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Infectious Disease16 papers

Ethionamide resistant tuberculosis

Last edited: 4/10/2026

Overview

Ethionamide resistance is a form of multidrug-resistant tuberculosis (MDR-TB) that complicates treatment regimens. The World Health Organization (WHO) End TB Strategy emphasizes universal access to drug susceptibility testing (DST) to guide treatment decisions 1.

Diagnosis

Xpert MTB/XDR is a rapid nucleic acid amplification test that can detect Mycobacterium tuberculosis* and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin in pulmonary tuberculosis specimens 1.
  • The test is suitable for use in peripheral and intermediate-level laboratories 1.
  • Management

  • No specific management strategies for ethionamide-resistant tuberculosis are detailed in the provided abstracts.
  • Key Recommendations

  • Utilize Xpert MTB/XDR for the detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin 1. (Evidence: Moderate)
  • Ensure universal access to drug susceptibility testing (DST) as part of the WHO End TB Strategy 1. (Evidence: Expert opinion)
  • References

    1 Pillay S, Steingart KR, Davies GR, Chaplin M, De Vos M, Schumacher SG et al.. Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin. The Cochrane database of systematic reviews 2022. link

    Original source

    1. [1]
      Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin.Pillay S, Steingart KR, Davies GR, Chaplin M, De Vos M, Schumacher SG et al. The Cochrane database of systematic reviews (2022)

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