Overview
Mixed collagen vascular disease refers to overlapping or concurrent conditions involving multiple vascular pathologies, often complicating diagnosis and management, particularly in patients with peripheral arterial disease (PAD) and other systemic vasculitides.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 1808 indexed papers.
1 Zhang HY, Xiao L, Chen K, Du XL, Tang T, Li WD et al.. A Real-World Pharmacovigilance Study of Cilostazol Based on the Food and Drug Administration Adverse Event Reporting System: A Cross-Sectional Disproportionality Analysis. Annals of vascular surgery 2026. link 2 Gaston BT, Bellomo TR, Salomon B, Mulaney-Topkar B, Demsas F, Anjorin A et al.. Direct comparison of frailty scores and their association with postoperative outcomes in patients undergoing lower extremity revascularization. Journal of vascular surgery 2026. link 3 Mashal S, Spiliotopoulos S, Kamani CK, Bouragbi A, Nauche B, Orcese B et al.. Scoping Review on Peripheral Arterial and Venous Outcomes in Intravenous Drug Users. Annals of vascular surgery 2026. link 4 Rohrich RN, Currin ME, Lin RP, Ferdousian S, Lee W, Li KR et al.. Lower Extremity Free Tissue Transfer in the Setting of Severe Medial Arterial Calcification: Limb Salvage Is Possible, But at What Cost?. Plastic and reconstructive surgery 2026. link 5 Fridling J, Gontarz B, Wurdeman SR, Bozeman P, Wrana K, Mather J et al.. Determinants of Prosthetic Referral and Functional Mobility for Vascular Patients after Major Lower Extremity Amputation. Annals of vascular surgery 2026. link 6 Broadhead GK, Phan L, Keenan TDL, Chin J, Hong T, Chew EY et al.. How to Judge Failure: Defining Treatment Resistance to Anti-VEGF Therapy in Exudative Maculopathies-A Systematic Scoping Review. Ophthalmology. Retina 2026. link 7 Bank NC, Kim SW, Lauck BJ, Jeffs AD, Patterson MM, Cleveland RJ et al.. Mortality Associated With Upper Extremity Amputations in Vasculopathic Patients: A Matched Cohort Analysis of 9,904 Individuals. The Journal of hand surgery 2026. link 8 Zhang J, Yang Z, Liu L, Wu D, Cheng C, Zhu P et al.. DOT1L-mediated H3K79me1 transcriptional activation of Acp5 aggravates inflammatory responses following diabetic vascular injury. Microvascular research 2026. link 9 Schurman AM, Curti Oborsky KY, Allison Aipa TS, Wolfe R, Corso J, Mannoia KA et al.. Area Deprivation Index Relationship to Patterns of Revascularization Among Chronic Limb-Threatening Ischemia Patients Presenting for Major Amputation: A Vascular Quality Initiative Study. Annals of vascular surgery 2026. link 10 Huang Y, Nofsinger S, Schesselman C, Bath J, Vogel TR. Disparities among Patients Experiencing Homelessness Undergoing Open Lower Extremity Bypass. Annals of vascular surgery 2026. link 11 Steele MJ, Liu SK, Azarbal AF, Jung E, Krishnamoorthi H, Nguyen KP et al.. Operative and Rehabilitation Outcomes After Transfemoral Amputation With or Without Adductor Myodesis. Annals of vascular surgery 2026. link 12 How Saw Keng M, Mohideen AT, Rahim AA, Hammoda MI, Mittapalli D. The Effect of Revascularization versus Amputations on Patient Mental Health in the Early Postoperative Period: A Prospective Observational Cohort Study. Annals of vascular surgery 2026. link 13 Abdelmalak M, Finch LM, Richards H, Tawadrous M, Makar R. Revision of below-knee amputation stumps to a higher level in patients with peripheral vascular disease. Journal of vascular surgery 2026. link 14 Zhu GC, Ong JH, Hung CH. Comparing the effects of different physical therapy modalities with physical exercise in improving the walking function of patients with peripheral vascular disease: A Network Meta-analysis. Brazilian journal of physical therapy 