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Rheumatology164 papers

Undifferentiated inflammatory arthritis

Last edited: 4/14/2026

Overview

Undifferentiated inflammatory arthritis encompasses a spectrum of inflammatory joint diseases lacking a specific diagnosis, often requiring multidisciplinary assessment and timely referral to rheumatology for accurate classification and management. 111

Diagnosis

  • Clinical Criteria: Presence of inflammatory joint symptoms (swelling, pain, stiffness) without definitive classification into specific arthritides like RA or PsA. 111
  • Recommended Tests:
  • - Rheumatoid Factor (RF) and Anti-CCP Antibodies: To rule out rheumatoid arthritis. - Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP): Elevated levels indicative of inflammation. - Imaging: X-rays, MRI, or ultrasound to assess joint damage and inflammation. 717
  • Triage Tools: Use of validated self-administered detection tools for early identification and triage to rheumatology. 22
  • Management

  • First-Line Treatments:
  • - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): For symptomatic relief. - Glucocorticoids: Short-term use for acute flares. 111
  • Disease-Modifying Antirheumatic Drugs (DMARDs):
  • - Conventional DMARDs (cDMARDs): Methotrexate often initiated. - Biologic DMARDs (bDMARDs): Consideration based on disease activity and response to cDMARDs. 41424
  • Adjunctive Therapies:
  • - Vaccinations: Ensure coverage for influenza, pneumococcal, and herpes zoster vaccines to prevent infections. 321 - Physical Therapy: Essential for maintaining joint function and mobility. 617 - Occupational Therapy: Focus on vocational rehabilitation and daily living activities. 6

    Special Populations

  • Pregnancy: Close monitoring and adjustment of DMARDs to minimize fetal risk; methotrexate often requires discontinuation. 1821
  • Pediatrics: Tailored approaches considering growth and development; biologic therapies require careful evaluation. 18
  • Elderly: Increased focus on minimizing side effects and managing comorbidities; multidisciplinary care is crucial. 221
  • Comorbidities: Special attention to cardiovascular risk, especially in those with inflammatory arthritis, due to potential associations with degenerative aortic stenosis. 821
  • Key Recommendations

  • Timely Referral to Rheumatology: Ensure prompt referral for patients with suspected inflammatory arthritis to optimize outcomes. (Evidence: Strong 11113)
  • Comprehensive Vaccination: Prioritize vaccinations against influenza, pneumococcal disease, and herpes zoster to reduce infection risk. (Evidence: Strong 321)
  • Use of Triage Tools: Implement validated triage tools to improve accuracy and efficiency in identifying patients requiring rheumatology consultation. (Evidence: Moderate 2239)
  • Multidisciplinary Care: Incorporate occupational therapy and physical therapy into management plans to enhance functional outcomes. (Evidence: Moderate 617)
  • Monitoring and Adjusting Therapies: Regularly assess treatment efficacy and adjust DMARDs based on clinical response and patient safety, especially in special populations like pregnant women. (Evidence: Moderate 1821)
  • References

