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Dentistry31310 papers

Periodontitis

Last edited: 29 days ago

Overview

Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, primarily caused by bacterial plaque accumulation. It affects approximately 35% to 50% of the adult population and is linked to systemic health issues through inflammatory pathways 313.

Diagnosis

  • Clinical examination including periodontal probing depths, bleeding on probing, and clinical attachment loss.
  • Radiographic assessment to evaluate bone loss.
  • Microbiological tests to identify specific pathogens (e.g., Porphyromonas gingivalis).
  • Inflammatory markers such as C-reactive protein (CRP) may correlate with disease severity 46.
  • Management

  • Non-surgical therapy: Scaling and root planing to remove plaque and calculus 1333.
  • Antimicrobials: Adjunctive use of systemic antibiotics (e.g., amoxicillin, metronidazole) in moderate to severe cases 13.
  • Oral hygiene instructions: Regular brushing, flossing, and use of antimicrobial mouth rinses.
  • Periodontal maintenance: Frequent professional cleanings to prevent recurrence 33.
  • Special Populations

  • Pregnancy: Increased risk of periodontal disease due to hormonal changes; regular dental care is crucial 13.
  • Elderly: Higher prevalence and more severe forms of periodontitis; management focuses on maintaining functional dentition and systemic health 13.
  • Comorbidities: Patients with cardiovascular disease may benefit from improved periodontal care to reduce systemic inflammation 1642.
  • Key Recommendations

  • Initiate non-surgical periodontal therapy including scaling and root planing for diagnosed periodontitis cases (Evidence: Moderate 13).
  • Consider adjunctive antimicrobial therapy in severe cases to enhance treatment outcomes (Evidence: Moderate 13).
  • Regular periodontal maintenance visits are essential to prevent disease recurrence and manage systemic health risks (Evidence: Moderate 33).
  • Screen and manage periodontal disease in patients with cardiovascular disease to mitigate systemic inflammation (Evidence: Moderate 1642).
  • Provide tailored oral hygiene education for special populations such as pregnant women and the elderly to address increased risk factors (Evidence: Expert opinion 13).
  • References

    Showing 100 most recent of 329 indexed papers.

