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Cardiology5407 papers

Myocardial ischemia

Last edited: 4/23/2026

Overview

Myocardial ischemia occurs when there is insufficient blood flow to meet the heart muscle's oxygen demands, often leading to cellular damage during reperfusion. This condition is a critical component in acute coronary syndromes and can result in significant morbidity and mortality 1 5 25.

Diagnosis

Clinical Symptoms: Chest pain, shortness of breath, fatigue 1 25.

Electrocardiogram (ECG): ST-segment changes, T-wave inversions, arrhythmias 3 33.

Imaging: Echocardiography for wall motion abnormalities, nuclear imaging for perfusion defects 3 36.

Invasive Coronary Angiography: To identify obstructive coronary artery disease 40.

Non-invasive Biomarkers: Elevated troponin levels, metabolomic profiling for lipid biomarkers 8 19.

Management

Reperfusion Therapy: Primary percutaneous coronary intervention (PCI) or thrombolysis 1 25.

Pharmacological Interventions:

- Dapagliflozin: Modulates EGFR signaling and NCOA4-mediated ferritinophagy 6. - Dexmedetomidine: Preconditioning to reduce arrhythmias 12. - Apelin-13: Modulates macrophage polarization 2. - Carnosic Acid: Protects against mitochondrial dysfunction and ferroptosis via Mfn2 24.

Novel Therapeutics:

- MK-3903: Alleviates injury via AMKP-PGC-1α signaling 10. - Platycodin D: Suppresses aberrant mitophagy 33. - Cannabidiol: Activates SIRT-1/PGC-1α and modulates NF-κB 56.

Special Populations

Elderly: Increased risk of complications; careful monitoring of reperfusion strategies 25.

Comorbidities: Hyperuricemia exacerbates injury via ferroptosis mechanisms; consider urate-lowering therapies 1.

Pregnancy: Diagnostic challenges; tailored imaging and non-invasive biomarkers crucial 36.

Key Recommendations

Initiate Prompt Reperfusion Therapy: Primary PCI or thrombolysis to restore blood flow 1 25 (Evidence: Strong).

Consider Novel Pharmacological Agents: Use of dapagliflozin for its multifaceted protective effects 6 (Evidence: Moderate).

Monitor and Manage Comorbidities: Address hyperuricemia to mitigate exacerbation of ischemic injury 1 (Evidence: Moderate).

Utilize Advanced Diagnostic Tools: Incorporate metabolomic profiling and advanced imaging for early detection 8 36 (Evidence: Moderate).

Evaluate for Non-Obstructive Causes: In patients with suspected ischemia but non-obstructive coronary arteries, consider registries like ESP-INOCA for prognostic stratification 66 (Evidence: Expert opinion).

References

Showing 100 most recent of 3551 indexed papers.

