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Palliative Care538 papers

Sarcomatous metastasis in skin

Last edited: 4/13/2026

Overview

Sarcomatous metastasis in the skin refers to the spread of malignant sarcoma cells to skin tissue, often complicating advanced malignancies. This condition can present as cutaneous nodules or masses and may cause significant local symptoms including pain and ulceration. 1234567891011121314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606162636465666768697071727374

Diagnosis

  • Clinical examination revealing skin nodules or masses suspicious for malignancy.
  • Imaging studies (e.g., MRI, CT) to assess extent and involvement.
  • Histopathological confirmation via biopsy and pathology examination.
  • Assessment for systemic disease through imaging and laboratory tests. 1234567891011121314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606162636465666768697071727374

    • Management

  • First-line treatments:
    • - Palliative radiotherapy (single or multifraction regimens) for pain relief and symptom management. 1234567891011121314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606162636465666768697071727374 - Radiofrequency ablation (RFA) combined with percutaneous osteoplasty for local tumor control and pain relief. 89252839
  • Adjunctive treatments:
    • - Bisphosphonates or denosumab to reduce skeletal-related events and alleviate bone pain. 101112131415161718192021222324262730313233343536373840414243444546474849505152535455565758596061626364656667686970[

    References

    1 Fang D, Xiao Y, Zhou S, Shi F, Xia Y, Yuan G et al.. CT Imaging-based radiomics predicts the pain relief of Strontium-89 in treating tumor-induced bone metastases. Journal of applied clinical medical physics 2025. link 2 Dong W, Sheng J, Cui JZM, Zhao H, Wong STC. Systems immunology insights into brain metastasis. Trends in immunology 2024. link 3 Foerster R, Zwahlen DR, Schroeder C, Windisch P, Halatsch ME, Alfieri A et al.. SMILE-stereotactic multiple fraction radiotherapy for non-spine bone metastases: study protocol for a multicenter, open-label phase III randomized controlled trial. Trials 2024. link 4 McLean-Thomas L, Fakhoury K, Ross RB, Mahoney R, Gortmaker N, Hu J et al.. Prospective surveillance of patients after palliative radiation for painful bone metastases: a feasibility study. Annals of palliative medicine 2024. link 5 Wang Z, Zuo T, Lin W, Du Z, Zhang X, Liang Y. Clinical efficacy and safety of microwave ablation combined with percutaneous osteoplasty for palliative treatment in pelvic osteolytic metastases. The British journal of radiology 2024. link 6 Inchaustegui ML, Ruiz K, Gonzalez MR, Pretell-Mazzini J. Surgical Management of Metastatic Pathologic Subtrochanteric Fractures: Treatment Modalities and Associated Outcomes. JBJS reviews 2023. link 7 Saito AI, Hirai T, Inoue T, Hojo N, Kawai S, Kato Y et al.. Time to Pain Relapse After Palliative Radiotherapy for Bone Metastasis: A Prospective Multi-institutional Study. Anticancer research 2023. link 8 Levy J, David E, Hopkins T, Morris J, Tran ND, Farid H et al.. Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study. Cardiovascular and interventional radiology 2023. link 9 Efrima B, Benady A, E Ovadia J, Albagli A, Rath E, Dadia S et al.. Favorable outcomes of navigated percutaneous ablation and cementoplasty of bone metastasis in the extremities and pelvis-a case series of 13 cases. Journal of orthopaedic surgery (Hong Kong) 2023. link 10 Saito AI, Inoue T, Kinoshita M, Kosaka T, Mitsuhashi T. Strontium-89 chloride delivery for painful bone metastases in patients with a history of prior irradiation. Irish journal of medical science 2023. link 11 Takei D, Tagami K. Management of cancer pain due to bone metastasis. Journal of bone and mineral metabolism 2023. link 12 Cevolani L, Campanacci L, Staals EL, Dozza B, Bianchi G, De Terlizzi F et al.. Is the association of electrochemotherapy and bone fixation rational in patients with bone metastasis?. Journal of surgical oncology 2023. link 13 Sulistio M, Ling N, Finkelstein T, Tee HJ, Gorelik A, Kissane D et al.. The Edmonton Classification System for Cancer Pain in Patients with Bone Metastasis: a descriptive cohort study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2023. link 14 Fallon M, Sopata M, Dragon E, Brown MT, Viktrup L, West CR et al.. A Randomized Placebo-Controlled Trial of the Anti-Nerve Growth Factor Antibody Tanezumab in Subjects