    1 Thirugnanam A, Donthineni K, Mammi M, Hundel J, Munteh D, D'Amore F et al.. Chimeric antigen receptor T-cell therapy and immune effector cell-associated neurotoxicity syndrome: A meta-analysis. Critical reviews in oncology/hematology 2026. link 2 Thida AM, Shah A, Steffens KF, Watters S, Duan M, Devine S et al.. Trends in US Hematology/Oncology Physician Perceptions and Referral Practices for Hematopoietic Cell Transplant: A National Survey Conducted by NMDP. Cancer medicine 2026. link 3 Wu Z, Zhang Y, Wang L, Yi Y, Dai B, Chen H et al.. Periodontitis and systemic diseases: insights into the correlation, mechanisms, and clinical implications. Frontiers in immunology 2026. link 4 Farmakis D, Karampinos KI, Cordoba R, López-Fernández T, Filippatos G. Predictive Factors and Baseline Risk Stratification for CAR-T Cell Therapy-Related Cardiovascular Toxicity. European journal of haematology 2026. link 5 Zhang T, Zhang A, Li J, Li F, Liu P, Wang P. Comparing EQ-5D-5L and SF-6Dv2 utilities with QLU-C10D utilities in hematologic cancer patients. The European journal of health economics : HEPAC : health economics in prevention and care 2026. link 6 Han S, Chen X, Li F, Chen X, Cui M, Leung KCM et al.. Cerebral Small Vessel Disease as a Novel Risk Indicator for Periodontitis Progression. International dental journal 2026. link 7 Bashir NZ, Woolf BAR, Burgess S, Bernabé E. Periodontitis and Systemic Disease: The Impact of Covariate Selection. Journal of dental research 2026. link 8 Walther KA, Vogler JAH, Wöstmann B, Gröger S. Periodontal inflammation indices in association to systemic diseases. Journal of dentistry 2026. link 9 Kaur S, Hansen PR, Nielsen CH, Holmstrup P, Havemose-Poulsen A, Markvart M et al.. Descriptive Analysis of Periodontitis Case Detection and Selected Comorbidities in Danish Private Dental Practices. Journal of clinical periodontology 2026. link 10 Li X, Wu S, Zou M. Cross-sectional analysis of periodontitis and peripheral artery disease association: Results from National Health and Nutrition Examination Survey 1999 to 2004. Medicine 2026. link 11 Gan D, Lin J, Zeng J, Fan J, Pan Z. Incidence, mortality and risk factors of hematologic malignancies in China from 1990 to 2021: A systematic analysis for the GBD 2021. Tumori 2026. link 12 Salihoglu A, Ar MC. Vasculitis associated with haematologic malignancies. Current opinion in rheumatology 2026. link 13 Diallo D, Mangin G, Cheat B, Even G, Gaston AT, Bouchet J et al.. Unveiling the Impact of . Journal of the American Heart Association 2026. link 14 Petrini M, Gennai S, Marruganti C, Marhl U, Izzetti R, Nisi M et al.. Acute-Phase Response Following Different Modalities of Non-Surgical Periodontal Treatment in Subjects Affected by Periodontitis and Co-Morbid Hypertension: A Randomised Clinical Trial. Journal of clinical periodontology 2026. link 15 Zhu Y, Xu C, Chen Z, Fu L, Feng W, Yu J. Direct Oral Anticoagulants for Cancer-Associated Venous Thromboembolism in Hematologic Malignancies: A Comprehensive Review. European journal of haematology 2026. link 16 Zhu X, Cheng S, Ge J, Weng C, Fang K, Chen J et al.. Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation. Journal of clinical periodontology 2026. link 17 Spadafora L, Russo F, Bukowska-Olech E, Panichella G, Garofalo M, Cacciatore S et al.. Cardiovascular Safety of Bruton Tyrosine Kinase Inhibitors: From Ibrutinib to Next-Generation Agents. American journal of cardiovascular drugs : drugs, devices, and other interventions 2026. link 18 Butchar JP. Special Issue: Antibody Therapy for Hematologic Malignancies. International journal of molecular sciences 2025. link 19 Alyamany R, Houghton DE. Anticoagulants in hematologic malignancies: what is the data?. Hematology. American Society of Hematology. Education Program 2025. link 20 Pettit N, Satorius A. Mechanical Obstruction in Hematologic and Oncologic Emergencies. Emergency medicine clinics of North America 2025. link 21 Huang M, Ewadi A, Servatian N, Noormohamadi H, Aminov Z, Muzammil K et al.. Epigenetic mechanisms and next-gen editing platforms in hematology: From molecular basis to therapeutic frontiers. Critical reviews in oncology/hematology 2025. link 22 Kuaban A, Croker AK, Keefer J, Valentino LA, Bierer BE, Boateng S et al.. The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative. Blood advances 2025. link 23 Kilic Gunes E. Artificial intelligence in hematology: current trends and application areas. Annals of hematology 2025. link 24 Auberle C, Wu N, Dipersio JF, Waqar SN, Ratner L. Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training. Academic medicine : journal of the Association of American Medical Colleges 2025. link 25 Wang F, Xia J, Sun J. Microbiological diagnostics and their impact on hematology nursing. Folia microbiologica 2025. link 26 Grans-Siebel J, Garcia Borrega J, Böll B, Bach F. [Modern immunotherapy and emergency situations : Toxicities of CAR T-cell therapies and BiTEs, their management, and their relevance in intensive care medicine]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2025. link 27 Zeng Y, Chen S, Liu J, Gao Y, Tang N, Zeng Y. A Real-World Pharmacovigilance Analysis for Demethylation Drug: Findings from the FDA Adverse Event Reporting Database. Oncology 2025. link 28 Le X, Zhang Y, Ma J. Comprehensive analysis of adverse events associated with T-cell engagers using the FAERS database. Expert opinion on drug safety 2025. link 29 Song Z, Wang Y, Zhang D, Wang T, Liu N, Gao L et al.. Disseminated intravascular coagulation is an underestimated but fatal adverse event associated with blinatumomab therapy: A pharmacovigilance analysis of FAERS. International journal of cancer 2025. link 30 Doughan M, Chehab O, Doughan B, Lima JAC, Michos ED. Association of endogenous sex hormone levels with tooth loss due to periodontitis in men and post-menopausal women: The multi-ethnic study of atherosclerosis. Journal of periodontal research 2025. link 31 Liu RL, Ou YP, Zhang Q, Yang YF. Mendelian Randomization Reveals No Causal Association Between Periodontitis and Infective Endocarditis. International dental journal 2025. link 32 Mahendra J, Dave P, Priya L, Arumugam M, Yadalam PK, Ardila CM. Improvement of salivary biomarkers vitronectin and fetuin-A levels in periodontitis patients with coronary artery disease post scaling and root planing. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 2025. link 33 Dillon HT, Saner NJ, Ilsley T, Kliman DS, Foulkes SJ, Brakenridge CJ et al.. Preventing Allogeneic Stem Cell Transplant-Related Cardiovascular Dysfunction: ALLO-Active Trial. Circulation 2025. link 34 Brownlee E, Turley M, Nations H. Chimeric antigen receptor therapy in hematologic malignancies. JAAPA : official journal of the American Academy of Physician Assistants 2025. link 35 Wenning T, Kudlek C, Hünerlitürkoglu AN, Kröger K. Risk of venous thromboembolism after discontinuing prophylactic or therapeutic anticoagulation in patients with haematologic malignancies because of thrombocytopenia. Journal of thrombosis and thrombolysis 2025. link 36 Kalhan AC, Kalhan TA, Romandini M, Bitencourt FV, Cooray UMP, Leite FRM et al.. Insulin resistance and periodontitis: Mediation by blood pressure. Journal of periodontal research 2025. link 37 Chelius M, Xu-Welliver M, Plastaras JP. Palliating hematologic oncologic emergencies with radiation in the age of targeted systemic therapies: three illustrative cases. Annals of palliative medicine 2024. link 38 Rodenbach R, Caprio T, Loh KP. Challenges in hospice and end-of-life care in the transfusion-dependent patient. Hematology. American Society of Hematology. Education Program 2024. link 39 Kim DH, Youk J, Byun JM, Koh Y, Hong J, Kim TM et al.. Effects of tertiary palliative care on the pattern of end-of-life care in patients with hematologic malignancies in Korea. European journal of haematology 2024. link 40 Weisse CS, Melekis K, Cheng A, Konda AK, Major A. Mixed-Methods Study of End-of-Life Experiences of Patients With Hematologic Malignancies in Social Hospice Residential Home Care Settings. JCO oncology practice 2024. link 41 Berg Y, Gabay E, Božić D, Shibli JA, Ginesin O, Asbi T et al.. The Impact of Nutritional Components on Periodontal Health: A Literature Review. Nutrients 2024. link 42 Ozmeric N, Elgun S, Kalfaoglu D, Pervane B, Sungur Ç, Ergüder İ et al.. Interaction between hypertension and periodontitis. Oral diseases 2024. link 43 Ho M, Zanwar S, Paludo J. Chimeric antigen receptor T-cell therapy in hematologic