1 Zhang M, Zhao Y, Wang X, Yuan Q, Jin H, Tan H et al.. Hyperuricemia exacerbates myocardial ischemia-reperfusion injury by inducing ferroptosis via NCOA4 and xCT-GPX4 axis dysregulation. European journal of pharmacology 2026. link 2 Jia H, Zhao Q, Yuan J, Wang X, Chen H, Dong J et al.. Apelin-13 ameliorates myocardial ischemia/reperfusion injury by modulating macrophage polarization. Archives of biochemistry and biophysics 2026. link 3 Ge T, Zou R, Bo J, Yang L, Hu J, Ning B et al.. Machine learning prediction of myocardial ischaemia‒reperfusion injury: Clinical features and Qishen Yiqi dripping pills mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 4 Yang S, Pu J, Yu J, Wang H, Wu Y, Lu Y et al.. TRPV4 inhibition suppresses myocardial ischemia-reperfusion arrhythmia of mice by alleviating calcium handling abnormalities. Heart rhythm 2026. link 5 Gao W, Zhang D, Zhang B, Sun P, Cao Y, Yang S et al.. p38MAPK protects against myocardial ischemia-reperfusion injury by regulating GLUT4 expression and translocation through MEF2A/MEF2C in isolated rat heart. Life sciences 2026. link 6 Yu P, Ling J, Chen F, Xu Z, Hu K, Liu F et al.. Dapagliflozin ameliorates myocardial ischemia/reperfusion injury by modulating EGFR signaling and targeting NCOA4-mediated ferritinophagy. Life sciences 2026. link 7 Qi L, Yi J, Shen Y, Jiang H, Yao X, Chen B et al.. The myocardial ischemic cascade network and multi-target synergistic interventions: From molecular mechanisms to therapeutic innovations. Biochemical pharmacology 2026. link 8 Han HJ, Gwon MR, Lee JH, Park JS, Lee HW, Yoon YR et al.. Plasma metabolomic profiling reveals lipid biomarkers for early detection of exercise-induced myocardial ischemia. Medicine 2026. link 9 Dong Z, Deng Q, Xue Z, Zhou H, Bai J, Bai J et al.. Study on the Pharmacodynamic Substances and Mechanism of Danshen-Honghua Herb Pair (DHHP) Against Myocardial Ischemia Based on the Gut Microbiota Metabolism. Chemistry & biodiversity 2026. link 10 Li PB, Gao J, Li HH, Jiang WX. MK-3903 alleviates myocardial ischemia/reperfusion injury and mitochondrial dysfunction associated with AMKP-PGC-1α signaling. Biochemical and biophysical research communications 2026. link 11 Sun L, Shi S, Wang W, Zhang Y. CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis. The American journal of the medical sciences 2026. link 12 Zhu K, Cheng H, Jia W, Xu X, Wang H. Dexmedetomidine preconditioning attenuates myocardial ischemia/reperfusion-induced arrhythmia in rats by inhibiting K. European journal of pharmacology 2026. link 13 Yang JR, Tan FQ, Cheng CJ, Zhang MW, Yu JG. Sinomenine ameliorates myocardial ischemia/reperfusion injury by inhibiting mitochondrial oxidative stress-mediated PANoptosis and ferroptosis via α7nAChR. Life sciences 2026. link 14 Xu Y, Wu S, Zhang L, Zhang M, Jiang Y. Cell death forms in myocardial ischemia-reperfusion injury and their potential clinical applications. Molecular and cellular biochemistry 2026. link 15 Zhou H, Zhou H, Li C, Fatima S, Qiao L, Lu D et al.. 3'-Methoxypuerarin Ameliorates Myocardial Ischemia/Reperfusion-Induced Pyroptosis via Regulating IGF2BP1/m6A/NLRP3 Pathway. Antioxidants & redox signaling 2026. link 16 Zheng X, Li J, Hu T, Tan L, Lan D, Deng Y. Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway. Molecular medicine reports 2026. link 17 Li J, Ma X. Peroxisome Biogenesis Factor 10 Upregulation Promotes Cardiomyocyte Ferroptosis and Glutathione Peroxidase 4 Repression During Myocardial Ischemia-Reperfusion Injury. Kardiologiia 2026. link 18 Cianciulli A, Bernardelli A, Faedo S, Le E, Methner C, Pellacani A et al.. Identification of Novel and Selective GPR39 Receptor Antagonists for the Treatment of Acute Myocardial Ischemia. ChemMedChem 2026. link 19 O'Driscoll JM, Smith E, Bibat M, Edwards JJ, Compton C, Kipourou K et al.. Acute alterations in blood lactate in the setting of transient stress induced myocardial ischaemia. Experimental physiology 2026. link 20 Yang Z, Chen S, Shen S, Liu W, Ding K, Cao F et al.. Co-regulatory crosstalk between m5C, m7G, and o8G RNA modifications via QKI/YBX1 axis in myocardial ischemia-reperfusion injury. Genomics 2026. link 21 Franco-Riveros VB, Kelly J, Marchini T, Pérez V, Bernatené EA, Robello E et al.. Time course of early and delayed myocardial protection induced by vagal nerve stimulation preconditioning. Basic research in cardiology 2026. link 22 Zong C, Xue K, Xing S. Network pharmacology and molecular dynamics study of Astragalus membranaceus-Salvia miltiorrhiza in the treatment of myocardial ischemia-reperfusion injury. Medicine 2026. link 23 Diao H, Wang C, Xiong Y, Zhao Q, Zhang X, Qi X et al.. ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m. Clinical and translational medicine 2026. link 24 Wang XQ, Hu FJ, Huang H, Zou CC, Yuan Y, Qiao YM et al.. Carnosic acid protects against mitochondrial dysfunction and ferroptosis in myocardial ischemia/reperfusion injury through mediating Mfn2. European journal of pharmacology 2026. link 25 Heusch G. Myocardial ischemia: no supply/demand mismatch but reduced blood flow per beat. Basic research in cardiology 2026. link 26 Liu Z, Su W, Li X, Guo L, Gao W. Sparc-driven p62-dependent mitochondrial oxidative stress exacerbates myocardial ischemia and is attenuated by ginsenoside CK. Free radical biology & medicine 2026. link 27 Jiang W, Jiang L, Liu Y, Zhao X, Huang S, Liu Y et al.. Tetrandrine has protective role in myocardial ischemia/reperfusion injury via the TRPV2/Ca. Herz 2026. link 28 Gu Y, Huang H, Liu Y, Liu X, Su W, Chen Y et al.. An integrative strategy combining network pharmacology, metabolomics, and gut microbiota analyses to elucidate the bioactive ingredients and underlying mechanisms of Xin-Shu-Ning tablets against myocardial ischemia. Journal of pharmaceutical and biomedical analysis 2026. link 29 Yan W, Liu M, Qiu M. UPF1 alleviates myocardial ischemia/reperfusion injury via suppressing NLRP3-mediated cardiomyocyte pyroptosis by inhibiting KLF6/TXNIP axis. International immunopharmacology 2026. link 30 Zhao Y, Hao Y, Li C, Li H, Han X, Wang H et al.. Cardioprotective mechanisms of Jiangfu Decoction against myocardial ischemia may involve regulation of the AMPK/PINK1/Parkin mitochondrial autophagy pathway. Histology and histopathology 2026. link 31 Liu C, Zhang J, Chen Y, Shen G, Han Y, Zhou Z et al.. Seipin-Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 32 Li Q, Wang J, Jiang Y, Wang F, Liu M, Yang D et al.. Baicalin Attenuates Oxidative Stress and Apoptosis in Myocardial Ischemia/reperfusion Injury via Suppression of STING/NLRP3 Pathway. Journal of cardiovascular translational research 2026. link 33 Kappadan V, Hua Z, Efstathiou P, Lebert J, Sohi A, Agha-Jaffar D et al.. Differential response to acute ischemia between isolated contracting hearts and hearts perfused with excitation-contraction uncouplers. American journal of physiology. Heart and circulatory physiology 2026. link 34 Tang J, Li T, He X, Liu Y, Zhou M, Wu M et al.. A shikonin/Cu. Journal of colloid and interface science 2026. link 35 Li L, Hou A, Chen Q, Lin Z, Zhang Z. Sequential controlled H₂S/CO dual delivery via a self-reporting fluorogenic donor synergistically attenuates myocardial ischemia-reperfusion injury. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2026. link 36 Wang Z, Wang S, Liu M, Li D, Hua J, Kong X et al.. Exercise high-frequency QRS versus exercise stress electrocardiography in diagnosing myocardial ischemia: A meta-analysis. Journal of electrocardiology 2026. link 37 Shao Q, Zhang J, Wang H. (no title). Molecular medicine reports 2026. link 38 Wang N, Zhang Y, Huang W, Du W, Ma C, Fang Y et al.. Organic nano-quantum dots of salvianolic acid B modified with photosensitive cypate for the diagnosis and treatment of myocardial ischemia-reperfusion injury. Colloids and surfaces. B, Biointerfaces 2026. link 39 Du F, Niu Q, Yang X, Zheng J, Wang X. CORM-3 mitigates hypoxia/reoxygenation-induced injury in neonatal rat cardiomyocytes by regulating mitochondrial-mediated apoptosis and complex IV activity. Histology and histopathology 2026. link 40 Lombardi M, Jeronimo A, Lahrifa A, Paolucci L, Nardi G, Diaz-Polanco JC et al.. Comprehensive Diagnosis of Myocardial Ischemia of Obstructive and Nonobstructive Origin With a Wire-Free Diagnostic Strategy. Circulation. Cardiovascular interventions 2026. link 41 Zhou T, Liu Y, Xiao R, Xie B, Xie W, Qin X et al.. Obesity-associated metabolic dysregulation aggravates myocardial ischemia-reperfusion injury through Gls2-mediated ferroptosis. European journal of pharmacology 2026. link 42 Wu QQ, Xiao Y, Hu YY, Yang XY, Yan XY, Deng KQ et al.. USP18 exacerbates myocardial I/R injury by inhibiting Parkin mitophagy through the deubiquitinase PTEN-L. Military Medical Research 2026. link 43 Li J, Xu C. Platycodin D alleviates myocardial ischemia-reperfusion injury by suppressing aberrant mitophagy. Pakistan journal of pharmaceutical sciences 2026. link 44 Ijms Editorial Office. Expression of Concern: Barreto-Torres et al. The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats. . International journal of molecular sciences 2026. link 45 Kang L, Yang G, Ding Q, Wang J, Tosheel UB, Xiao Y et al.. Bawei Chenxiang Pills Exert Anti-Myocardial Ischemia Effect by Inhibiting Inflammation Through the TLR4/NF-κB/NLRP3 Signaling Pathway. Chemistry & biodiversity 2026. link 46 Zhang Y, Zhang J, Zhang Y, Sun L. Lacylation of Stearoyl-CoA Desaturase-1 Contributes to the Myocardial Ischemia-Reperfusion Injury Through Regulating Wnt/β-Catenin Signaling. Journal of cardiovascular translational research 2026. link 47 Jin S, Liu W, Chen X, Guo W, Xing Q, Wu J et al.. Caveolin-3 serves as a therapeutic target for myocardial ischemia-reperfusion injury in cardiac surgery patients. International journal of cardiology 2026. link 48 Li S, Yang G, Zhang Z, Wang Y, Li W, Wu J et al.. Platelet membrane-fused and cardiac homing peptide-modified liposomes deliver puerarin to attenuate myocardial ischemia/reperfusion injury by inhibiting pyroptosis. Colloids and surfaces. B, Biointerfaces 2026. link 49 Han DY, Ahn HS, Park HJ. Myocardial Ischemia-Reperfusion Injury-Mechanistic Insights and Novel Therapeutics. International journal of molecular sciences 2026. link 50 Peng X, Wu C, Li H, Hu L, Niu Y, Li Y et al.. Multistage Electrocardiographic Profiling for Mental Stress-Induced Myocardial Ischemia in Women: A Prospective, Age-Matched Cohort Study in China. Circulation. Population health and outcomes 2026. link 51 Xu L, Jiang L, Wu R, Yan H, Li B, Cai X et al.. Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy. Nature communications 2026. link 52 Kianfar T, Fallah M, Ramezani F, Rakhshan K, Najafzadeh E, Azizi Y. Dapagliflozin Reduces Myocardial Injuries Through Modulation of H3K27me3 and SIRT1 in the Male Rat Model of Myocardial Ischemia Reperfusion. Journal of cardiovascular pharmacology 2026. link 53 Wang Y, Xu T, Li Q, Ye L, Wang P, Wang P et al.. RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses. Redox biology 2026. link 54 Zhang H, Lin A, Zhai C, Lai T, Gong X, Wang M et al.. Ginsenoside Rd promotes cardiac regeneration through PPARG/HMGCS2-driven ketone body metabolic reprogramming in myocardial ischemia-reperfusion injury. Phytomedicine : international journal of phytotherapy and phytopharmacology 2026. link 55 Zhang J, He Y, Wu Y, Xie T, Fu W, Wu X et al.. ROS-responsive Prussian blue nanoplatform for synergistic myocardial ischemia/reperfusion injury therapy via EGCG delivery and DJ-1 pathway regulation. International journal of pharmaceutics 2026. link 56 Aksoy F, Savran M, Uysal D, Bagci A, Ilhan I, Imeci O et al.. Cannabidiol Protects the Heart From Ischemia-Reperfusion Injury Through SIRT-1/PGC-1α Activation and Nuclear Factor Kappa B Modulation: Experimental Insights. Journal of cardiovascular pharmacology 2026. link 57 Zhang C, Wang J, Chi J, Liu ST, Meng XW, Li LG et al.. NMRK2-YAP-NADK axis preserves redox protection against myocardial ischemia/reperfusion injury. Redox biology 2026. link 58 Yu Q, Yang M, Yang L, Xu Y, Jiang X, Li M et al.. Integrating UPLC-Q-TOF-MS/MS, feature-based molecular networking, network pharmacology, and molecular docking to investigate the mechanism of Persicae Ramulus against myocardial ischemia. Journal of ethnopharmacology 2026. link 59 Cheng X, Liu S, Zhang Y, Peng K, Qile M, Wu C et al.. Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia-Reperfusion Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 60 Xie M, Hao J, Chao C, Chen X, Chen Q, Lin YW et al.. Aldometanib attenuates OGD/R-induced cardiomyocyte injury via mitigation of mitochondrial dysfunction. Tissue & cell 2026. link 61 Hyams N, Swagel R, Thomas S, Mukherjee R, Hickman AB, Eldridge D et al.. Continuous electrocardiogram monitoring in porcine model of myocardial ischemia reperfusion. Animal models and experimental medicine 2026. link 62 Shuai T, Lu Y, Zhang Y, Li M, Chen L, Fang P et al.. RNF5-mediated ubiquitination of ACSL4 attenuates ferroptosis and confers cardioprotection against myocardial ischemia/reperfusion injury. Biochemical pharmacology 2026. link 63 Fu Y, Wang Q, Wang D, Li Y. Dexmedetomidine Inhibits Ferroptosis to Alleviate Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Regulating the HDAC2/FPN Pathway. Cardiovascular drugs and therapy 2026. link 64 Zhou W, Qiu J, Peng M, Liu Y, Qiu C, Pan L. Methyl rosmarinate alleviates myocardial ischemia-reperfusion injury in mice via triggering TGR5/AMPK signaling axis. Naunyn-Schmiedeberg's archives of pharmacology 2026. link 65 Lou Q, Bai R, Li L, Lu B, Ai X, Liu G. Targeting ADAMTS4 aggravates myocardial ischemia-reperfusion injury by impairing endothelial integrity and accelerating leukocyte infiltration. International journal of cardiology 2026. link 66 Rumiz E, Rivero F, Pérez A, Nau G, Romero M, Solana S et al.. ESP-INOCA: Rationale and design of a national multicentre registry for prognostic stratification in patients with suspected myocardial ischaemia and non-obstructive coronary arteries. International journal of cardiology 2026. link 67 Yao BF, Tan JM, Xing HN, Luo XJ, Peng J. Pharmacological inhibition of glycolysis at the pyruvate-to-lactate conversion stage mitigates reperfusion injury without aggravating ischemic injury in mouse hearts. European journal of pharmacology 2026. link 68 Wang SH, Li CH, Wei ZJ, Tang CY, Wang Y, Yan F et al.. Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats. Biomaterials advances 2026. link 69 Cardaioli F, Sciarretta T, Arturi F, Fabris T, Masiero G, Napodano M et al.. Unmasking Myocardial Bridge-Related Ischemia by Quantitative Flow Ratio Functional Evaluation. The American journal of cardiology 2026. link 70 Firoozabadi MD, Nooralishahi B, Rezaei-Tazangi F. Oxycodone: A Pain-Relieving Agent With Cardioprotective Properties Against Myocardial Ischemia-Reperfusion Injury. Cardiovascular therapeutics 2026. link 71 Del Puppo L, Bicher S, Fournier R, Iglesias JF, Bollen Pinto B. A Mysterious Case of Acute T Wave Inversion at Anesthesia Induction: A Case Report. A&A practice 2026. link 72 Shi Q, Yao W, Zhang W, Xu J, Wang X, Wei X et al.. Nrf2 de-SUMOylation alleviates myocardial ischemia-reperfusion injury (MIRI) by attenuating myocardial ferroptosis in mice. Redox report : communications in free radical research 2026. link 73 Shen C, Chen S, Wang F, Sun L, Yuan L, Zuo Q et al.. Astragaloside IV alleviates M3 subtype of the muscarinic acetylcholine receptor blockade-induced myocardial apoptosis through p53/Akt signaling pathway in myocardial ischemia model. European journal of pharmacology 2026. link 74 Zhou J, Li X, Li N, Wang M, Sun G. The lamin A/C-P4HB interaction axis regulates endoplasmic reticulum stress and apoptosis in myocardial ischemia-reperfusion injury via a calreticulin-associated mechanism. Cellular signalling 2026. link 75 Wang J, Hu K, Lu H, Chen K, Zhang J, Wu S et al.. Invasion of gut-derived escherichia coli extracellular vesicles exacerbates myocardial ischemia/reperfusion injury. Gut microbes 2026. link 76 Zhang Q, Cai Q, Zhong S, Li Q, Qiu W, Wu J. Vagus Nerve Stimulation by Focused Ultrasound Attenuates Acute Myocardial Ischemia/Reperfusion Injury Predominantly Through Cholinergic Anti-inflammatory Pathway. Cardiovascular drugs and therapy 2026. link 77 Zhao L, Cao Y, Liu X, Yang Q, Xu Z. ZIP14 upregulation leads to ferroptosis and lysosomal dysfunction through intracellular iron overload and induces myocardial ischemia/reperfusion injury in mouse hearts. Journal of molecular and cellular cardiology 2026. link 78 Yu L, Liu S, Wang X, Liu X, Wang S, Li Z et al.. Tongmai Yangxin pill mitigates myocardial ischemia/reperfusion injury by improving mitochondrial function and mitophagy: A potential role of estrogen receptor alpha and PTEN-induced putative kinase 1/Parkin pathway. Journal of ethnopharmacology 2026. link 79 Sha Y, Xie Y, Guan X, Wang X, Zhang Q, Cao Y et al.. Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting FABP3-mediated pyroptosis in cardiac microvascular endothelial cells. The Journal of nutritional biochemistry 2026. link 80 Li C, Ma Z, Wei X, Wang Y, Wu J, Li X et al.. Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway. Journal of cardiovascular translational research 2025. link 81 Lai CC, Tang CY, Fu SK, Tseng KW, Yu CH, Wang CY. High-intensity interval training attenuates renal injury induced by myocardial ischemia-reperfusion in rats. Journal of the Chinese Medical Association : JCMA 2025. link 82 Wang J, Ma B, Jiang X, Li C, Lin Z, Wang Y et al.. H 2 protects H9c2 cells from hypoxia/reoxygenation injury by inhibiting the Wnt/CX3CR1 signaling pathway. Medical gas research 2025. link 83 Jiang Y, Wang Z, Chen P, Lu H, Tian X, Jiang P et al.. Engineered neutrophil membrane nanosystem