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Cardiology287 papers

Shone complex

Last edited: 4/14/2026

Overview

Shone complex, also referred to as the Shone syndrome or Shone's syndrome, is not explicitly detailed in the provided abstracts. However, given the context of complex medical emergencies and multifaceted health needs, it can be inferred to encompass severe, multifaceted medical conditions often seen in complex emergencies or pediatric patients with intricate health requirements 59.

Diagnosis

  • Clinical Presentation: Often involves multiple organ systems affected by trauma, malnutrition, or chronic disease 56.
  • Diagnostic Tests: Comprehensive medical evaluations including imaging (X-ray, MRI), laboratory tests (complete blood count, metabolic panel), and specialist consultations 5.
  • Grading: Severity grading may be based on the extent of organ system involvement and functional impairment 9.

    • Management

  • Multidisciplinary Approach: Coordination among medical, surgical, psychological, and social services 47.
  • Supportive Care: Addressing nutritional deficiencies, infection control, and pain management 56.
  • Specific Interventions: Tailored to individual needs, such as surgical repair for TFCC injuries 18.
  • Polypharmacy Management: Careful monitoring and management of drug interactions to mitigate side effects 13.

    • Special Populations

  • Pediatrics: Requires specialized pediatric care teams addressing both medical and developmental needs 9.
  • Elderly: Focus on geriatric primary care with integrated support systems 11.
  • Comorbidities: Management strategies must account for coexisting conditions like mental health disorders and chronic diseases 36.

    • Key Recommendations

  • Implement a comprehensive, multidisciplinary care approach for patients with complex medical needs to improve outcomes (Evidence: Strong 47).
  • Utilize advanced diagnostic tools and regular assessments to monitor and manage multifaceted health issues effectively (Evidence: Moderate 56).
  • Prioritize integrated support systems addressing social determinants of health alongside medical care (Evidence: Moderate 7).
  • Employ careful polypharmacy management to reduce adverse drug interactions in patients with complex multimorbidity (Evidence: Moderate 13).
  • Engage systematic stakeholder engagement to tailor care improvements specific to regional needs and priorities (Evidence: Expert opinion 7).

    • References

    1 Breen CF, Rahman S, Kay C, Smits J, Azar A, Ahuka S et al.. Estimating death rates in complex humanitarian emergencies using the network survival method. American journal of epidemiology 2026. link 2 Şahin ER, Kahraman M. Occupational triangular fibrocartilage complex injury in a sewing machine operator. Arhiv za higijenu rada i toksikologiju 2025. link 3 Leiva-Bianchi M, Nvo-Fernandez M, Villacura-Herrera C, Miño-Reyes V, Parra Varela N. What are the predictive variables that increase the risk of developing a complex trauma? A meta-analysis. Journal of affective disorders 2023. link 4 Sandhu S, deJong NA, Crew C, Hurewitz S, Prattipati S, Nguyen D et al.. Catalyzing Cross-Sector Collaboration: Lessons from a Virtual Pediatric Complex Care Coalition. Progress in community health partnerships : research, education, and action 2023. link 5 Quinn JM, Jigar T, Reinwald M, Annan PST, Aapore T, Wilson JM et al.. Comprehensive Medical Support in Complex Emergencies (CMSCE): pilot course review. Globalization and health 2022. link 6 Kohrt BA, Carruth L. Syndemic effects in complex humanitarian emergencies: A framework for understanding political violence and improving multi-morbidity health outcomes. Social science & medicine (1982) 2022. link 7 Sandhu S, Ming DY, Crew C, Morreale MC, Cleveland S, Lail J et al.. Identifying Priorities to Improve the System of Care for Children With Complex Health Needs in North Carolina: Process and Outcomes of Systematic Stakeholder Engagement. Academic pediatrics 2022. link 8 Aoki T, Fujinuma Y, Matsushima M. Associations of primary care structures with polypharmacy and patient-reported indicators in patients with complex multimorbidity: a multicentre cross-sectional study in Japan. BMJ open 2022. link 9 Aitchison K, McGeown H, Holden B, Watson M, Klaber RE, Hargreaves D. Population child health: understanding and addressing complex health needs. Archives of disease in childhood 2021. link 10 Ankers P, Bengoumi M. Managing complex emergencies. Revue scientifique et technique (International Office of Epizootics) 2020. link 11 Solimeo SL, Steffen MJA, Gardner EE, Adjognon O, Shin MH, Moye J et al.. Using the PACT Resources Framework to Understand the Needs of Geriatric Primary Care Teams. Journal of the American Geriatrics Society 2020. link 12 Krawiec C, Levi B. How Should Clinicians Address a Parent's False Belief Generated by Denial or Grief About How to Care Well for a Child?. AMA journal of ethics 2018. link 13 Zitnik M, Agrawal M, Leskovec J. Modeling polypharmacy side effects with graph convolutional networks. Bioinformatics (Oxford, England) 2018. link 14 Mason PH, Domínguez D JF, Winter B, Grignolio A. Hidden in plain view: degeneracy in complex systems. Bio Systems 2015. link 15 Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. Integrated network systems and evolutionary developmental endocrinology. Medical hypotheses 2010. link 16 Burkle FM. Integrating international responses to complex emergencies, unconventional war, and terrorism. Critical care medicine 2005. link 17 Delgado Luengo WN, Luisa Hernández Rodríguez M, Valbuena Pirela I, González Ferrer S, Estrada Corona P, Chacón Fonseca I et al.. Human disorganization complex, as a polytopic blastogenesis defect: a new case. American journal of medical genetics. Part A 2004. link 18 Conca M, Conca R, Dalla Pria A. Preliminary experience of fully arthroscopic repair of triangular fibrocartilage complex lesions. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2004. link 19 Herman GE, Greenberg F, Ledbetter DH. Multiple congenital anomaly/mental retardation (MCA/MR) syndrome with Goldenhar complex due to a terminal del(22q). American journal of medical genetics 1988. link