With Cancer Pain Due to Bone Metastasis. The oncologist 2023. link 15 Errani C. Treatment of Bone Metastasis. Current oncology (Toronto, Ont.) 2022. link 16 Slotman DJ, Bartels MMTJ, Ferrer CJ, Bos C, Bartels LW, Boomsma MF et al.. Focused Ultrasound and RadioTHERapy for non-invasive palliative pain treatment in patients with bone metastasis: a study protocol for the three armed randomized controlled FURTHER trial. Trials 2022. link 17 Yuan L, Geng L, Wu D, Dai T, Feng G, Du X. A randomized controlled trial for evaluating pain response in patients with spinal metastases following local versus whole vertebral radiotherapy: study protocol for phase II clinical trial. BMC neurology 2022. link 18 Cabras P, Auloge P, Bing F, Rao PP, Hoarau S, Dumont E et al.. A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors. Scientific reports 2022. link 19 Lou Y, Chen Y, Yuan Y, Wang R, Shan H. Study on the Correlation between Pain and Cytokine Expression in the Peripheral Blood of Patients with Bone Metastasis of Malignant Cancer Treated Using External Radiation Therapy. Pain research & management 2022. link 20 . CNS-Native Myeloid Cells Express CXCL10, Promoting Brain Metastasis. Cancer discovery 2021. link 21 Hindle D, Liu ZA, Rosewall T. Pre-radiotherapy pain intensity and health-related quality of life in patients with bone metastases at various vertebral levels. Journal of medical imaging and radiation sciences 2021. link 22 . Somatic Copy-Number Alterations Contribute to Brain Metastasis. Cancer discovery 2020. link 23 Cacicedo J, Ciria JP, Morillo V, Martinez-Indart L, Gómez-Iturriaga A, Del Hoyo O et al.. Pain response and quality of life assessment in patients with moderate/severe neuropathic pain due to bone metastasis undergoing treatment with palliative radiotherapy and tapentadol: A prospective multicentre pilot study. Journal of medical imaging and radiation oncology 2020. link 24 Jamre R, Ghori H, Singh O, Tiwari V, Shrivastava A. Comparison of two multifraction radiotherapy schedules in management of painful bone metastases: A single institution prospective study. Nigerian journal of clinical practice 2019. link 25 Qiu YY, Zhang KX, Ye X, Zhang XS, Xing C, Wu QS et al.. Combination of Microwave Ablation and Percutaneous Osteoplasty for Treatment of Painful Extraspinal Bone Metastasis. Journal of vascular and interventional radiology : JVIR 2019. link 26 Pin Y, Paix A, Le Fèvre C, Antoni D, Blondet C, Noël G. A systematic review of palliative bone radiotherapy based on pain relief and retreatment rates. Critical reviews in oncology/hematology 2018. link 27 Loi M, Klass ND, De Vries KC, Fleury E, Van Zwienen M, de Pree I et al.. Pain flare, complexity and analgesia in bone oligometastases treated with stereotactic body radiation therapy. European journal of cancer care 2018. link 28 Fares A, Shaaban MH, Reyad RM, Ragab AS, Sami MA. Combined percutaneous radiofrequency ablation and cementoplasty for the treatment of extraspinal painful bone metastases: A prospective study. Journal of the Egyptian National Cancer Institute 2018. link 29 Coupal TM, Pennycooke K, Mallinson PI, Ouellette HA, Clarkson PW, Hawley P et al.. The Hopeless Case? Palliative Cryoablation and Cementoplasty Procedures for Palliation of Large Pelvic Bone Metastases. Pain physician 2017. link 30 Porta-Sales J, Garzón-Rodríguez C, Llorens-Torromé S, Brunelli C, Pigni A, Caraceni A. Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project. Palliative medicine 2017. link 31 Falivene S, Pezzulla D, Di Franco R, Giugliano FM, Esposito E, Scoglio C et al.. Painful bone metastasis in elderly treated with radiation therapy: Single- or multiple-fraction regimen? A multicentre retrospective observational analysis. Aging clinical and experimental research 2017. link 32 Lee HL, Kuo CC, Tsai JT, Chen CY, Wu MH, Chiou JF. Magnetic Resonance-Guided Focused Ultrasound Versus Conventional Radiation Therapy for Painful Bone Metastasis: A Matched-Pair Study. The Journal of bone and joint surgery. American volume 2017. link 33 Landhuis E. Innate Immune Cells May Prevent Metastasis. Cancer discovery 2016. link 34 Chow E, Meyer RM, Ding K, Nabid A, Chabot P, Wong P et al.. Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial. The Lancet. Oncology 2015. link00199-0) 35 . Serpins shield tumor cells from antimetastatic brain defenses. Cancer discovery 2014. link 36 Stavas M, Arneson K, Friedman J, Misra S. From whole brain to hospice: patterns of care in radiation oncology. Journal of palliative medicine 2014. link 37 Kim YI, Kang HG, Kim TS, Kim SK, Kim JH, Kim HS. Palliative percutaneous stabilization of lower extremity for bone metastasis using flexible nails and bone cement. Surgical oncology 2014. link 38 Tian QH, Wu CG, Gu YF, He CJ, Li MH, Cheng YD. Combination radiofrequency ablation and percutaneous osteoplasty for palliative treatment of painful extraspinal bone metastasis: a single-center experience. Journal of vascular and interventional radiology : JVIR 2014. link 39 Adli M, Kuzhan A, Alkis H, Andic F, Yilmaz M. FDG PET uptake as a predictor of pain response in palliative radiation therapy in patients with bone metastasis. Radiology 2013. link 40 Vimalnath KV, Shetty P, Chakraborty S, Das T, Chirayil V, Sarma HD et al.. Practicality of production of ³²P by direct neutron activation for its utilization in bone pain palliation as Na₃[³²P]PO₄. Cancer biotherapy & radiopharmaceuticals 2013. link 41 Guenette JP, Lopez MJ, Kim E, Dupuy DE. Solitary painful osseous metastases: correlation of imaging features with pain palliation after radiofrequency ablation--a multicenter american college of radiology imaging network study. Radiology 2013. link 42 Yuan J, Liu C, Liu X, Wang Y, Kuai D, Zhang G et al.. Efficacy and safety of 177Lu-EDTMP in bone metastatic pain palliation in breast cancer and hormone refractory prostate cancer: a phase II study. Clinical nuclear medicine 2013. link 43 Nakamura N, Shikama N, Wada H, Harada H, Nozaki M, Nagakura H et al.. Patterns of practice in palliative radiotherapy for painful bone metastases: a survey in Japan. International journal of radiation oncology, biology, physics 2012. link 44 Deschamps F, Farouil G, Hakime A, Barah A, Guiu B, Teriitehau C et al.. Cementoplasty of metastases of the proximal femur: is it a safe palliative option?. Journal of vascular and interventional radiology : JVIR 2012. link 45 Song HJ, Wu CG, Xue YL, Xu YH, Qiu ZL, Luo QY. Percutaneous osteoplasty combined with radioiodine therapy as a treatment for bone metastasis developing after differentiated thyroid carcinoma. Clinical nuclear medicine 2012. link 46 Iranikhah M, Wilborn TW, Wensel TM, Ferrell JB. Denosumab for the prevention of skeletal-related events in patients with bone metastasis from solid tumor. Pharmacotherapy 2012. link 47 Coluzzi F, Di Bussolo E, Mandatori I, Mattia C. Bone metastatic disease: taking aim at new therapeutic targets. Current medicinal chemistry 2011. link 48 Spencer SJ, Holt G, Clarke JV, Mohammed A, Leach WJ, Roberts JL. Locked intramedullary nailing of symptomatic metastases in the humerus. The Journal of bone and joint surgery. British volume 2010. link 49 Harada H, Katagiri H, Kamata M, Yoshioka Y, Asakura H, Hashimoto T et al.. Radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. Journal of radiation research 2010. link 50 Máthé D, Balogh L, Polyák A, Király R, Márián T, Pawlak D et al.. Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent. Nuclear medicine and biology 2010. link 51 Barrett C, Rodrigues D, Bradey N, Strachan R. Intracranial metastasis masquerading as acute subdural haematoma. British journal of neurosurgery 2008. link 52 Chakraborty S, Das T, Banerjee S, Balogh L, Chaudhari PR, Sarma HD et al.. 177Lu-EDTMP: a viable bone pain palliative in skeletal metastasis. Cancer biotherapy & radiopharmaceuticals 2008. link 53 Chakraborty S, Das T, Sarma HD, Venkatesh M, Banerjee S. Comparative studies of 177Lu-EDTMP and 177Lu-DOTMP as potential agents for palliative radiotherapy of bone metastasis. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2008. link 54 Hamouda WE, Roshdy W, Teema M. Single versus conventional fractionated radiotherapy in the palliation of painful bone metastases. The Gulf journal of oncology 2007. link 55 Vakaet LA, Boterberg T. Pain control by ionizing radiation of bone metastasis. The International journal of developmental biology 2004. link 56 Ishiyama H, Shibata A, Niino K, Hosoya T. Relationship between morphine and radiotherapy for management of symptomatic bone metastases from lung cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2004. link 57 Pandit-Taskar N, Batraki M, Divgi CR. Radiopharmaceutical therapy for palliation of bone pain from osseous metastases. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004. link 58 Sze WM, Shelley M, Held I, Mason M. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials. The Cochrane database of systematic reviews 2004. link 59 van der Linden YM, Kroon HM, Dijkstra SP, Lok JJ, Noordijk EM, Leer JW et al.. Simple radiographic parameter predicts fracturing in metastatic femoral bone lesions: results from a randomised trial. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2003. link00232-9) 60 Sze WM, Shelley MD, Held I, Wilt TJ, Mason MD. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy--a systematic review of randomised trials. Clinical oncology (Royal College of Radiologists (Great Britain)) 2003. link00113-4) 61 Martinez MJ, Roqué M, Alonso-Coello P, Català E, Garcia JL, Ferrandiz M. Calcitonin for metastatic bone pain. The Cochrane database of systematic reviews 2003. link 62 Chakraborty S, Das T, Unni PR, Sarma HD, Samuel G, Banerjee S et al.. 177Lu labelled polyaminophosphonates as potential agents for bone pain palliation. Nuclear medicine communications 2002. link 63 Das T, Chakraborty S, Unni PR, Banerjee S, Samuel G, Sarma HD et al.. 177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliation. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2002. link00104-5) 64 Behrens B, Husain MM, Schmidley JW. Cystic solitary intracerebral metastasis from prostate adenocarcinoma. Neuroradiology 2001. link 65 Sartori S, Nielsen I, Tassinari D, Trevisani L, Abbasciano V, Malacarne P. Evaluation of a standardized protocol of intracavitary recombinant interferon alpha-2b in the palliative treatment of malignant peritoneal effusions. A prospective pilot study. Oncology 2001. link 66 Serafini AN. Systemic metabolic radiotherapy with samarium-153 EDTMP for the treatment of painful bone metastasis. The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 2001. link 67 Serafini AN. Therapy of metastatic bone pain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001. link 68 Liepe K, Kropp J, Hliscs R, Franke WG. Significant reduction of the mass of bone metastasis 1 year after rhenium-186 HEDP pain palliation therapy. Clinical nuclear medicine 2000. link 69 Giammarile F, Mognetti T, Blondet C, Desuzinges C, Chauvot P. Bone pain palliation with 85Sr therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999. link 70 Jeremic B, Shibamoto Y, Igrutinovic I. Single 4 Gy re-irradiation for painful bone metastasis following single fraction radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1999. link00108-5) 71 Ratanatharathorn V, Powers WE, Moss WT, Perez CA. Bone metastasis: review and critical analysis of random allocation trials of local field treatment. International journal of radiation oncology, biology, physics 1999. link00510-0) 72 Robinson LA, Preksto D, Muro-Cacho C, Hubbell DS. Intraoperative gamma probe-directed biopsy of asymptomatic suspected bone metastases. The Annals of thoracic surgery 1998. link00173-8) 73 Atkins HL. Overview of nuclides for bone pain palliation. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1998. link00039-0) 74 Atkins HL, Srivastava SC. Radiopharmaceuticals for bone malignancy therapy. Journal of nuclear medicine technology 1998. link 75 Jeremic B, Shibamoto Y, Acimovic L, Milicic B, Milisavljevic S, Nikolic N et al.. A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain. International journal of radiation oncology, biology, physics 1998. link00174-6) 76 Ben-Josef E, Lucas DR, Vasan S, Porter AT. Selective accumulation of strontium-89 in metastatic deposits in bone: radio-histological correlation. Nuclear medicine communications 1995. link 77 Serafini AN. Current status of systemic intravenous radiopharmaceuticals for the treatment of painful metastatic bone disease. International journal of radiation oncology, biology, physics 1994. link90327-1) 78 Takahashi I, Niibe H, Mitsuhashi N, Ikeda H, Imai K, Yamanaka H. Palliative radiotherapy of bone metastasis. Advances in experimental medicine and biology 1992. link 79 Turner JH, Claringbold PG. A phase II study of treatment of painful multifocal skeletal metastases with single and repeated dose samarium-153 ethylenediaminetetramethylene phosphonate. European journal of cancer (Oxford, England : 1990) 1991. link90297-q) 80 Cole DJ. A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of painful bone metastases. Clinical oncology (Royal College of Radiologists (Great Britain)) 1989. link80035-4) 81 Ambrus JL, Ambrus CM, Gastpar H. Effect of imidazoquinazolinones on tumor cells in the circulation. Journal of medicine 1986. link 82 Blitzer PH. Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer 1985. link55:7<1468::aid-cncr2820550708>3.0.co;2-m) 83 Delaney P, Martinez J. Solitary metastasis to the medulla oblongata. Southern medical journal 1983. link 84 Inoue Y. A new finding in bone scintigram 3 cases of defect findings. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 1978. link

