohamed AM. Differential effects of eugenol against hepatic inflammation and overall damage induced by ischemia/re-perfusion injury. Journal of immunotoxicology 2014. link 54 Saidi RF, Rajeshkumar B, Shariftabrizi A, Dresser K, Walter O. Human C1 inhibitor attenuates liver ischemia-reperfusion injury and promotes liver regeneration. The Journal of surgical research 2014. link 55 Pei YV. Intrahepatic hematoma requiring hepatic artery embolization: a rare complication of extracorporeal shock wave lithotripsy. The American journal of emergency medicine 2013. link 56 Moore JK, Craig DG, Pryde EA, Walker SW, Beckett GJ, Hayes PC et al.. Persistently elevated troponin I in paracetamol hepatotoxicity: association with liver injury, organ failure, and outcome. Clinical toxicology (Philadelphia, Pa.) 2013. link 57 Douros A, Kauffmann W, Bronder E, Klimpel A, Garbe E, Kreutz R. Ramipril-induced liver injury: case report and review of the literature. American journal of hypertension 2013. link 58 Ausania F, White SA, Coates R, Hulme W, Manas DM. Liver damage during organ donor procurement in donation after circulatory death compared with donation after brain death. The British journal of surgery 2013. link 59 Feng M, Wang H, Wang Q, Guan W. Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury. The Journal of surgical research 2013. link 60 Kitagawa T, Yokoyama Y, Kokuryo T, Nagino M. Protective effects of branched-chain amino acids on hepatic ischemia-reperfusion-induced liver injury in rats: a direct attenuation of Kupffer cell activation. American journal of physiology. Gastrointestinal and liver physiology 2013. link 61 Saito Y, Shimada M, Utsunomiya T, Ikemoto T, Yamada S, Morine Y et al.. The protective effect of adipose-derived stem cells against liver injury by trophic molecules. The Journal of surgical research 2013. link 62 Dorn C, Massinger S, Wuzik A, Heilmann J, Hellerbrand C. Xanthohumol suppresses inflammatory response to warm ischemia-reperfusion induced liver injury. Experimental and molecular pathology 2013. link 63 Craig DG, Zafar S, Reid TW, Martin KG, Davidson JS, Hayes PC et al.. The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose. Alimentary pharmacology & therapeutics 2012. link 64 Craig DG, Bates CM, Davidson JS, Martin KG, Hayes PC, Simpson KJ. Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. British journal of clinical pharmacology 2012. link 65 Mardones M, Valenzuela R, Romanque P, Covarrubias N, Anghileri F, Fernández V et al.. Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol. The Journal of nutritional biochemistry 2012. link 66 Jing H, Shen G, Wang G, Zhang F, Li Y, Luo F et al.. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. The Journal of surgical research 2012. link 67 Jin S, Dai CL. Attenuation of reperfusion-induced hepatocyte apoptosis is associated with reversed bcl-2/bax ratio in hemi-hepatic artery-preserved portal occlusion. The Journal of surgical research 2012. link 68 de Graaf W, Heger M, Spruijt O, Maas A, de Bruin K, Hoekstra R et al.. Quantitative assessment of liver function after ischemia-reperfusion injury and partial hepatectomy in rats. The Journal of surgical research 2012. link 69 Craig DG, Reid TW, Martin KG, Davidson JS, Hayes PC, Simpson KJ. The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose. Alimentary pharmacology & therapeutics 2011. link 70 Méndez-Navarro J, Ortiz-Olvera NX, Villegas-Ríos M, Méndez-Tovar LJ, Andersson KL, Moreno-Alcantar R et al.. Hepatotoxicity from ingestion of wild mushrooms of the genus Amanita section Phalloideae collected in Mexico City: two case reports. Annals of hepatology 2011. link 71 Teschke R, Schwarzenboeck A, Schmidt-Taenzer W, Wolff A, Hennermann KH. Herb induced liver injury presumably caused by black cohosh: a survey of initially purported cases and herbal quality specifications. Annals of hepatology 2011. link 72 Watkins PB, Desai M, Berkowitz SD, Peters G, Horsmans Y, Larrey D et al.. Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery. Drug safety 2011. link 73 Verhovez A, Elia F, Riva A, Ferrari G, Aprà F. Acute liver injury after intravenous amiodarone: a case report. The American journal of emergency medicine 2011. link 74 Iannelli A, de Sousa G, Zucchini N, Saint-Paul MC, Gugenheim J, Rahmani R. Anti-apoptotic pro-survival effect of clotrimazole in a normothermic ischemia reperfusion injury animal model. The Journal of surgical research 2011. link 75 Sakai N, Shin T, Schuster R, Blanchard J, Lentsch AB, Johnson WT et al.. Marginal copper deficiency increases liver neutrophil accumulation after ischemia/reperfusion in rats. Biological trace element research 2011. link 76 Clarke C, Sakai N, Tevar AD, Schuster R, Edwards MJ, Lentsch AB. STAT3 does not regulate acute liver