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Urology3 papers

Squamous cell carcinoma of prostate

Last edited: 4/10/2026

Overview

Squamous cell carcinoma (SCC) of the prostate is a rare and aggressive form of prostate cancer. It is distinct from the more common acinar adenocarcinoma of the prostate.

Diagnosis

  • Diagnosis is typically made via prostate biopsy, which reveals squamous cell morphology.
  • Histological grading follows standard prostate cancer grading systems, such as Gleason score, though SCC may have unique features.
  • Management

  • Management strategies for prostate SCC are not well-established due to its rarity and lack of specific clinical trials.
  • Treatment approaches may be extrapolated from those used for other aggressive prostate cancers or squamous cell carcinomas in other locations, potentially including surgery, radiation therapy, and chemotherapy.
  • Key Recommendations

  • Plant-forward diets may confer a protective effect on prostate cancer 1. (Evidence: Moderate)
  • References

    1 Feiertag N, Tawfik MM, Loloi J, Patel RD, Green B, Zhu M et al.. Should Men Eat More Plants? A Systematic Review of the Literature on the Effect of Plant-Forward Diets on Men's Health. Urology 2023. link

    Original source

    1. [1]
      Should Men Eat More Plants? A Systematic Review of the Literature on the Effect of Plant-Forward Diets on Men's Health.Feiertag N, Tawfik MM, Loloi J, Patel RD, Green B, Zhu M et al. Urology (2023)

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