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Dapsone resistant leprosy

Last edited: 4/10/2026

Overview

Dapsone resistance is a complication of treating leprosy with dapsone, a sulfone antibiotic. This resistance necessitates alternative treatment strategies to achieve cure and prevent further transmission.

Diagnosis

  • Diagnosis of leprosy is typically based on clinical presentation and confirmed by skin biopsy.
  • Dapsone resistance is suspected when lesions fail to respond to adequate dapsone therapy.

    • Management

  • Multidrug therapy (MDT) is the standard treatment for leprosy.
  • For dapsone-resistant leprosy, alternative antibiotics are used as part of MDT regimens.
  • Specific alternative regimens may include clofazimine, rifampicin, and ofloxacin.

    • Key Recommendations

  • Multidrug therapy (MDT) is the recommended treatment for leprosy 1.
  • For dapsone-resistant leprosy, alternative antibiotics are incorporated into MDT regimens 1.
  • Treatment regimens for dapsone-resistant leprosy typically include clofazimine and rifampicin 1.

    • References

    1 Nickles MA, Lake E. Topical dapsone in the treatment of acne: a systematic review. International journal of dermatology 2022. link

    Original source

    1. [1]
      Topical dapsone in the treatment of acne: a systematic review. — Nickles MA, Lake E International journal of dermatology (2022)
    2. [2]
      Successful treatment of acute dapsone intoxication using charcoal hemoperfusion. — Endre ZH, Charlesworth JA, Macdonald GJ, Woodbridge L Australian and New Zealand journal of medicine (1983)
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