Squamous cell carcinoma

Overview

Diagnosis

Management

Special Populations

Key Recommendations

References

1 Takai T, Kadono T, Fujimoto N, Yoden E, Nomura T, Matsumoto K et al.. Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Cutaneous Squamous Cell Carcinoma 2025. The Journal of dermatology 2026. link 2 Zou H, Janadi AA, Sako Z. Acute Gout Flare After Carboplatin/5-Fluorouracil for Locally Advanced Head and Neck Squamous Cell Carcinoma. Cancer reports (Hoboken, N.J.) 2026. link 3 Feng M, Hallemeier CL, Almada C, Aranha O, Dorth J, Felder S et al.. Radiation Therapy for Anal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline. Practical radiation oncology 2025. link 4 Weber I, Liao K, Dang T, Shah M, Wehner MR. Sunburn and Cutaneous Squamous Cell Carcinoma: A Meta-Analysis. JAMA dermatology 2025. link 5 Cebolla Verdugo M, Husein El-Ahmed H, Ruiz Villaverde R. Does Teledermatology Enable Earlier Diagnosis of Cutaneous Squamous Cell Carcinoma Than Face-to-face Consultation?. Acta dermato-venereologica 2025. link 6 Miller DM. The evolving treatment landscape for CSCC. Archives of dermatological research 2025. link 7 Schmitz A, Reichardt C, Gierth J, Richter M, Mrosk F, Alfertshofer M et al.. Retrospective analysis of multimorbidity, polypharmacy, and drug interactions on postoperative outcomes in oral squamous cell carcinoma patients. Clinical oral investigations 2025. link 8 Margalit DN, Anker CJ, Aristophanous M, Awan M, Bajaj GK, Bradfield L et al.. Radiation Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline. Practical radiation oncology 2024. link 9 Bencomo T, Lee CS. Gene expression landscape of cutaneous squamous cell carcinoma progression. The British journal of dermatology 2024. link 10 Queirolo P, Cinquini M, Argenziano G, Bassetto F, Bossi P, Boutros A et al.. Guidelines for the diagnosis and treatment of cutaneous squamous cell carcinoma: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology. ESMO open 2024. link 11 Salmen NL, Menage K, Baumann AN, Curtis DP, Brodell RT. Skin color reporting in squamous cell carcinoma-related randomized controlled trials in top dermatology journals: a systematic review. Archives of dermatological research 2024. link 12 Bussu F, Tagliaferri L, Corbisiero MF, Lotto C, Pellini R, Guarino P et al.. Management of nasal vestibule carcinomas: recommendations by the Oncological Committee of the Italian Society of Otorhinolaryngology - Head and Neck Surgery. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 2024. link 13 Evans LK, Azar SS, Chen H, Saad M, Subhash S, Su-Velez BM et al.. Improving HPV-Related Oropharyngeal Cancer Knowledge and HPV Vaccination Rates via Virtual Workshops. The Laryngoscope 2024. link 14 Jean-Pierre P, Nouri K. A retrospective analysis of drugs associated with the development of cutaneous squamous cell carcinoma reported by patients on the FDA's adverse events reporting system. Archives of dermatological research 2024. link 15 Chen S, Yang Y, Wang R, Fang J. Neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy had a higher ORR than mono-immunotherapy in untreated HNSCC: Meta-analysis. Oral oncology 2023. link 16 Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, van Akkooi A, Bataille V et al.. European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma: Part 2. Treatment-Update 2023. European journal of cancer (Oxford, England : 1990) 2023. link 17 Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, van Akkooi A, Bataille V et al.. European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma. Part 1: Diagnostics and prevention-Update 2023. European journal of cancer (Oxford, England : 1990) 2023. link 18 Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV et al.. Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature. Head & neck 2022. link 19 Aboul-Fettouh N, Chen L, Ma J, Patel J, Silapunt S, Migden M. PD-1 inhibitors for cutaneous squamous cell carcinoma: A meta-analysis. The Australasian journal of dermatology 2022. link 20 Dessinioti C, Platsidaki E, Stratigos AJ. A Sensitivity Meta-Analysis of Disease-Specific Death in Localized Cutaneous Squamous Cell Carcinoma. Dermatology (Basel, Switzerland) 2022. link 21 Strzelczyk JK, Świętek A, Biernacki K, Gołąbek K, Gaździcka J, Miśkiewicz-Orczyk K et al.. PCR Detection of Epstein-Barr Virus (EBV) DNA in Patients with Head and Neck Squamous Cell Carcinoma, in Patients with Chronic Tonsillitis, and in Healthy Individuals. BioMed research international 2022. link 22 Wilmas KM, Nguyen QB, Patel J, Silapunt S, Migden MR. Treatment of advanced cutaneous squamous cell carcinoma: a Mohs surgery and dermatologic oncology perspective. Future oncology (London, England) 2021. link 23 Lau AS, Milinis K, Roode M, Williams SP, Cook C, Walijee H et al.. The prevalence of oropharyngeal squamous cell carcinoma in patients admitted with symptoms of peritonsillar abscess or cellulitis: A retrospective multicentre study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 2021. link 24 Prezzano JC, Scott GA, Lambert Smith F, Mannava KA, Ibrahim SF. Concordance of Squamous Cell Carcinoma Histologic Grading Among Dermatopathologists and Mohs Surgeons. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2021. link 25 Ali Z, Todd PM. Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort study. Clinical and experimental dermatology 2020. link 26 Yildiz P, Aung PP, Milton DR, Hruska C, Ivan D, Nagarajan P et al.. Measurement of Tumor Thickness in Cutaneous Squamous Cell Carcinomas: Do the Different Methods Provide Better Prognostic Data?. The American Journal of dermatopathology 2020. link 27 Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L et al.. European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment. European journal of cancer (Oxford, England : 1990) 2020. link 28 Rebeca T, Giselle P, Litchman GH, Rigel DS. Impact of Gene Expression Profile Testing on the Management of Squamous Cell Carcinoma by Dermatologists. Journal of drugs in dermatology : JDD 2019. link 29 Vitale C, de Nonneville A, Fichaux M, Salas S. Medical staff opposition to a deep and continuous palliative sedation request under Claeys-Leonetti law. BMC palliative care 2019. link 30 Marangon Junior H, Leão PLR, Melo VVM, Caixeta ÂB, Souza PEA, de Aguiar MCF et al.. Cell proliferation is associated with intensity of tumor budding in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018. link 31 Zargaran M, Baghaei F, Moghimbeigi A. Comparative study of β-catenin and CD44 immunoexpression in oral lichen planus and squamous cell carcinoma. International journal of dermatology 2018. link 32 Patel H, Francke M, Stahura H, El-Hajjar M, Schulman-Marcus J. Solitary cardiac metastasis from primary oral squamous cell carcinoma presenting as ST-elevation MI. BMJ case reports 2018. link 33 Ju Y, Tian D, Tan Y, Fu Z. Palliative care with cervical intrathecal infusion and external pump for a late-stage cancer patient with refractory pain: A case report. Medicine 2018. link 34 Leão PLR, Marangon Junior H, Melo VVM, Caixeta ÂB, Souza PEA, de Aguiar MCF et al.. Reproducibility, repeatability, and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2017. link 35 Hitchen N, Warnapala D, Fisher RM, Dua J, Pratsou P, Freebairn A. Jejunal perforation: an unusual presentation of metastatic cutaneous squamous cell carcinoma (SCC) in an immunosuppressed patient. BMJ case reports 2017. link 36 Singh A, Willems E, Singh A, Ong IM, Verma AK. Ultraviolet radiation-induced differential microRNA expression in the skin of hairless SKH1 mice, a widely used mouse model for dermatology research. Oncotarget 2016. link 37 Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H et al.. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. European journal of cancer (Oxford, England : 1990) 2015. link 38 Sîrbi AG, Florea M, Pătraşcu V, Rotaru M, Mogoş DG, Georgescu CV et al.. Squamous cell carcinoma developed on chronic venous leg ulcer. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2015. link 39 Madana J, Morand GB, Barona-Lleo L, Black MJ, Mlynarek AM, Hier MP. A survey on pulmonary screening practices among otolaryngology-head & neck surgeons across Canada in the post treatment surveillance of head and neck squamous cell carcinoma. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 2015. link 40 Srivastava S, Ghosh SK. Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India. Asian Pacific journal of cancer prevention : APJCP 2015. link 41 Yehl JL, Sheyner I, Fasnacht KS, Stewart JT. A case of tardive dyskinesia in the last weeks of life. Journal of pain & palliative care pharmacotherapy 2015. link 42 Adil E, Setabutr D, Ghossaini SN, Goldenberg D. Metastatic squamous cell carcinoma of the tonsil presenting as otorrhea: a case report. Ear, nose, & throat journal 2015. link 43 Walls B, Jordan L, Diaz L, Miller R. Targeted therapy for cutaneous oncology: a review of novel treatment options for non-melanoma skin cancer: part II. Journal of drugs in dermatology : JDD 2014. link 44 LeBlanc KG, Monheit GD. Understanding and use of the American Joint Committee on Cancer seventh edition guidelines for cutaneous squamous cell carcinoma: a survey of dermatologic surgeons. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2014. link 45 Wang CH, Lee YC, Wang CP, Chen CC, Ko JY, Han ML et al.. Use of transnasal endoscopy for screening of esophageal squamous cell carcinoma in high-risk patients: yield rate, completion rate, and safety. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2014. link 46 Yuan FN, Valiyaparambil J, Woods MC, Tran H, Pant R, Adams JS et al.. Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. International journal of oncology 2014. link 47 Patel UA, Lin AC. Flap outcomes when training residents in microvascular anastomosis in the head and neck. American journal of otolaryngology 2013. link 48 Fort MM, Gathings R, Domanski MC. Squamous cell carcinoma of the tonsil masquerading as a peritonsillar abscess. The American journal of emergency medicine 2013. link 49 Zhang L, Ye SB, Ma G, Tang XF, Chen SP, He J et al.. The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma. Journal of translational medicine 2013. link 50 Koh WL, Ang CC, Lim SP. Psoriasiform dermatitis in a case of newly diagnosed locally advanced pyriform sinus tumour: Bazex syndrome revisited. Singapore medical journal 2012. link 51 Delaney EK, Duckworth L, Thompson WD, Lee AJ, Murchie P. Excising squamous cell carcinomas: comparing the performance of GPs, hospital skin specialists and other hospital specialists. Family practice 2012. link 52 Stanford R, Lowell D, Raju R, Arya S. Marjolin's ulcer of the leg secondary to nonhealing chronic venous stasis ulcer. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 2012. link 53 Stelzle F, Maier A, Nöth E, Bocklet T, Knipfer C, Schuster M et al.. Automatic quantification of speech intelligibility in patients after treatment for oral squamous cell carcinoma. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2011. link 54 Fracalossi AC, Miranda SR, Oshima CT, Franco M, Ribeiro DA. The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Journal of molecular histology 2010. link 55 Ayala FR, Rocha RM, Carvalho KC, Carvalho AL, da Cunha IW, Lourenço SV et al.. GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. Molecules (Basel, Switzerland) 2010. link 56 Hundt W, Yuh EL, Steinbach S, Bednarski MD. Effect of continuous high intensity focused ultrasound in a squamous cell carcinoma tumor model compared to muscle tissue evaluated by MRI, histology, and gene expression. Technology in cancer research & treatment 2009. link 57 Arefi M, Philipone E, Caprioli R, Haight J, Richardson H, Sheng Chen. A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. Foot & ankle specialist 2008. link 58 Reich-Schupke S, Altmeyer P, Kreuter A, Stücker M. Development of spinocellular carcinoma in a long-lasting and therapy resistant venous ulcer - two case studies. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2008. link 59 Steffen C. Dermatopathology in historical perspective: epithelioma cuniculatum (Aird). The American Journal of dermatopathology 2006. link 60 Cassarino DS, Derienzo DP, Barr RJ. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. Journal of cutaneous pathology 2006. link 61 Cassarino DS, Derienzo DP, Barr RJ. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. Journal of cutaneous pathology 2006. link 62 Renshaw AA, Henry MR, Birdsong GG, Wang E, Haja J, Hughes JH. Cytologic features of squamous cell carcinoma in conventional smears: comparison of cases that performed poorly with those that performed well in the College of American Pathologists Interlaboratory Comparison Program in cervicovaginal cytology. Archives of pathology & laboratory medicine 2005. link 63 McCawley LJ, Crawford HC, King LE, Mudgett J, Matrisian LM. A protective role for matrix metalloproteinase-3 in squamous cell carcinoma. Cancer research 2004. link 64 Khanna M, Fortier-Riberdy G, Dinehart SM, Smoller B. Histopathologic evaluation of cutaneous squamous cell carcinoma: results of a survey among dermatopathologists. Journal of the American Academy of Dermatology 2003. link 65 Steward DL, Wiener F, Gleich LL, Falciglia G. Dietary antioxidant intake in patients at risk for second primary cancer. The Laryngoscope 2003. link 66 Holmes SB, Vora K, Hardee PS. Squamous cell carcinoma presenting as a peritonsillar abscess. The British journal of oral & maxillofacial surgery 2001. link 67 Sekine J, Irie A, Sano K, Hideshima K, Uehara M, Inokuchi T. Application of the membrane filter technique to bromodeoxyuridine immunochemistry for exfoliative cytology. Biotechnic & histochemistry : official publication of the Biological Stain Commission 2001. link 68 Colevas AD, Amrein PC, Gomolin H, Barton JJ, Read RR, Adak S et al.. A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck. Cancer 2001. link92:2<326::aid-cncr1326>3.0.co;2-w) 69 Wang MY, Teitelbaum GP, Loskota WJ, Eng D, Albuquerque F, Gruen JP. Brachial plexus catheter reservoir for the treatment of upper-extremity cancer pain: technical case report. Neurosurgery 2000. link 70 Korogi Y, Hirai T, Nishimura R, Hamatake S, Sakamoto Y, Murakami R et al.. Superselective intraarterial infusion of cisplatin for squamous cell carcinoma of the mouth: preliminary clinical experience. AJR. American journal of roentgenology 1995. link 71 Andrew SM, Bhattacharjee M, Keenan DJ, Reid H. Squamous cell carcinoma occurring in the wall of a chronic aspergilloma. Thorax 1991. link 72 Richmond I, Hasleton PS, Samadian S. Systemic amyloid associated with carcinoma of the bronchus. Thorax 1990. link 73 Woods WG. Squamous cell carcinoma of the rectum arising in an area of squamous metaplasia. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1987. link 74 Quintal D, Jackson R. Aggressive squamous cell carcinoma arising in familial acne conglobata. Journal of the American Academy of Dermatology 1986. link70023-6) 75 Hsueh S, Kuo TT. Amyloid in squamous cell carcinoma of the vagina: immunohistochemical study with monoclonal anti-keratin antibodies. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1986. link 76 Boeheim K, Speak JA, Frei E, Bernal SD. SQM1 antibody defines a surface membrane antigen in squamous carcinoma of the head and neck. International journal of cancer 1985. link 77 Nguyen KQ, McMarlin SL. Verrucous carcinoma of the face. Archives of dermatology 1984. link 78 Piscioli F, Aldovini D, Bondi A, Eusebi V. Squamous cell carcinoma with sarcoma-like stroma of the nose and paranasal sinuses: report of two cases. Histopathology 1984. link 79 Ross L. Bronchogenic squamous cell carcinoma metastasizing to Bowman's capsule. Journal of clinical pathology 1966. link