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Pediatrics237 papers

Oligohydramnios sequence

Last edited: 4/14/2026

Overview

Oligohydramnios sequence refers to a condition characterized by reduced amniotic fluid volume, often associated with adverse fetal outcomes including respiratory compromise and developmental issues, particularly when linked with conditions like chronic abruption 2.

Diagnosis

  • Key Diagnostic Criteria: Oligohydramnios detected via ultrasound, often associated with vaginal bleeding and fetal anomalies 2.
  • Recommended Tests: Detailed ultrasound evaluation to assess amniotic fluid volume, fetal anatomy, and placental position 7.
  • Grading: No specific grading system universally accepted; clinical assessment and severity of associated conditions guide management 2.
  • Management

  • First-Line Treatments: Close monitoring, maternal hydration, and bed rest in some cases 7.
  • Adjunctive Treatments: Amnioinfusion may be considered to relieve compression and improve fetal lung fluid dynamics 7.
  • Specific Interventions: Cordocentesis and amniocentesis for diagnostic purposes, though not therapeutic for oligohydramnios itself 17.
  • Special Populations

  • Pregnancy: Focus on monitoring and supportive care; termination criteria remain controversial 2.
  • Pediatrics: Postnatal management includes addressing respiratory issues and feeding difficulties, often requiring multidisciplinary care 211.
  • Key Recommendations

  • Regular Ultrasound Monitoring: Essential for early detection and management of oligohydramnios and associated complications 2 (Evidence: Moderate).
  • Consider Amnioinfusion: For severe cases to alleviate compression and improve fetal outcomes 7 (Evidence: Moderate).
  • Multidisciplinary Approach Postnatally: Necessary for infants with chronic abruption-oligohydramnios sequence to address respiratory and feeding challenges 211 (Evidence: Moderate).
  • Evaluate Respiratory Function Longitudinally: Monitor respiratory status up to three years postnatally to assess long-term prognosis 2 (Evidence: Weak).
  • Consult Pediatric Otolaryngology for Airway Management: Especially in cases with suspected airway obstruction postnatally 11 (Evidence: Expert opinion).
  • References

    1 Perez-Estrada BA, Acevedo-Gallegos S, Lumbreras-Marquez MI, Gardner R, Gallardo-Gaona JM. Cumulative sum learning curve for cordocentesis among maternal-fetal medicine fellows in a low-cost simulation model. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2024. link 2 Nishikawa S, Taki M, Okamoto H, Kawamura Y, Chigusa Y, Tomotaki S et al.. The prognosis of neonatal respiratory status within three years after birth in chronic abruption-oligohydramnios sequence. The journal of obstetrics and gynaecology research 2023. link 3 Fayoux P, Daniel SJ, Allen G, Balakrishnan K, Boudewyns A, Cheng A et al.. International Pediatric ORL Group (IPOG) Robin Sequence consensus recommendations. International journal of pediatric otorhinolaryngology 2020. link 4 Ramieri V, Basile E, Bosco G, Caresta E, Papoff P, Cascone P. Three-dimensional airways volumetric analysis before and after fast and early mandibular osteodistraction. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2017. link 5 Pinto MDB, Pegoraro-Krook MI, Andrade LKF, Correa APC, Rosa-Lugo LI, Dutka JCR. Intensive treatment of speech disorders in robin sequence: a case report. CoDAS 2017. link 6 de Buys Roessingh AS, Herzog G, Cherpillod J, Trichet-Zbinden C, Hohlfeld J. Speech prognosis and need of pharyngeal flap for non syndromic vs syndromic Pierre Robin Sequence. Journal of pediatric surgery 2008. link 7 Zubair I, Marcotte MP, Weinstein L, Brost BC. A novel amniocentesis model for learning stereotactic skills. American journal of obstetrics and gynecology 2006. link 8 Wilcox BK, Tatum SA. Cerebro-costo-mandibular syndrome presenting as Pierre Robin sequence. American journal of otolaryngology 2004. link 9 Denion E, Capon N, Martinot V, Pellerin P. Neonatal permanent jaw constriction because of oral synechiae and Pierre Robin sequence in a child with van der Woude syndrome. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2002. link 10 Maher JE, Kleinman GE, Lile W, Tolaymat L, Steele D, Bernard J. The construction and utility of an amniocentesis trainer. American journal of obstetrics and gynecology 1998. link70136-x) 11 Myer CM, Reed JM, Cotton RT, Willging JP, Shott SR. Airway management in Pierre Robin sequence. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1998. link 12 Deegan PC, McGlone B, McNicholas WT. Treatment of Robin sequence with nasal CPAP. The Journal of laryngology and otology 1995. link 13 Elliott MA, Studen-Pavlovich DA, Ranalli DN. Prevalence of selected pediatric conditions in children with Pierre Robin sequence. Pediatric dentistry 1995. link 14 Sherer DM, Spafford P. Prenatal sonographic evidence supporting an in utero developmental etiology of Möbius sequence. American journal of perinatology 1994. link 15 St Charles S, DiMario FJ, Grunnet ML. Möbius sequence: further in vivo support for the subclavian artery supply disruption sequence. American journal of medical genetics 1993. link 16 Reiser P, Briner J, Schinzel A. Skeletal muscular changes in Pena-Shokeir sequence. Journal of perinatal medicine 1990. link 17 Schrander-Stumpel C, Schrander J, Fryns JP, Hamers G. Caudal deficiency sequence in 7q terminal deletion. American journal of medical genetics 1988. link 18 Chappard D, Lauras B. Unusual morphodysplasia as a result of early amnion rupture: umbilico-cephalic adherence. Journal de genetique humaine 1983. link

