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Dermatology1 paper

Mixed eccrine/pilar adnexal carcinoma of skin

Last edited: 4/10/2026

Overview

Mixed eccrine/pilar adnexal carcinoma is a rare cutaneous malignancy originating from sweat glands 1. These tumors can occur in unusual locations, such as the periungual region 1.

Diagnosis

  • Nonspecific presentations can lead to misdiagnosis and delayed treatment 1.
  • Consider these tumors in the differential diagnosis for nail unit afflictions 1.

    • Management

  • Treatment data is limited due to rarity 1.
  • Surgical excision is typically the primary treatment modality for adnexal neoplasms 1.

    • Key Recommendations

  • Periungual eccrine neoplasms should be considered in the differential diagnosis for nail unit afflictions due to nonspecific presentations 1. (Evidence: Weak)
  • Misdiagnosis of periungual eccrine neoplasms can lead to delayed treatment 1. (Evidence: Weak)

    • References

    1 Rao EM, Knackstedt TJ. A systematic review of periungual eccrine neoplasms. International journal of dermatology 2022. link

    Original source

    1. [1]
      A systematic review of periungual eccrine neoplasms. — Rao EM, Knackstedt TJ International journal of dermatology (2022)
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