2026. link 15 Nchinda NN, Coleman DM, White JV, Williams RF, Rothstein DH. The scope of vascular surgery expertise in pediatric surgery: A survey of division chiefs at United States children's hospitals. Journal of pediatric surgery 2026. link 16 Sickels AD, Filiberto AC, Novak Z, Rowse J, Kopecky K, Jones DW et al.. Textbook outcomes for lower extremity bypass: A useful quality metric for care optimization. Journal of vascular surgery 2026. link 17 Zeller T, Zhang Z, Parise H, Mascho C, Holden A, Schmidt A et al.. Early Tibial Vessel Recoil Following Treatment With the Bare Temporary Spur Stent System: Results From the DEEPER OUS Vessel Recoil Substudy. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2026. link 18 Murray-Ramcharan M, Guevara-Kissel M, Escurra MF, Donaldson B, Raza Rizvi SA. The role of non-invasive vascular assessment prior to lower extremity amputation. Vascular 2026. link 19 Kim Y, Cui CL, Seymour KA, Seidelman JL, Johnson AP. Implementation of an Evidence-Based Quality Improvement Protocol to Reduce Surgical Site Infections after Lower Extremity Bypass Surgery. Annals of vascular surgery 2026. link 20 Khan J, Batool F, Rasheed A, Farooq SMY, Gilani SA, Khadija S. Accuracy of Ultrasound for the Diagnosis of Peripheral Vascular Disease in Diabetic Foot: A Systematic Review. Seminars in ultrasound, CT, and MR 2026. link 21 Trivedi N, Tsai R, Shin L, Saldana-Ruiz N, Wepman JI, Stillwell R. Amputation Levels in High-Risk Chronic Limb-Threatening Ischemia Patients. Techniques in vascular and interventional radiology 2026. link 22 Felder JM, Orr J, Schott H, Geraghty P. Objective Grading of Peripheral Vascular Disease Strongly Predicts Morbidity in Microsurgical Lower Limb Salvage. Plastic and reconstructive surgery 2026. link 23 Zalewski D, Chmiel P, Kołodziej P, Feldo M, Stępniewski A, Ziaja-Sołtys M et al.. Molecular Signatures Related to Inflammation and Angiogenesis in Patients with Lower Extremity Artery Disease, Abdominal Aortic Aneurysm, and Varicose Veins: Shared and Distinct Pathways. International journal of molecular sciences 2025. link 24 Jensen PS, Kallemose T, Kirketerp-Møller K, Juul-Larsen HG. Identifying long-term healthcare and sociodemographic risk factors for lower extremity amputation: a 10-year national registry-based case-control study in Denmark. BMJ open 2025. link 25 Kirkham AM, Candeliere J, Nagpal SK, Stelfox HT, Kubelik D, Hajjar G et al.. A systematic review and meta-analysis of outcomes associated with development of surgical site infection after lower-limb revascularization surgery. Vascular 2025. link 26 Tulimieri MT, Callas PW, Bertges DJ. Effectiveness of Closed Incision Negative Pressure Wound Therapy for Suprainguinal Bypass in the Vascular Quality Initiative. Annals of vascular surgery 2025. link 27 Ward Z, Ridgewell E, Quigley M, Fatone S, Dillon MP. Proportionate mortality following dysvascular partial foot amputation and how this compares to transtibial amputation: a systematic review. Disability and rehabilitation 2025. link 28 Laamanen P, Laivuori M, Noronen K, Venermo M. Reliability of a portable toe pressure photoplethysmography device compared to a stationary laser doppler flowmeter. Vascular 2025. link 29 Howe EE, Bent LR. Pressure-Induced Microvascular Reactivity With Whole Foot Loading Is Unique Across the Human Foot Sole. Microcirculation (New York, N.Y. : 1994) 2025. link 30 Destrieux L. Safety and Effectiveness of Ultrasound-Guided Percutaneous Versus Open Brachial Artery Access: Results of the Multicenter Prospective ARCHIBAL Study Percutaneous or Open Brachial Artery Access. Annals of vascular surgery 2025. link 31 Altreuther M, Grima MJ. Editor's Choice - International Validation of the Vascular Registry of Switzerland, Swissvasc: A VASCUNET Report. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2025. link 32 Hamouda M, Rogers UH, Farber A, Rowe VL, Conte MS, Malas MB. Impact of skin closure with staples vs sutures on perioperative outcomes following lower extremity bypass surgery. Journal of vascular surgery 2025. link 33 Kim Y, Cui CL, Seidelman JL, Johnson AP, Coleman DM, Southerland KW. Characterizing Early-Onset Surgical Site Infection After Lower Extremity Bypass Surgery. Annals of vascular surgery 2025. link 34 Kovacic JC, Skelding KA, Arya S, Ballard-Hernandez J, Goyal M, Ijioma NN et al.. Radial Access Approach to Peripheral Vascular Interventions: A Scientific Statement From the American Heart Association. Circulation. Cardiovascular interventions 2025. link 35 Manesh MN, DiBartolomeo AD, Potter HA, Ding L, Han SM, Tan TW et al.. Association of Anemia and Transfusion with Major Adverse Cardiac Events and Major Adverse Limb Events in Patients Undergoing Open Infrainguinal Bypass. Annals of vascular surgery 2025. link 36 Rice JR, Rothenberg KA, Ramadan OI, Savage D, Kalapatapu V, Julien HM et al.. Factors Associated with Urgent Amputation Status and Its Impact on Mortality. Annals of vascular surgery 2024. link 37 Porubcova S, Szmicsekova K, Lajtmanova K, Slezakova V, Jakubik M, Drobna E et al.. Pharmacist-led interventions for vascular surgery patients: a prospective study on reducing drug-related problems. BMC health services research 2024. link 38 Urie BR, Laskowski T, Richard M, Tihonov N, Katz D, d'Audiffret A et al.. Impact of Care Fragmentation after Major Lower Extremity Amputation. Annals of vascular surgery 2024. link 39 Elsabbagh MA, Kay M, Tiwari A. Pediatric Vascular Surgery: A Review of Cases from a Dedicated Pediatric Vascular Surgery Clinic. Annals of vascular surgery 2024. link 40 Ali M, Noureldin M, Kashef OE, Zaghlol H. Safety and Effectiveness of Carbon Dioxide Contrast Medium in Infra-Inguinal Endovascular Interventions for Patients With Chronic Threatening Lower Limb Ischemia and Renal Impairment: A Multicentric Trial. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2024. link 41 Aimanan K, Loi L, Pian PM, Pillay KVK, Hussein H. Internal Iliac Artery Patency as a Predictor of Above-Knee Amputation Stump Healing. Annals of vascular surgery 2024. link 42 Hunter L, Wiley A, Mckinney G, Craven T, Bush K, Corriere M et al.. Neuropathy Screening for Patients with Peripheral Vascular Disease Helps to Identify Those at an Increased Risk of Amputation, Revascularization, and Death. Annals of vascular surgery 2024. link 43 Wedig IJ, Lennox IM, Petushek EJ, McDaniel J, Durocher JJ, Elmer SJ. Development of a prediction equation to estimate lower-limb arterial occlusion pressure with a thigh sphygmomanometer. European journal of applied physiology 2024. link 44 Korosoglou G, Torsello G, Saratzis A, Isernia G, Kontopodis N, González TM et al.. Editor's Choice - Endovascular Versus Surgical Treatment for All Comer Patients With Prosthetic Bypass Graft Occlusion: The Multicentre ENSUPRO Study. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2024. link 45 Chen SX, Zhang B, Hao YX, Xiao H. Comparison of Distal Transradial and Femoral Access in Endovascular Treatment of Non-coronary Arterial Disease. Angiology 2024. link 46 Lane RJ, Keogh SE, Khin NY. An arterial access system for targeted chemotherapy delivery and arterial-arterial extracorporeal recirculation for 'end stage' peripheral vascular disease. The journal of vascular access 2024. link 47 Limoli C, Raja LD, Wagner SK, Ferraz D, Bolz M, Vujosevic S et al.. Exploring Patient Demographics and Presence of Retinal