    Original source

    1. [1]
      Cumulative sum learning curve for cordocentesis among maternal-fetal medicine fellows in a low-cost simulation model.Perez-Estrada BA, Acevedo-Gallegos S, Lumbreras-Marquez MI, Gardner R, Gallardo-Gaona JM International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2024)
    2. [2]
      The prognosis of neonatal respiratory status within three years after birth in chronic abruption-oligohydramnios sequence.Nishikawa S, Taki M, Okamoto H, Kawamura Y, Chigusa Y, Tomotaki S et al. The journal of obstetrics and gynaecology research (2023)
    3. [3]
      International Pediatric ORL Group (IPOG) Robin Sequence consensus recommendations.Fayoux P, Daniel SJ, Allen G, Balakrishnan K, Boudewyns A, Cheng A et al. International journal of pediatric otorhinolaryngology (2020)
    4. [4]
      Three-dimensional airways volumetric analysis before and after fast and early mandibular osteodistraction.Ramieri V, Basile E, Bosco G, Caresta E, Papoff P, Cascone P Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery (2017)
    5. [5]
      Intensive treatment of speech disorders in robin sequence: a case report.Pinto MDB, Pegoraro-Krook MI, Andrade LKF, Correa APC, Rosa-Lugo LI, Dutka JCR CoDAS (2017)
    6. [6]
      Speech prognosis and need of pharyngeal flap for non syndromic vs syndromic Pierre Robin Sequence.de Buys Roessingh AS, Herzog G, Cherpillod J, Trichet-Zbinden C, Hohlfeld J Journal of pediatric surgery (2008)
    7. [7]
      A novel amniocentesis model for learning stereotactic skills.Zubair I, Marcotte MP, Weinstein L, Brost BC American journal of obstetrics and gynecology (2006)
    8. [8]
      Cerebro-costo-mandibular syndrome presenting as Pierre Robin sequence.Wilcox BK, Tatum SA American journal of otolaryngology (2004)
    9. [9]
      Neonatal permanent jaw constriction because of oral synechiae and Pierre Robin sequence in a child with van der Woude syndrome.Denion E, Capon N, Martinot V, Pellerin P The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association (2002)
    10. [10]
      The construction and utility of an amniocentesis trainer.Maher JE, Kleinman GE, Lile W, Tolaymat L, Steele D, Bernard J American journal of obstetrics and gynecology (1998)
    11. [11]
      Airway management in Pierre Robin sequence.Myer CM, Reed JM, Cotton RT, Willging JP, Shott SR Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (1998)
    12. [12]
      Treatment of Robin sequence with nasal CPAP.Deegan PC, McGlone B, McNicholas WT The Journal of laryngology and otology (1995)
    13. [13]
      Prevalence of selected pediatric conditions in children with Pierre Robin sequence.Elliott MA, Studen-Pavlovich DA, Ranalli DN Pediatric dentistry (1995)
    14. [14]
      Prenatal sonographic evidence supporting an in utero developmental etiology of Möbius sequence.Sherer DM, Spafford P American journal of perinatology (1994)
    15. [15]
      Möbius sequence: further in vivo support for the subclavian artery supply disruption sequence.St Charles S, DiMario FJ, Grunnet ML American journal of medical genetics (1993)
    16. [16]
      Skeletal muscular changes in Pena-Shokeir sequence.Reiser P, Briner J, Schinzel A Journal of perinatal medicine (1990)
    17. [17]
      Caudal deficiency sequence in 7q terminal deletion.Schrander-Stumpel C, Schrander J, Fryns JP, Hamers G American journal of medical genetics (1988)
    18. [18]
      Unusual morphodysplasia as a result of early amnion rupture: umbilico-cephalic adherence.Chappard D, Lauras B Journal de genetique humaine (1983)

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