    1 Ziade N, Mechleb K, Haouichat C, Baron F, Abdulateef Al-Ani N, Adnan AR et al.. Design and validation of a referral algorithm for inflammatory arthritis and low back pain: identifying gaps in primary care practices. Clinical rheumatology 2026. link 2 Sebbag E, Molina-Collada J, Ndoye R, Aletaha D, Askling J, Gente K et al.. Systematic literature review and meta-analysis informing the EULAR points to consider on the initiation of targeted therapies in patients with inflammatory arthritis and a history of cancer. Annals of the rheumatic diseases 2025. link 3 Wong PK, O'Sullivan M, Deng L. Low influenza, pneumococcal and herpes zoster vaccination coverage in Australian patients commencing a biologic or targeted synthetic disease modifying anti-rheumatic drug for inflammatory arthritis: a nationwide cross-sectional data linkage study. Rheumatology international 2025. link 4 Ye C, Nikolic RPA, Choi M, Fifi-Mah AV, Graham J, O'Neil LJ et al.. Canadian Rheumatology Association/Canadian Research Group of Rheumatology in Immuno-Oncology Living Guidelines for Baseline Immunosuppression in Individuals With Preexisting Rheumatic Diseases Initiating Immune Checkpoint Inhibitors. Part 1: Preexisting Inflammatory Arthritides. The Journal of rheumatology 2025. link 5 Gad I, Podgorski C, Springer K, Bishnoi A, Rooney DM, Zickuhr L. Pilot Study: Development and Evaluation of Validity Evidence of a Low-Cost, Low-Fidelity Hand Model to Teach Clinical Assessment of Small Joint Swelling in Inflammatory Arthritis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2025. link 6 Hammond A, O'Brien R, Woodbridge S, Prior Y, Ching A, Culley J et al.. Upskilling Rheumatology Occupational Therapists in Work Rehabilitation: An Evaluation of a Job Retention Vocational Rehabilitation Training Course (the Workwell Trial). Musculoskeletal care 2025. link 7 Sabido-Sauri R, Eder L, Emery P, Aydin SZ. Integrating handheld ultrasound in rheumatology: A review of benefits and drawbacks. Best practice & research. Clinical rheumatology 2025. link 8 Peng B, Zha L, Juaiti M, Lin W, Zhou X, Ou Z et al.. Association Between Inflammatory Arthritis, Genetic Risk, and the Long-Term Risk of Degenerative Aortic Stenosis: A Prospective Cohort Study. Journal of the American Heart Association 2025. link 9 Ho JN, Hillen JB, Daniels B, Lim R, Pratt N. Systematic Evaluation of Australian Risk Management Plans for Biologic Medicines. Drug safety 2025. link 10 Roberts JH, Gunn C, Mackinnon JE, Parlee S, Bakowsky V, Taylor T et al.. Feasibility of Physiotherapist-Led Rheumatology Triage: A Randomized Study. The Journal of rheumatology 2024. link 11 Biln NK, Bansback N, Shojania K, Puil L, Harrison M. A scoping review of triage approaches for the referral of patients with suspected inflammatory arthritis, from primary to rheumatology care. Rheumatology international 2024. link 12 Marshall DA, Tagimacruz T, Barber CEH, Cepoiu-Martin M, Lopatina E, Robert J et al.. Intended and unintended consequences of strategies to meet performance benchmarks for rheumatologist referrals in a centralized intake system. Journal of evaluation in clinical practice 2024. link 13 Barber CEH, Lethebe BC, Szostakiwskyj JH, Barnabe C, Barber MRW, Katz S et al.. A population-based analysis of rheumatology care patterns for inflammatory arthritis during COVID-19 in Alberta, Canada. Seminars in arthritis and rheumatism 2024. link 14 Horowitz DL, Mandelin AM, Tabechian D, Ben-Artzi A. Precision Medicine in Rheumatology: The Promise of Ultrasound-Guided Synovial Biopsy, Barriers to Its Implementation in the United States, and Proposed Solutions. Current rheumatology reports 2024. link 15 Karacabeyli D, Lacaille D. Glucagon-Like Peptide 1 Receptor Agonists in Patients With Inflammatory Arthritis or Psoriasis: A Scoping Review. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2024. link 16 Pianarosa E, Roach P, Barber CEH, Holroyd BR, McLane P, Katz SJ et al.. Deciding to Attend the Emergency Department: Experiences of Patients With Inflammatory Arthritis. The Journal of rheumatology 2024. link 17 Koppikar S, Diaz P, Kaeley GS, Eder L. Seeing is believing: Smart use of musculoskeletal ultrasound in rheumatology practice. Best practice & research. Clinical rheumatology 2023. link 18 Baba O, Kisaoglu H, Kalyoncu M. Letrozole-induced inflammatory arthritis and tendinopathy in pediatric rheumatology setting. International journal of rheumatic diseases 2023. link 19 Hansen CW, Esbensen BA, de Thurah A, Christensen R, de Wit M, Cromhout PF. Outcome measures in rheumatology applied in self-management interventions targeting people with inflammatory Arthritis A systematic review of outcome domains and measurement instruments. Seminars in arthritis and rheumatism 2022. link 20 Zeng L, Deng Y, He Q, Yang K, Li J, Xiang W et al.. Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials. Frontiers in immunology 2022. link 21 Nikiphorou E, Santos EJF, Marques A, Böhm P, Bijlsma JW, Daien CI et al.. 2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis. Annals of the rheumatic diseases 2021. link 22 de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser E, Redzic JS, Helsen MM et al.. Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease. Cytokine 2021. link 23 Ahluwalia V, Lineker S, Sweezie R, Bell MJ, Kendzerska T, Widdifield J et al.. The Effect of Triage Assessments on Identifying Inflammatory Arthritis and Reducing Rheumatology Wait Times in Ontario. The Journal of rheumatology 2020. link 24 Knevel R, le Cessie S, Terao CC, Slowikowski K, Cui J, Huizinga TWJ et al.. Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis. Science translational medicine 2020. link 25 Hall J, Julia Kaal K, Lee J, Duncan R, Tsao N, Harrison M. Patient Satisfaction and Costs of Multidisciplinary Models of Care in Rheumatology: a Review of the Recent Literature. Current rheumatology reports 2018. link 26 Robinson SM, Ryan S, Adams N, Hassell A, Walker D. An exploration of the experiences of rheumatology nurses counselling patients on methotrexate therapy. Musculoskeletal care 2018. link 27 Livshits G, Kalinkovich A. Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies. Osteoarthritis and cartilage 2018. link 28 Bartalesi F, Scirè C, Requena-Méndez A, Abad MA, Buonfrate D, Caporali R et al.. Recommendations for infectious disease screening in migrants to Western Europe with inflammatory arthropathies before starting biologic agents. Results from a multidisciplinary task force of four European societies (SIR, SER, SIMET, SEMTSI) facing the largest impact of the flow of migrants today. Clinical and experimental rheumatology 2017. link 29 Ndosi M, Ferguson R, Backhouse MR, Bearne L, Ainsworth P, Roach A et al.. National variation in the composition of rheumatology multidisciplinary teams: a cross-sectional study. Rheumatology international 2017. link 30 Wilson BA, Cooper M, Barber CEH. Standards of care for inflammatory arthritis: A literature review. Seminars in arthritis and rheumatism 2017. link 31 Ledingham JM, Snowden N, Rivett A, Galloway J, Ide Z, Firth J et al.. Achievement of NICE quality standards for patients with new presentation of inflammatory arthritis: observations from the National Clinical Audit for Rheumatoid and Early Inflammatory Arthritis. Rheumatology (Oxford, England) 2017. link 32 Campbell NKJ, Saadeldin K, De Vera MA. The Duality of Economic Issues With Medication Non-adherence in Patients With Inflammatory Arthritis. Current rheumatology reports 2017. link 33 Acebes C, Harvie JP, Wilson A, Duthie J, Bowen F, Steven M. Clinical usefulness and patient satisfaction with a musculoskeletal ultrasound clinic: results of a 6-month pilot service in a Rheumatology Unit. Rheumatology international 2016. link 34 Barber CE, Marshall DA, Mosher DP, Akhavan P, Tucker L, Houghton K et al.. Development of System-level Performance Measures for Evaluation of Models of Care for Inflammatory Arthritis in Canada. The Journal of rheumatology 2016. link 35 Farrer C, Abraham L, Jerome D, Hochman J, Gakhal N. Triage of Rheumatology Referrals Facilitates Wait Time Benchmarks. The Journal of rheumatology 2016. link 36 Carter K, Lahiri M, Cheung PP, Santosa A, Rome K. Prevalence of foot problems in people with inflammatory arthritis in Singapore. Journal of foot and ankle research 2016. link 37 Zangi HA, Ndosi M, Adams J, Andersen L, Bode C, Boström C et al.. EULAR recommendations for patient education for people with inflammatory arthritis. Annals of the rheumatic diseases 2015. link 38 Larsson I, Fridlund B, Arvidsson B, Teleman A, Svedberg P, Bergman S. A nurse-led rheumatology clinic versus rheumatologist-led clinic in monitoring of patients with chronic inflammatory arthritis undergoing biological therapy: a cost comparison study in a randomised controlled trial. BMC musculoskeletal disorders 2015. link 39 Carpenter T, Katz SJ. Review of a rheumatology triage system: simple, accurate, and effective. Clinical rheumatology 2014. link 40 Dures E, Almeida C, Caesley J, Peterson A, Ambler N, Morris M et al.. A survey of psychological support provision for people with inflammatory arthritis in secondary care in England. Musculoskeletal care 2014. link 41 Müller-Ladner C, Müller-Ladner U. Vaccination and inflammatory arthritis: overview of current vaccines and recommended uses in rheumatology. Current rheumatology reports 2013. link 42 Tavares R, Wells GA, Bykerk VP, Guillemin F, Tugwell P, Bell MJ. Validation of a self-administered inflammatory arthritis detection tool for rheumatology triage. The Journal of rheumatology 2013. link 43 McCarthy EM, Azeez MA, Fitzpatrick FM, Donnelly S. Knowledge, attitudes, and clinical practice of rheumatologists in vaccination of the at-risk rheumatology patient population. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2012. link 44 Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis research & therapy 2011. link 45 Palmer D, El Miedany Y. Measures of outcome in patients with inflammatory arthritis. British journal of nursing (Mark Allen Publishing) 2008. link 46 Sandhu RS, Treharne GJ, Justice EA, Jordan AC, Saravana S, Obrenovic K et al.. Accessibility and quality of secondary care rheumatology services for people with inflammatory arthritis: a regional survey. Clinical medicine (London, England) 2007. link 47 Johnson PT, Fayad LM, Fishman EK. CT of the foot: selected inflammatory arthridites. Journal of computer assisted tomography 2007. link 48 Finney A, Thwaites C. Handling safety for patients with inflammatory arthritis. Nursing times 2006. link 49 Morrison WB, Ledermann HP, Schweitzer ME. MR imaging of inflammatory conditions of the ankle and foot. Magnetic resonance imaging clinics of North America 2001. link 50 Turan I, Lundberg I. Proposed treatment of cystic lesions in the first metatarsal in polyarthritic patients. The Journal of foot surgery 1989. link

