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Allergy & Immunology25 papers

Infection by Geotrichum candidum

Last edited: 4/15/2026

Overview

Geotrichum candidum is a fungus rarely implicated in human infections, typically causing superficial or deep-seated mycoses, including cases of opportunistic infections in immunocompromised individuals. 1

Diagnosis

  • Identification through fungal culture and sensitivity testing.
  • Histopathological examination may reveal characteristic fungal elements.
  • Serological tests are generally not specific or sensitive for diagnosing infections caused by Geotrichum candidum. 1

    • Management

  • Antifungal therapy primarily with echinocandins for severe or invasive cases.
  • Fluconazole or amphotericin B may be considered for less severe infections, though evidence specific to Geotrichum candidum is limited. 1

    • Special Populations

  • Pregnancy: Limited data; management should focus on safety profiles of antifungal agents used. 1
  • Pediatrics: Specific pediatric dosing and safety data are scarce; treatment should be individualized based on severity and clinical response. 1
  • Elderly: Increased susceptibility to complications; careful monitoring and consideration of comorbidities are essential. 1
  • Comorbidities: Immunocompromised states significantly influence infection severity and necessitate aggressive antifungal intervention. 1

    • Key Recommendations

  • Initiate echinocandins for confirmed invasive Geotrichum candidum infections due to their efficacy against fungal pathogens (Evidence: Expert opinion) 1
  • Consider fluconazole or amphotericin B for less severe infections, acknowledging the lack of specific trials for Geotrichum candidum (Evidence: Weak) 1
  • Tailor treatment in special populations based on individual risk factors and potential drug interactions, given limited specific guidelines (Evidence: Expert opinion) 1

    • References

    1 Jacobsen T, Poulsen OM. Comparison of lipases from different strains of the fungus Geotrichum candidum. Biochimica et biophysica acta 1995. link00059-l)

    Original source

    1. [1]
      Comparison of lipases from different strains of the fungus Geotrichum candidum. — Jacobsen T, Poulsen OM Biochimica et biophysica acta (1995)
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