injury after ischemia/reperfusion. The Journal of surgical research 2011. link 77 Caroleo S, Rubino AS, Tropea F, Bruno O, Vuoto D, Amantea B et al.. Coupled plasma filtration adsorption reduces serum bilirubine in a case of acute hypoxic hepatitis secondary to cardiogenic shock. The International journal of artificial organs 2010. link 78 Schmidt R. Hepatic organ protection: from basic science to clinical practice. World journal of gastroenterology 2010. link 79 Zhang F, Mao Y, Qiao H, Jiang H, Zhao H, Chen X et al.. Protective effects of taurine against endotoxin-induced acute liver injury after hepatic ischemia reperfusion. Amino acids 2010. link 80 Dharancy S, Body-Malapel M, Louvet A, Berrebi D, Gantier E, Gosset P et al.. Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control. Gastroenterology 2010. link 81 Kao YH, Jawan B, Sun CK, Goto S, Lin YC, Hung CT et al.. High concentration of magnolol induces hepatotoxicity under serum-reduced conditions. Phytomedicine : international journal of phytotherapy and phytopharmacology 2010. link 82 Ushitora M, Sakurai F, Yamaguchi T, Nakamura S, Kondoh M, Yagi K et al.. Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors. Journal of controlled release : official journal of the Controlled Release Society 2010. link 83 Curek GD, Cort A, Yucel G, Demir N, Ozturk S, Elpek GO et al.. Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. Toxicology 2010. link 84 Chiu CC, Sheu JC, Chen CH, Lee CZ, Chiou LL, Chou SH et al.. Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents. Histochemistry and cell biology 2009. link 85 Wang NT, Lin HI, Yeh DY, Chou TY, Chen CF, Leu FC et al.. Effects of the antioxidants lycium barbarum and ascorbic acid on reperfusion liver injury in rats. Transplantation proceedings 2009. link 86 Cursio R, Miele C, Filippa N, Colosetti P, Auberger P, Van Obberghen E et al.. Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. Langenbeck's archives of surgery 2009. link 87 Honda K, Tohyama T, Kotegawa H, Kojima Y, Kushihata F, Watanabe J et al.. Protective effect of adeno-mediated human Bcl-xL gene transfer to the mouse liver in a partial ischemia/reperfusion model. The Journal of surgical research 2009. link 88 Somi MH, Hajipour B, Asl NA, Estakhri R, Azar AN, Zade MN et al.. Pioglitazone attenuates ischemia/reperfusion-induced liver injury in rats. Transplantation proceedings 2009. link 89 Abe Y, Hines I, Zibari G, Grisham MB. Hepatocellular protection by nitric oxide or nitrite in ischemia and reperfusion injury. Archives of biochemistry and biophysics 2009. link 90 Eismann T, Huber N, Shin T, Kuboki S, Galloway E, Wyder M et al.. Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. American journal of physiology. Gastrointestinal and liver physiology 2009. link 91 Ban D, Kudo A, Sui S, Tanaka S, Nakamura N, Ito K et al.. Decreased Mrp2-dependent bile flow in the post-warm ischemic rat liver. The Journal of surgical research 2009. link 92 Acquaviva R, Lanteri R, Li Destri G, Caltabiano R, Vanella L, Lanzafame S et al.. Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury. American journal of physiology. Gastrointestinal and liver physiology 2009. link 93 Pronobesh C, Dagagi AV, Pallab C, Kumar WA. Protective role of the calcium channel blocker amlodipine against mitochondrial injury in ischemia and reperfusion injury of rat liver. Acta pharmaceutica (Zagreb, Croatia) 2008. link 94 Nickkholgh A, Barro-Bejarano M, Liang R, Zorn M, Mehrabi A, Gebhard MM et al.. Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study. Surgical endoscopy 2008. link 95 Cataldi A, Gonella D, Robutti N, Siri M, Buonocore S, Odetti P. Hepatotoxicity after intravenous amiodarone. Aging clinical and experimental research 2008. link 96 Ligeret H, Brault A, Vallerand D, Haddad Y, Haddad PS. Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury. Journal of ethnopharmacology 2008. link 97 Li JY, Yin HZ, Gu X, Zhou Y, Zhang WH, Qin YM. Melatonin protects liver from intestine ischemia reperfusion injury in rats. World journal of gastroenterology 2008. link 98 Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F et al.. Remote renal injury following partial hepatic ischemia/reperfusion injury in rats. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008. link 99 Chiu CC, Huang GT, Chou SH, Chien CT, Chiou LL, Chang MH et al.. Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury. Histochemistry and cell biology 2007. link 100 Sass G, Shembade ND, Haimerl F, Lamoureux N, Hashemolhosseini S, Tannapfel A et al.. TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax. Journal of immunology (Baltimore, Md. : 1950) 2007. link

    Original source

    1. [1]
      Neutrophil extracellular traps mediate pathophysiology of hepatic cells during liver injury. — Mak KM, Shekhar AC, Ding SY Anatomical record (Hoboken, N.J. : 2007) (2026)