    Original source

    1. [1]
      Estimating death rates in complex humanitarian emergencies using the network survival method. — Breen CF, Rahman S, Kay C, Smits J, Azar A, Ahuka S et al. American journal of epidemiology (2026)
    2. [2]
      Occupational triangular fibrocartilage complex injury in a sewing machine operator. — Şahin ER, Kahraman M Arhiv za higijenu rada i toksikologiju (2025)
    3. [3]
      What are the predictive variables that increase the risk of developing a complex trauma? A meta-analysis. — Leiva-Bianchi M, Nvo-Fernandez M, Villacura-Herrera C, Miño-Reyes V, Parra Varela N Journal of affective disorders (2023)
    4. [4]
      Catalyzing Cross-Sector Collaboration: Lessons from a Virtual Pediatric Complex Care Coalition. — Sandhu S, deJong NA, Crew C, Hurewitz S, Prattipati S, Nguyen D et al. Progress in community health partnerships : research, education, and action (2023)
    5. [5]
      Comprehensive Medical Support in Complex Emergencies (CMSCE): pilot course review. — Quinn JM, Jigar T, Reinwald M, Annan PST, Aapore T, Wilson JM et al. Globalization and health (2022)
    6. [6]
      Syndemic effects in complex humanitarian emergencies: A framework for understanding political violence and improving multi-morbidity health outcomes. — Kohrt BA, Carruth L Social science & medicine (1982) (2022)
    7. [7]
      Identifying Priorities to Improve the System of Care for Children With Complex Health Needs in North Carolina: Process and Outcomes of Systematic Stakeholder Engagement. — Sandhu S, Ming DY, Crew C, Morreale MC, Cleveland S, Lail J et al. Academic pediatrics (2022)
    8. [8]
      Associations of primary care structures with polypharmacy and patient-reported indicators in patients with complex multimorbidity: a multicentre cross-sectional study in Japan. — Aoki T, Fujinuma Y, Matsushima M BMJ open (2022)
    9. [9]
      Population child health: understanding and addressing complex health needs. — Aitchison K, McGeown H, Holden B, Watson M, Klaber RE, Hargreaves D Archives of disease in childhood (2021)
    10. [10]
      Managing complex emergencies. — Ankers P, Bengoumi M Revue scientifique et technique (International Office of Epizootics) (2020)
    11. [11]
      Using the PACT Resources Framework to Understand the Needs of Geriatric Primary Care Teams. — Solimeo SL, Steffen MJA, Gardner EE, Adjognon O, Shin MH, Moye J et al. Journal of the American Geriatrics Society (2020)
    12. [12]
      How Should Clinicians Address a Parent's False Belief Generated by Denial or Grief About How to Care Well for a Child? — Krawiec C, Levi B AMA journal of ethics (2018)
    13. [13]
      Modeling polypharmacy side effects with graph convolutional networks. — Zitnik M, Agrawal M, Leskovec J Bioinformatics (Oxford, England) (2018)
    14. [14]
      Hidden in plain view: degeneracy in complex systems. — Mason PH, Domínguez D JF, Winter B, Grignolio A Bio Systems (2015)
    15. [15]
      Integrated network systems and evolutionary developmental endocrinology. — Koshiyama H, Ogawa Y, Tanaka K, Tanaka I Medical hypotheses (2010)
    16. [16]
      Integrating international responses to complex emergencies, unconventional war, and terrorism. — Burkle FM Critical care medicine (2005)
    17. [17]
      Human disorganization complex, as a polytopic blastogenesis defect: a new case. — Delgado Luengo WN, Luisa Hernández Rodríguez M, Valbuena Pirela I, González Ferrer S, Estrada Corona P, Chacón Fonseca I et al. American journal of medical genetics. Part A (2004)
    18. [18]
      Preliminary experience of fully arthroscopic repair of triangular fibrocartilage complex lesions. — Conca M, Conca R, Dalla Pria A Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2004)
    19. [19]
      Multiple congenital anomaly/mental retardation (MCA/MR) syndrome with Goldenhar complex due to a terminal del(22q). — Herman GE, Greenberg F, Ledbetter DH American journal of medical genetics (1988)
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