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Cardiology2655 papers

Chronic lung disease

Last edited: 4/23/2026

Overview

Chronic lung disease encompasses a range of conditions characterized by persistent airflow obstruction and lung tissue damage, impacting respiratory function and quality of life. These conditions often require multifaceted management strategies including pharmacological interventions, interventional procedures, and supportive care.

Diagnosis

  • Clinical Evaluation: History and physical examination to assess symptoms and severity 15.
  • Pulmonary Function Tests (PFTs): Essential for diagnosing airflow obstruction and assessing lung function 515.
  • Imaging Studies: Chest X-rays, CT scans to evaluate structural lung changes 421.
  • Bronchoscopy: Useful for diagnostic sampling and assessing airway pathology 1028.
  • Cardiopulmonary Exercise Testing (CPET): Provides insights into functional capacity and physiological responses 21.
  • Lung Ultrasound: Emerging tool for assessing pleural effusions and lung aeration 1932.
  • Management

  • Pharmacotherapy:
  • - Bronchodilators: Short-acting (e.g., albuterol) and long-acting (e.g., tiotropium) for symptom relief 16. - Inhaled Corticosteroids: Reduce airway inflammation (e.g., fluticasone) 16. - Phosphodiesterase-4 Inhibitors: For severe COPD (e.g., roflumilast) 16.
  • Oxygen Therapy: To maintain adequate oxygen saturation 16.
  • Interventional Procedures:
  • - Bronchoscopic Interventions: Including stent placement, airway clearance techniques 828. - Lung Volume Reduction Surgery (LVRS): For selected patients with severe emphysema 28.
  • Pulmonary Rehabilitation: Exercise training, education, and behavioral changes to improve quality of life 16.
  • Management of Comorbidities: Addressing cardiovascular, metabolic, and other related conditions 14.
  • Special Populations

  • Pediatrics: Early intervention crucial; CPET useful for monitoring lung function 21.
  • Elderly: Consider sedation risks; local anesthesia may be safer 77.
  • Comorbidities: Advanced cardiovascular-kidney-metabolic syndrome increases risk of CLD progression 14.
  • Pregnancy: Limited data; careful monitoring of respiratory status and interventions 516.
  • Key Recommendations

  • Utilize Pulmonary Function Tests (PFTs) for Diagnosis and Monitoring: Regular PFTs are essential for assessing disease progression and treatment efficacy (Evidence: Strong 5).
  • Implement Pulmonary Rehabilitation Programs: Multidisciplinary programs improve functional capacity and quality of life (Evidence: Moderate 16).
  • Consider Bronchoscopic Interventions for Selected Patients: For those with severe airway obstruction or complications, bronchoscopic procedures can be beneficial (Evidence: Moderate 828).
  • Manage Comorbid Conditions Aggressively: Addressing comorbidities like cardiovascular disease can mitigate CLD progression (Evidence: Moderate 14).
  • Use Local Anesthesia in Elderly Patients for Bronchoscopy: To minimize risks associated with sedation (Evidence: Expert opinion 77).
  • References

    Showing 100 most recent of 388 indexed papers.

