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Lyme uveitis

Last edited: 4/15/2026

Overview

Lyme uveitis is an ocular manifestation of Lyme disease, characterized by inflammation within the uveal tract, often presenting as anterior uveitis with potential complications affecting vision if untreated 1.

Diagnosis

  • Clinical suspicion based on history of tick exposure and characteristic uveitis symptoms 1.
  • Diagnostic confirmation typically involves serological testing for Borrelia burgdorferi antibodies (e.g., ELISA followed by Western blot) 1.
  • Imaging studies such as fluorescein angiography may be used to assess retinal involvement 1.
  • Exclusion of other uveitis causes through comprehensive ocular examination and ancillary testing 1.

    • Management

  • First-line treatment often includes systemic antibiotics targeting Borrelia, such as doxycycline, amoxicillin, or ceftriaxone, depending on severity and patient factors 1.
  • Adjunctive corticosteroid therapy (topical or systemic) may be necessary to control inflammation 1.
  • Close monitoring for treatment response and potential complications is essential 1.

    • Special Populations

  • No specific guidelines provided in the abstracts regarding pregnancy, pediatrics, elderly, or comorbidities 1.

    • Key Recommendations

  • Initiate empirical antibiotic therapy targeting Borrelia upon clinical suspicion of Lyme uveitis (Evidence: Moderate) 1.
  • Incorporate corticosteroid treatment alongside antibiotics to manage intraocular inflammation effectively (Evidence: Moderate) 1.
  • Ensure interdisciplinary communication and referral for comprehensive care, especially in complex cases (Evidence: Expert opinion) 1.

    • References

    1 Kaplan R. An interdisciplinary course for optometry students specializing in vision training. American journal of optometry and physiological optics 1978. link

    Original source

    1. [1]
      An interdisciplinary course for optometry students specializing in vision training. — Kaplan R American journal of optometry and physiological optics (1978)
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