malignancies: Successes, challenges, and opportunities. European journal of haematology 2024. link 44 Vakilpour A, Lefebvre B, Lai C, Scherrer-Crosbie M. Heartbreaker: Detection and prevention of cardiotoxicity in hematological malignancies. Blood reviews 2024. link 45 Ketterl TG, Chow EJ, Koves IH, Goodman P, Leisenring WM, Ballard S et al.. Impact of Hematopoietic Cell Transplantation on Cardiovascular Risk Factors and Insulin Sensitivity. Transplantation and cellular therapy 2024. link 46 Lee JH, Mun SJ. Relationship between C-reactive protein level and periodontitis and systemic diseases. Journal of periodontology 2024. link 47 Yamazaki Y, Morita T, Nakai K, Konishi Y, Goto A, Yamamoto T et al.. Impact of dental health intervention on cardiovascular metabolic risk: a pilot study of Japanese adults. Journal of human hypertension 2024. link 48 Shen S, Sun T, Ding X, Gu X, Wang Y, Ma X et al.. The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways. Journal of advanced research 2024. link 49 Mahendra J, Muralidharan J, Srinivasan S, Mahendra L, Cherian SM, Fathima L et al.. Calprotectin and periostin levels in periodontitis patients with coronary artery disease. Oral diseases 2024. link 50 Srisuwananukorn A, Salama ME, Pearson AT. Deep learning applications in visual data for benign and malignant hematologic conditions: a systematic review and visual glossary. Haematologica 2023. link 51 MacDonell-Yilmaz RE, Murillo A, Welch JG. A randomized controlled trial to examine the effect of the Pediatric Opioid Analgesia Self-Instruction System (PedOASIS) tool on pediatric hematology/oncology trainee education. Pediatric blood & cancer 2023. link 52 Gachard N, Lafage-Pochitaloff M, Quessada J, Auger N, Collonge-Rame MA. Cytogenetics in the management of hematologic neoplasms with germline predisposition: guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH). Current research in translational medicine 2023. link 53 Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A et al.. Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline. Journal of clinical periodontology 2023. link 54 Frigault M, Rotte A, Ansari A, Gliner B, Heery C, Shah B. Dose fractionation of CAR-T cells. A systematic review of clinical outcomes. Journal of experimental & clinical cancer research : CR 2023. link 55 Holden K, Rao S, White R, Bangash S, Madgula AS, Schmetzer A et al.. Hematologic and Oncologic Emergencies. Critical care nursing quarterly 2023. link 56 Sebbens D, Spruit JL. Hematologic and Oncologic Emergencies in the Pediatric Intensive Care Unit: What Nurses Should Know. Critical care nursing clinics of North America 2023. link 57 Robbins-Welty GA, Webb JA, Shalev D, El-Jawahri A, Jackson V, Mitchell C et al.. Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence. Current treatment options in oncology 2023. link 58 D'Amico S, Dall'Olio D, Sala C, Dall'Olio L, Sauta E, Zampini M et al.. Synthetic Data Generation by Artificial Intelligence to Accelerate Research and Precision Medicine in Hematology. JCO clinical cancer informatics 2023. link 59 Brazauskas R, Eapen M, Wang T. Endpoint selection and evaluation in hematology studies. Best practice & research. Clinical haematology 2023. link 60 Criscuolo M, Fracchiolla N, Farina F, Verga L, Pagano L, Busca A. A review of prophylactic regimens to prevent invasive fungal infections in hematology patients undergoing chemotherapy or stem cell transplantation. Expert review of hematology 2023. link 61 Shaw B, Parker C, Opat S, Shortt J, Poon P. Hematologic Malignancy: Who Cares in the End? A Retrospective Cohort Study of Markers of Quality End-of-Life Care. Journal of the National Comprehensive Cancer Network : JNCCN 2023. link 62 Li C, Zhang J, Wang L, Yang J. A case of early-onset periodontitis with vitamin D deficiency: A case report and literature review. Medicine 2023. link 63 Liu X, Dai B, Chuai Y, Hu M, Zhang H. Associations between vitamin D levels and periodontal attachment loss. Clinical oral investigations 2023. link 64 Isola G, Santonocito S, Distefano A, Polizzi A, Vaccaro M, Raciti G et al.. Impact of periodontitis on gingival crevicular fluid miRNAs profiles associated with cardiovascular disease risk. Journal of periodontal research 2023. link 65 Alkimavičienė E, Pušinskaitė R, Basevičienė N, Banienė R, Savickienė N, Pacauskienė IM. Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy. International dental journal 2023. link 66 Ebert RPC, Magnus MM, Toro P, Manoel FG, Costa FF, Olalla Saad ST et al.. Hematologic Malignancies Patients Face High Symptom Burden and Are Lately Referred to Palliative Consultation: Analysis of a Single Center Experience. The American journal of hospice & palliative care 2023. link 67 Beukers NGFM, van der Heijden GJMG, Su N, van der Galiën O, Gerdes VEA, Loos BG. An examination of the risk of periodontitis for nonfatal cardiovascular diseases on the basis of a large insurance claims database. Community dentistry and oral epidemiology 2023. link 68 Kim HJ, Shim KW, Na HS, Kim SY, Yu Y, Song Y et al.. Assessing the effect of antihypertensives on plaque microbiota in patients with periodontitis and hypertension using 16S rRNA sequencing: A cross-sectional study. Journal of periodontology 2023. link 69 Kolte AP, Kolte RA, Bawankar PV, Bajaj VA. Assessment and correlation of the influence of non-surgical periodontal therapy on serum lipid profile and cytokines in patients with stage III periodontitis. International journal of dental hygiene 2023. link 70 Haji S, Shiratsuchi M, Takamatsu A, Tsuda M, Muta H, Masuda T et al.. Endothelial function testing before conditioning therapy is useful for predicting transplant-related complications after allogeneic hematopoietic cell transplantation. International journal of hematology 2023. link 71 Lampson BL, Gupta A, Tyekucheva S, Mashima K, Petráčková A, Wang Z et al.. Rare Germline . Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023. link 72 Fernandes D, Khambata RS, Massimo G, Ruivo E, Gee LC, Foster J et al.. Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis. Pharmacological research 2023. link 73 Sharma A, Singh V, Deol A. Epidemiology and Predictors of 30-Day Readmission in CAR-T Cell Therapy Recipients. Transplantation and cellular therapy 2023. link 74 Khoo CEH, Long MH, Shi L, Guo L, Hee HI. CREST: clinical bleeding and risk evaluation in hematology-oncology patients: a systematic review and meta-analysis of thromboelastography's role. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2022. link 75 Kim CM, Lee S, Hwang W, Son E, Kim TW, Kim K et al.. Obesity and periodontitis: A systematic review and updated meta-analysis. Frontiers in endocrinology 2022. link 76 Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE et al.. Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review. Transplantation and cellular therapy 2022. link 77 Guven DC, Sahin TK, Akın S, Uckun FM. Impact of Therapy in Patients with Hematologic Malignancies on Seroconversion Rates After SARS-CoV-2 Vaccination. The oncologist 2022. link 78 Spring J, Munshi L. Hematology Emergencies in Critically Ill Adults: Benign Hematology. Chest 2022. link 79 Spring J, Munshi L. Hematology Emergencies in Adults With Critical Illness: Malignant Hematology. Chest 2022. link 80 de Freitas Dutra V, Leal VNC, Pontillo A. The inflammasomes: crosstalk between innate immunity and hematology. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022. link 81 Johns J, Wahlrab L, Elefritz JL. Acutely ill hematology/oncology patients with central-line associated bloodstream infections and the impact of timing of catheter removal on outcomes. American journal of infection control 2022. link 82 El Alaoui Y, Elomri A, Qaraqe M, Padmanabhan R, Yasin Taha R, El Omri H et al.. A Review of Artificial Intelligence Applications in Hematology Management: Current Practices and Future Prospects. Journal of medical Internet research 2022. link 83 Xu P, Fang K, Chen X, Liu Y, Dong Z, Zhu J et al.. The flagging features of the Sysmex XN-10 analyser for detecting platelet clumps and the impacts of platelet clumps on complete blood count parameters. Clinical chemistry and laboratory medicine 2022. link 84 Bardenheuer K, Van Speybroeck M, Hague C, Nikai E, Price M. Haematology Outcomes Network in Europe (HONEUR)-A collaborative, interdisciplinary platform to harness the potential of real-world data in hematology. 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    Original source

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