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Metastatic transitional cell carcinoma

Last edited: 4/10/2026

Overview

Metastatic transitional cell carcinoma, also known as urothelial carcinoma, refers to bladder cancer that has spread to distant sites. Management involves a multidisciplinary approach and shared decision-making with patients 1.

Diagnosis

  • Thorough diagnosis is emphasized for muscle-invasive and metastatic bladder cancer (MMIBC) 1.
  • Management

  • Consider susceptible FGFR3 alterations to select patients with unresectable or metastatic urothelial carcinoma for treatment 1.
  • Key Recommendations

  • Emphasize thorough diagnosis, treatment, and follow-up for patients with MMIBC 1. (Evidence: Expert opinion)
  • Stress the importance of a multidisciplinary approach to the treatment of MMIBC patients 1. (Evidence: Expert opinion)
  • Highlight the importance of shared decision-making with patients regarding MMIBC management 1. (Evidence: Expert opinion)
  • References

    1 van der Heijden AG, Bruins HM, Carrion A, Cathomas R, Compérat E, Dimitropoulos K et al.. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines. European urology 2025. link

    Original source

    1. [1]
      European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines.van der Heijden AG, Bruins HM, Carrion A, Cathomas R, Compérat E, Dimitropoulos K et al. European urology (2025)

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