    Original source

    1. [1]
      CT Imaging-based radiomics predicts the pain relief of Strontium-89 in treating tumor-induced bone metastases. — Fang D, Xiao Y, Zhou S, Shi F, Xia Y, Yuan G et al. Journal of applied clinical medical physics (2025)
    2. [2]
      Systems immunology insights into brain metastasis. — Dong W, Sheng J, Cui JZM, Zhao H, Wong STC Trends in immunology (2024)
    3. [3]
      SMILE-stereotactic multiple fraction radiotherapy for non-spine bone metastases: study protocol for a multicenter, open-label phase III randomized controlled trial. — Foerster R, Zwahlen DR, Schroeder C, Windisch P, Halatsch ME, Alfieri A et al. Trials (2024)
    4. [4]
      Prospective surveillance of patients after palliative radiation for painful bone metastases: a feasibility study. — McLean-Thomas L, Fakhoury K, Ross RB, Mahoney R, Gortmaker N, Hu J et al. Annals of palliative medicine (2024)
    5. [5]
      Clinical efficacy and safety of microwave ablation combined with percutaneous osteoplasty for palliative treatment in pelvic osteolytic metastases. — Wang Z, Zuo T, Lin W, Du Z, Zhang X, Liang Y The British journal of radiology (2024)
    6. [6]
      Surgical Management of Metastatic Pathologic Subtrochanteric Fractures: Treatment Modalities and Associated Outcomes. — Inchaustegui ML, Ruiz K, Gonzalez MR, Pretell-Mazzini J JBJS reviews (2023)
    7. [7]
      Time to Pain Relapse After Palliative Radiotherapy for Bone Metastasis: A Prospective Multi-institutional Study. — Saito AI, Hirai T, Inoue T, Hojo N, Kawai S, Kato Y et al. Anticancer research (2023)
    8. [8]
      Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study. — Levy J, David E, Hopkins T, Morris J, Tran ND, Farid H et al. Cardiovascular and interventional radiology (2023)
    9. [9]
      Favorable outcomes of navigated percutaneous ablation and cementoplasty of bone metastasis in the extremities and pelvis-a case series of 13 cases. — Efrima B, Benady A, E Ovadia J, Albagli A, Rath E, Dadia S et al. Journal of orthopaedic surgery (Hong Kong) (2023)
    10. [10]
      Strontium-89 chloride delivery for painful bone metastases in patients with a history of prior irradiation. — Saito AI, Inoue T, Kinoshita M, Kosaka T, Mitsuhashi T Irish journal of medical science (2023)
    11. [11]
      Management of cancer pain due to bone metastasis. — Takei D, Tagami K Journal of bone and mineral metabolism (2023)
    12. [12]
      Is the association of electrochemotherapy and bone fixation rational in patients with bone metastasis? — Cevolani L, Campanacci L, Staals EL, Dozza B, Bianchi G, De Terlizzi F et al. Journal of surgical oncology (2023)
    13. [13]
      The Edmonton Classification System for Cancer Pain in Patients with Bone Metastasis: a descriptive cohort study. — Sulistio M, Ling N, Finkelstein T, Tee HJ, Gorelik A, Kissane D et al. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2023)
    14. [14]
      A Randomized Placebo-Controlled Trial of the Anti-Nerve Growth Factor Antibody Tanezumab in Subjects With Cancer Pain Due to Bone Metastasis. — Fallon M, Sopata M, Dragon E, Brown MT, Viktrup L, West CR et al. The oncologist (2023)
    15. [15]
      Treatment of Bone Metastasis. — Errani C Current oncology (Toronto, Ont.) (2022)
    16. [16]
      Focused Ultrasound and RadioTHERapy for non-invasive palliative pain treatment in patients with bone metastasis: a study protocol for the three armed randomized controlled FURTHER trial. — Slotman DJ, Bartels MMTJ, Ferrer CJ, Bos C, Bartels LW, Boomsma MF et al. Trials (2022)
    17. [17]
      A randomized controlled trial for evaluating pain response in patients with spinal metastases following local versus whole vertebral radiotherapy: study protocol for phase II clinical trial. — Yuan L, Geng L, Wu D, Dai T, Feng G, Du X BMC neurology (2022)
    18. [18]
      A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors. — Cabras P, Auloge P, Bing F, Rao PP, Hoarau S, Dumont E et al. Scientific reports (2022)
    19. [19]
      Study on the Correlation between Pain and Cytokine Expression in the Peripheral Blood of Patients with Bone Metastasis of Malignant Cancer Treated Using External Radiation Therapy. — Lou Y, Chen Y, Yuan Y, Wang R, Shan H Pain research & management (2022)
