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Papillary hyperplasia of palate

Last edited: 4/22/2026

Overview

Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson's tumor, is a rare benign lesion characterized by excessive proliferation of endothelial cells within blood vessels, often following a thrombotic event 12.

Diagnosis

  • Histological Confirmation: Essential for definitive diagnosis, showing papillary structures composed of endothelial cells with a connective core 12.
  • Imaging: MRI and Doppler ultrasound may show heterogeneous signal intensities and masses, aiding in clinical suspicion but not definitive diagnosis 3.
  • Differential Diagnosis: Includes hematoma, lymphangioma, hemangioma, and angiosarcoma 2.

    • Management

  • Surgical Resection: Recommended for symptomatic lesions or parental concern, aiming for complete removal to prevent recurrence 2.
  • Follow-Up: Necessary for monitoring residual lesions, as incomplete resection can lead to persistent symptoms 2.

    • Special Populations

  • Pediatrics: IPEH can occur in children, presenting as painful subcutaneous masses; surgical intervention is often required 2.

    • Key Recommendations

  • Histological Examination is Crucial for Diagnosis (Evidence: Strong 12).
  • Surgical Excision Should Be Considered for Symptomatic Lesions (Evidence: Moderate 2).
  • Post-Surgical Follow-Up is Essential to Monitor for Residual Disease (Evidence: Expert opinion 2).

    • References

    1 Díaz-Flores L, Gutiérrez R, González-Gómez M, García MP, Carrasco JL, Díaz-Flores L et al.. Myriad pillars formed by intussusceptive angiogenesis as the basis of intravascular papillary endothelial hyperplasia (IPEH). IPEH is intussusceptive angiogenesis made a lesion. Histology and histopathology 2021. link 2 Liné A, Sanchez J, Jayyosi L, Birembaut P, Ohl X, Poli-Mérol ML et al.. Papillary endothelial hyperplasia (Masson's tumor) in children. Annales de chirurgie plastique et esthetique 2017. link 3 Kitagawa Y, Tamai K, Kim Y, Hayashi M, Makino A, Takai S. Intravascular papillary endothelial hyperplasia of the digit: MRI features with histological correlation. The Journal of hand surgery, European volume 2013. link

    Original source

    1. [1]
      Myriad pillars formed by intussusceptive angiogenesis as the basis of intravascular papillary endothelial hyperplasia (IPEH). IPEH is intussusceptive angiogenesis made a lesion. — Díaz-Flores L, Gutiérrez R, González-Gómez M, García MP, Carrasco JL, Díaz-Flores L et al. Histology and histopathology (2021)
    2. [2]
      Papillary endothelial hyperplasia (Masson's tumor) in children. — Liné A, Sanchez J, Jayyosi L, Birembaut P, Ohl X, Poli-Mérol ML et al. Annales de chirurgie plastique et esthetique (2017)
    3. [3]
      Intravascular papillary endothelial hyperplasia of the digit: MRI features with histological correlation. — Kitagawa Y, Tamai K, Kim Y, Hayashi M, Makino A, Takai S The Journal of hand surgery, European volume (2013)
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