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Gastroenterology607 papers

Gastrointestinal Crohn's disease

Last edited: 4/23/2026

Overview

Crohn's disease is a chronic inflammatory condition affecting any part of the gastrointestinal tract, characterized by transmural inflammation, granulomas, and a relapsing-remitting course. It often leads to complications such as strictures, fistulas, and malnutrition 630.

Diagnosis

  • Clinical Presentation: Abdominal pain, diarrhea, weight loss, and extraintestinal manifestations like arthritis 6.
  • Endoscopic Findings: Patchy areas of inflammation, ulcers, and cobblestoning 9.
  • Imaging: CT enterography, MRI enterography, and small bowel follow-through to assess bowel wall thickness, fistulas, and strictures 9.
  • Laboratory Tests: Elevated inflammatory markers, anemia, and electrolyte imbalances 6.
  • Histopathology: Biopsy showing transmural inflammation, non-caseating granulomas (not always present), and cryptitis 6.
  • Diagnostic Criteria: Use of the Lennard-Jones criteria or the Montreal classification for classification 6.
  • Management

  • First-Line Treatments:
  • - Aminosalicylates: For mild to moderate disease (e.g., mesalamine) 6. - Antibiotics: Metronidazole or ciprofloxacin for specific infections 6. - Corticosteroids: Prednisone for moderate to severe flares 6.
  • Second-Line Treatments:
  • - Immunomodulators: Azathioprine, 6-mercaptopurine for maintenance therapy 6. - Biologic Agents: Anti-TNF agents (e.g., infliximab), integrin antagonists (e.g., vedolizumab), and IL-12/23 inhibitors (e.g., ustekinumab) 617.
  • Nutritional Support: Enteral or parenteral nutrition for severe malnutrition 636.
  • Surgical Intervention: For complications like strictures, fistulas, or bowel obstruction 6.
  • Special Populations

  • Pediatrics: Early diagnosis and tailored nutritional support are crucial 3036.
  • Elderly: Increased risk of complications; careful monitoring and individualized treatment plans 6.
  • Comorbidities: Management requires consideration of comorbidities like cardiovascular disease, especially with corticosteroid use 939.
  • Key Recommendations

  • Use of Biologics for Refractory Disease: Initiate biologic therapy in patients with moderate to severe Crohn's disease who fail conventional therapy (Evidence: Strong 617).
  • Regular Monitoring for Complications: Regular endoscopic surveillance for complications such as strictures and fistulas in patients with long-standing disease (Evidence: Moderate 9).
  • Nutritional Assessment and Support: Implement comprehensive nutritional assessment and support strategies, particularly in pediatric and elderly patients (Evidence: Moderate 366).
  • Endoscopic Training and Competency: Ensure gastroenterologists are proficient in endoscopic techniques through structured training programs (Evidence: Expert opinion 9).
  • Telemedicine Utilization: Leverage telemedicine for follow-up and management, especially during pandemics, to maintain continuity of care (Evidence: Moderate 55).
  • References

    Showing 100 most recent of 263 indexed papers.