    1 Ntiamoah P, Shirakawa T, Mehta AC. History of bronchoscopy: from inception to the modern era of interventional pulmonology. Current opinion in pulmonary medicine 2026. link 2 Calandri M, Crocetti L, Ronot M, Rosiak G, Tselikas L, Mosconi C. From Blue Ocean Strategy to Mare Nostrum Tactics: The Challenges of Interventional Radiology in the Thoracic Arena. Cardiovascular and interventional radiology 2026. link 3 Verma HK, Morrone C, Rehm SR, Jeridi A, Smirnova NF, Doryab A et al.. Cystatin C prevents tissue injury after lung transplantation. Life science alliance 2026. link 4 Singh A, Alcali O, Hunsaker AR, Hammer MM. Quantitative and qualitative imaging in marijuana users and smokers. Current problems in diagnostic radiology 2026. link 5 Jenkinson A, Harris C, Bafadhel M, Razavi R, Dassios T, Greenough A. Longitudinal changes in cardiopulmonary outcomes of adults born extremely prematurely: United Kingdom Oscillation Study. Pediatric research 2026. link 6 Kiely DG, Wort SJ, Funes D, Fernandez Delgado M, Petrica N, Proenca C et al.. Incidence and prevalence of pulmonary hypertension in chronic lung disease: insights from a retrospective cohort study using a UK nationwide health database. BMJ open 2026. link 7 Lang JE, Hill KD. Chronic Lung Disease-Related Pulmonary Hypertension in Children. Acta paediatrica (Oslo, Norway : 1992) 2026. link 8 Anca D, Shostak E, Fessler J. Interventional pulmonology: anesthetic management and beyond. Current opinion in anaesthesiology 2025. link 9 Aravena C, Mehta AC. Rigid versus flexible bronchoscopy in interventional pulmonology: perspective from the master clinicians. Current opinion in pulmonary medicine 2025. link 10 Gerretsen ECF, Groenier M, Annema JT, van der Heijden EHFM, van Mook WNKA, Aldenkamp AF et al.. Basic Bronchoscopy Competence Achieved by a Nationwide One-day Simulation-based Training. Journal of bronchology & interventional pulmonology 2025. link 11 Hostetter LJ, Nelson DR. Competency-based medical education in interventional pulmonology: current state and future opportunities. Current opinion in pulmonary medicine 2025. link 12 Kanbayashi Y, Kaneko Y, Kobayashi M, Wakabayashi H, Shimizu T, Uchida M. Evaluation of Lung Adverse Events Associated With Lenvatinib: A Post-marketing Surveillance Study. In vivo (Athens, Greece) 2025. link 13 Miyashita Y, Kaiho T, Kurihara C. Unveiling the potential of lung transplantation for situs inversus. Expert review of respiratory medicine 2025. link 14 Yang B, Zhang H, Zhang X, Wang F, Tong Z. Association of advanced stages of Cardiovascular-kidney-metabolic syndrome with the risk of developing chronic lung disease: evidence from a nationwide prospective cohort study. Heart & lung : the journal of critical care 2025. link 15 Ishiwata T, Yasufuku K. Artificial intelligence in interventional pulmonology. Current opinion in pulmonary medicine 2024. link 16 Granados L, John M, Edelman JD. New Therapies in Outpatient Pulmonary Medicine. The Medical clinics of North America 2024. link 17 Sikachi RR, Mishra KL, Anders M. Anesthetic considerations in interventional pulmonology. Current opinion in pulmonary medicine 2024. link 18 Pottash M, Suguness A, Joseph L, Cuneo B, Woods C. Practicing Serious Illness Conversations in a Pulmonary Medicine Teaching Clinic. The American journal of hospice & palliative care 2024. link 19 Silva BS, Ferraz B, Costa MI, Brandão ME, Cortesão N. The Influence of Thoracic Ultrasound on the Clinical Practice of Pulmonologists in Portugal. Journal of bronchology & interventional pulmonology 2024. link 20 Guedes F, Ferreira AJ, Dionísio J, Rodrigues LV, Bugalho A. Pre- and post-COVID practice of interventional pulmonology in adults in Portugal. Pulmonology 2024. link 21 Takken T, Hulzebos EH. Practical Aspects of Cardiopulmonary Exercise Testing in Children. International journal of sports medicine 2024. link 22 Beaulieu J, Vu C, Kalra S, Ouazani Chahdi H, Cousineau J, Matteau A et al.. Right Ventricular Assist Device With an Oxygenator for the Management of Combined Right Ventricular and Respiratory Failure: A Systematic Review. The Canadian journal of cardiology 2024. link 23 DeBolt CL, Rheuban KS, Harris D. Telehealth Services: Improving Equity in Pulmonary Health Outcomes. Clinics in chest medicine 