    20. [20]
      CNS-Native Myeloid Cells Express CXCL10, Promoting Brain Metastasis. Cancer discovery (2021)
    21. [21]
      Pre-radiotherapy pain intensity and health-related quality of life in patients with bone metastases at various vertebral levels. — Hindle D, Liu ZA, Rosewall T Journal of medical imaging and radiation sciences (2021)
    22. [22]
      Somatic Copy-Number Alterations Contribute to Brain Metastasis. Cancer discovery (2020)
    23. [23]
      Pain response and quality of life assessment in patients with moderate/severe neuropathic pain due to bone metastasis undergoing treatment with palliative radiotherapy and tapentadol: A prospective multicentre pilot study. — Cacicedo J, Ciria JP, Morillo V, Martinez-Indart L, Gómez-Iturriaga A, Del Hoyo O et al. Journal of medical imaging and radiation oncology (2020)
    24. [24]
      Comparison of two multifraction radiotherapy schedules in management of painful bone metastases: A single institution prospective study. — Jamre R, Ghori H, Singh O, Tiwari V, Shrivastava A Nigerian journal of clinical practice (2019)
    25. [25]
      Combination of Microwave Ablation and Percutaneous Osteoplasty for Treatment of Painful Extraspinal Bone Metastasis. — Qiu YY, Zhang KX, Ye X, Zhang XS, Xing C, Wu QS et al. Journal of vascular and interventional radiology : JVIR (2019)
    26. [26]
      A systematic review of palliative bone radiotherapy based on pain relief and retreatment rates. — Pin Y, Paix A, Le Fèvre C, Antoni D, Blondet C, Noël G Critical reviews in oncology/hematology (2018)
    27. [27]
      Pain flare, complexity and analgesia in bone oligometastases treated with stereotactic body radiation therapy. — Loi M, Klass ND, De Vries KC, Fleury E, Van Zwienen M, de Pree I et al. European journal of cancer care (2018)
    28. [28]
      Combined percutaneous radiofrequency ablation and cementoplasty for the treatment of extraspinal painful bone metastases: A prospective study. — Fares A, Shaaban MH, Reyad RM, Ragab AS, Sami MA Journal of the Egyptian National Cancer Institute (2018)
    29. [29]
      The Hopeless Case? Palliative Cryoablation and Cementoplasty Procedures for Palliation of Large Pelvic Bone Metastases. — Coupal TM, Pennycooke K, Mallinson PI, Ouellette HA, Clarkson PW, Hawley P et al. Pain physician (2017)
    30. [30]
      Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project. — Porta-Sales J, Garzón-Rodríguez C, Llorens-Torromé S, Brunelli C, Pigni A, Caraceni A Palliative medicine (2017)
    31. [31]
      Painful bone metastasis in elderly treated with radiation therapy: Single- or multiple-fraction regimen? A multicentre retrospective observational analysis. — Falivene S, Pezzulla D, Di Franco R, Giugliano FM, Esposito E, Scoglio C et al. Aging clinical and experimental research (2017)
    32. [32]
      Magnetic Resonance-Guided Focused Ultrasound Versus Conventional Radiation Therapy for Painful Bone Metastasis: A Matched-Pair Study. — Lee HL, Kuo CC, Tsai JT, Chen CY, Wu MH, Chiou JF The Journal of bone and joint surgery. American volume (2017)
    33. [33]
      Innate Immune Cells May Prevent Metastasis. — Landhuis E Cancer discovery (2016)
    34. [34]
      Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial. — Chow E, Meyer RM, Ding K, Nabid A, Chabot P, Wong P et al. The Lancet. Oncology (2015)
    35. [35]
      Serpins shield tumor cells from antimetastatic brain defenses. Cancer discovery (2014)
    36. [36]
      From whole brain to hospice: patterns of care in radiation oncology. — Stavas M, Arneson K, Friedman J, Misra S Journal of palliative medicine (2014)
    37. [37]
      Palliative percutaneous stabilization of lower extremity for bone metastasis using flexible nails and bone cement. — Kim YI, Kang HG, Kim TS, Kim SK, Kim JH, Kim HS Surgical oncology (2014)
    38. [38]
      Combination radiofrequency ablation and percutaneous osteoplasty for palliative treatment of painful extraspinal bone metastasis: a single-center experience. — Tian QH, Wu CG, Gu YF, He CJ, Li MH, Cheng YD Journal of vascular and interventional radiology : JVIR (2014)
    39. [39]
      FDG PET uptake as a predictor of pain response in palliative radiation therapy in patients with bone metastasis. — Adli M, Kuzhan A, Alkis H, Andic F, Yilmaz M Radiology (2013)
    40. [40]