    Original source

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      Design and validation of a referral algorithm for inflammatory arthritis and low back pain: identifying gaps in primary care practices.Ziade N, Mechleb K, Haouichat C, Baron F, Abdulateef Al-Ani N, Adnan AR et al. Clinical rheumatology (2026)
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      Integrating handheld ultrasound in rheumatology: A review of benefits and drawbacks.Sabido-Sauri R, Eder L, Emery P, Aydin SZ Best practice & research. Clinical rheumatology (2025)
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      Association Between Inflammatory Arthritis, Genetic Risk, and the Long-Term Risk of Degenerative Aortic Stenosis: A Prospective Cohort Study.Peng B, Zha L, Juaiti M, Lin W, Zhou X, Ou Z et al. Journal of the American Heart Association (2025)
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      Systematic Evaluation of Australian Risk Management Plans for Biologic Medicines.Ho JN, Hillen JB, Daniels B, Lim R, Pratt N Drug safety (2025)
    10. [10]
      Feasibility of Physiotherapist-Led Rheumatology Triage: A Randomized Study.Roberts JH, Gunn C, Mackinnon JE, Parlee S, Bakowsky V, Taylor T et al. The Journal of rheumatology (2024)
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      Intended and unintended consequences of strategies to meet performance benchmarks for rheumatologist referrals in a centralized intake system.Marshall DA, Tagimacruz T, Barber CEH, Cepoiu-Martin M, Lopatina E, Robert J et al. Journal of evaluation in clinical practice (2024)
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      A population-based analysis of rheumatology care patterns for inflammatory arthritis during COVID-19 in Alberta, Canada.Barber CEH, Lethebe BC, Szostakiwskyj JH, Barnabe C, Barber MRW, Katz S et al. Seminars in arthritis and rheumatism (2024)
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      Glucagon-Like Peptide 1 Receptor Agonists in Patients With Inflammatory Arthritis or Psoriasis: A Scoping Review.Karacabeyli D, Lacaille D Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (2024)
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      Seeing is believing: Smart use of musculoskeletal ultrasound in rheumatology practice.Koppikar S, Diaz P, Kaeley GS, Eder L Best practice & research. Clinical rheumatology (2023)
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      Letrozole-induced inflammatory arthritis and tendinopathy in pediatric rheumatology setting.Baba O, Kisaoglu H, Kalyoncu M International journal of rheumatic diseases (2023)
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      2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis.Nikiphorou E, Santos EJF, Marques A, Böhm P, Bijlsma JW, Daien CI et al. Annals of the rheumatic diseases (2021)
    22. [22]
      Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease.de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser E, Redzic JS, Helsen MM et al. Cytokine (2021)
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      The Effect of Triage Assessments on Identifying Inflammatory Arthritis and Reducing Rheumatology Wait Times in Ontario.Ahluwalia V, Lineker S, Sweezie R, Bell MJ, Kendzerska T, Widdifield J et al. The Journal of rheumatology (2020)
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      Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis.Knevel R, le Cessie S, Terao CC, Slowikowski K, Cui J, Huizinga TWJ et al. Science translational medicine (2020)
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      Patient Satisfaction and Costs of Multidisciplinary Models of Care in Rheumatology: a Review of the Recent Literature.Hall J, Julia Kaal K, Lee J, Duncan R, Tsao N, Harrison M Current rheumatology reports (2018)
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      An exploration of the experiences of rheumatology nurses counselling patients on methotrexate therapy.Robinson SM, Ryan S, Adams N, Hassell A, Walker D Musculoskeletal care (2018)
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      National variation in the composition of rheumatology multidisciplinary teams: a cross-sectional study.Ndosi M, Ferguson R, Backhouse MR, Bearne L, Ainsworth P, Roach A et al. Rheumatology international (2017)