    1 Shalish W, Neu J, Sant'Anna G. Application of AI in neonatal gastroenterology and nutrition. Seminars in fetal & neonatal medicine 2026. link 2 Eslami K, Diaz Calderon LM, Racherla VR, Giudice EL, Sikorski MJ, Doll S et al.. Impact of an Interactive, Case-Based Pediatric Gastroenterology and Nutrition Curriculum on General Pediatric Resident Competency and Knowledge Retention. MedEdPORTAL : the journal of teaching and learning resources 2026. link 3 Bryan MR, Bensen GP, Wipper B, Dunleavy KA, Felicien S, Ingabire P et al.. Developing Global Gastrointestinal Care Capacity: Lessons Learned From a New GI Partnership Care Delivery Model in Rwanda. Journal of clinical gastroenterology 2026. link 4 Dong Q, Li S, Zhu X, Lin K, Li Y, Wang S et al.. Prevalence of anxiety, depression and associated risk factors in gastroenterology outpatients: a multicenter cross-sectional study. BMC gastroenterology 2026. link 5 Gross SA, Shaukat A, Afzali A, Ahn JC, Bajaj JS, Barkin JA et al.. Artificial Intelligence for Gastroenterology Practice: A Modified Delphi Consensus. The American journal of gastroenterology 2026. link 6 Broekaert IJ, Assa A, Borrelli O, Saccomani MD, Homan M, Martin-de-Carpi J et al.. Approach to anaemia in gastrointestinal disease: A position paper by the ESPGHAN Gastroenterology Committee. Journal of pediatric gastroenterology and nutrition 2025. link 7 Stammers M, Ramgopal B, Owusu Nimako A, Vyas A, Nouraei R, Metcalf C et al.. A foundation systematic review of natural language processing applied to gastroenterology & hepatology. BMC gastroenterology 2025. link 8 Sonnenberg A, Buchner AM. Will Rogers Paradox in Gastroenterology. Digestive diseases and sciences 2025. link 9 Sathiaseelan M, Grammatikopoulos T. Utility of endoscopy in paediatric gastroenterology and hepatology-Review and updates. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2025. link 10 Holt NM, Byrne MF. The Role of Artificial Intelligence and Big Data for Gastrointestinal Disease. Gastrointestinal endoscopy clinics of North America 2025. link 11 Gardezi SA, Albagshi JM, Almuhaidb A, Alajlan B, Al Jawad M. Empowering GI fellows to lead the change: A national survey on strengths and opportunities to enhance gastroenterology training in Saudi Arabia. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2025. link 12 Storås AM, Dreyer M, Pahde F, Lapuschkin S, Samek W, Halvorsen P et al.. Exploring the clinical value of concept-based AI explanations in gastrointestinal disease detection. Scientific reports 2025. link 13 Szkodny LE, Bardach SH, Hacker K, Tormey LK, Gohres K, Siegel CA et al.. Implementation of a Trauma-Informed Care Approach in a Gastroenterology Setting. Digestive diseases and sciences 2025. link 14 Murray J, Kefayat A, Finlayson M, Seenan JP, Hsu R, Din S. RCPE in association with the American College of Gastroenterology and the Scottish Society of Gastroenterology - Gastroenterology: A global perspective. The journal of the Royal College of Physicians of Edinburgh 2025. link 15 Mehta Y, Mehta S, Bhayani V, Parikh S, Mehta R. Gastroenterology in the age of artificial intelligence: Bridging technology and clinical practice. World journal of gastroenterology 2025. link 16 Cheloff AZ, Lee B, Kim L, Karnik N, Lin E, Lee M et al.. Multicenter evaluation of the impact of COVID-19 on the uptake of endoscopic skills by gastroenterology trainees. Surgical endoscopy 2025. link 17 Shrestha UK. Emerging role of artificial intelligence in gastroenterology and hepatology. World journal of gastroenterology 2025. link 18 Chen ZL, Wang C, Wang F. Revolutionizing gastroenterology and hepatology with artificial intelligence: From precision diagnosis to equitable healthcare through interdisciplinary practice. World journal of gastroenterology 2025. link 19 Cui Y. Investigating the "off-hour effect" on outcomes of neonates undergoing emergency gastrointestinal surgery. PeerJ 2025. link 20 Gouel-Chéron A, Sallah K, Sawadogo S, Dupont A, Montravers P. Impact of COVID-19 on urgent gastrointestinal surgery outcomes: increased mortality in 2020. World journal of emergency surgery : WJES 2025. link 21 Liu Y, Shen Y, Zhong H. Dexmedetomidine-Propofol Versus Propofol Alone for Sedation in Upper Gastrointestinal Endoscopic Ultrasound: A Randomized Comparative Study. Clinical therapeutics 2025. link 22 Abbasi F, Ayremlu P, Niazkhani Z. From classroom to clinic: evaluating a clinical pathology course to strengthen pathology report literacy of medical interns. BMC medical education 2025. link 23 Mastrorocco E, Terrin M, Migliorisi G, Masoni B, Farinola V, De Deo D et al.. Gender authorship in major American and European gastroenterology journals: the gap is still unfilled. Endoscopy 2024. link 24 Alizadeh M, Sampaio Moura N, Schledwitz A, Patil SA, Ravel J, Raufman JP. Gastroenterology Fellowship and Postdoctoral Training in Omics and Statistics-Part I: Why Is It Needed?. Digestive diseases and sciences 2024. link 25 Facciorusso A, Domislovic V, Fuccio L, Boskoski I, Spada C, Capurso G et al.. Principle of sample size calculation in gastroenterology research: a practical guide for clinicians. Expert review of gastroenterology & hepatology 2024. link 