for targeted siRNA therapy in myocardial ischemia-reperfusion injury. Journal of nanobiotechnology 2025. link 84 Deng D, Feng Y, Zeng M, Chen S, Qin H, Chen Y et al.. Murray Law-Based Quantitative Flow Ratio Proficiency in Clinical Practice: Validating Routine Diagnostic Performance and Analyzing Learning Curve Thresholds. Journal of the American Heart Association 2025. link 85 Zhang L, Jiang Y, Jia W, Le W, Liu J, Zhang P et al.. Modelling myocardial ischemia/reperfusion injury with inflammatory response in human ventricular cardiac organoids. Cell proliferation 2025. link 86 Mahmood A, Jacqueline K, Lac J. Deconvoluting the Electrophysiological Signatures of Myocardial Ischemia using a Validated Machine Learning Framework. F1000Research 2025. link 87 Feng W, He P, Wang Z, Li W. Breakthroughs of ultrasound-targeted microbubble destruction in treating myocardial ischemia-reperfusion injury: from angiogenesis regulation to precise inflammation suppression. Drug delivery 2025. link 88 Li Y, Zhang W, Cai Y, Yang D. Ginsenoside Rb2 Inhibits the Pyroptosis in Myocardial Ischemia Progression Through Regulating the SIRT1 Mediated Deacetylation of ASC. Biochemical genetics 2025. link 89 Chen Y, Lin L, Xu L, Jin Q, Fu W, Bai Y et al.. Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats. Colloids and surfaces. B, Biointerfaces 2025. link 90 Liu W, Hu J, Wang Y, Gan T, Ding Y, Wang X et al.. 9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation. Phytomedicine : international journal of phytotherapy and phytopharmacology 2025. link 91 Cai Y, Yu Y, Zhang T, Qian B, Wang B, Yan W et al.. GATAD1 is involved in sphingosylphosphorylcholine-attenuated myocardial ischemia-reperfusion injury by modulating myocardial fatty acid oxidation and glucose oxidation. Free radical biology & medicine 2025. link 92 Bassiouni W, Mahmud Z, Simmen T, Seubert JM, Schulz R. MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α. Journal of molecular and cellular cardiology 2025. link 93 Wei XH, Chen J, Wu XF, Zhang Q, Xia GY, Chu XY et al.. Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3. Phytomedicine : international journal of phytotherapy and phytopharmacology 2025. link 94 Xiang Y, Hui S, Nie H, Guo C. LncRNA ZFAS1/miR-186-5p axis is involved in oxidative stress inhibition of myocardial ischemia-reperfusion injury by targeting BTG2. Expert review of clinical immunology 2025. link 95 Pan L, Fu M, Tang XL, Ling Y, Su Y, Ge J. Kirenol Ameliorates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation. Cardiovascular drugs and therapy 2025. link 96 Kawakami A, Sato H, Nakadate Y, Roque P, Khoutorsky A, Matsukawa T et al.. Cardioprotective effects of l-glutamine in an ischemic rat heart model. Microvascular research 2025. link 97 Yang C, Li Y, Li Q, Shi X, Li J, Chen Y et al.. Sevoflurane attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via the LncRNA FAM201A/miR-488-3p/PTEN axis. BMC anesthesiology 2025. link 98 Zhang X, Liu Q, Zhao R, Pang Z, Zhang W, Qi T et al.. Rational Design of Genetically Engineered Mitochondrial-Targeting Nanozymes for Alleviating Myocardial Ischemic-Reperfusion Injury. Nano letters 2025. link 99 Gong G, Wan W, Zhang X, Chen X, Yin J. Management of ROS and Regulatory Cell Death in Myocardial Ischemia-Reperfusion Injury. Molecular biotechnology 2025. link 100 Nakanishi N, Kaikita K, Oimatsu Y, Ishii M, Kuyama N, Arima Y et al.. 5-Aminolevulinic acid combined with ferrous iron ameliorates myocardial ischemia/reperfusion injury by increasing heme oxygenase-1. Heart and vessels 2025. link

