Overview
Squamous cell carcinoma (SCC) of the penis is an uncommon malignancy. Treatment should be managed at an expert center 1.Diagnosis
No information on diagnosis was provided in the abstracts.Management
Exclusive brachytherapy is indicated for early-stage penile glans cancer, yielding excellent disease control and organ preservation 1.
External beam radiation therapy (EBRT) may be considered in the palliative setting for primary tumor irradiation 1.
EBRT (with or without chemotherapy) can be discussed for lymph node irradiation as a neoadjuvant approach for massive inguinal lymph node invasion or as an adjuvant approach for high-risk relapse 1.
These latter indications for EBRT require individual discussion due to poor evidence levels 1.Special Populations
No information on special populations was provided in the abstracts.Key Recommendations
Exclusive brachytherapy is recommended for early-stage penile glans cancer for disease control and organ preservation 1. (Evidence: Moderate)
External beam radiation therapy may be considered for palliative treatment of the primary penile tumor 1. (Evidence: Weak)
External beam radiation therapy with or without chemotherapy can be considered for inguinal lymph node irradiation in specific neoadjuvant or adjuvant settings, but requires individual assessment due to limited evidence 1. (Evidence: Weak)References
1 Escande A, Peiffert D, Dejean C, Hannoun-Lévi JM, Cordoba A, Pommier P et al.. Radiotherapy for penile cancers. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 2022. link