26 Duijvestein M, Sidhu R, Zimmermann K, Carrington EV, Hann A, Sousa P et al.. The United European Gastroenterology green paper-climate change and gastroenterology. United European gastroenterology journal 2024. link 27 Shang BH, Yang FH, Lin Y, Bialka S, Rensburg DCJV, Tonelli AR et al.. Discrepancies between pre-specified and reported primary outcomes: A cross-sectional analysis of randomized controlled trials in gastroenterology and hepatology journals. PloS one 2024. link 28 Dumitrascu DI, Rusu I, Filip A. Anatomical Benchmarks in the Training of Gastroenterologists. Journal of gastrointestinal and liver diseases : JGLD 2024. link 29 Yuan S, Sun Y, Chen J, Li X, Larsson SC. Long-term risk of venous thromboembolism among patients with gastrointestinal non-neoplastic and neoplastic diseases: A prospective cohort study of 484 211 individuals. American journal of hematology 2024. link 30 Krishnan U, Day AS. Advances in Nutrition in Pediatric Gastroenterology. Nutrients 2023. link 31 Candelli M, Franceschi F. New Advances in Gastroenterology: The Crucial Role of Molecular Medicine. International journal of molecular sciences 2023. link 32 Persaud A, Bilal M. Involvement in National Gastroenterological Societies for Professional Development and Career Advancement: Tips for Trainees. Digestive diseases and sciences 2023. link 33 Reeves PT, Min SB, Kolasinski NT. Development and Implementation of DIGEST: The Digital Interactive Gastroenterology Education Suite for Trainees. Military medicine 2023. link 34 Goodman MC, Chesner JH, Pourmand K, Farouk SS, Shah BJ, Rao BB. Developing a Novel Case-Based Gastroenterology/Hepatology Online Resource for Enhanced Education During and After the COVID-19 Pandemic. Digestive diseases and sciences 2023. link 35 Busing JD, Stone CA, Nicholson MR. Clinical Presentation of Alpha-Gal Syndrome in Pediatric Gastroenterology and Response to Mammalian Dietary Elimination. The American journal of gastroenterology 2023. link 36 Walia CLS, Cerezo CS, Smith A, Turner J, Moses J, Vermilyea S et al.. The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position on the Role of the Registered Dietitian Nutritionist in the Care of the Pediatric Patient With Chronic Gastrointestinal Diseases. Journal of pediatric gastroenterology and nutrition 2023. link 37 Christou CD, Tsoulfas G. Challenges involved in the application of artificial intelligence in gastroenterology: The race is on!. World journal of gastroenterology 2023. link 38 Alizadeh M, Sampaio Moura N, Schledwitz A, Patil SA, Ravel J, Raufman JP. Big Data in Gastroenterology Research. International journal of molecular sciences 2023. link 39 Ali H, Shahzad M, Sarfraz S, Sewell KB, Alqalyoobi S, Mohan BP. Application and impact of Lasso regression in gastroenterology: A systematic review. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2023. link 40 Liu JJ, DeCuir N, Kia L, Peterson J, Miller C, Issaka RB. Tools to Measure the Impact of Structural Racism and Discrimination on Gastrointestinal and Hepatology Disease Outcomes: A Scoping Review. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 41 Kasper P, Demir M, Chon SH, Bruns CJ, Goeser T, Michels G. [Gastrointestinal and hepatic emergencies in acute and emergency care]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2023. link 42 Diesing TS. Neurologic Manifestations of Gastrointestinal and Nutritional Disorders. Continuum (Minneapolis, Minn.) 2023. link 43 Candelli M. Translational, Precision, and Personalized Medicine in Gastroenterology. International journal of molecular sciences 2022. link 44 Culpepper-Morgan JA, Guillaume A, Louissaint J, Williams R. Black voices in gastroenterology and hepatology. Nature reviews. Gastroenterology & hepatology 2022. link 45 Yılmaz H, Kocyigit B. Factors associated with non-attendance at appointments in the gastroenterology endoscopy unit: a retrospective cohort study. PeerJ 2022. link 46 Kumar R, Khan FU, Sharma A, Aziz IBA, Poddar NK. Recent Applications of Artificial Intelligence in the Detection of Gastrointestinal, Hepatic and Pancreatic Diseases. Current medicinal chemistry 2022. link 47 Ben Abderrahim S, Gharbaoui M, Békir O, Hamdoun M, Allouche M. Sudden death related to the gastrointestinal system in Tunisia: A 13 year autopsy study. Journal of forensic sciences 2022. link 48 Romano C, Dipasquale V. Nutrition in Pediatric Gastroenterology. Nutrients 2021. link 49 Janssen DF. Gastroenterology: Naming a discipline. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2021. link 50 Pérez-Cuadrado Martínez E. Arrival in port. Revista espanola de enfermedades digestivas 2021. link 51 Borbath I, Fiasse R, Van Hootegem P. The "Fonds Georges Brohée": a longstanding Belgian national initiative to stimulate research in hepatogastroenterology. Acta gastro-enterologica Belgica 2021. link 52 Shung DL, Sung JJY. Challenges of developing artificial intelligence-assisted tools for clinical medicine. Journal of gastroenterology and hepatology 2021. link 53 Tan MB, Tan KP, Beh JCY, Chan EYK, Chin KFW, Chin ZY et al.. SingHealth Radiology Archives pictorial essay Part 2: gastroenterology, musculoskeletal, and obstetrics and gynaecology cases. Singapore medical journal 2021. link 54 Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE et al.. Artificial intelligence in gastroenterology: A state-of-the-art review. World journal of gastroenterology 2021. link 55 Costantino A, Bortoluzzi F, Giuffrè M, Vassallo R, Montalbano LM, Monica F et al.. Correct use of telemedicine in gastroenterology, hepatology, and endoscopy during and after the COVID-19 pandemic: Recommendations from the Italian association of hospital gastroenterologists and endoscopists (AIGO). Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2021. link 56 Ou A, Shin CM, Goodman AJ, Poles MA, Popov VB. Endoscopic part-task training box scores correlate with endoscopic outcomes. Surgical endoscopy 2021. link 57 Perisetti A, Goyal H. Successful Distancing: Telemedicine in Gastroenterology and Hepatology During the COVID-19 Pandemic. Digestive diseases and sciences 2021. link 58 Mathis MS, Badewa TE, Obiarinze RN, Wilkinson LT, Martin CA. A Novel Use of Artificial Intelligence to Examine Diversity and Hospital Performance. The Journal of surgical research 2021. link 59 Cao JS, Lu ZY, Chen MY, Zhang B, Juengpanich S, Hu JH et al.. Artificial intelligence in gastroenterology and hepatology: Status and challenges. World journal of gastroenterology 2021. link 60 Chen H, Sung JJY. Potentials of AI in medical image analysis in Gastroenterology and Hepatology. Journal of gastroenterology and hepatology 2021. link 61 Bojo Canales C, Perdiguero-Gil E. A bibliometric study of Revista Española de Enfermedades Digestivas (REED) based on SciELO indicators for the period 2004-2018. Revista espanola de enfermedades digestivas 2021. link 62 Isoldi S, Cucchiara S, Repici A, Lerner DG, Thomson M, Oliva S. Gastrointestinal endoscopy in children and adults: How do they differ?. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2021. link 63 Vrba R, Neoral Č, Gregořík M, Hlaváčová L, Katherine V, Stašek M. Gastropericardial fistula in a patient with upside-down stomach and stomach perforation: a case report. Acta chirurgica Belgica 2021. link 64 Holm MO, Mikkelsen S, Zacher N, Østergaard T, Rasmussen HH, Holst M. High risk of disease-related malnutrition in gastroenterology outpatients. Nutrition (Burbank, Los Angeles County, Calif.) 2020. link 65 Wills JW, Robertson J, Summers HD, Miniter M, Barnes C, Hewitt RE et al.. Image-Based Cell Profiling Enables Quantitative Tissue Microscopy in Gastroenterology. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2020. link 66 Leite C, Trindade EN, Grillo LW, Trindade MRM. Gastrointestinal emergency care during the COVID-19 pandemic: rapid communication. Revista da Associacao Medica Brasileira (1992) 2020. link 67 Chen D, Wu L, Li Y, Zhang J, Liu J, Huang L et al.. Comparing blind spots of unsedated ultrafine, sedated, and unsedated conventional gastroscopy with and without artificial intelligence: a prospective, single-blind, 3-parallel-group, randomized, single-center trial. 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Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 2019. link 73 O'Morain N, O'Morain C. The burden of digestive disease across Europe: Facts and policies. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2019. link 74 Cheung KS, Leung WK, Seto WK. Application of Big Data analysis in gastrointestinal research. World journal of gastroenterology 2019. link 75 Ruffle JK, Farmer AD, Aziz Q. Artificial Intelligence-Assisted Gastroenterology- Promises and Pitfalls. The American journal of gastroenterology 2019. link 76 Günther C, Brevini T, Sampaziotis F, Neurath MF. What gastroenterologists and hepatologists should know about organoids in 2019. 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Fecal calprotectin: beyond intestinal organic diseases. Panminerva medica 2018. link 82 Klenske E, Neurath MF, Atreya R, Rath T. Molecular imaging in gastroenterology: A route for personalized endoscopy. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2018. link 83 Jeejeebhoy KN, Duerksen DR. Malnutrition in Gastrointestinal Disorders: Detection and Nutritional Assessment. Gastroenterology clinics of North America 2018. link 84 Torramadé E. United European Gastroenterology Week (UEGW) 2017 - 25th Annual Conference (October 28-November 1, 2017 - Barcelona, Spain). Drugs of today (Barcelona, Spain : 1998) 2017. link 85 Crespo J, Jorquera Plaza F. Gastroenterology, a historical specialty with a great future. Revista espanola de enfermedades digestivas 2017. link 86 Siegel CA. Transforming Gastroenterology Care With Telemedicine. 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    Original source

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      Application of AI in neonatal gastroenterology and nutrition.Shalish W, Neu J, Sant'Anna G Seminars in fetal & neonatal medicine (2026)
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      Approach to anaemia in gastrointestinal disease: A position paper by the ESPGHAN Gastroenterology Committee.Broekaert IJ, Assa A, Borrelli O, Saccomani MD, Homan M, Martin-de-Carpi J et al. Journal of pediatric gastroenterology and nutrition (2025)
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