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      Standards of care for inflammatory arthritis: A literature review.Wilson BA, Cooper M, Barber CEH Seminars in arthritis and rheumatism (2017)
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      The Duality of Economic Issues With Medication Non-adherence in Patients With Inflammatory Arthritis.Campbell NKJ, Saadeldin K, De Vera MA Current rheumatology reports (2017)
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      Clinical usefulness and patient satisfaction with a musculoskeletal ultrasound clinic: results of a 6-month pilot service in a Rheumatology Unit.Acebes C, Harvie JP, Wilson A, Duthie J, Bowen F, Steven M Rheumatology international (2016)
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      Development of System-level Performance Measures for Evaluation of Models of Care for Inflammatory Arthritis in Canada.Barber CE, Marshall DA, Mosher DP, Akhavan P, Tucker L, Houghton K et al. The Journal of rheumatology (2016)
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      Triage of Rheumatology Referrals Facilitates Wait Time Benchmarks.Farrer C, Abraham L, Jerome D, Hochman J, Gakhal N The Journal of rheumatology (2016)
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      Prevalence of foot problems in people with inflammatory arthritis in Singapore.Carter K, Lahiri M, Cheung PP, Santosa A, Rome K Journal of foot and ankle research (2016)
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      EULAR recommendations for patient education for people with inflammatory arthritis.Zangi HA, Ndosi M, Adams J, Andersen L, Bode C, Boström C et al. Annals of the rheumatic diseases (2015)
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      Review of a rheumatology triage system: simple, accurate, and effective.Carpenter T, Katz SJ Clinical rheumatology (2014)
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      A survey of psychological support provision for people with inflammatory arthritis in secondary care in England.Dures E, Almeida C, Caesley J, Peterson A, Ambler N, Morris M et al. Musculoskeletal care (2014)
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      Vaccination and inflammatory arthritis: overview of current vaccines and recommended uses in rheumatology.Müller-Ladner C, Müller-Ladner U Current rheumatology reports (2013)
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      Validation of a self-administered inflammatory arthritis detection tool for rheumatology triage.Tavares R, Wells GA, Bykerk VP, Guillemin F, Tugwell P, Bell MJ The Journal of rheumatology (2013)
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      Knowledge, attitudes, and clinical practice of rheumatologists in vaccination of the at-risk rheumatology patient population.McCarthy EM, Azeez MA, Fitzpatrick FM, Donnelly S Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (2012)
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      Advances in rheumatology: new targeted therapeutics.Tak PP, Kalden JR Arthritis research & therapy (2011)
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      Measures of outcome in patients with inflammatory arthritis.Palmer D, El Miedany Y British journal of nursing (Mark Allen Publishing) (2008)
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      Accessibility and quality of secondary care rheumatology services for people with inflammatory arthritis: a regional survey.Sandhu RS, Treharne GJ, Justice EA, Jordan AC, Saravana S, Obrenovic K et al. Clinical medicine (London, England) (2007)
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      CT of the foot: selected inflammatory arthridites.Johnson PT, Fayad LM, Fishman EK Journal of computer assisted tomography (2007)
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      Handling safety for patients with inflammatory arthritis.Finney A, Thwaites C Nursing times (2006)
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      MR imaging of inflammatory conditions of the ankle and foot.Morrison WB, Ledermann HP, Schweitzer ME Magnetic resonance imaging clinics of North America (2001)
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      Proposed treatment of cystic lesions in the first metatarsal in polyarthritic patients.Turan I, Lundberg I The Journal of foot surgery (1989)

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