2023. link 24 Wahidi MM, Lamb CR, Kovitz K, Keyes C, Bechara R, Giovacchini CX et al.. Interventional Pulmonology Productivity, Compensation, and Practice Benchmarks: The AABIP 2022 Report. Journal of bronchology & interventional pulmonology 2023. link 25 Mondoni M, Rinaldo RF, Solidoro P, Di Marco F, Patrucco F, Pavesi S et al.. Interventional pulmonology techniques in lung transplantation. Respiratory medicine 2023. link 26 Nguyen ET, Bayanati H, Hurrell C, Aitken M, Cheung EM, Gupta A et al.. Canadian Association of Radiologists/Canadian Association for Interventional Radiology/Canadian Society of Thoracic Radiology Guidelines on Thoracic Interventions. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 2023. link 27 Jain S, Witt LJ, Ferrante LE. Clin-STAR corner: Recent practice-changing studies at the interface of pulmonary and critical care medicine and geriatrics. Journal of the American Geriatrics Society 2023. link 28 Zhang M, Ge MJ. Lingular division of the left lung: Only superior and inferior bronchi?. Clinical anatomy (New York, N.Y.) 2023. link 29 Chan EG, Hyzny EJ, Furukawa M, Ryan JP, Subramaniam K, Morrell MR et al.. Intraoperative Support for Primary Bilateral Lung Transplantation: A Propensity-Matched Analysis. The Annals of thoracic surgery 2023. link 30 Baciu C, Shin J, Hsin M, Cypel M, Keshavjee S, Liu M. Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation. Thorax 2023. link 31 Jiao G, Ye S, Zhang J, Wu B, Wei D, Liu D et al.. Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years. Frontiers of medicine 2023. link 32 Parri N, Allinovi M, Giacalone M, Corsini I. To B or not to B. The rationale for quantifying B-lines in pediatric lung diseases. Pediatric pulmonology 2023. link 33 . Radiation Exposure Primes Neutrophil-Mediated Metastasis to the Lung. Cancer discovery 2022. link 34 Semmelmann A, Loop T. Anesthesia for interventional pulmonology. Current opinion in anaesthesiology 2022. link 35 Neelakantan S, Xin Y, Gaver DP, Cereda M, Rizi R, Smith BJ et al.. Computational lung modelling in respiratory medicine. Journal of the Royal Society, Interface 2022. link 36 Sirohiya P, Kumar V, Mittal S, Gupta N, Garg R, Bharati SJ et al.. Dexmedetomidine Versus Midazolam for Sedation During Medical Thoracoscopy: A Pilot Randomized-Controlled Trial (RCT). Journal of bronchology & interventional pulmonology 2022. link 37 Bast A, Drent M. Altered pharmacology and toxicology during ageing: implications for lung disease. Current opinion in pulmonary medicine 2022. link 38 Prasad KN, Bondy SC. Electronic cigarette aerosol increases the risk of organ dysfunction by enhancing oxidative stress and inflammation. Drug and chemical toxicology 2022. link 39 Seaton A, Cherrie JW, Cowie H, Aitken RJ. Science With Purpose: 50 Years of the Institute of Occupational Medicine. Frontiers in public health 2022. link 40 Aggarwal R, Jackson S, Lemke NT, Shumway SJ, Kelly RF, Hertz M et al.. Lung Transplant Recipients With Prior Coronary Artery Bypass Grafting Are at Increased Risk of Death and Early Perioperative Hemorrhage. Seminars in thoracic and cardiovascular surgery 2022. link 41 Iablonskii P, Carlens J, Mueller C, Aburahma K, Niehaus A, Boethig D et al.. Indications and outcome after lung transplantation in children under 12 years of age: A 16-year single center experience. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022. link 42 Cerdán de Las Heras J, Tulppo M, Kiviniemi AM, Hilberg O, Løkke A, Ekholm S et al.. Augmented reality glasses as a new tele-rehabilitation tool for home use: patients' perception and expectations. Disability and rehabilitation. Assistive technology 2022. link 43 Ahmad K, Khangoora V, Nathan SD. Lung Disease-Related Pulmonary Hypertension. Cardiology clinics 2022. link 44 Ruan R, Deng X, Dong X, Wang Q, Lv X, Si C. Microbiota Emergencies in the Diagnosis of Lung Diseases: A Meta-Analysis. Frontiers in cellular and infection microbiology 2021. link 45 Lee HJ, Corbetta L. Training in interventional pulmonology: the European and US perspective. European respiratory review : an official journal of the European Respiratory Society 2021. link 46 Herkenrath SD, Dreher M, Gompelmann D, Held M, Koczulla AR, Köhnlein T et al.. Technical Innovations in Pneumology: E-Health, Screening, Diagnostics, and Therapy. Respiration; international review of thoracic diseases 2021. link 47 Green DB, Groner LK, Lee JJ, Shin J, Broncano J, Vargas D et al.. Overview of Interventional Pulmonology for Radiologists. Radiographics : a review publication of the Radiological Society of North America, Inc 2021. link 48 Agrawal A. Interventional Pulmonology: Diagnostic and Therapeutic Advances in Bronchoscopy. American journal of therapeutics 2021. link 49 Nayir Buyuksahin H, Emiralioglu N, Ademhan Tural D, Ozsezen B, Sunman B, Guzelkas I et al.. Impact of COVID-19 on pediatric pulmonology healthcare practice. Pediatric pulmonology 2021. link 50 Qaqish R, Watanabe Y, Hoetzenecker K, Yeung J, Chen M, Pierre A et al.. Impact of donor time to cardiac arrest in lung donation after circulatory death. The Journal of thoracic and cardiovascular surgery 2021. link 51 Huckaby LV, Aranda-Michel E, Sultan I, Chu D, Chen S, Thoma F et al.. Outcomes in Patients With Severe Chronic Lung Disease Undergoing Index Cardiac Operations. The Annals of thoracic surgery 2021. link 52 Okahara S, Levvey B, McDonald M, D'Costa R, Opdam H, Pilcher DV et al.. Common Criteria for Ex Vivo Lung Perfusion Have No Significant Impact on Posttransplant Outcomes. The Annals of thoracic surgery 2021. link 53 Baczynski M, Kelly E, McNamara PJ, Shah PS, Jain A. Short and long-term outcomes of chronic pulmonary hypertension in preterm infants managed using a standardized algorithm. Pediatric pulmonology 2021. link 54 Oliveira EP, Medeiros Junior P. Palliative care in pulmonary medicine. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2020. link 55 Mahajan AK, Bautista J, Hodson E, Khandhar SJ, Folch E, Carroll S et al.. Financial Justification for Interventional Pulmonology Programs: Terminology and Programmatic Models. Chest 2020. link 56 Nakajima D, Ohsumi A, Hamaji M, Chen-Yoshikawa TF, Date H. Expanded indications for auto-lung transplant technique. General thoracic and cardiovascular surgery 2020. link 57 Noda N, Hara M, Ise S, Ose M, Tatsuta M, Nagaoka A et al.. Comfort and safety of bronchoscopy performed under sedation and local anesthesia in elderly patients. Medicine 2020. link 58 Hoetzenecker K, Benazzo A, Stork T, Sinn K, Schwarz S, Schweiger T et al.. Bilateral lung transplantation on intraoperative extracorporeal membrane oxygenator: An observational study. The Journal of thoracic and cardiovascular surgery 2020. link 59 Schiopu SRI, Zacherl M, Todica A, Bartenstein P, Milger K, Leuschner G et al.. Feasibility and accuracy of SPECT myocardial perfusion imaging in end-stage lung disease. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2020. link 60 Reck Dos Santos P, Yeung J, Andrade B, Reeb J, Wada H, Keshavjee S et al.. Bilateral Lobar Transplants Using One Donor for Two Small-Sized Recipients. The Annals of thoracic surgery 2020. link 61 Ten VS, Ratner V. Mitochondrial bioenergetics and pulmonary dysfunction: Current progress and future directions. Paediatric respiratory reviews 2020. link 62 Axtell AL, Moonsamy P, Melnitchouk S, Tolis G, D'Alessandro DA, Villavicencio MA. Increasing donor sequence number is not associated with inferior outcomes in lung transplantation. Journal of cardiac surgery 2020. link 63 Fazekas L, Ghimessy Á, Gieszer B, Radeczky P, Mészáros L, Török K et al.. Lung Transplantation in Hungary From Cardiac Surgeons' Perspective. Transplantation proceedings 2019. link 64 Corbetta L, Arru LB, Mereu C, Pasini V, Patelli M. Competence and training in interventional pulmonology. Panminerva medica 2019. link 65 Rabin R, Hirsch Y, Johansson MM, Ekstein J, Zeevi DA, Keena B et al.. Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases. American journal of medical genetics. Part A 2019. link 66 Ninan N, Wahidi MM. Basic Bronchoscopy: Technology, Techniques, and Professional Fees. Chest 2019. link 67 Horinouchi H, Asano F, Okubo K, Okada Y, Ohsaki Y, Komase Y et al.. Current status of diagnostic and therapeutic bronchoscopy in Japan: 2016 national survey of bronchoscopy. Respiratory investigation 2019. link 68 Pepedil-Tanrikulu F, Sen N, Buyukkurt N, Sariturk C, Kozanoglu I. 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    Original source

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