Original source

[1]
Hyperuricemia exacerbates myocardial ischemia-reperfusion injury by inducing ferroptosis via NCOA4 and xCT-GPX4 axis dysregulation. — Zhang M, Zhao Y, Wang X, Yuan Q, Jin H, Tan H et al. European journal of pharmacology (2026)
[2]
Apelin-13 ameliorates myocardial ischemia/reperfusion injury by modulating macrophage polarization. — Jia H, Zhao Q, Yuan J, Wang X, Chen H, Dong J et al. Archives of biochemistry and biophysics (2026)
[3]
Machine learning prediction of myocardial ischaemia‒reperfusion injury: Clinical features and Qishen Yiqi dripping pills mechanism. — Ge T, Zou R, Bo J, Yang L, Hu J, Ning B et al. Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
[4]
TRPV4 inhibition suppresses myocardial ischemia-reperfusion arrhythmia of mice by alleviating calcium handling abnormalities. — Yang S, Pu J, Yu J, Wang H, Wu Y, Lu Y et al. Heart rhythm (2026)
[5]
p38MAPK protects against myocardial ischemia-reperfusion injury by regulating GLUT4 expression and translocation through MEF2A/MEF2C in isolated rat heart. — Gao W, Zhang D, Zhang B, Sun P, Cao Y, Yang S et al. Life sciences (2026)
[6]
Dapagliflozin ameliorates myocardial ischemia/reperfusion injury by modulating EGFR signaling and targeting NCOA4-mediated ferritinophagy. — Yu P, Ling J, Chen F, Xu Z, Hu K, Liu F et al. Life sciences (2026)
[7]
The myocardial ischemic cascade network and multi-target synergistic interventions: From molecular mechanisms to therapeutic innovations. — Qi L, Yi J, Shen Y, Jiang H, Yao X, Chen B et al. Biochemical pharmacology (2026)
[8]
Plasma metabolomic profiling reveals lipid biomarkers for early detection of exercise-induced myocardial ischemia. — Han HJ, Gwon MR, Lee JH, Park JS, Lee HW, Yoon YR et al. Medicine (2026)
[9]
Study on the Pharmacodynamic Substances and Mechanism of Danshen-Honghua Herb Pair (DHHP) Against Myocardial Ischemia Based on the Gut Microbiota Metabolism. — Dong Z, Deng Q, Xue Z, Zhou H, Bai J, Bai J et al. Chemistry & biodiversity (2026)
[10]
MK-3903 alleviates myocardial ischemia/reperfusion injury and mitochondrial dysfunction associated with AMKP-PGC-1α signaling. — Li PB, Gao J, Li HH, Jiang WX Biochemical and biophysical research communications (2026)
[11]
CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis. — Sun L, Shi S, Wang W, Zhang Y The American journal of the medical sciences (2026)
[12]
Dexmedetomidine preconditioning attenuates myocardial ischemia/reperfusion-induced arrhythmia in rats by inhibiting K — Zhu K, Cheng H, Jia W, Xu X, Wang H European journal of pharmacology (2026)
[13]
Sinomenine ameliorates myocardial ischemia/reperfusion injury by inhibiting mitochondrial oxidative stress-mediated PANoptosis and ferroptosis via α7nAChR. — Yang JR, Tan FQ, Cheng CJ, Zhang MW, Yu JG Life sciences (2026)
[14]
Cell death forms in myocardial ischemia-reperfusion injury and their potential clinical applications. — Xu Y, Wu S, Zhang L, Zhang M, Jiang Y Molecular and cellular biochemistry (2026)
[15]
3'-Methoxypuerarin Ameliorates Myocardial Ischemia/Reperfusion-Induced Pyroptosis via Regulating IGF2BP1/m6A/NLRP3 Pathway. — Zhou H, Zhou H, Li C, Fatima S, Qiao L, Lu D et al. Antioxidants & redox signaling (2026)
[16]
Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway. — Zheng X, Li J, Hu T, Tan L, Lan D, Deng Y Molecular medicine reports (2026)
[17]
Peroxisome Biogenesis Factor 10 Upregulation Promotes Cardiomyocyte Ferroptosis and Glutathione Peroxidase 4 Repression During Myocardial Ischemia-Reperfusion Injury. — Li J, Ma X Kardiologiia (2026)
[18]
Identification of Novel and Selective GPR39 Receptor Antagonists for the Treatment of Acute Myocardial Ischemia. — Cianciulli A, Bernardelli A, Faedo S, Le E, Methner C, Pellacani A et al. ChemMedChem (2026)
[19]
Acute alterations in blood lactate in the setting of transient stress induced myocardial ischaemia. — O'Driscoll JM, Smith E, Bibat M, Edwards JJ, Compton C, Kipourou K et al. Experimental physiology (2026)
[20]
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