Overview
Hemorrhagic gastropathy refers to a condition characterized by diffuse mucosal hemorrhage within the stomach, often associated with underlying nutritional deficiencies, particularly of fat-soluble vitamins. 1Diagnosis
Elevated levels of PIVKA-II (protein induced in vitamin K absence) in cord blood may indicate increased risk 1.
Low levels of beta-carotene and cryptoxanthin in cord blood can suggest inadequate intake of green-yellow vegetables 1.
Assessment of fat-soluble vitamins (A, D, E, K) in cord blood and colostrum can provide diagnostic clues 1.Management
Supplementation with fat-soluble vitamins, particularly vitamin K and vitamin A, may be necessary to correct deficiencies 1.
Dietary counseling to increase intake of green-yellow vegetables rich in beta-carotene and other essential nutrients is recommended 1.Special Populations
Newborns from populations with restricted intake of green-yellow vegetables may have an increased risk of hemorrhagic disease 1.Key Recommendations
Monitor and supplement fat-soluble vitamins, especially vitamin K and vitamin A, in newborns from populations with documented deficiencies 1 (Evidence: Moderate).
Encourage dietary intake of green-yellow vegetables to prevent micronutrient deficiencies associated with hemorrhagic gastropathy 1 (Evidence: Moderate).
Evaluate PIVKA-II levels in cord blood to identify newborns at risk for hemorrhagic conditions due to vitamin K deficiency 1 (Evidence: Weak).References
1 Tamai H, Mingci Z, Kawamura N, Kuno T, Ogihara T, Mino M. Fat-soluble vitamins in cord blood and colostrum in the south of China. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 1996. link