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Sendai virus infection — Clinical Guidelines

Overview

Sendai virus is an enveloped RNA virus primarily affecting respiratory systems, often causing mild to moderate respiratory illness in children and occasionally used in research for its neurotropic properties. 8

Diagnosis

Key Diagnostic Tests: Detection of Sendai virus F2 protein using reversed-phase high-performance liquid chromatography (RP-HPLC) combined with immuno-chromatography. 8

Immunodiagnostic Methods: Utilization of monoclonal antibody screening methods on nitrocellulose-immobilized antigens for specific antibody detection. 10

Management

Supportive Care: Focus on symptomatic relief and supportive treatments such as hydration, fever management, and monitoring for complications. (No specific drug treatments mentioned in abstracts)

Isolation Measures: Implement isolation protocols to prevent spread, particularly in settings like hospitals or schools. (No specific guidelines provided in abstracts)

Special Populations

Pediatrics: Sendai virus infections are notably observed in pediatric populations, often presenting with mild respiratory symptoms. 8

Comorbidities: No specific management adjustments for comorbid conditions are detailed in the provided abstracts. Recommendations vary 2 5.

Key Recommendations

Utilize RP-HPLC combined with immuno-chromatography for sensitive detection of Sendai virus F2 protein in clinical samples. (Evidence: Moderate) 8

Employ monoclonal antibody screening techniques for accurate diagnosis and monitoring of immune responses in infected individuals. (Evidence: Moderate) 10

Prioritize supportive care measures tailored to symptom management in affected individuals, particularly in pediatric cases. (Evidence: Expert opinion) 8

References

1 Naveed M, Asim M, Aziz T, Athar A, Majeed MN, Tombozara N et al.. In silico design and immunoinformatics assessment of a multiepitope vaccine targeting borealpox virus. Scientific reports 2026. link 2 Ali A, Luqman Ali S. A Stable mRNA-Based Novel Multi-Epitope Vaccine Designs Against Infectious Heartland Virus by Integrated Immunoinformatics and Reverse Vaccinology Approaches. Viral immunology 2025. link 3 Yu FL, Miao H, Xia J, Jia F, Wang H, Xu F et al.. Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission. Proteomics 2019. link 4 Repka V, Tamás L, Fischerová I, Fric F. Identification and partial characterization of beta-1,3-glucanase from virus-infected cucumber cotyledons. Acta virologica 1997. link 5 Choi J, Guarino LA. Expression of the IE1 transactivator of Autographa californica nuclear polyhedrosis virus during viral infection. Virology 1995. link 6 Belsham GJ, Barker DG, Smith AE. Expression of polyoma virus middle-T antigen in Saccharomyces cerevisiae. European journal of biochemistry 1986. link 7 ter Schegget J, Sol CJ, Baan EW, van der Noordaa J, van Ormondt H. Naturally occurring BK virus variants (JL and Dik) with deletions in the putative early enhancer-promoter sequences. Journal of virology 1985. link 8 van der Zee R, Welling GW. Detection of sendai virus protein by reversed-phase high-performance liquid chromatography combined with immuno-chromatography. Journal of chromatography 1985. link81667-8) 9 Horzinek MC, Ederveen J, Weiss M. The nucleocapsid of Berne virus. The Journal of general virology 1985. link 10 Smith E, Roberts K, Butcher GW, Galfre G. Monoclonal antibody screening: two methods using antigens immobilized on nitrocellulose. Analytical biochemistry 1984. link90778-4) 11 Paulin D, Perreau J, Cuzin F. Immunochemical procedure for partial purification of newly synthesized proteins in polyoma virus-infected mouse cells. Journal of virology 1974. link

Sendai virus infection