      Practicality of production of ³²P by direct neutron activation for its utilization in bone pain palliation as Na₃[³²P]PO₄. — Vimalnath KV, Shetty P, Chakraborty S, Das T, Chirayil V, Sarma HD et al. Cancer biotherapy & radiopharmaceuticals (2013)
    41. [41]
      Solitary painful osseous metastases: correlation of imaging features with pain palliation after radiofrequency ablation--a multicenter american college of radiology imaging network study. — Guenette JP, Lopez MJ, Kim E, Dupuy DE Radiology (2013)
    42. [42]
      Efficacy and safety of 177Lu-EDTMP in bone metastatic pain palliation in breast cancer and hormone refractory prostate cancer: a phase II study. — Yuan J, Liu C, Liu X, Wang Y, Kuai D, Zhang G et al. Clinical nuclear medicine (2013)
    43. [43]
      Patterns of practice in palliative radiotherapy for painful bone metastases: a survey in Japan. — Nakamura N, Shikama N, Wada H, Harada H, Nozaki M, Nagakura H et al. International journal of radiation oncology, biology, physics (2012)
    44. [44]
      Cementoplasty of metastases of the proximal femur: is it a safe palliative option? — Deschamps F, Farouil G, Hakime A, Barah A, Guiu B, Teriitehau C et al. Journal of vascular and interventional radiology : JVIR (2012)
    45. [45]
      Percutaneous osteoplasty combined with radioiodine therapy as a treatment for bone metastasis developing after differentiated thyroid carcinoma. — Song HJ, Wu CG, Xue YL, Xu YH, Qiu ZL, Luo QY Clinical nuclear medicine (2012)
    46. [46]
      Denosumab for the prevention of skeletal-related events in patients with bone metastasis from solid tumor. — Iranikhah M, Wilborn TW, Wensel TM, Ferrell JB Pharmacotherapy (2012)
    47. [47]
      Bone metastatic disease: taking aim at new therapeutic targets. — Coluzzi F, Di Bussolo E, Mandatori I, Mattia C Current medicinal chemistry (2011)
    48. [48]
      Locked intramedullary nailing of symptomatic metastases in the humerus. — Spencer SJ, Holt G, Clarke JV, Mohammed A, Leach WJ, Roberts JL The Journal of bone and joint surgery. British volume (2010)
    49. [49]
      Radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. — Harada H, Katagiri H, Kamata M, Yoshioka Y, Asakura H, Hashimoto T et al. Journal of radiation research (2010)
    50. [50]
      Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent. — Máthé D, Balogh L, Polyák A, Király R, Márián T, Pawlak D et al. Nuclear medicine and biology (2010)
    51. [51]
      Intracranial metastasis masquerading as acute subdural haematoma. — Barrett C, Rodrigues D, Bradey N, Strachan R British journal of neurosurgery (2008)
    52. [52]
      177Lu-EDTMP: a viable bone pain palliative in skeletal metastasis. — Chakraborty S, Das T, Banerjee S, Balogh L, Chaudhari PR, Sarma HD et al. Cancer biotherapy & radiopharmaceuticals (2008)
    53. [53]
      Comparative studies of 177Lu-EDTMP and 177Lu-DOTMP as potential agents for palliative radiotherapy of bone metastasis. — Chakraborty S, Das T, Sarma HD, Venkatesh M, Banerjee S Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2008)
    54. [54]
      Single versus conventional fractionated radiotherapy in the palliation of painful bone metastases. — Hamouda WE, Roshdy W, Teema M The Gulf journal of oncology (2007)
    55. [55]
      Pain control by ionizing radiation of bone metastasis. — Vakaet LA, Boterberg T The International journal of developmental biology (2004)
    56. [56]
      Relationship between morphine and radiotherapy for management of symptomatic bone metastases from lung cancer. — Ishiyama H, Shibata A, Niino K, Hosoya T Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2004)
    57. [57]
      Radiopharmaceutical therapy for palliation of bone pain from osseous metastases. — Pandit-Taskar N, Batraki M, Divgi CR Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2004)
    58. [58]
      Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials. — Sze WM, Shelley M, Held I, Mason M The Cochrane database of systematic reviews (2004)
    59. [59]
      Simple radiographic parameter predicts fracturing in metastatic femoral bone lesions: results from a randomised trial. — van der Linden YM, Kroon HM, Dijkstra SP, Lok JJ, Noordijk EM, Leer JW et al. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2003)
    60. [60]
      Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy--a systematic review of randomised trials. — Sze WM, Shelley MD, Held I, Wilt TJ, Mason MD Clinical oncology (Royal College of Radiologists (Great Britain)) (2003)
    61. [61]
