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Psychiatry1 paper

Bipolar disorder in full remission

Last edited: 4/10/2026

Overview

Bipolar disorder (BD) is a chronic mental health condition characterized by significant mood swings. Even with appropriate treatment and symptomatic recovery, a substantial proportion of individuals with BD experience suboptimal functional adjustment 2. Cognitive impairment is a strong correlate of socio-occupational outcomes and quality of life in BD 2.

Diagnosis

No information provided in the abstracts.

Management

  • Maintenance Treatment: Lamotrigine was associated with a significantly lower relapse/recurrence rate compared to placebo 1.
  • Depressive Episodes: Lamotrigine as add-on treatment was associated with greater decreases in depressive symptomatology compared to placebo 1.
  • Cognitive Remediation (CR): CR is a promising treatment to bridge the gap between symptomatic and full functional recovery by improving cognitive and functional outcomes 2.

    • Special Populations

    No information provided in the abstracts.

    Key Recommendations

  • Lamotrigine should be considered as a maintenance treatment for bipolar disorder, as it is associated with a significantly lower relapse/recurrence rate than placebo 1. (Evidence: Strong)
  • Lamotrigine may be used as an add-on treatment for depressive episodes in bipolar disorder, showing greater decreases in depressive symptomatology compared to placebo 1. (Evidence: Strong)
  • Cognitive remediation approaches should be explored to improve cognitive and functional outcomes in patients with bipolar disorder, aiming for full functional recovery 2. (Evidence: Moderate)

    • References

    1 Haenen N, Kamperman AM, Prodan A, Nolen WA, Boks MP, Wesseloo R. The efficacy of lamotrigine in bipolar disorder: A systematic review and meta-analysis. Bipolar disorders 2024. link 2 Samamé C, Durante P, Cattaneo B, Aprahamian I, Strejilevich S. Efficacy of cognitive remediation in bipolar disorder: systematic review and meta-analysis of randomized controlled trials. Psychological medicine 2023. link 3 Harrison PJ, Hall N, Mould A, Al-Juffali N, Tunbridge EM. Cellular calcium in bipolar disorder: systematic review and meta-analysis. Molecular psychiatry 2021. link

    Original source

    1. [1]
      The efficacy of lamotrigine in bipolar disorder: A systematic review and meta-analysis. — Haenen N, Kamperman AM, Prodan A, Nolen WA, Boks MP, Wesseloo R Bipolar disorders (2024)
    2. [2]
      Efficacy of cognitive remediation in bipolar disorder: systematic review and meta-analysis of randomized controlled trials. — Samamé C, Durante P, Cattaneo B, Aprahamian I, Strejilevich S Psychological medicine (2023)
    3. [3]
      Cellular calcium in bipolar disorder: systematic review and meta-analysis. — Harrison PJ, Hall N, Mould A, Al-Juffali N, Tunbridge EM Molecular psychiatry (2021)
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