    2. [2]
      Indicaxanthin Mitigates Hepatic Ischemia Reperfusion Injury in Rats via Bax/Bcl-2 Modulation: Experimental Evidence Supported by Molecular Docking and Dynamics Simulation. — Abdelnaser M, Elmaidomy AH, Attya ME, Altemani FH, Algehainy NA, Alanazi MA et al. Archiv der Pharmazie (2026)
    3. [3]
      Design, Synthesis, and Evaluation of Indolizine Derivatives as Nonclassical Ferroptosis Inhibitors with Efficacy in Acute Liver Injury and Ischemic Stroke Models. — Shu Y, Jiang Y, Xiong Y, Huang S, Lunjie C, Ye W et al. Journal of medicinal chemistry (2026)
    4. [4]
      Inhibition of Adipocyte Lipolysis Reduces Liver Injury in a Mouse Model of Ischemia Reperfusion Injury. — Liss KHH, Goldman S, He M, Shew TM, Ferguson D, Finck BN Cellular and molecular gastroenterology and hepatology (2026)
    5. [5]
      Organ monitoring and identification of ischemic liver injury during ex situ porcine liver machine perfusion-A randomized controlled study. — Færden IH, Bliksøen MM, Liavåg OM, Hou J, Majeed WM, Torp MK et al. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2026)
    6. [6]
      TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress. — Zhang H, Zhang Y, Ren T, Tsung C, Song P, Xu P et al. The Journal of clinical investigation (2026)
    7. [7]
      Hepatic adverse events associated with ketamine and esketamine: A population-based disproportionality analysis. — Kwan ATH, Lakhani M, Teopiz KM, Wong S, Le GH, Ho RC et al. Journal of affective disorders (2025)
    8. [8]
      Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury. — Qu X, Xu D, Yang T, Tian Y, King CT, Wang X et al. Redox biology (2025)
    9. [9]
      Changes in Hepatic Density Due to Oral Amiodarone-induced Liver injury Shown by Computed Tomography. — Kishimoto K, Tobita H, Kataoka M, Yazaki T, Oka A, Ishimura N et al. Internal medicine (Tokyo, Japan) (2025)
    10. [10]
      High-grade liver injuries with contrast extravasation managed initially with interventional radiology versus observation: A secondary analysis of a WTA multicenter study. — Aryan N, Grigorian A, Tay-Lasso E, Cripps M, Carmichael H, McIntyre R et al. American journal of surgery (2024)
    11. [11]
      An investigation of broad-spectrum antibiotic-induced liver injury based on the FDA Adverse Event Reporting System and retrospective observational study. — Shiraishi C, Kato H, Ogura T, Iwamoto T Scientific reports (2024)
    12. [12]
      Electrospun nanofiber membranes for rapid liver hemostasis via N-alkylated chitosan doped chitosan/PEO. — Liu T, Liu S, Shi Y, Zhang Z, Ding S, Hou K et al. International journal of biological macromolecules (2024)
    13. [13]
      Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway. — Wu M, Liu X, Yu Q, Shi J, Guo W, Zhang S European journal of pharmacology (2024)
    14. [14]
      Nuclear Acly protects the liver from ischemia-reperfusion injury. — Gao W, Zhang L, Li Z, Wu T, Lang C, Mulholland MW et al. Hepatology (Baltimore, Md.) (2024)
    15. [15]
      Macrophage superclusters to the rescue. — Louwe PA, Guilliams M Science (New York, N.Y.) (2023)
    16. [16]
      Therapeutic strategies for pseudoaneurysm following blunt liver and spleen injuries: A multicenter cohort study in the pediatric population. — Katsura M, Kondo Y, Yasuda H, Fukuma S, Matsushima K, Shiraishi A et al. The journal of trauma and acute care surgery (2023)
    17. [17]
      Acute Liver Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. — Squires JE, McKiernan PJ, Squires RH Pediatrics (2022)
    18. [18]
      Timing and Type of Venous Thromboembolic Prophylaxis in Isolated Severe Liver Injury Managed Non-Operatively. — Jakob DA, Benjamin ER, Liasidis P, Demetriades D World journal of surgery (2021)
    19. [19]
      Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury. — Huang J, Xie P, Dong Y, An W Cell death and differentiation (2021)
    20. [20]
      Liver trauma: hepatic vascular injury on computed tomography as a predictor of patient outcome. — Lada NE, Gupta A, Anderson SW, Dinh DC, Campbell JM, Maggi A et al. European radiology (2021)
    21. [21]
      Arterio-Hepatic Venous Fistula Following Liver Biopsy: A Rare Case Report and Literature Review. — Dutta S, Chapa UK, Ansari MI, Vaka S, Jain A, Abhinaya R et al. Vascular and endovascular surgery (2021)
    22. [22]
      Empirical assessment of case-based methods for drug safety alert identification in the French National Healthcare System database (SNDS): Methodology of the ALCAPONE project. — Thurin NH, Lassalle R, Schuemie M, Pénichon M, Gagne JJ, Rassen JA et al. Pharmacoepidemiology and drug safety (2020)
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