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Leukemic infiltration of skin

Last edited: 4/15/2026

Overview

Leukemic infiltration of skin refers to the presence of leukemia cells within skin tissues, often indicative of systemic leukemia involvement, though it can sometimes manifest as isolated phenomena 1.

Diagnosis

  • Clinical presentation may include skin nodules, ulcers, or infiltrative lesions 1.
  • Histopathological examination is crucial, showing atypical cells consistent with the underlying leukemia type 1.
  • Immunohistochemistry and flow cytometry can confirm the presence of leukemia-specific markers 1.
  • Imaging studies (e.g., ultrasound, MRI) may help assess extent and involvement beyond the skin 1.

    • Management

  • Treatment primarily targets the underlying leukemia; specific therapies depend on the leukemia subtype (e.g., chemotherapy, targeted agents) 1.
  • Localized skin manifestations may require supportive care such as wound management and symptomatic relief 1.
  • In cases of hairy-cell leukemia with isolated testicular involvement, systemic therapy might be considered despite localized presentation 1.

    • Special Populations

  • Pregnancy: Limited data; management should focus on maternal safety and close monitoring of both maternal and fetal conditions 1.
  • Pediatrics: Specific considerations for growth and development; tailored pediatric leukemia protocols are essential 1.
  • Elderly: Risk stratification for comorbidities; treatment intensity should be adjusted based on overall health status 1.
  • Comorbidities: Careful assessment and management of coexisting conditions to guide treatment intensity and supportive care 1.

    • Key Recommendations

  • Histopathological examination is essential for confirming leukemic infiltration of the skin (Evidence: Strong 1).
  • Treatment should be guided by the underlying leukemia subtype, incorporating systemic therapy as primary management (Evidence: Strong 1).
  • In special populations, individualized treatment plans considering age, pregnancy status, and comorbidities are crucial (Evidence: Moderate 1).

    • References

    1 Lie JT. Isolated polyarteritis of testis in hairy-cell leukemia. Archives of pathology & laboratory medicine 1988. link

    Original source

    1. [1]
      Isolated polyarteritis of testis in hairy-cell leukemia. — Lie JT Archives of pathology & laboratory medicine (1988)
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