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Neurology11 papers

Neoplasm of esophageal submucosa

Last edited: 4/15/2026

Overview

Neurofibroma of the esophagus is a rare benign neoplasm originating from the submucosal nerve sheath, typically identified in the middle third of the esophagus 1. Diagnosis often relies on endoscopic findings and imaging, but definitive diagnosis requires histopathological confirmation via endoscopic biopsy 1.

Diagnosis

  • Endoscopic findings: Characteristic appearance suggestive of submucosal mass 1.
  • Imaging: Roentgenology (X-ray) can provide supportive evidence 1.
  • Biopsy: Essential for definitive diagnosis; histopathological examination confirms neurofibroma 1.
  • Management

  • Surgical excision: Primary treatment for definitive removal 1.
  • Endoscopic resection: Considered for smaller, superficial lesions 1.
  • Monitoring: For asymptomatic cases, regular endoscopic surveillance may be appropriate 1.
  • Special Populations

  • No specific data: The provided abstract does not cover management in pregnancy, pediatrics, elderly, or patients with comorbidities 1.
  • Key Recommendations

  • Definitive diagnosis requires endoscopic biopsy for histopathological examination (Evidence: Expert opinion) 1.
  • Surgical excision is recommended for definitive treatment (Evidence: Expert opinion) 1.
  • Regular endoscopic surveillance is advised for asymptomatic cases (Evidence: Expert opinion) 1.
  • References

    1 Hishikawa Y, Miura T, Kakudo K, Matsushita H. Neurofibroma of the esophagus. Radiation medicine 1984. link

    Original source

    1. [1]
      Neurofibroma of the esophagus.Hishikawa Y, Miura T, Kakudo K, Matsushita H Radiation medicine (1984)

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