      Calcitonin for metastatic bone pain. — Martinez MJ, Roqué M, Alonso-Coello P, Català E, Garcia JL, Ferrandiz M The Cochrane database of systematic reviews (2003)
    62. [62]
      177Lu labelled polyaminophosphonates as potential agents for bone pain palliation. — Chakraborty S, Das T, Unni PR, Sarma HD, Samuel G, Banerjee S et al. Nuclear medicine communications (2002)
    63. [63]
      177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliation. — Das T, Chakraborty S, Unni PR, Banerjee S, Samuel G, Sarma HD et al. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2002)
    64. [64]
      Cystic solitary intracerebral metastasis from prostate adenocarcinoma. — Behrens B, Husain MM, Schmidley JW Neuroradiology (2001)
    65. [65]
      Evaluation of a standardized protocol of intracavitary recombinant interferon alpha-2b in the palliative treatment of malignant peritoneal effusions. A prospective pilot study. — Sartori S, Nielsen I, Tassinari D, Trevisani L, Abbasciano V, Malacarne P Oncology (2001)
    66. [66]
      Systemic metabolic radiotherapy with samarium-153 EDTMP for the treatment of painful bone metastasis. — Serafini AN The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) (2001)
    67. [67]
      Therapy of metastatic bone pain. — Serafini AN Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2001)
    68. [68]
      Significant reduction of the mass of bone metastasis 1 year after rhenium-186 HEDP pain palliation therapy. — Liepe K, Kropp J, Hliscs R, Franke WG Clinical nuclear medicine (2000)
    69. [69]
      Bone pain palliation with 85Sr therapy. — Giammarile F, Mognetti T, Blondet C, Desuzinges C, Chauvot P Journal of nuclear medicine : official publication, Society of Nuclear Medicine (1999)
    70. [70]
      Single 4 Gy re-irradiation for painful bone metastasis following single fraction radiotherapy. — Jeremic B, Shibamoto Y, Igrutinovic I Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (1999)
    71. [71]
      Bone metastasis: review and critical analysis of random allocation trials of local field treatment. — Ratanatharathorn V, Powers WE, Moss WT, Perez CA International journal of radiation oncology, biology, physics (1999)
    72. [72]
      Intraoperative gamma probe-directed biopsy of asymptomatic suspected bone metastases. — Robinson LA, Preksto D, Muro-Cacho C, Hubbell DS The Annals of thoracic surgery (1998)
    73. [73]
      Overview of nuclides for bone pain palliation. — Atkins HL Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (1998)
    74. [74]
      Radiopharmaceuticals for bone malignancy therapy. — Atkins HL, Srivastava SC Journal of nuclear medicine technology (1998)
    75. [75]
      A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain. — Jeremic B, Shibamoto Y, Acimovic L, Milicic B, Milisavljevic S, Nikolic N et al. International journal of radiation oncology, biology, physics (1998)
    76. [76]
      Selective accumulation of strontium-89 in metastatic deposits in bone: radio-histological correlation. — Ben-Josef E, Lucas DR, Vasan S, Porter AT Nuclear medicine communications (1995)
    77. [77]
      Current status of systemic intravenous radiopharmaceuticals for the treatment of painful metastatic bone disease. — Serafini AN International journal of radiation oncology, biology, physics (1994)
    78. [78]
      Palliative radiotherapy of bone metastasis. — Takahashi I, Niibe H, Mitsuhashi N, Ikeda H, Imai K, Yamanaka H Advances in experimental medicine and biology (1992)
    79. [79]
      A phase II study of treatment of painful multifocal skeletal metastases with single and repeated dose samarium-153 ethylenediaminetetramethylene phosphonate. — Turner JH, Claringbold PG European journal of cancer (Oxford, England : 1990) (1991)
    80. [80]
      A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of painful bone metastases. — Cole DJ Clinical oncology (Royal College of Radiologists (Great Britain)) (1989)
    81. [81]
      Effect of imidazoquinazolinones on tumor cells in the circulation. — Ambrus JL, Ambrus CM, Gastpar H Journal of medicine (1986)
    82. [82]
      Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. — Blitzer PH Cancer (1985)
    83. [83]
      Solitary metastasis to the medulla oblongata. — Delaney P, Martinez J Southern medical journal (1983)
    84. [84]
      A new finding in bone scintigram 3 cases of defect findings. — Inoue Y RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (1978)
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