Vascular Disease in Paracentral Acute Middle Maculopathy. American journal of ophthalmology 2024. link 48 Smolderen KG, Romain G, Cleman J, Scierka L, Mena-Hurtado C. Variability in guideline-directed medical therapy across sites and operators and long-term mortality and amputation outcomes risk in patients undergoing peripheral vascular interventions. American heart journal 2024. link 49 Heinrich T, Bähring R, Larena-Avellaneda A, Querengässer J, Solbrig O, Ehmke H et al.. Bridging vascular physiology to vascular medicine: an integrative laboratory class. Advances in physiology education 2023. link 50 Ørskov M, Vorum H, Larsen TB, Lip GYH, Bek T, Skjøth F. Similarities and differences in systemic risk factors for retinal artery occlusion and retinal vein occlusion: A nationwide case-control study. International ophthalmology 2023. link 51 Nazeha N, Meng L, Ho P, Ng YZ, Graves N. The burden of costs on health services by patients with neuro-ischaemic ulcers in Singapore. International wound journal 2023. link 52 Camazine MN, Rountree KM, Smith JB, Bath J, Vogel TR. Opioid utilization after lower extremity amputation for peripheral vascular disease and discharge prescribing recommendations. Vascular 2023. link 53 Gu L, Liu X, Wu S, Chu K, Bao JJ. A cross-sectional study on the tea consumption effects of ankle-brachial index. Vascular 2023. link 54 Lohani KR, Chen MQ. Blind Obturator Bypass-A Scope for Improvisation. The American surgeon 2023. link 55 Balazic E, Axler E, Konisky H, Khanna U, Kobets K. Pentoxifylline in dermatology. Journal of cosmetic dermatology 2023. link 56 Ishikawa S, Arai K, Kurihara T, Sato T, Ichioka S. Endovascular therapy and free flap transfer in chronic limb-threatening ischemia. Journal of plastic surgery and hand surgery 2023. link 57 Raja A, Karch J, Shih AF, De La Garza H, De Zepeda Diaz AJ, Maymone MBC et al.. Part II: Cutaneous manifestations of peripheral vascular disease. Journal of the American Academy of Dermatology 2023. link 58 Suarez L, Melikian R, Alnahhal KI, Allison GM, Jimenez D, Urhiafe V et al.. Preoperative Depression is Associated with Worse Outcomes after The Lower Extremity Revascularization. Vascular 2023. link 59 Sanon O, Carnevale M, Indes J, Gao Q, Lipsitz E, Koleilat I. Incidence of Procedure-Related Complications in Patients Treated With Atherectomy in the Femoropopliteal and Tibial Vessels in the Vascular Quality Initiative. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2023. link 60 DiLosa K, Brown C, Rajasekar G, Nuno M, Humphries MD. Provider ankle brachial index and wound classification teaching as part of a comprehensive limb preservation outreach program. Journal of vascular surgery 2023. link 61 Almazedi B, West D, Nicholls M, Bowker A. Safety of short 3-hour recovery and same-day discharge following lower-limb angioplasty in outpatients with intermittent claudication and critical limb ischaemia. Clinical radiology 2023. link 62 Stutsrim AE, Brastauskas IM, Craven TE, Callahan KE, Pajewski NM, Davis RP et al.. Automated Electronic Frailty Index is Associated with Non-home Discharge in Patients Undergoing Open Revascularization for Peripheral Vascular Disease. The American surgeon 2023. link 63 Shiraev T, de Boer M, Qasabian R. Indications for and outcomes of major lower limb amputations at a tertiary-referral centre in Australia. Vascular 2023. link 64 Al Yafi M, Nasif A, Glosser LD, Ren G, Ahemd A, Nazzal M et al.. The relationship between lower extremity amputation and body mass index. Vascular 2023. link 65 Smolderen KG, Romain G, Provance JB, Scierka LE, Mao J, Goodney PP et al.. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC. Cardiovascular interventions 2023. link 66 John J, Tate S, Price A. Non-surgical treatment for arterial leg ulcers: a narrative review. Journal of wound care 2022. link 67 Cabot JH, Buckner J, Fields A, Brahmbhatt R, Jayakumar L, Pounds LL et al.. Predictive Accuracy of the American College of Surgeons Risk Calculator in Patients Undergoing Major Lower Extremity Amputation. Annals of vascular surgery 2022. link 68 Asimakidou E, Matis GK. Spinal cord stimulation in the treatment of peripheral vascular disease: a systematic review - revival of a promising therapeutic option?. British journal of neurosurgery 2022. link 69 Kugler NW, Lewis BD, Malinowski M. Axillary pullout syndrome: A novel approach to managing a devastating complication. Vascular 2022. link 70 Deery SE, Goldsborough E, Dun C, Abularrage CJ, Black JH, Makary MA et al.. Use of Intravascular Ultrasound During First-Time Femoropopliteal Peripheral Vascular Interventions Among Medicare Beneficiaries. Annals of vascular surgery 2022. link 71 Boyd S, Dittman JM, Tse W, Lavingia KS, Amendola MF. Modern Lower Extremity Bypass Outcomes by Anesthesia Type in the Veteran Population. Annals of vascular surgery 2022. link 72 Martin G, Antonietti A, Patrone L. Removal of Partially Deployed Supera Stents: Case-Based Review and Technical Considerations. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2022. link 73 Alfawaz A, Kotha VS, Nigam M, Bekeny JC, Black CK, Tefera E et al.. Popliteal artery patency is an indicator of ambulation and healing after below-knee amputation in vasculopaths. Vascular 2022. link 74 Prasad A, Amin AP, Ryan MP, Gunnarsson C, Brilakis ES. Use of iso-osmolar contrast media during endovascular revascularization is associated with a lower incidence of major adverse renal, cardiac, or limb events. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2022. link 75 MacKay C, Cimino SR, Guilcher SJT, Mayo AL, Devlin M, Dilkas S et al.. A qualitative study exploring individuals' experiences living with dysvascular lower limb amputation. Disability and rehabilitation 2022. link 76 Damasceno NA, Yannuzzi NA, Maia M, Eid Farah M, Flynn HW, Damasceno EF. Transient central retina artery occlusion in patients undergoing intravitreal anti vegf injections. European journal of ophthalmology 2022. link 77 Collins PM, Joyce DP, O'Beirn ES, Elkady R, Boyle E, Egan B et al.. Re-amputation and survival following toe amputation: outcome data from a tertiary referral centre. Irish journal of medical science 2022. link 78 Kraiss LW, Al-Dulaimi R, Allen CM, Mell MW, Arya S, Presson AP et al.. A Vascular Quality Initiative frailty assessment predicts postdischarge mortality in patients undergoing arterial reconstruction. Journal of vascular surgery 2022. link 79 Huo Yung Kai S, Ferrières J, Carles C, Turpin M, Lapébie FX, Dutheil F et al.. Lower limb venous and arterial peripheral diseases and work conditions: systematic review. Occupational and environmental medicine 2021. link 80 Harding JP, Hedayati N. Challenges of treating mixed arterial-venous disease of lower extremities. The Journal of cardiovascular surgery 2021. link 81 Bastas G, Dallas J, Miller PB, Kloosterman N, Yannopoulos I. Polypharmacy, Dosing Trends, and Drug-Drug Interaction Patterns After High-Level Limb Amputation Surgery. American journal of physical medicine & rehabilitation 2021. link 82 Blegen MB, Balceniuk MD, Calderon T, Negron T, Ayers BC, Cardelli F et al.. Postdischarge Opioid Use after Lower Extremity Bypass Surgery. Annals of vascular surgery 2021. link 83 Chahrour MA, Homsi M, Wehbe MR, Hmedeh C, Hoballah JJ, Haddad FF. Major lower extremity amputations in a developing country: 10-Year experience at a tertiary medical center. Vascular 2021. link 84 Balceniuk MD, Sebastian A, Schroeder AC, Ayers BC, Raman K, Ellis JL et al.. Regional Variation in Usage of Ultrasound-Guided Femoral Access in the Vascular Quality Initiative. Annals of vascular surgery 2021. link 85 Björkman P, Weselius EM, Venermo M. No Difference in Mid-term and Long-Term Mortality After Vascular Paclitaxel Exposure. Annals of vascular surgery 2021. link 86 Campochiaro PA, Akhlaq A. Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases. Progress in retinal and eye research 2021. link 87 Almoosawy SA, McGowan M, Hijazi K, Patey R, Bachoo P, Cherukara G. The oral health status of patients with peripheral vascular disorders: A systematic review. Vascular 2021. link 88 DeCarlo C, Latz CA, Boitano LT, Pendleton AA, Mohebali J, Conrad MF et al.. Percutaneous brachial access associated with increased incidence of complications compared with open exposure for peripheral vascular interventions in a contemporary series. Journal of vascular surgery 2021. link 89 Chang H, Maldonado TS, Rockman CB, Cayne NS, Berland TL, Barfield ME et al.. Closed incision negative pressure wound therapy may decrease wound complications in major lower extremity amputations. Journal of vascular surgery 2021. link 90 Teixeira G, Almeida P, Loureiro L, Antunes I, Rego D, Teixeira S et al.. Arterial percutaneous angioplasty in hemodialysis access: Endovascular treatment of hand ischemia. The journal of vascular access 2021. link 91 Aerden LK, Wuite S, Houthoofd S, Matricali GA. Reviving the debate: Articular cartilage preservation during disarticulation at the lower limb? A systematic review. Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons 2021. link 92 Stabile E, Piccolo R, Franzese M, Accarino G, Bracale UM, Cappello E et al.. A cross-sectional study evaluating hospitalization rates for chronic limb-threatening ischemia during the COVID-19 outbreak in Campania, Italy. Vascular medicine (London, England) 2021. link 93 Cheng TW, Raulli SJ, Farber A, Levin SR, Kalish JA, Jones DW et al.. The Association of the Day of the Week with Outcomes of Infrainguinal Lower Extremity Bypass. Annals of vascular surgery 2021. link 94 Weissler EH, Annapureddy A, Wang Y, Secemsky EA, Shishehbor MH, Mena-Hurtado C et al.. Paclitaxel-coated devices in the treatment of femoropopliteal stenosis among patients ≥65 years old: An ACC PVI Registry Analysis. American heart journal 2021. link 95 Adedigba JA, Volk AS, Roach HM. Periprosthetic seroma occurrence after femoropopliteal bypass grafting: Surgical management after failure of non-surgical measures in relieving symptoms. Vascular 2021. link 96 Harris RC, Fang W. Transmetatarsal Amputation Outcomes When Utilized to Address Foot Gangrene and Infection: A Retrospective Chart Review. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 2021. link 97 Andersen JC, Mannoia KA, Patel ST, Leong BV, Murga AG, Teruya TH et al.. Factors Affecting One-Year Outcomes After Major Lower Extremity Amputation in the Vascular Quality Initiative Amputation Registry. The American surgeon 2021. link 98 Anderson J, King R, Brothers T, Robison J, Veeraswamy R, Wooster M et al.. Discharge to a Post-Acute Care Facility after Emergent Femoral Artery Repair is Not Protective Against Wound Complications. Annals of vascular surgery 2020. link 99 Cohn DM, Mabud TS, Arendt VA, Souffrant AD, Jeon GS, An X et al.. Toward Data-Driven Learning Healthcare Systems in Interventional Radiology: Implementation to Evaluate Venous Stent Patency. Journal of digital imaging 2020. link 100 Affan ET, Hong S, Qasabian RA. Complete Erosion of an Aortobifemoral Bypass Graft Limb into Duodenum. Annals of vascular surgery 2020. link